Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase | 0.0043 | 0.0944 | 0.1953 |
Onchocerca volvulus | 0.0043 | 0.0944 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Onchocerca volvulus | 0.0043 | 0.0944 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0944 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0944 | 0.1953 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4836 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0944 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0854 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0944 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0944 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0944 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1591 | 0.3289 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0944 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0944 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0944 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1591 | 0.3289 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1591 | 0.3289 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1591 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4836 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0944 | 0.1953 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0944 | 0.1953 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0944 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0944 | 0.1953 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0944 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0944 | 0.1953 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0944 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0944 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0944 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0854 | 0.1767 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0944 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0944 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4836 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0854 | 0.9048 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0944 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0944 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0944 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0944 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0944 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.