Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.2469 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0373 | 0.0373 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2469 | 0.3546 |
Loa Loa (eye worm) | ctsf protein | 0.0016 | 0.0174 | 0.0174 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0373 | 0.0536 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.3124 | 0.4487 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2469 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.1466 | 0.4692 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0026 | 0.0855 | 0.1228 |
Onchocerca volvulus | 0.0019 | 0.0373 | 0.1543 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2469 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0019 | 0.0349 | 0.1116 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.2414 | 0.7249 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0174 | 0.0249 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.333 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0373 | 0.0373 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.3124 | 0.4487 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.2314 | 0.3323 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.3124 | 0.9381 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0373 | 0.0536 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.3124 | 0.4487 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0373 | 0.0536 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.6963 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.333 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0174 | 0.0249 |
Loa Loa (eye worm) | cysteine protease | 0.0016 | 0.0174 | 0.0174 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.333 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0016 | 0.0174 | 0.0174 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.1466 | 0.2105 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.2469 | 0.7413 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0049 | 0.2469 | 0.7413 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.2469 | 0.7903 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.2469 | 0.7413 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0049 | 0.2469 | 0.7413 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0174 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.6963 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0174 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0373 | 0.0373 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.3124 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0026 | 0.0855 | 0.1228 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.2469 | 0.3546 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.0174 | 0.0249 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0174 | 0.5 |
Leishmania major | cysteine peptidase A (CPA) | 0.0016 | 0.0174 | 0.0521 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.1466 | 0.2105 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Schistosoma mansoni | single-minded | 0.0047 | 0.2314 | 0.3323 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.333 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0019 | 0.0349 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0019 | 0.0349 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0373 | 0.0373 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0373 | 0.0373 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.333 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.333 | 1 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.4582 | 0.658 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.6963 | 1 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0174 | 0.0521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Toxoplasma gondii | cathepsin CPL | 0.0016 | 0.0174 | 0.0556 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0019 | 0.0349 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0174 | 0.0249 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0373 | 0.0536 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0016 | 0.0174 | 0.0174 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.3124 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.3124 | 0.4487 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.2469 | 0.3546 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2469 | 0.7413 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.0174 | 0.0174 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0373 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.0174 | 0.0249 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0016 | 0.0174 | 0.5 |
Echinococcus granulosus | RUN | 0.0019 | 0.0373 | 0.0536 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3124 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.2959 | 0.8885 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.2469 | 0.7413 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.2469 | 0.7413 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.2469 | 0.2469 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.2469 | 0.7413 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.0174 | 0.0521 |
Chlamydia trachomatis | glutamine binding protein | 0.0019 | 0.0349 | 0.5 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.0174 | 0.0249 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3124 | 1 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0373 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0174 | 0.0174 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0174 | 0.0249 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.2314 | 0.2314 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2469 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0146 | 0.9152 | 0.9152 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0373 | 0.0536 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0174 | 0.0249 |
Onchocerca volvulus | 0.0019 | 0.0373 | 0.1543 | |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.1466 | 0.1466 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0174 | 0.0521 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0373 | 0.0536 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0373 | 0.0536 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0373 | 0.0536 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0174 | 0.0521 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0373 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0174 | 0.0249 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.256 | 0.256 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.2469 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0146 | 0.9152 | 0.9152 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0373 | 0.0536 |
Loa Loa (eye worm) | fibroinase | 0.0016 | 0.0174 | 0.0174 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0373 | 0.0536 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0026 | 0.0855 | 0.1228 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.333 | 1 |
Onchocerca volvulus | 0.0035 | 0.1466 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.2469 | 0.3546 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.2469 | 0.3546 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0373 | 0.0536 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0019 | 0.0349 | 0.1116 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0373 | 0.0373 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0174 | 0.0521 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3124 | 1 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0174 | 0.0521 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.2469 | 0.2469 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0174 | 0.0249 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.333 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0174 | 0.0174 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.256 | 0.256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.