Detailed information for compound 1400264

Basic information

Technical information
  • TDR Targets ID: 1400264
  • Name: N-[[3-(4-chlorophenyl)sulfonyl-1,3-oxazolidin -2-yl]methyl]-N'-[2-(2-methoxyphenyl)ethyl]ox amide
  • MW: 481.95 | Formula: C21H24ClN3O6S
  • H donors: 2 H acceptors: 4 LogP: 2.44 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CCNC(=O)C(=O)NCC1OCCN1S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C21H24ClN3O6S/c1-30-18-5-3-2-4-15(18)10-11-23-20(26)21(27)24-14-19-25(12-13-31-19)32(28,29)17-8-6-16(22)7-9-17/h2-9,19H,10-14H2,1H3,(H,23,26)(H,24,27)
  • InChiKey: CGBKGLPIYJIXDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[3-(4-chlorophenyl)sulfonyloxazolidin-2-yl]methyl]-N'-[2-(2-methoxyphenyl)ethyl]oxamide
  • N-[[3-(4-chlorophenyl)sulfonyl-2-oxazolidinyl]methyl]-N'-[2-(2-methoxyphenyl)ethyl]oxamide
  • N-[[3-(4-chlorophenyl)sulfonyl-1,3-oxazolidin-2-yl]methyl]-N'-[2-(2-methoxyphenyl)ethyl]ethanediamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0021 0.0099
Mycobacterium ulcerans DNA polymerase IV 0.0164 0.1157 0.5462
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0037 0.0227
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0186 0.0186
Toxoplasma gondii thioredoxin reductase 0.0103 0.0679 0.5339
Brugia malayi Carboxylesterase family protein 0.0503 0.3831 0.3825
Echinococcus granulosus carboxylesterase 5A 0.0503 0.3831 0.552
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0105 0.0105
Schistosoma mansoni regulator of G protein signaling 0.004 0.0186 0.0256
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0268 0.1452
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0081 0.0072
Brugia malayi chromobox protein homolog 3 0.0041 0.0189 0.018
Treponema pallidum phosphoglycerate kinase 0.0177 0.1265 0.6155
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0037 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0149 0.112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0235 0.1718 0.8906
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0035 0.0039
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0538 0.0764
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0919 0.5092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Schistosoma mansoni coup transcription factor 0.003 0.0105 0.0139
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0207 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0117 0.0792 0.0784
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0009 0.0009
Echinococcus multilocularis acetylcholinesterase 0.0503 0.3831 0.552
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0037 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0387 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0268 0.1452
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.002 0.002
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0036 0.004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.1265 0.7026
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0037 0.0159
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0023 0.0081
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0339 0.0478
Schistosoma mansoni neuroligin 3 (S09 family) 0.0085 0.0538 0.0764
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0105 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0268 0.1452
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0105 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0021
Onchocerca volvulus 0.0085 0.0538 0.0519
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0105 0.0139
Brugia malayi Carboxylesterase family protein 0.0085 0.0538 0.053
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0787
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0149 0.0914
Echinococcus multilocularis nibrin 0.0021 0.0037 0.0041
Echinococcus multilocularis transcription factor eb 0.0114 0.0763 0.109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Onchocerca volvulus 0.0085 0.0538 0.0519
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0387 0.3011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Leishmania major DNA damage repair protein, putative 0.0051 0.0268 0.1452
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0268 0.1452
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0203
Trypanosoma brucei unspecified product 0.0164 0.1157 0.6424
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0021 0.0018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0105 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0213 0.0972
Brugia malayi PHD-finger family protein 0.006 0.0342 0.0333
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.087
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0051 0.0268 0.2067
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0021 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0387 0.0546
Plasmodium falciparum phosphoglycerate kinase 0.0177 0.1265 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.1468 0.1468
Onchocerca volvulus 0.0032 0.0119 0.01
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0314 0.0441
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0149 0.112
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Schistosoma mansoni gliotactin 0.0085 0.0538 0.0764
Echinococcus granulosus regulator of G protein signaling 7 0.005 0.0265 0.037
Trypanosoma brucei DNA polymerase eta, putative 0.0245 0.1797 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0105 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0136
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0652 0.0633
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0105 0.0139
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0149 0.0669
Schistosoma mansoni jumonji domain containing protein 0.0157 0.11 0.1577
Schistosoma mansoni terminal deoxycytidyl transferase 0.0164 0.1157 0.1659
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0679 0.3751
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0023 0.0115
Brugia malayi MH2 domain containing protein 0.0043 0.0207 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0105 0.0105
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0021 0.0018
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0085 0.0538 0.0764
Brugia malayi MH1 domain containing protein 0.0043 0.0207 0.0199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0387 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0105 0.0096
Schistosoma mansoni nuclear hormone receptor 0.003 0.0105 0.0139
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Brugia malayi MH2 domain containing protein 0.0043 0.0207 0.0199
Echinococcus granulosus FTZ F1 alpha 0.003 0.0105 0.0139
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0021 0.0018
Plasmodium vivax DNA repair protein REV1, putative 0.0051 0.0268 0.2067
Brugia malayi N-terminal motif family protein 0.0203 0.1468 0.146
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0189 0.0189
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0387 0.2116
Brugia malayi nuclear receptor NHR-88 0.003 0.0105 0.0096
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0021 0.0099
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0164 0.1157 0.1659
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0023 0.0115
Loa Loa (eye worm) hypothetical protein 0.0503 0.3831 0.3831
Brugia malayi glutathione reductase 0.0103 0.0679 0.0671
Echinococcus granulosus geminin 0.0897 0.6933 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0149 0.112
Plasmodium falciparum glutathione reductase 0.0103 0.0679 0.5339
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.1265 0.1814
Brugia malayi ecdysteroid receptor 0.003 0.0105 0.0096
Echinococcus granulosus bloom syndrome protein 0.0027 0.0081 0.0104
Brugia malayi MH1 domain containing protein 0.0043 0.0207 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Giardia lamblia DNA damage repair protein 0.0051 0.0268 0.1272
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0186 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0273 0.0383
Loa Loa (eye worm) acetylcholinesterase 1 0.0503 0.3831 0.3831
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0191 0.1368 0.1963
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0268 0.1452
Loa Loa (eye worm) hypothetical protein 0.005 0.0265 0.0265
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0235 0.1718 0.8923
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0277 0.205 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0037 0.0227
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0105 0.0096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1157 0.5994
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.002 0.002
Brugia malayi Phosphoglycerate kinase 0.0177 0.1265 0.1257
Brugia malayi AF-10 protein 0.002 0.0023 0.0014
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0186 0.0178
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.044 0.044
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0177 0.1265 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0105 0.0139
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0652 0.3596
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0037 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0164 0.1157 0.6424
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0117 0.0792 0.1132
Loa Loa (eye worm) hypothetical protein 0.0254 0.1865 0.1865
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0149 0.0787
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0191 0.1368 0.1963
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0032 0.0119 0.0119
Echinococcus granulosus dna polymerase kappa 0.0164 0.1157 0.1659
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0503 0.3831 0.3831
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0105 0.0139
Schistosoma mansoni DNA polymerase IV / kappa 0.0051 0.0268 0.0375
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0235 0.1718 0.8923
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0105 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0213 0.0972
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0387 0.0546
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0186 0.0256
Brugia malayi hypothetical protein 0.0021 0.0037 0.0029
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0021 0.0018
Echinococcus granulosus chromobox protein 1 0.0073 0.044 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0757 0.4186
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.002 0.0016
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0037 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.068 0.068
Entamoeba histolytica hypothetical protein 0.0191 0.1368 0.6661
Entamoeba histolytica hypothetical protein 0.0191 0.1368 0.6661
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0456 0.0646
Schistosoma mansoni DNA polymerase eta 0.0245 0.1797 0.2582
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0021
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0189 0.026
Trypanosoma brucei polo-like protein kinase 0.01 0.0652 0.3596
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0105 0.0139
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0081 0.0344
Loa Loa (eye worm) hypothetical protein 0.0177 0.1265 0.1265
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0207 0.0287
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0047
Schistosoma mansoni hypothetical protein 0.0117 0.0792 0.1132
Echinococcus multilocularis geminin 0.0897 0.6933 1
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0342 0.2652
Treponema pallidum NADH oxidase 0.0036 0.0149 0.0689
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.0792 0.1132
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0149 0.0787
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Brugia malayi Smad1 0.0043 0.0207 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0105 0.0096
Loa Loa (eye worm) hypothetical protein 0.0117 0.0792 0.0792
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0387 0.2116
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0757 0.4186
Echinococcus granulosus acetylcholinesterase 0.0503 0.3831 0.552
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0021 0.0099
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.1925 1
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0679 0.0679
Echinococcus granulosus expressed protein 0.0786 0.606 0.8739
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0197 0.1419 0.2037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.0155
Brugia malayi Pax transcription factor protein 2 0.0497 0.3778 0.3772
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0787
Brugia malayi hypothetical protein 0.0133 0.0919 0.0911
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Echinococcus multilocularis acetylcholinesterase 0.0503 0.3831 0.552
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0197 0.1419 0.2037
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0919 0.7247
Plasmodium vivax JmjC domain containing protein 0.0019 0.0021 0.0099
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0036 0.004
Brugia malayi hypothetical protein 0.004 0.0186 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0919 0.7247
Schistosoma mansoni topbp1 0.0021 0.0037 0.0041
Giardia lamblia Phosphoglycerate kinase 0.0177 0.1265 0.6155
Schistosoma mansoni Smad4 0.0019 0.002 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0538 0.2761
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0037 0.0029
Trypanosoma brucei chrX additional, unordered contigs 0.0051 0.0268 0.1452
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0186 0.0256
Loa Loa (eye worm) hypothetical protein 0.0039 0.0172 0.0172
Trichomonas vaginalis glutaminase, putative 0.0285 0.2112 1
Brugia malayi DKFZp564C0469 protein 0.0021 0.0037 0.0029
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0177 0.1265 0.6556
Giardia lamblia DINP protein human, muc B family 0.0164 0.1157 0.5628
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0037 0.0041
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0387 0.3011
Echinococcus multilocularis Smad4 0.0043 0.0207 0.0287
Plasmodium vivax glutathione reductase, putative 0.0103 0.0679 0.5339
Echinococcus multilocularis dna polymerase kappa 0.0164 0.1157 0.1659
Schistosoma mansoni hypothetical protein 0.0897 0.6933 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0085 0.0538 0.0764
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0105 0.0139
Onchocerca volvulus Alhambra homolog 0.006 0.0342 0.0323
Echinococcus multilocularis peregrin 0.0062 0.0359 0.0507
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0538 0.0764
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0105 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0387 0.3011
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.002 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0757 0.4186
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0381 0.2082
Schistosoma mansoni Smad4 0.0019 0.002 0.0016
Onchocerca volvulus 0.0085 0.0538 0.0519
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0387 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Entamoeba histolytica deoxycytidyl transferase, putative 0.0164 0.1157 0.5628
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0105 0.0139
Schistosoma mansoni hypothetical protein 0.0117 0.0792 0.1132
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0186 0.0256
Loa Loa (eye worm) glutaminase 2 0.0285 0.2112 0.2112
Loa Loa (eye worm) carboxylesterase 0.0085 0.0538 0.0538
Giardia lamblia Kinase, PLK 0.01 0.0652 0.3151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0371 0.2789 0.2783
Echinococcus multilocularis smad 0.0043 0.0207 0.0287
Loa Loa (eye worm) carboxylesterase 0.0085 0.0538 0.0538
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0149 0.0689
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0149 0.0141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.0792 0.1132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.1468 0.1451
Schistosoma mansoni smad1 5 8 and 0.0043 0.0207 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0105 0.0096
Mycobacterium ulcerans phosphoglycerate kinase 0.0177 0.1265 0.5974
Echinococcus granulosus axis inhibition protein axin 0.004 0.0186 0.0256
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0652 0.3596
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0105 0.0096
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.087
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Treponema pallidum fructose-bisphosphate aldolase 0.0277 0.205 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0085 0.0538 0.2516
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.002 0.0016
Mycobacterium ulcerans hypothetical protein 0.0051 0.0268 0.1235
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0012
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0037 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0371 0.2789 0.2789
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0652 0.0644
Schistosoma mansoni smad1 5 8 and 0.0043 0.0207 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0095 0.0412
Brugia malayi jmjC domain containing protein 0.0197 0.1419 0.1412
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0105 0.0085
Loa Loa (eye worm) hypothetical protein 0.0113 0.0759 0.0759
Schistosoma mansoni thyroid hormone receptor 0.003 0.0105 0.0139
Plasmodium falciparum phd finger protein, putative 0.006 0.0342 0.2652
Entamoeba histolytica hypothetical protein 0.0191 0.1368 0.6661
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0037 0.0136
Leishmania major hypothetical protein, conserved 0.0133 0.0919 0.5092
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0105 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Brugia malayi Bromodomain containing protein 0.0071 0.0428 0.042
Leishmania major DNA polymerase eta, putative 0.0132 0.0908 0.5029
Loa Loa (eye worm) hypothetical protein 0.0136 0.0939 0.0939
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.1925 1
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0037 0.014
Entamoeba histolytica hypothetical protein 0.0021 0.0037 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0456 0.0456
Schistosoma mansoni axis inhibition protein axin 0.004 0.0186 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0632 0.4845 0.4845
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Brugia malayi Heterochromatin protein 1 0.0073 0.044 0.0432
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0186 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0189 0.026
Entamoeba histolytica phosphoglycerate kinase, putative 0.0177 0.1265 0.6155
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.005 0.0265 0.0265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0136
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0036 0.004
Schistosoma mansoni axis inhibition protein axin 0.004 0.0186 0.0256
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.1265 0.7026
Echinococcus multilocularis carboxylesterase 5A 0.0503 0.3831 0.552
Echinococcus granulosus chromobox protein 1 0.0073 0.044 0.0623
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0149 0.112
Mycobacterium tuberculosis Probable reductase 0.0235 0.1718 0.8923
Schistosoma mansoni bromodomain containing protein 0.006 0.034 0.0479
Brugia malayi hypothetical protein 0.0191 0.1368 0.1361
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0023 0.0115
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0105 0.0139
Schistosoma mansoni regulator of G protein signaling 0.005 0.0265 0.037
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0177 0.1265 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0135 0.0934 0.4751
Loa Loa (eye worm) glutathione reductase 0.0103 0.0679 0.0679
Echinococcus granulosus nibrin 0.0021 0.0037 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0189 0.0857
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0652 0.0929
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.1265 0.5974
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0149 0.0787
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0387 0.0546
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0189 0.0189
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0189 0.026
Echinococcus multilocularis phosphoglycerate kinase 1 0.0177 0.1265 0.1814
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Onchocerca volvulus 0.0085 0.0538 0.0519
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0037 0.0041
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0652 0.3596
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0191 0.1368 0.1963
Onchocerca volvulus 0.0085 0.0538 0.0519
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0235 0.1718 0.8923
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Echinococcus multilocularis regulator of G protein signaling 7 0.005 0.0265 0.037
Mycobacterium ulcerans carboxylesterase, LipT 0.0085 0.0538 0.2516
Chlamydia trachomatis phosphoglycerate kinase 0.0177 0.1265 1
Brugia malayi Carboxylesterase family protein 0.0085 0.0538 0.053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0105 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0136 0.0185
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0035 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0164 0.1157 0.5462
Loa Loa (eye worm) nuclear factor I 0.0024 0.0056 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0273 0.0383
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0339 0.0478
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0342 0.0481
Echinococcus granulosus Smad4 0.0043 0.0207 0.0287
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0021 0.0018
Echinococcus multilocularis dna polymerase eta 0.0245 0.1797 0.2582
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Trypanosoma brucei DNA polymerase IV, putative 0.0164 0.1157 0.6424
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0105 0.0096
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0149 0.112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0679 0.0969
Plasmodium vivax ataxin-2 like protein, putative 0.0133 0.0919 0.7247
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0037 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Echinococcus multilocularis expressed protein 0.0786 0.606 0.8739
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0652 0.0929
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0213 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0105 0.0139
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0387 0.0387
Brugia malayi ImpB/MucB/SamB family protein 0.0245 0.1797 0.179
Brugia malayi polk-prov protein 0.0051 0.0268 0.026
Schistosoma mansoni smad 0.0019 0.002 0.0016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0021 0.007
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0037 0.0227
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0387 0.2116
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0105 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Trichomonas vaginalis chromobox protein, putative 0.0073 0.044 0.2051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0105 0.0139
Echinococcus multilocularis chromobox protein 1 0.0073 0.044 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0105 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0105 0.0096
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0037 0.0159
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0135 0.0934 0.44
Schistosoma mansoni hypothetical protein 0.0254 0.1865 0.2681
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.002 0.0011
Schistosoma mansoni thyroid hormone receptor 0.003 0.0105 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0105 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0273 0.0265
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0186 0.0256
Loa Loa (eye worm) pax transcription factor protein 2 0.0497 0.3778 0.3778
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0679 0.0969
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0105 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0268 0.1452
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.1265 0.5974
Brugia malayi Thioredoxin reductase 0.0103 0.0679 0.0671
Leishmania major trypanothione reductase 0.0103 0.0679 0.3751
Brugia malayi hypothetical protein 0.0021 0.0037 0.0029
Brugia malayi glutaminase DH11.1 0.0285 0.2112 0.2105
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0075 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0273 0.0383
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Entamoeba histolytica hypothetical protein 0.004 0.0186 0.087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.0792 0.0792
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0527 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0105 0.0105
Echinococcus granulosus phd:f box containing protein 0.0019 0.0021 0.0018
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0021 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0919 0.5092
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0075 0.0066
Echinococcus granulosus peregrin 0.0062 0.0359 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0105 0.0105
Brugia malayi ImpB/MucB/SamB family protein 0.0164 0.1157 0.115
Echinococcus granulosus para nitrobenzyl esterase 0.0085 0.0538 0.0764
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0081 0.0344
Echinococcus multilocularis para nitrobenzyl esterase 0.0085 0.0538 0.0764
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.1925 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0164 0.1157 0.5462
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0189 0.0169
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0342 0.0481
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0037 0.0041
Brugia malayi isocitrate dehydrogenase 0.0066 0.0387 0.0379
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0021 0.0018
Schistosoma mansoni acetylcholinesterase 0.0085 0.0538 0.0764
Leishmania major phosphoglycerate kinase C, glycosomal 0.0177 0.1265 0.7026
Onchocerca volvulus 0.0021 0.0037 0.0017
Schistosoma mansoni regulator of G protein signaling 0.004 0.0186 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trypanosoma brucei DNA polymerase IV, putative 0.0164 0.1157 0.6424
Schistosoma mansoni BC026374 protein (S09 family) 0.0085 0.0538 0.0764
Schistosoma mansoni z-protein (S1r protein) 0.005 0.0265 0.037
Leishmania major DNA polymerase kappa, putative 0.0051 0.0268 0.1452
Brugia malayi steroid hormone receptor 0.003 0.0105 0.0096
Brugia malayi Bromodomain containing protein 0.0062 0.0359 0.0351
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Plasmodium vivax hypothetical protein, conserved 0.006 0.0342 0.2652
Brugia malayi jmjC domain containing protein 0.0075 0.0456 0.0447
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0133 0.0919 0.0919
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0652 0.0652
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0256 0.1177
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0314 0.0441
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0149 0.0787
Onchocerca volvulus 0.0497 0.3778 0.3765
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0085 0.0538 0.0764
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0342 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0186 0.0256
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0023 0.0081
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0387 0.0379
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0105 0.0139
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0177 0.1265 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0105 0.0139
Brugia malayi PHD-finger family protein 0.0024 0.0054 0.0046
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0387 0.2116
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0186 0.0256
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0203
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0037 0.0136
Leishmania major DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0189 0.0857
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0503 0.3831 0.552
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0652 0.3151
Trypanosoma cruzi DNA polymerase eta, putative 0.0245 0.1797 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0105 0.0105
Schistosoma mansoni kinase 0.0051 0.0266 0.0372
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0186 0.0256
Echinococcus granulosus neuroligin 0.0085 0.0538 0.0764
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0387 0.3011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0149 0.0669
Trypanosoma brucei trypanothione reductase 0.0103 0.0679 0.3751
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trypanosoma brucei unspecified product 0.0113 0.0757 0.4186
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0105 0.0139
Echinococcus granulosus smad 0.0043 0.0207 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Brugia malayi hypothetical protein 0.0085 0.0538 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0383
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0081 0.0104
Echinococcus multilocularis regulator of G protein signaling 7 0.005 0.0265 0.037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0105 0.0139
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.1265 0.7026
Loa Loa (eye worm) hypothetical protein 0.006 0.0342 0.0342
Schistosoma mansoni DNA ligase IV 0.0021 0.0037 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Brugia malayi Bromodomain containing protein 0.0036 0.0154 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0105 0.0105
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0186 0.0178
Leishmania major DNA polymerase eta, putative 0.0245 0.1797 1
Brugia malayi PXA domain containing protein 0.004 0.0186 0.0178
Brugia malayi MH2 domain containing protein 0.0019 0.002 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0456 0.0646
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0527 0.0749
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0277 0.205 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0268 0.1452
Giardia lamblia Fructose-bisphosphate aldolase 0.0277 0.205 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Schistosoma mansoni hypothetical protein 0.0191 0.1368 0.1963
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.1265 0.7026
Echinococcus multilocularis neuroligin 0.0085 0.0538 0.0764
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0189 0.026
Echinococcus granulosus transcription factor eb 0.0114 0.0763 0.109
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Mycobacterium ulcerans DNA polymerase IV 0.0164 0.1157 0.5462
Schistosoma mansoni hypothetical protein 0.006 0.0339 0.0478
Trypanosoma brucei PAB1-binding protein , putative 0.0133 0.0919 0.5092
Toxoplasma gondii LsmAD domain-containing protein 0.0133 0.0919 0.7247
Onchocerca volvulus 0.003 0.0105 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0383
Brugia malayi MH2 domain containing protein 0.0632 0.4845 0.4841
Echinococcus granulosus phosphoglycerate kinase 1 0.0177 0.1265 0.1814
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0037 0.0159
Schistosoma mansoni regulator of G protein signaling 0.004 0.0186 0.0256
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.112
Trichomonas vaginalis chromobox protein, putative 0.0073 0.044 0.2051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0105 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0037 0.0159
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0164 0.1157 0.1659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0387 0.2116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0371 0.2789 0.2783
Plasmodium falciparum DNA repair protein REV1, putative 0.0051 0.0268 0.2067
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0085 0.0538 0.2516
Plasmodium vivax phosphoglycerate kinase, putative 0.0177 0.1265 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0164 0.1157 0.1157
Loa Loa (eye worm) glutaminase 0.0285 0.2112 0.2112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0273 0.0273
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0441 0.0625
Schistosoma mansoni hypothetical protein 0.006 0.0342 0.0481
Entamoeba histolytica hypothetical protein 0.0191 0.1368 0.6661
Brugia malayi PXA domain containing protein 0.004 0.0186 0.0178
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0186 0.0256
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0021 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0268 0.1452
Mycobacterium tuberculosis Probable dehydrogenase 0.0235 0.1718 0.8923
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0117 0.0792 0.1132
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0021 0.0018
Trypanosoma brucei unspecified product 0.0113 0.0757 0.4186
Schistosoma mansoni hypothetical protein 0.0117 0.0792 0.1132
Trypanosoma cruzi DNA polymerase eta, putative 0.0132 0.0908 0.5029
Brugia malayi Phosphoglycerate kinase 0.0065 0.0381 0.0373
Schistosoma mansoni smad1 5 8 and 0.0043 0.0207 0.0287
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0381 0.2082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0105 0.0096
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0679 0.5339
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0652 0.3058
Echinococcus granulosus zinc finger protein 0.0019 0.0014 0.0008
Schistosoma mansoni smad 0.0043 0.0207 0.0287
Schistosoma mansoni regulator of G protein signaling 0.004 0.0186 0.0256
Brugia malayi hypothetical protein 0.0086 0.0547 0.0539
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Schistosoma mansoni topbp1 0.0021 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0371 0.2789 0.2789
Plasmodium falciparum thioredoxin reductase 0.0103 0.0679 0.5339
Brugia malayi Carboxylesterase family protein 0.0085 0.0538 0.053
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0135 0.0934 0.4829
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0342 0.0342
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0164 0.1157 0.1659
Leishmania major phosphoglycerate kinase B, cytosolic 0.0177 0.1265 0.7026
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0186 0.0844
Schistosoma mansoni chromobox protein 0.0073 0.044 0.0623
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0186 0.0256
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0055 0.037
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0652 0.0929
Echinococcus multilocularis chromobox protein 1 0.0073 0.044 0.0623
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0105 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0021 0.0018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0203
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0105 0.0139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0679 0.35
Echinococcus granulosus acetylcholinesterase 0.0503 0.3831 0.552
Treponema pallidum DNA ligase (lig) 0.0021 0.0037 0.014
Schistosoma mansoni hypothetical protein 0.002 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0095 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0189 0.026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0207 0.0287
Brugia malayi hypothetical protein 0.004 0.0186 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0268 0.1452
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0105 0.0139
Brugia malayi Carboxylesterase family protein 0.0085 0.0538 0.053
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0037 0.014
Brugia malayi Carboxylesterase family protein 0.0503 0.3831 0.3825
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0012
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0164 0.1157 0.5994
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0186 0.0256
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0177 0.1265 0.6504
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0186 0.0256
Plasmodium falciparum thioredoxin reductase 0.0036 0.0149 0.112
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0149 0.0669
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0381 0.2082
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0113 0.0759 0.0759
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0186 0.0256
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0105 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Plasmodium vivax hypothetical protein, conserved 0.002 0.0023 0.0115
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0235 0.1718 0.8923
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0387 0.1974
Echinococcus granulosus axis inhibition protein axin 0.004 0.0186 0.0256
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0387 0.0546
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0136 0.0185
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0117 0.0792 0.1132
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0186 0.0256
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0012 0.0027
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0268 0.1452
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0105 0.0096
Brugia malayi latrophilin 2 splice variant baaae 0.0254 0.1865 0.1858
Echinococcus multilocularis zinc finger protein 0.0019 0.0014 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0273 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0846 0.0846
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0105 0.0085
Brugia malayi nuclear hormone receptor 0.003 0.0105 0.0096
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0022 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0268 0.2067
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0456 0.0646
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0189
Echinococcus granulosus dna polymerase eta 0.0245 0.1797 0.2582
Loa Loa (eye worm) transcription factor SMAD2 0.0632 0.4845 0.4845
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0021
Echinococcus granulosus BC026374 protein S09 family 0.0085 0.0538 0.0764
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0021 0.0018
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0149 0.0734
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0207 0.0207
Giardia lamblia PHD finger protein 15 0.006 0.0342 0.1632
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.112
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0669
Plasmodium falciparum glutathione reductase 0.0036 0.0149 0.112
Loa Loa (eye worm) hypothetical protein 0.0245 0.1797 0.1797
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0105 0.0139
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0207 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0105 0.0096
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0149 0.0787
Loa Loa (eye worm) carboxylesterase 0.0503 0.3831 0.3831
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.0792 0.0784
Schistosoma mansoni Smad4 0.0043 0.0207 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0105 0.0139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.0787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0105 0.0096
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0538 0.2761
Brugia malayi regulator of G-protein signaling egl-10 0.005 0.0265 0.0257
Trypanosoma cruzi DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0036 0.004
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0114 0.0763 0.0755
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0047
Mycobacterium tuberculosis Carboxylesterase LipT 0.0085 0.0538 0.2761
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0023 0.0021
Brugia malayi PHD-finger family protein 0.0021 0.0037 0.0029
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0149 0.0669
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0132 0.0908 0.7157
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0256 0.1177
Echinococcus multilocularis GPCR, family 2 0.0117 0.0792 0.1132
Loa Loa (eye worm) hypothetical protein 0.004 0.0186 0.0186
Loa Loa (eye worm) RGS-3 protein 0.004 0.0186 0.0186
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.002 0.0016
Echinococcus granulosus GPCR family 2 0.0117 0.0792 0.1132
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0037 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.001 0.0014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0164 0.1157 0.6424
Brugia malayi topoisomerase 0.0021 0.0037 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.0787
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.1265 0.1814
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0342 0.2652
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0189 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.0787
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0186 0.0844
Loa Loa (eye worm) hypothetical protein 0.0051 0.0268 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0164 0.1157 0.6424
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0538 0.0764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0277 0.205 0.9706
Mycobacterium ulcerans glutaminase 0.0285 0.2112 1
Schistosoma mansoni zinc finger protein 0.0019 0.0014 0.0008
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0037 0.0136
Echinococcus granulosus regulator of G protein signaling 7 0.005 0.0265 0.037
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0897 0.6933 1
Loa Loa (eye worm) RecQ helicase 0.0027 0.0081 0.0081
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0149 0.112
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0136
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0037 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0105 0.0105
Schistosoma mansoni glutaminase 0.0285 0.2112 0.3037
Loa Loa (eye worm) Smad1 0.0043 0.0207 0.0207
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.1925 1
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0021 0.0018
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0186 0.0178
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0021 0.0018
Schistosoma mansoni chromobox protein 0.0073 0.044 0.0623

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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