Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0195 | 0.3149 | 0.3059 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.013 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0651 | 0.0798 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0123 | 0.1711 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0123 | 0.1711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0107 | 0.1387 | 0.5044 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0169 | 0.2622 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0195 | 0.3149 | 0.1734 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0046 | 0.0175 | 0.0157 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0188 | 0.301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0651 | 0.0798 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0107 | 0.1387 | 0.5044 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0099 | 0.1235 | 0.112 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0107 | 0.1387 | 0.5044 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0123 | 0.1711 | 1 |
Onchocerca volvulus | 0.0447 | 0.8162 | 1 | |
Brugia malayi | hypothetical protein | 0.0447 | 0.8162 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0123 | 0.1711 | 0.1969 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0195 | 0.3149 | 0.2671 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0195 | 0.3149 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.8162 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0169 | 0.2622 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0123 | 0.1711 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0116 | 0.1569 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0123 | 0.1711 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Brugia malayi | Probable DNA topoisomerase II | 0.0123 | 0.1711 | 0.1969 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0123 | 0.1711 | 0.1602 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.8162 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0195 | 0.3149 | 0.3059 |
Schistosoma mansoni | lozenge | 0.0056 | 0.0381 | 0.1586 |
Leishmania major | DNA topoisomerase ii | 0.0107 | 0.1387 | 0.5044 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0123 | 0.1711 | 0.1969 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0169 | 0.2622 | 1 |
Loa Loa (eye worm) | runx1 | 0.0056 | 0.0381 | 0.0466 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0169 | 0.2622 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0123 | 0.1711 | 0.1969 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0149 | 0.2238 | 0.1697 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.013 | 0.0159 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0123 | 0.1711 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0123 | 0.1711 | 0.1602 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0107 | 0.1387 | 0.5044 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0123 | 0.1711 | 0.1969 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.013 | 0.0159 |
Echinococcus multilocularis | Protein lozenge | 0.0056 | 0.0381 | 0.1586 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.4793 | 0.4725 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0123 | 0.1711 | 0.1969 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.