Detailed information for compound 1399940

Basic information

Technical information
  • TDR Targets ID: 1399940
  • Name: 6-ethyl-4-[(4-methylpiperidin-1-yl)methyl]chr omen-2-one
  • MW: 285.381 | Formula: C18H23NO2
  • H donors: 0 H acceptors: 1 LogP: 3.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)c(CN1CCC(CC1)C)cc(=O)o2
  • InChi: 1S/C18H23NO2/c1-3-14-4-5-17-16(10-14)15(11-18(20)21-17)12-19-8-6-13(2)7-9-19/h4-5,10-11,13H,3,6-9,12H2,1-2H3
  • InChiKey: ZLVPOCYJHQQKHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-ethyl-4-[(4-methyl-1-piperidyl)methyl]chromen-2-one
  • 6-ethyl-4-[(4-methyl-1-piperidinyl)methyl]-2-chromenone
  • 6-ethyl-4-[(4-methyl-1-piperidyl)methyl]coumarin
  • MLS000083458
  • SMR000047940

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1213 0.1587
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1113 0.8025
Brugia malayi follicle stimulating hormone receptor 0.0046 0.1213 0.1587
Echinococcus multilocularis muscleblind protein 1 0.0146 0.5006 0.6929
Trichomonas vaginalis esterase, putative 0.0043 0.1113 0.0933
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0991 0.7141
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0052 0.1439 0.1883
Brugia malayi intermediate filament protein 0.0033 0.07 0.0915
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0187 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0187 0.0244
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trichomonas vaginalis set domain proteins, putative 0.0245 0.8772 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1387 1
Schistosoma mansoni biogenic amine receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0032 0.0677 0.0885
Loa Loa (eye worm) hypothetical protein 0.0033 0.07 0.0915
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0326 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Schistosoma mansoni ap endonuclease 0.0023 0.0326 0.0451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1113 0.1541
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0881 0.1153
Echinococcus granulosus g protein coupled receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis musashi 0.0033 0.07 0.0968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0326 0.2926
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1559 0.2158
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1113 0.742
Echinococcus granulosus allatostatin A receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis cpg binding protein 0.0033 0.0713 0.0986
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.1213 0.1679
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1213 0.1679
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.585 0.7652
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1213 0.1679
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4932 0.6452
Echinococcus granulosus zinc finger protein 0.0025 0.0424 0.0586
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0187 0.0259
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.1213 0.1679
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Brugia malayi ORL1-like opioid receptor 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0043 0.1113 0.0671
Brugia malayi Dopamine receptor protein 2 0.0046 0.1213 0.1587
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0881 0.1153
Onchocerca volvulus 0.0046 0.1213 0.0793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0881 0.0658
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.1213 0.1679
Onchocerca volvulus 0.0043 0.1113 0.0671
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.006 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0881 0.0658
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4932 0.6452
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0991 0.8898
Leishmania major hypothetical protein, conserved 0.0043 0.1113 0.8025
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.1213 0.1679
Schistosoma mansoni lamin 0.0033 0.07 0.0968
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0591 0.0818
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus g-protein coupled receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1213 0.1679
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0326 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0326 0.2348
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis geminin 0.0205 0.7226 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1113 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1113 0.1113
Onchocerca volvulus 0.0046 0.1213 0.0793
Onchocerca volvulus 0.0046 0.1213 0.0793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1559 0.2158
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.585 0.8096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus lamin 0.0033 0.07 0.0968
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.1213 0.1679
Schistosoma mansoni amine GPCR 0.0046 0.1213 0.1679
Brugia malayi Cytochrome P450 family protein 0.004 0.0991 0.1296
Schistosoma mansoni biogenic amine receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.1213 0.1679
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1113 0.1541
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1113 0.0933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1559 0.2158
Brugia malayi neuropeptide F receptor 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.1387 0.8178
Schistosoma mansoni cpg binding protein 0.0033 0.0713 0.0986
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1213 0.1679
Brugia malayi hypothetical protein 0.0051 0.1387 0.1815
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0187 0.0244
Schistosoma mansoni intermediate filament proteins 0.0033 0.07 0.0968
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi CXXC zinc finger family protein 0.0029 0.0563 0.0736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi neuropeptide F receptor 0.0046 0.1213 0.1587
Schistosoma mansoni cpg binding protein 0.0033 0.0713 0.0986
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1113 0.1541
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1213 0.1679
Schistosoma mansoni lamin 0.0033 0.07 0.0968
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1213 0.1679
Brugia malayi putative neuropeptide receptor 0.0046 0.1213 0.1587
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Mycobacterium tuberculosis Conserved protein 0.0043 0.1113 0.1113
Echinococcus granulosus somatostatin receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trypanosoma brucei cytochrome P450, putative 0.004 0.0991 0.7141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.006 0.1748 0.2286
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1113 0.0933
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0046 0.1213 0.0793
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0326 0.5
Schistosoma mansoni biogenic amine receptor 0.0046 0.1213 0.1679
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.1213 0.1587
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.1213 0.1679
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi Dopamine receptor 0.0046 0.1213 0.1587
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0881 0.0658
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.1387 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1213 0.1679
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1113 0.1456
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.1213 0.1587
Toxoplasma gondii ABC1 family protein 0.0043 0.1113 0.6564
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.1213 0.1679
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Brugia malayi beta-lactamase family protein 0.0043 0.1113 0.1456
Plasmodium vivax SET domain protein, putative 0.0031 0.0658 0.3132
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0097 0.3157 0.3161
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptide s receptor 0.0046 0.1213 0.1679
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus granulosus orexin receptor type 2 0.0046 0.1213 0.1679
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1387 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.07 0.0915
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Echinococcus granulosus hypothetical protein 0.0046 0.1213 0.1679
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1213 0.1679
Onchocerca volvulus 0.0046 0.1213 0.0793
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis muscleblind protein 0.0146 0.5006 0.6929
Schistosoma mansoni alpha glucosidase 0.0037 0.0881 0.122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1559 0.2158
Loa Loa (eye worm) hypothetical protein 0.0026 0.0455 0.0595
Trypanosoma brucei ISWI complex protein 0.0018 0.0165 0.119
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.1213 0.1679
Leishmania major hypothetical protein, conserved 0.0051 0.1387 1
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Mycobacterium tuberculosis Conserved protein 0.0043 0.1113 0.1113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1213 0.1679
Brugia malayi Pre-SET motif family protein 0.0031 0.0658 0.0861
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1213 0.1679
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0881 0.0658
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1559 0.2158
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.585 0.7652
Loa Loa (eye worm) hypothetical protein 0.0146 0.5006 0.6548
Echinococcus granulosus geminin 0.0205 0.7226 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1387 1
Loa Loa (eye worm) CYP4Cod1 0.004 0.0991 0.1296
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.1213 0.1587
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0658 0.0911
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1213 0.1679
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0326 0.0451
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.1213 0.1587
Schistosoma mansoni opsin-like receptor 0.0046 0.1213 0.1679
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0991 0.7141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.1213 0.1679
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0326 0.0426
Mycobacterium ulcerans beta-lactamase 0.0043 0.1113 1
Onchocerca volvulus 0.0043 0.1113 0.0671
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1213 0.1679
Brugia malayi beta-lactamase family protein 0.0043 0.1113 0.1456
Echinococcus granulosus serotonin receptor 0.0046 0.1213 0.1679
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0126 0.0165
Brugia malayi beta-lactamase 0.0043 0.1113 0.1456
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1113 0.0933
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1559 0.2158
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0046 0.1213 0.1679
Brugia malayi hypothetical protein 0.0033 0.0706 0.0923
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1113 0.1113
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0991 0.1296
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1213 0.1679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.1439 0.1992
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1213 0.1679
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0245 0.034
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0126 0.0165
Schistosoma mansoni neuropeptide receptor 0.0046 0.1213 0.1679
Schistosoma mansoni myosin xvIII 0.0046 0.1213 0.1679
Schistosoma mansoni amine GPCR 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0046 0.1213 0.1679
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1559 0.2158
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0046 0.1213 0.0793
Brugia malayi Melatonin receptor type 1A 0.0046 0.1213 0.1587
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0559 0.0774
Echinococcus granulosus lamin dm0 0.0033 0.07 0.0968
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0046 0.1213 0.0793
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0881 0.0658
Echinococcus granulosus g protein coupled receptor 0.0046 0.1213 0.1679
Brugia malayi Muscleblind-like protein 0.0146 0.5006 0.6548
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.1213 0.1587
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0327 0.0452
Echinococcus multilocularis orexin receptor type 2 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0019 0.0187 0.0244
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0041 0.1025 0.1341
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.1213 0.1587
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1025 0.1341
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1213 0.1679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.1439 0.1992
Schistosoma mansoni opsin-like receptor 0.0046 0.1213 0.1679
Onchocerca volvulus 0.0046 0.1213 0.0793
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1113 0.1113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1213 0.1679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0658 0.0911
Schistosoma mansoni hypothetical protein 0.0019 0.0187 0.0259
Schistosoma mansoni hypothetical protein 0.0205 0.7226 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.496 0.6865
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0881 0.5195
Brugia malayi Dopamine receptor protein 1 0.0046 0.1213 0.1587
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0273 0.0358
Schistosoma mansoni hypothetical protein 0.0019 0.0187 0.0259
Loa Loa (eye worm) hypothetical protein 0.0051 0.1387 0.1815
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.585 0.8096
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0881 0.0658
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.1387 1
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis lamin 0.0033 0.07 0.0968
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0881 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0165 0.119
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.1213 0.1679
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.1213 0.1587
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0053 0.148 0.1936
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1213 0.1679
Mycobacterium ulcerans lipase LipD 0.0043 0.1113 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0327 0.0452
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1213 0.1679
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1387 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1113 0.0933
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1113 0.1456
Brugia malayi Bromodomain containing protein 0.0092 0.2962 0.3875
Brugia malayi AKH receptor 0.0046 0.1213 0.1587
Mycobacterium ulcerans hypothetical protein 0.0043 0.1113 1
Onchocerca volvulus 0.0046 0.1213 0.0793
Schistosoma mansoni neuropeptide receptor 0.0046 0.1213 0.1679
Schistosoma mansoni cpg binding protein 0.0029 0.0563 0.0779
Schistosoma mansoni histamine h1 receptor 0.0046 0.1213 0.1679
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0881 0.0658
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.1439 0.1992
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0023 0.0327 0.0452
Mycobacterium leprae Probable lipase LipE 0.0043 0.1113 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1113 0.0933
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.2261 0.313
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0881 0.122
Brugia malayi Pre-SET motif family protein 0.0216 0.7645 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.1213 0.1679
Brugia malayi Bromodomain containing protein 0.0046 0.1219 0.1594
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Leishmania major cytochrome p450-like protein 0.004 0.0991 0.7141
Brugia malayi RE15519p 0.0046 0.1213 0.1587
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.07 0.0915
Onchocerca volvulus 0.0033 0.07 0.0167
Schistosoma mansoni amine GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1213 0.1679
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.1213 0.1679
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1559 0.204
Schistosoma mansoni hypothetical protein 0.0041 0.1025 0.1419
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1213 0.1679
Schistosoma mansoni opsin-like receptor 0.0046 0.1213 0.1679
Brugia malayi Serotonin receptor 0.0046 0.1213 0.1587
Brugia malayi PHD-finger family protein 0.0032 0.0668 0.0874
Echinococcus multilocularis somatostatin receptor 0.0046 0.1213 0.1679
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0187 0.0259
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.1213 0.1679
Echinococcus granulosus cpg binding protein 0.0033 0.0713 0.0986
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.006 0.0084
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.1213 0.1587
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.1213 0.1587
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1113 0.1113
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.1213 0.1679
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Trypanosoma cruzi ISWI complex protein 0.0018 0.0165 0.119
Echinococcus granulosus intermediate filament protein 0.0033 0.07 0.0968
Schistosoma mansoni neuropeptide receptor 0.0046 0.1213 0.1679
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1748 0.2286
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.1213 0.1679
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1559 0.204
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1213 0.1679
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.111 0.1536
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.111 0.1536
Onchocerca volvulus 0.0046 0.1213 0.0793
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0326 0.2348
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0326 0.0426
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0049
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0245 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.1213 0.1679
Brugia malayi Cytochrome P450 family protein 0.004 0.0991 0.1296
Schistosoma mansoni amine GPCR 0.0046 0.1213 0.1679
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.1213 0.1679
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0991 0.1296
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0079
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis serotonin receptor 0.0046 0.1213 0.1679
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis serotonin receptor 0.0046 0.1213 0.1679
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.1213 0.0793
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0409 0.0536
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0326 0.2348
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0658 0.0911
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0658 0.388
Schistosoma mansoni amine GPCR 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptide receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1113 0.8025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0205 0.7226 1
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.1439 0.1992
Echinococcus granulosus muscleblind protein 0.0146 0.5006 0.6929
Brugia malayi G-protein coupled receptor 0.0046 0.1213 0.1587
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.1213 0.1587
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0881 0.122
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.585 0.8096
Schistosoma mansoni zinc finger protein 0.0025 0.0424 0.0586
Schistosoma mansoni bromodomain containing protein 0.0078 0.2425 0.3357
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.07 0.0915
Onchocerca volvulus 0.0046 0.1213 0.0793
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.1213 0.1679
Leishmania major hypothetical protein, conserved 0.0018 0.0165 0.119
Brugia malayi MH2 domain containing protein 0.0144 0.4932 0.6452
Echinococcus multilocularis GPCR, family 2 0.0019 0.0187 0.0259
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0881 0.0658
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus granulosus GPCR family 2 0.0019 0.0187 0.0259
Schistosoma mansoni hypothetical protein 0.0019 0.0187 0.0259
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1213 0.1679
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.1213 0.0793
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.1213 0.1679
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.7645 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1113 0.8025
Schistosoma mansoni hypothetical protein 0.0018 0.0165 0.0228
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0881 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0326 0.0326
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0563 0.0736
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1222 0.1598
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1213 0.1679
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0881 0.6352
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus sex peptide receptor 0.0046 0.1213 0.1679
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.2261 0.313
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1113 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0046 0.1213 0.1679
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.1213 0.1679
Echinococcus granulosus fmrfamide receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0049 0.133 0.174
Brugia malayi G protein-coupled receptor 0.0046 0.1213 0.1587
Mycobacterium tuberculosis Conserved protein 0.0043 0.1113 0.1113
Echinococcus granulosus g protein coupled receptor 0.0046 0.1213 0.1679
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1113 0.1113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.1213 0.1587
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1748 0.2286
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1696 1
Onchocerca volvulus 0.0033 0.07 0.0167
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.1213 0.1679
Brugia malayi larval opioid receptor 0.0046 0.1213 0.1587
Loa Loa (eye worm) hypothetical protein 0.0043 0.1113 0.1456
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1213 0.1679
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1213 0.1679
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0881 0.0658
Echinococcus multilocularis sex peptide receptor 0.0046 0.1213 0.1679
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0559 0.0774
Echinococcus multilocularis zinc finger protein 0.0025 0.0424 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Onchocerca volvulus 0.0046 0.1213 0.0793
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1213 0.1679
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0559 0.0774
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1213 0.1587
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0326 0.0451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1748 0.2286
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1213 0.1587
Toxoplasma gondii exonuclease III APE 0.0023 0.0326 0.192
Loa Loa (eye worm) hypothetical protein 0.0085 0.2704 0.3536
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Trypanosoma brucei glucosidase, putative 0.0037 0.0881 0.6352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0187 0.0244
Schistosoma mansoni hypothetical protein 0.0019 0.0187 0.0259
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0049
Brugia malayi G-protein coupled receptor 0.0046 0.1213 0.1587
Brugia malayi GnHR receptor homolog 0.0046 0.1213 0.1587
Schistosoma mansoni neuropeptide receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0146 0.5006 0.6548
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0245 0.8772 1
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Brugia malayi Serotonin receptor 0.0046 0.1213 0.1587
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1113 1
Brugia malayi sulfakinin receptor protein 0.0046 0.1213 0.1587
Loa Loa (eye worm) beta-lactamase 0.0043 0.1113 0.1456
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0881 0.6352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0187 0.0259
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1213 0.1679
Schistosoma mansoni ap endonuclease 0.0023 0.0326 0.0451
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1213 0.1679
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1213 0.1679
Brugia malayi hypothetical protein 0.0046 0.1213 0.1587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0326 0.2348
Schistosoma mansoni adenoreceptor 0.0046 0.1213 0.1679
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1113 0.1541
Schistosoma mansoni hypothetical protein 0.0046 0.1213 0.1679
Echinococcus multilocularis allatostatin A receptor 0.0046 0.1213 0.1679
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.1213 0.1587
Echinococcus granulosus neuropeptide receptor 0.0046 0.1213 0.1679
Schistosoma mansoni hypothetical protein 0.0025 0.0409 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0881 0.6352
Echinococcus multilocularis lamin dm0 0.0033 0.07 0.0968
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0245 0.034
Schistosoma mansoni alpha-glucosidase 0.0145 0.496 0.6865
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.1213 0.1587
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1213 0.1679
Schistosoma mansoni zinc finger protein 0.0018 0.0165 0.0228
Loa Loa (eye worm) hypothetical protein 0.0046 0.1213 0.1587
Onchocerca volvulus 0.0031 0.0658 0.0117
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0245 0.034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1837 0.2542
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.1213 0.1679

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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