Detailed information for compound 1400085

Basic information

Technical information
  • TDR Targets ID: 1400085
  • Name: N-[(4-methylcyclohexylidene)amino]-2-pyrrol-1 -ylbenzamide
  • MW: 295.379 | Formula: C18H21N3O
  • H donors: 1 H acceptors: 1 LogP: 3.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC/C(=N/NC(=O)c2ccccc2n2cccc2)/CC1
  • InChi: 1S/C18H21N3O/c1-14-8-10-15(11-9-14)19-20-18(22)16-6-2-3-7-17(16)21-12-4-5-13-21/h2-7,12-14H,8-11H2,1H3,(H,20,22)/b19-15-
  • InChiKey: YNUYLOSMZWGDHJ-CYVLTUHYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(4-methylcyclohexylidene)amino]-2-pyrrol-1-yl-benzamide
  • N-[(4-methylcyclohexylidene)amino]-2-(1-pyrrolyl)benzamide
  • ZINC07889903

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1025 0.1165
Onchocerca volvulus 0.003 0.0604 0.4685
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0571 1
Entamoeba histolytica hypothetical protein 0.0028 0.0571 1
Echinococcus granulosus geminin 0.0205 0.4796 0.4796
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1651 1
Schistosoma mansoni ran 0.0026 0.0509 0.0509
Echinococcus multilocularis transportin 1 0.0007 0.0053 0.0053
Echinococcus granulosus Smad4 0.001 0.013 0.013
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3348 0.3805
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0071 0.0071
Brugia malayi MH1 domain containing protein 0.0005 0.0025 0.0037
Loa Loa (eye worm) nuclear factor I 0.0005 0.0025 0.0028
Echinococcus granulosus cpg binding protein 0.0031 0.0645 0.0645
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0114 0.0114
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0729 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1651 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1651 0.1651
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1651 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0222 0.0222
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0509 0.2853
Echinococcus granulosus importin subunit beta 1 0.0035 0.0729 0.0729
Brugia malayi kap beta 3 protein 0.0007 0.0053 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0624 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.013 0.0148
Brugia malayi MH2 domain containing protein 0.0144 0.3348 0.4971
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Brugia malayi CXXC zinc finger family protein 0.003 0.0604 0.0897
Echinococcus granulosus snurportin 1 0.0372 0.8798 0.8798
Brugia malayi hypothetical protein 0.002 0.0366 0.0543
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0729 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0053 0.006
Schistosoma mansoni cpg binding protein 0.0031 0.0645 0.0645
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1651 0.1651
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6734 0.6734
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Brugia malayi MH1 domain containing protein 0.001 0.013 0.0193
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0509 0.0509
Schistosoma mansoni cpg binding protein 0.0031 0.0645 0.0645
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0624 0.8448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1025 0.1025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0071 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0509 0.5
Brugia malayi MH1 domain containing protein 0.001 0.013 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1025 0.1025
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.013 0.013
Leishmania major hypothetical protein, conserved 0.003 0.0624 0.3574
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0509 0.0509
Echinococcus multilocularis translational activator gcn1 0.0007 0.0053 0.0053
Brugia malayi MH2 domain containing protein 0.001 0.013 0.0193
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0056 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Entamoeba histolytica Ran family GTPase 0.0026 0.0509 0.8795
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.013 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Schistosoma mansoni hypothetical protein 0.0014 0.0222 0.0222
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6734 0.6734
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Echinococcus granulosus translational activator gcn1 0.0007 0.0053 0.0053
Brugia malayi MH1 domain containing protein 0.0005 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0058 0.129 0.129
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0729 0.4231
Echinococcus multilocularis geminin 0.0205 0.4796 0.4796
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0729 0.0729
Echinococcus multilocularis snurportin 1 0.0372 0.8798 0.8798
Schistosoma mansoni ran 0.0026 0.0509 0.0509
Brugia malayi MH2 domain containing protein 0.001 0.013 0.0193
Trichomonas vaginalis ran, putative 0.0026 0.0509 0.8795
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0509 0.6744
Schistosoma mansoni cpg binding protein 0.003 0.0604 0.0604
Schistosoma mansoni importin beta-1 0.0035 0.0729 0.0729
Echinococcus multilocularis Smad4 0.001 0.013 0.013
Plasmodium falciparum importin beta, putative 0.0035 0.0729 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0624 1
Echinococcus granulosus smad 0.001 0.013 0.013
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.003 0.0624 0.0709
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0624 0.8448
Loa Loa (eye worm) hypothetical protein 0.0005 0.0025 0.0028
Brugia malayi hypothetical protein 0.003 0.0624 0.0926
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0071 0.0071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.8798 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1025 0.1522
Brugia malayi RNA, U transporter 1 0.0099 0.2266 0.3366
Schistosoma mansoni importin-beta 2 0.0007 0.0053 0.0053
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0604 0.0687
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0624 0.3574
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0509 0.0578
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0509 0.6744
Schistosoma mansoni survival motor neuron protein 0.0058 0.129 0.129
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Echinococcus multilocularis importin 5 0.0007 0.0053 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0071 0.0071
Echinococcus granulosus transportin 1 0.0007 0.0053 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1651 0.5
Loa Loa (eye worm) hypothetical protein 0.0286 0.6734 0.7654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1025 0.1025
Echinococcus granulosus importin 5 0.0007 0.0053 0.0053
Brugia malayi Importin beta-1 subunit 0.0035 0.0729 0.1082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1025 0.1025
Schistosoma mansoni hypothetical protein 0.0205 0.4796 0.4796
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.013 0.013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0509 0.6744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1239 0.7422
Schistosoma mansoni Smad4 0.001 0.013 0.013
Echinococcus multilocularis smad 0.001 0.013 0.013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0222 0.0222
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3348 0.3805
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Leishmania major importin beta-1 subunit, putative 0.0028 0.0571 0.3244
Leishmania major GTP-binding protein, putative 0.0026 0.0509 0.2853
Brugia malayi hypothetical protein 0.0286 0.6734 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Plasmodium vivax importin-beta 2, putative 0.0035 0.0729 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0645 0.0645
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1651 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1651 0.1651
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.013 0.013
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0571 1
Onchocerca volvulus 0.0058 0.129 1
Schistosoma mansoni hypothetical protein 0.0205 0.4796 0.4796
Schistosoma mansoni hypothetical protein 0.0372 0.8798 0.8798
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0112 0.0166
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0071 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1651 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1025 0.1025
Brugia malayi Smad1 0.001 0.013 0.0193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0729 0.0828
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Schistosoma mansoni smad1 5 8 and 0.001 0.013 0.013
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0114 0.013
Schistosoma mansoni smad1 5 8 and 0.001 0.013 0.013
Trichomonas vaginalis helicase, putative 0.0007 0.0056 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.129 0.1915
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1025 0.1025
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1651 0.1651
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0056 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0056 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0056 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0624 0.8448
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0624 0.8448
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0571 1
Schistosoma mansoni smad 0.001 0.013 0.013
Schistosoma mansoni smad1 5 8 and 0.001 0.013 0.013
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0053 0.006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.013 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1025 0.1025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0571 0.542
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0509 0.0755
Loa Loa (eye worm) Smad1 0.001 0.013 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.14 0.14

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.