Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0001 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0001 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0001 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0001 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0001 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0001 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4298 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0001 | 1 |
Onchocerca volvulus | 0.0043 | 0.0001 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0001 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0001 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0001 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4298 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0001 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0001 | 0.5 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0001 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0001 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0001 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0001 | 0.0003 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0001 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0001 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4298 | 1 |
Onchocerca volvulus | 0.0043 | 0.0001 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0001 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0001 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0001 | 0.0003 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0001 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0001 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0001 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0001 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.