Detailed information for compound 1399886

Basic information

Technical information
  • TDR Targets ID: 1399886
  • Name: 3-(4-methoxyphenyl)-1,6-dimethylpyrimido[5,6- e][1,2,4]triazine-5,7-dione
  • MW: 299.285 | Formula: C14H13N5O3
  • H donors: 0 H acceptors: 2 LogP: 0.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nn(C)c2c(n1)c(=O)n(c(=O)n2)C
  • InChi: 1S/C14H13N5O3/c1-18-13(20)10-12(16-14(18)21)19(2)17-11(15-10)8-4-6-9(22-3)7-5-8/h4-7H,1-3H3
  • InChiKey: BVFGFWOGCVXIFG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(4-methoxyphenyl)-1,6-dimethyl-pyrimido[5,6-e][1,2,4]triazine-5,7-dione
  • 3-(4-methoxyphenyl)-1,6-dimethyl-pyrimido[5,6-e][1,2,4]triazine-5,7-quinone
  • Oprea1_129099
  • STK249717
  • ZINC00342257
  • Oprea1_322265

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras No references
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Get druggable targets OG5_126968 All targets in OG5_126968
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase Get druggable targets OG5_127362 All targets in OG5_127362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dihydrolipoamide dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00382 dihydrolipoamide dehydrogenase [EC1.8.1.4], putative Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans dihydrolipoamide acetyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania mexicana dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme complexes of the mitochondria Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis glutathione reductase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide [EC2.3.1.61], putative Get druggable targets OG5_127362 All targets in OG5_127362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase Get druggable targets OG5_127362 All targets in OG5_127362
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis mercuric reductase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania infantum dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Theileria parva dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense 2-oxoglutarate dehydrogenase E2 component, putative Get druggable targets OG5_127362 All targets in OG5_127362
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense dihydrolipoyl dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei dihydrolipoyl dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis dihydrolipoyl dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Dihydrolipoamide S-succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component Get druggable targets OG5_127362 All targets in OG5_127362
Mycobacterium ulcerans dihydrolipoamide dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative Get druggable targets OG5_127362 All targets in OG5_127362
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras Get druggable targets OG5_126968 All targets in OG5_126968
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126968 All targets in OG5_126968
Brugia malayi dihydrolipoamide succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127362 All targets in OG5_127362
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme complexes of the mitochondria Get druggable targets OG5_126968 All targets in OG5_126968
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Get druggable targets OG5_126968 All targets in OG5_126968
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dihydrolipoamide dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania donovani 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania mexicana 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis dihydrolipoamide succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_127362 All targets in OG5_127362
Plasmodium yoelii dihydrolipoamide dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative Get druggable targets OG5_127362 All targets in OG5_127362
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_126968 All targets in OG5_126968
Candida albicans Dihydrolipoamide S-succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127362 All targets in OG5_127362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex Get druggable targets OG5_127362 All targets in OG5_127362
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni dihydrolipoamide dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB Get druggable targets OG5_127362 All targets in OG5_127362
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase Get druggable targets OG5_127362 All targets in OG5_127362
Onchocerca volvulus Get druggable targets OG5_127362 All targets in OG5_127362
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative Get druggable targets OG5_127362 All targets in OG5_127362
Leishmania braziliensis 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative Get druggable targets OG5_127362 All targets in OG5_127362
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma congolense dihydrolipoyl dehydrogenase Get druggable targets OG5_126968 All targets in OG5_126968
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Plasmodium vivax vivapain-2 0.002 0.0702 0.4338
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0702 0.077
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0012 0.0121 0.0179
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4536 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Echinococcus multilocularis cysteine protease 0.002 0.0702 0.3092
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0012 0.0121 0.0179
Leishmania major cathepsin L-like protease 0.002 0.0702 0.1316
Echinococcus multilocularis cathepsin L 0.001 0.004 0.0176
Treponema pallidum NADH oxidase 0.002 0.0672 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4536 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0672 0.4147
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0026 0.1073 0.0964
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.9107 0.9097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0251 0.138
Onchocerca volvulus 0.002 0.0702 1
Plasmodium falciparum thioredoxin reductase 0.002 0.0672 0.4147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.1565 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0702 0.1472
Brugia malayi dihydrolipoamide succinyltransferase 0.0015 0.0365 0.0403
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0251 0.0944
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.8127 0.7901
Onchocerca volvulus 0.002 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0251 0.0276
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0012 0.0121 0.0532
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0012 0.0121 0.0133
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0012 0.0121 0.0179
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Echinococcus granulosus cathepsin l1 0.002 0.0702 0.3092
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.1565 0.3392
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.004 0.0176
Onchocerca volvulus 0.002 0.0702 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.4536 1
Brugia malayi cathepsin L-like precursor 0.0014 0.0251 0.0276
Loa Loa (eye worm) cysteine protease 0.002 0.0702 0.0774
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0012 0.0121 0.0532
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.1565 0.3271
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0702 0.0774
Loa Loa (eye worm) glutathione reductase 0.002 0.0672 0.0742
Loa Loa (eye worm) hypothetical protein 0.0014 0.0251 0.0276
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0021 0.0785 0.4596
Toxoplasma gondii cathepsin CPL 0.002 0.0702 0.4022
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0702 0.3092
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2269 0.2491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.8127 0.8104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi MH2 domain containing protein 0.0144 0.9066 1
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.1565 1
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0251 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0702 0.0774
Brugia malayi glutathione reductase 0.002 0.0672 0.0742
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.9107 0.9097
Echinococcus granulosus thioredoxin glutathione reductase 0.002 0.0672 0.2964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Loa Loa (eye worm) hypothetical protein 0.0014 0.0251 0.0276
Plasmodium vivax vivapain-2 0.002 0.0702 0.4338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.4085 0.8997
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.125
Leishmania major cysteine peptidase A (CPA) 0.002 0.0702 0.1316
Entamoeba histolytica cysteine protease, putative 0.002 0.0702 0.2968
Plasmodium falciparum thioredoxin reductase 0.002 0.0672 0.4147
Schistosoma mansoni hypothetical protein 0.0043 0.2269 0.2491
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0026 0.1073 0.4492
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0672 0.1407
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.1565 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.004 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Loa Loa (eye worm) thioredoxin reductase 0.002 0.0672 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.1565 0.1726
Echinococcus multilocularis Biotin lipoyl attachment 0.0012 0.0121 0.0532
Loa Loa (eye worm) ctsf protein 0.002 0.0702 0.0774
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0702 0.4338
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.9066 1
Trypanosoma brucei trypanothione reductase 0.002 0.0672 0.1407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0785 0.0865
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0012 0.0121 0.0133
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0318 0.0351
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0012 0.0121 0.0179
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.001 0.0045 0.005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.8127 0.8104
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0318 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0021 0.0785 0.1504
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.1565 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0702 0.4338
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0021 0.0785 0.3458
Onchocerca volvulus Cathepsin L homolog 0.002 0.0702 1
Entamoeba histolytica hypothetical protein 0.0043 0.2269 1
Loa Loa (eye worm) fibroinase 0.002 0.0702 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Onchocerca volvulus 0.002 0.0702 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0672 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0251 0.138
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0672 0.1407
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0026 0.1073 0.6596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Toxoplasma gondii thioredoxin reductase 0.002 0.0672 0.382
Leishmania major cathepsin L-like protease 0.0077 0.4536 1
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0021 0.0785 0.3458
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0702 0.3092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.1565 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.8127 0.8104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0702 0.0774
Entamoeba histolytica hypothetical protein 0.0043 0.2269 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Plasmodium falciparum glutathione reductase 0.002 0.0672 0.4147
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0021 0.0785 0.1656
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0012 0.0121 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Entamoeba histolytica hypothetical protein 0.0043 0.2269 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0672 0.4147
Leishmania major trypanothione reductase 0.002 0.0672 0.125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Echinococcus granulosus cathepsin l1 0.0014 0.0251 0.1104
Plasmodium vivax thioredoxin reductase, putative 0.002 0.0672 0.4147
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.1565 0.1718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0702 0.4338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Leishmania major cathepsin L-like protease 0.0077 0.4536 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.002 0.0672 0.2964
Echinococcus granulosus cathepsin L 0.001 0.004 0.0176
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.004 0.0044
Echinococcus granulosus Biotin lipoyl attachment 0.0012 0.0121 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0702 0.4338
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.002 0.0672 0.0558
Entamoeba histolytica hypothetical protein 0.0043 0.2269 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.1565 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0672 0.1407
Onchocerca volvulus Cathepsin L homolog 0.002 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0702 0.0774
Onchocerca volvulus 0.002 0.0702 1
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.1565 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi Cathepsin L-like precursor 0.002 0.0702 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Leishmania major cathepsin L-like protease 0.002 0.0702 0.1316
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.004 0.0044
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0672 0.125
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0012 0.0121 0.0179
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.8127 0.8104
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.001 0.0045 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.4536 1
Echinococcus granulosus cysteine protease 0.001 0.004 0.0176
Brugia malayi Thioredoxin reductase 0.002 0.0672 0.0742
Brugia malayi Cathepsin L-like precursor 0.0014 0.0251 0.0276
Leishmania major cathepsin L-like protease 0.002 0.0702 0.1316
Onchocerca volvulus 0.002 0.0702 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.1565 1
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0021 0.0785 0.4596
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.1565 0.3392
Plasmodium vivax glutathione reductase, putative 0.002 0.0672 0.4147
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0702 0.3092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0672 0.382
Echinococcus multilocularis cysteine protease 0.002 0.0702 0.3092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.4536 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0702 0.3092
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0021 0.0785 0.1656
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0702 0.3092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Plasmodium falciparum glutathione reductase 0.002 0.0672 0.4147
Onchocerca volvulus Cathepsin F homolog 0.002 0.0702 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0702 0.2968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi Papain family cysteine protease containing protein 0.001 0.004 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.1565 0.3392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2269 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.1565 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0251 0.0276
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0021 0.0785 0.0861
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0702 0.077
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.1565 0.6897
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.1565 0.6897
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0021 0.0785 0.4882
Brugia malayi Papain family cysteine protease containing protein 0.001 0.004 0.0044
Leishmania major cathepsin L-like protease 0.002 0.0702 0.1316
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2269 1
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0672 0.1407
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.8127 0.8104
Brugia malayi Cathepsin L-like precursor 0.0014 0.0251 0.0276
Onchocerca volvulus 0.002 0.0702 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0702 0.3092
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0672 0.0558
Leishmania major cathepsin L-like protease 0.0077 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0702 0.4338
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0021 0.0785 0.0865
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.3423 0.7525
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0702 0.4338
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0021 0.0785 0.1656
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0672 0.1407
Brugia malayi hypothetical protein 0.0043 0.2269 0.2503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Loa Loa (eye worm) hypothetical protein 0.0015 0.0365 0.0403
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0672 0.1407
Onchocerca volvulus 0.0015 0.0365 0.2543
Mycobacterium tuberculosis Probable reductase 0.013 0.8127 0.8104
Leishmania major cathepsin L-like protease 0.002 0.0702 0.1316
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0702 0.2968
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0021 0.0785 0.4882
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0672 0.125
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.9066 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 40 nM Inhibition Assay BINDINGDB. No reference
IC50 (binding) = 70 nM Inhibition Assay BINDINGDB. No reference
Potency (functional) 0.1632 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 0.3548 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.8493 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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