Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.016 | 0.016 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.063 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5059 | 0.5059 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.063 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.016 | 0.016 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.063 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.063 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.063 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.063 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.016 | 0.016 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.063 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.063 | 0.063 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.063 | 0.063 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.016 | 0.016 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.016 | 0.016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5059 | 0.5059 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.063 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.063 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.063 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.063 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.063 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.063 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.063 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.063 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5059 | 0.5059 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.016 | 0.016 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.063 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.016 | 0.016 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.063 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.063 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.063 | 0.5 |
Brugia malayi | Smad1 | 0.001 | 0.016 | 0.016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0562 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.