Detailed information for compound 1400473

Basic information

Technical information
  • TDR Targets ID: 1400473
  • Name: 4-[4-(4-fluorophenyl)-5-[[3-(2-methylphenyl)- 1,2,4-oxadiazol-5-yl]methylsulfanyl]-1,2,4-tr iazol-3-yl]pyridine
  • MW: 444.484 | Formula: C23H17FN6OS
  • H donors: 0 H acceptors: 5 LogP: 4.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)n1c(SCc2onc(n2)c2ccccc2C)nnc1c1ccncc1
  • InChi: 1S/C23H17FN6OS/c1-15-4-2-3-5-19(15)21-26-20(31-29-21)14-32-23-28-27-22(16-10-12-25-13-11-16)30(23)18-8-6-17(24)7-9-18/h2-13H,14H2,1H3
  • InChiKey: GFBUIYFWWYPBMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[4-(4-fluorophenyl)-5-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methylthio]-1,2,4-triazol-3-yl]pyridine
  • D141-0010
  • NCGC00141469-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0061 0.0061
Echinococcus granulosus high affinity choline transporter 1 0.0366 0.2021 0.6199
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0006 0.0019
Onchocerca volvulus Cathepsin L homolog 0.0126 0.0664 0.3625
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0037 0.0158 0.1771
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0061 0.0188
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0037 0.0158 0.1771
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0061 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0061 0.0061
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0006 0.0019
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Schistosoma mansoni cathepsin S (C01 family) 0.0037 0.0158 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.025 0.0765
Echinococcus multilocularis solute carrier family 5 0.004 0.0176 0.0176
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0033 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Brugia malayi MH2 domain containing protein 0.014 0.0739 0.2264
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0158 0.1771
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0061 0.0185
Brugia malayi nuclear receptor RXR 0.001 0.0006 0.0016
Brugia malayi fibroinase precursor 0.0037 0.0158 0.048
Schistosoma mansoni hypothetical protein 0.043 0.2388 0.7323
Brugia malayi hypothetical protein 0.001 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0158 0.0911
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0013 0.0038
Loa Loa (eye worm) RGS-3 protein 0.002 0.0061 0.0188
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0467
Schistosoma mansoni cpg binding protein 0.0032 0.0128 0.039
Echinococcus multilocularis cathepsin b 0.0584 0.326 0.326
Echinococcus granulosus cathepsin L cysteine proteinase 0.0126 0.0664 0.2036
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Onchocerca volvulus 0.0028 0.0108 0.0561
Leishmania major cathepsin L-like protease 0.0126 0.0664 0.5757
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0072 0.0219
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0363 0.111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.031 0.095
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0061 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Echinococcus multilocularis cysteine protease 0.0126 0.0664 0.0664
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0038
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0309 0.244
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0049 0.0049
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.0664 0.0664
Entamoeba histolytica cysteine protease, putative 0.0126 0.0664 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0186 0.1179
Echinococcus multilocularis cpg binding protein 0.0032 0.0128 0.0128
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0363 0.5003
Onchocerca volvulus 0.0042 0.0186 0.0991
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0001 0.0003
Echinococcus multilocularis lamin 0.0028 0.0108 0.0108
Leishmania major hypothetical protein, conserved 0.0042 0.0186 0.1284
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0363 0.111
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.014 0.0742 0.2159
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0158 0.048
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0061 0.0185
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0037 0.0158 0.1771
Plasmodium falciparum serine repeat antigen 2 0.0037 0.0158 0.1771
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Loa Loa (eye worm) hypothetical protein 0.0584 0.326 1
Trypanosoma cruzi cruzipain precursor, putative 0.0176 0.0947 0.2798
Plasmodium falciparum serine repeat antigen 1 0.0037 0.0158 0.1771
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0185
Echinococcus granulosus dnaJ subfamily B 0.043 0.2388 0.7324
Plasmodium falciparum cysteine proteinase falcipain 1 0.0073 0.0363 0.5107
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0152 0.0323
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0013 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0219
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0459 0.3762
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0247 0.0758
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Trypanosoma cruzi cysteine proteinase, putative 0.0073 0.0363 0.0978
Brugia malayi hypothetical protein 0.002 0.0061 0.0185
Echinococcus multilocularis dnaJ subfamily B 0.043 0.2388 0.2388
Echinococcus multilocularis neuropeptide receptor A26 0.0527 0.2936 0.2936
Schistosoma mansoni lamin 0.0028 0.0108 0.0328
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0037 0.0158 0.048
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0006 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0596 0.1824
Echinococcus multilocularis lamin dm0 0.0028 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0219 0.149
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0186 0.0567
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0061 0.0185
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0061 0.0185
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0158 0.0339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Schistosoma mansoni sodium/solute symporter 0.004 0.0176 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0037 0.0158 0.0911
Plasmodium vivax vivapain-2 0.0126 0.0664 1
Echinococcus multilocularis protein patched 0.0048 0.0219 0.0219
Entamoeba histolytica hypothetical protein 0.0037 0.0158 0.1596
Brugia malayi hypothetical protein 0.001 0.0006 0.0016
Schistosoma mansoni nuclear receptor 0.001 0.0006 0.0016
Onchocerca volvulus 0.0126 0.0664 0.3625
Brugia malayi hypothetical protein 0.002 0.0061 0.0185
Toxoplasma gondii preprocathepsin c precursor, putative 0.0037 0.0158 0.102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Brugia malayi Sodium:solute symporter family protein 0.004 0.0176 0.0536
Toxoplasma gondii cathepsin B 0.0206 0.1117 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0206 0.1117 0.3327
Entamoeba histolytica cysteine proteinase 1, putative 0.0073 0.0363 0.5003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.025 0.0765
Brugia malayi isocitrate dehydrogenase 0.0018 0.0049 0.0146
Onchocerca volvulus 0.004 0.0176 0.0935
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0072 0.0222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.004
Brugia malayi nuclear receptor NHR-88 0.0022 0.0072 0.0219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Onchocerca volvulus Cathepsin F homolog 0.0126 0.0664 0.3625
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.058 0.8609
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0072 0.0365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0158 0.048
Schistosoma mansoni hypothetical protein 0.0053 0.0247 0.0755
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.0896 0.2745
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Schistosoma mansoni axis inhibition protein axin 0.002 0.0061 0.0185
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0363 0.5003
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0219
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.0664 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0158 0.1596
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0072 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0072 0.0219
Echinococcus multilocularis cathepsin L 0.0037 0.0158 0.0158
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0186 0.0567
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Echinococcus granulosus axis inhibition protein axin 0.002 0.0061 0.0188
Loa Loa (eye worm) hypothetical protein 0.009 0.0459 0.1406
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0076
Plasmodium falciparum serine repeat antigen 5 0.0037 0.0158 0.1771
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.0664 0.5706
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0061 0.0061
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0061 0.0188
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0006 0.0016
Brugia malayi hypothetical protein 0.033 0.182 0.5582
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0309 0.0946
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0061 0.0188
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0186 0.1179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0037 0.0158 0.1771
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Schistosoma mansoni zinc finger protein 0.001 0.0006 0.0016
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0006 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0126 0.0664 1
Echinococcus granulosus neuropeptide s receptor 0.0527 0.2936 0.9004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0309 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0126 0.0664 0.2036
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0037 0.0158 0.1771
Mycobacterium tuberculosis Conserved protein 0.0042 0.0186 0.0964
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0331
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0001 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0186 0.057
Echinococcus granulosus lamin 0.0028 0.0108 0.0331
Brugia malayi cathepsin B-like cysteine proteinase 0.0584 0.326 1
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Brugia malayi nuclear receptor NHR-67 0.001 0.0006 0.0016
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.0459 0.1404
Onchocerca volvulus 0.0042 0.0186 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.058 0.1777
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0037 0.0158 0.1771
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0272 0.2088
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.0664 0.2034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0186 0.0567
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0072 0.0219
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.058 0.058
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0363 0.5003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0158 0.1771
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0061 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0186 0.1179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.0852 0.0852
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.0664 0.1916
Brugia malayi nuclear receptor RXR 0.0012 0.0013 0.0038
Loa Loa (eye worm) DR-78 0.001 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Brugia malayi cathepsin L precursor 0.0037 0.0158 0.048
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0037 0.0158 0.1771
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0037 0.0158 0.1771
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0108 0.0328
Schistosoma mansoni hypothetical protein 0.0046 0.0209 0.0638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0049 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0072 0.0219
Schistosoma mansoni hypothetical protein 0.0046 0.0209 0.0638
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.0664 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0037 0.0158 0.048
Trypanosoma cruzi cysteine peptidase, putative 0.0176 0.0947 0.2798
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0739 0.2266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0186 0.0427
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0152 0.0464
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0152 0.0464
Schistosoma mansoni hypothetical protein 0.0053 0.0247 0.0755
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Plasmodium vivax vivapain-2 0.0126 0.0664 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0176 0.0539
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0309 0.244
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0158 0.1596
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Trichomonas vaginalis esterase, putative 0.0042 0.0186 0.1179
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0061 0.0061
Toxoplasma gondii cathepsin CPL 0.0126 0.0664 0.5757
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.004
Toxoplasma gondii cathepsin CPC2 0.0037 0.0158 0.102
Brugia malayi steroid hormone receptor 0.0022 0.0072 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus granulosus cathepsin b 0.0584 0.326 1
Echinococcus granulosus cathepsin L 0.0073 0.0363 0.1113
Brugia malayi ecdysteroid receptor 0.0022 0.0072 0.0219
Echinococcus granulosus cathepsin L cysteine protease 0.0073 0.0363 0.1113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0222
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0309 0.1831
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0467
Schistosoma mansoni axis inhibition protein axin 0.002 0.0061 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0038
Mycobacterium tuberculosis Conserved protein 0.0042 0.0186 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.0664 0.5706
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.0852 0.2612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Onchocerca volvulus 0.0126 0.0664 0.3625
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Onchocerca volvulus 0.003 0.0118 0.0619
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0006 0.0016
Brugia malayi cathepsin L-like precursor 0.009 0.0459 0.1404
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0108 0.0331
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0072
Brugia malayi GH02984p 0.0366 0.2021 0.6198
Loa Loa (eye worm) hypothetical protein 0.009 0.0459 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0219
Schistosoma mansoni intermediate filament proteins 0.0028 0.0108 0.0328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0584 0.326 1
Brugia malayi Cathepsin L-like precursor 0.009 0.0459 0.1404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Trypanosoma cruzi cysteine protease, putative 0.0073 0.0363 0.0978
Echinococcus granulosus neuropeptide receptor A26 0.0527 0.2936 0.9004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Echinococcus granulosus cathepsin b 0.0584 0.326 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0363 0.294
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0186 0.0964
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0176 0.0176
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0073 0.0363 0.0978
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Echinococcus multilocularis GPCR, family 2 0.0053 0.0247 0.0247
Loa Loa (eye worm) fibroinase 0.0126 0.0664 0.2036
Plasmodium falciparum serine repeat antigen 7 0.0037 0.0158 0.1771
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.0158 0.1771
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0247 0.0758
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0061 0.0188
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0584 0.326 1
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.0664 0.0664
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0176 0.0539
Echinococcus granulosus GPCR family 2 0.0053 0.0247 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0206 0.1117 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0072 0.0222
Echinococcus multilocularis musashi 0.0028 0.0108 0.0108
Onchocerca volvulus 0.0126 0.0664 0.3625
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0247 0.0755
Schistosoma mansoni nuclear receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0037 0.0158 0.0483
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0049 0.0146
Leishmania major cathepsin L-like protease 0.0126 0.0664 0.5757
Onchocerca volvulus 0.0028 0.0108 0.0561
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0006 0.0016
Onchocerca volvulus Cathepsin L homolog 0.0126 0.0664 0.3625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0158 0.048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus multilocularis protein dispatched 1 0.0055 0.0257 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0186 0.1179
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0072 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0222
Plasmodium vivax unspecified product 0.0037 0.0158 0.1771
Loa Loa (eye worm) hypothetical protein 0.033 0.182 0.5583
Schistosoma mansoni hypothetical protein 0.0046 0.0209 0.0638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0363 0.294
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0001 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.0664 0.0664
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0061 0.0188
Trypanosoma brucei cysteine peptidase C (CPC) 0.0206 0.1117 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0219
Plasmodium vivax vivapain-3 0.0073 0.0363 0.5107
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.0664 0.2034
Brugia malayi intermediate filament protein 0.0028 0.0108 0.0328
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0072 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Echinococcus multilocularis neuropeptide s receptor 0.0527 0.2936 0.2936
Schistosoma mansoni cathepsin s 0.0036 0.0152 0.0464
Loa Loa (eye worm) hypothetical protein 0.0126 0.0664 0.2036
Brugia malayi Nuclear hormone receptor E75 0.001 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0072 0.0219
Echinococcus multilocularis smad 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0206 0.1117 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0049 0.0149
Brugia malayi beta-lactamase family protein 0.0042 0.0186 0.0567
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0158 0.0483
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0158 0.048
Echinococcus multilocularis high affinity choline transporter 1 0.0366 0.2021 0.2021
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0072 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.025 0.025
Echinococcus multilocularis expressed conserved protein 0.0105 0.0542 0.0542
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0186 0.1179
Schistosoma mansoni hypothetical protein 0.0046 0.0209 0.0638
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0309 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0061 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0363 0.0978
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0126 0.0664 0.2036
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0222
Schistosoma mansoni cathepsin B (C01 family) 0.0037 0.0158 0.048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0247 0.0247
Echinococcus granulosus solute carrier family 5 0.004 0.0176 0.0539
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0158 0.0483
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0072 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.0896 0.2745
Loa Loa (eye worm) hypothetical protein 0.0059 0.028 0.0858
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0185
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0152 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0219
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0072
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0061 0.0185
Leishmania major cathepsin L-like protease 0.0176 0.0947 0.8409
Schistosoma mansoni cpg binding protein 0.0032 0.0128 0.039
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0185
Schistosoma mansoni cathepsin C 0.0037 0.0158 0.048
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0158 0.048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Loa Loa (eye worm) ctsf protein 0.0126 0.0664 0.2036
Schistosoma mansoni patched 1 0.0048 0.0219 0.0668
Echinococcus granulosus cpg binding protein 0.0032 0.0128 0.0393
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus granulosus cathepsin l1 0.009 0.0459 0.1406
Echinococcus granulosus expressed conserved protein 0.0105 0.0542 0.1661
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0158 0.048
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.0664 0.2034
Brugia malayi tailless protein 0.001 0.0006 0.0016
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0158 0.0911
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0584 0.326 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0176 0.0176
Brugia malayi nuclear hormone receptor 0.0022 0.0072 0.0219
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0072 0.0219
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0176 0.0539
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0467
Loa Loa (eye worm) hypothetical protein 0.0114 0.0596 0.1826
Leishmania major cathepsin L-like protease 0.0176 0.0947 0.8409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.025 0.0765
Schistosoma mansoni hypothetical protein 0.0053 0.0247 0.0755
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0186 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0186 0.0964
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0186 0.0964
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0013 0.004
Echinococcus granulosus axis inhibition protein axin 0.002 0.0061 0.0188
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0061 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0186 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0158 0.0911
Leishmania major cathepsin L-like protease 0.0176 0.0947 0.8409
Echinococcus granulosus Smad4 0.001 0.0001 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0186 0.057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Echinococcus multilocularis cathepsin b 0.0584 0.326 0.326
Brugia malayi Cathepsin L-like precursor 0.009 0.0459 0.1404
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Trypanosoma cruzi cysteine peptidase, putative 0.0176 0.0947 0.2798
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0006 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0158 0.048
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0309 0.0946
Mycobacterium leprae Probable lipase LipE 0.0042 0.0186 0.5
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0061 0.0185
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0186 0.0964
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.0896 0.2747
Leishmania major cathepsin L-like protease 0.0126 0.0664 0.5757
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0049 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0222
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0158 0.048
Brugia malayi beta-lactamase family protein 0.0042 0.0186 0.0567
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0072 0.0219
Trypanosoma cruzi major cysteine proteinase, putative 0.0087 0.0441 0.1221
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0363 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0363 0.2855
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0016
Loa Loa (eye worm) cathepsin B 0.0206 0.1117 0.3426
Brugia malayi hypothetical protein 0.0012 0.0013 0.0038
Entamoeba histolytica cysteine proteinase 2 0.0073 0.0363 0.5003
Schistosoma mansoni high-affinity choline transporter 0.0366 0.2021 0.6198
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0118 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0158 0.0911
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0061 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Brugia malayi conserved hypotetical protein 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0112 0.058 0.1779
Brugia malayi PXA domain containing protein 0.002 0.0061 0.0185
Brugia malayi PXA domain containing protein 0.002 0.0061 0.0185
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0309 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0158 0.048
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.025 0.0768
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.0664 0.0664
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0158 0.048
Onchocerca volvulus 0.0126 0.0664 0.3625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.025 0.0765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0013 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.009 0.0459 0.6593
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0176 0.0176
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0049 0.0149
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0049 0.0146
Mycobacterium tuberculosis Conserved protein 0.0042 0.0186 0.0964
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Plasmodium falciparum serine repeat antigen 9 0.0037 0.0158 0.1771
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0247 0.0755
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0176 0.0539
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0049 0.0049
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0126 0.0664 1
Echinococcus granulosus lamin dm0 0.0028 0.0108 0.0331
Leishmania major cysteine peptidase A (CPA) 0.0126 0.0664 0.5757
Schistosoma mansoni inositol transporter 0.004 0.0176 0.0536
Loa Loa (eye worm) hypothetical protein 0.0042 0.0186 0.057
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.0664 0.5706
Loa Loa (eye worm) hypothetical protein 0.0053 0.0247 0.0758
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0219 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0219
Toxoplasma gondii cathepsin CPC1 0.0037 0.0158 0.102
Plasmodium vivax unspecified product 0.0036 0.0152 0.1685
Loa Loa (eye worm) hypothetical protein 0.0167 0.0896 0.2747
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0584 0.326 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0219
Schistosoma mansoni coup transcription factor 0.0022 0.0072 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0459 0.3762
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0186 0.2231
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0158 0.0911
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0158 0.0835
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0033 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0158 0.0911
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0061 0.0188
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0247 0.0758
Plasmodium falciparum serine repeat antigen 6 0.0037 0.0158 0.1771
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.059 0.1807
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0006 0.0016
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0016
Brugia malayi hypothetical protein 0.0012 0.0013 0.0038
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0037 0.0158 0.1771
Loa Loa (eye worm) hypothetical protein 0.009 0.0459 0.1406
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0061 0.0185
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0219
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0219
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0061 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0072 0.0365
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Onchocerca volvulus 0.0037 0.0158 0.0835
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0366 0.2021 0.6199
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0222
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0158 0.048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0158 0.048
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0219 0.0671
Trypanosoma cruzi cysteine peptidase, putative 0.0176 0.0947 0.2798
Leishmania major cathepsin L-like protease 0.0126 0.0664 0.5757
Giardia lamblia Cathepsin B precursor 0.0206 0.1117 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0219
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0006 0.0019
Brugia malayi Cathepsin L-like precursor 0.0036 0.0152 0.0464
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0072 0.0222
Schistosoma mansoni cpg binding protein 0.003 0.0118 0.036
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0219 0.0219
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0363 0.111
Brugia malayi ecdysone receptor 0.001 0.0006 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0114 0.0596 0.1824
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0671
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0037 0.0158 0.048
Echinococcus granulosus smad 0.001 0.0001 0.0003
Brugia malayi Cathepsin L-like cysteine proteinase 0.009 0.0459 0.1404
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0072 0.0219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0072 0.0222
Plasmodium vivax vivapain-1 0.0073 0.0363 0.5107
Plasmodium falciparum serine repeat antigen 4 0.0037 0.0158 0.1771
Giardia lamblia Cathepsin B precursor 0.0206 0.1117 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0176 0.0947 0.8409
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0186 0.0964
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0072 0.0219
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0222
Loa Loa (eye worm) Smad1 0.001 0.0001 0.0003
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0061 0.0061
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0037 0.0158 0.1771
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0584 0.326 1
Echinococcus multilocularis cathepsin L 0.0073 0.0363 0.0363
Plasmodium vivax unspecified product 0.0073 0.0363 0.5107
Onchocerca volvulus 0.009 0.0459 0.2494
Echinococcus granulosus intermediate filament protein 0.0028 0.0108 0.0331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0126 0.0664 0.2036
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0363 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Brugia malayi cathepsin L-like cysteine proteinase 0.0037 0.0158 0.048
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Schistosoma mansoni hypothetical protein 0.0053 0.0247 0.0755
Giardia lamblia Cathepsin B precursor 0.0206 0.1117 1
Onchocerca volvulus 0.0126 0.0664 0.3625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0206 0.1117 0.3425
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0037 0.0158 0.0911
Brugia malayi Cathepsin L-like precursor 0.0126 0.0664 0.2034
Entamoeba histolytica cysteine protease, putative 0.0037 0.0158 0.1596
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0186 0.1284
Plasmodium falciparum cysteine proteinase falcipain 3 0.0126 0.0664 1
Onchocerca volvulus 0.0126 0.0664 0.3625
Brugia malayi Nuclear hormone receptor E75 0.001 0.0006 0.0016
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0037 0.0158 0.0911
Onchocerca volvulus 0.0042 0.0186 0.0991
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.1473 1
Plasmodium falciparum serine repeat antigen 8 0.0037 0.0158 0.1771
Echinococcus granulosus cathepsin l1 0.0126 0.0664 0.2036
Echinococcus multilocularis cysteine protease 0.0126 0.0664 0.0664
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0186 0.0964
Brugia malayi CXXC zinc finger family protein 0.003 0.0118 0.036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0072 0.0365
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.058 0.1779
Toxoplasma gondii ABC1 family protein 0.0042 0.0186 0.1284
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0037 0.0158 0.1771
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.025 0.0768
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0152 0.0467
Onchocerca volvulus 0.033 0.182 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0025 0.0076
Echinococcus multilocularis Smad4 0.001 0.0001 0.0001
Trypanosoma cruzi cysteine proteinase, putative 0.0073 0.0363 0.0978
Schistosoma mansoni inositol transporter 0.004 0.0176 0.0536
Echinococcus granulosus cathepsin L 0.0037 0.0158 0.0483
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0176 0.119
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0073 0.0363 0.5003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.025 0.0768
Leishmania major cathepsin L-like protease 0.0126 0.0664 0.5757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.0664 0.5706
Onchocerca volvulus 0.0126 0.0664 0.3625
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0072 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0222
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0158 0.048
Brugia malayi CHE-14 protein 0.0048 0.0219 0.0668
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0188
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0006 0.0006
Echinococcus multilocularis expressed protein 0.0393 0.2174 0.2174
Loa Loa (eye worm) cysteine protease 0.0126 0.0664 0.2036
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0061 0.0185
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0061 0.0188
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0019
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0019
Echinococcus granulosus expressed protein 0.0393 0.2174 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0363 0.2855
Schistosoma mansoni lamin 0.0028 0.0108 0.0328
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.0158 0.1771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0222
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0025 0.0025
Plasmodium falciparum serine repeat antigen 3 0.0037 0.0158 0.1771
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0309 0.0309
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0186 0.0964
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0219 0.0671
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0322
Echinococcus granulosus cysteine protease 0.0073 0.0363 0.1113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0219
Brugia malayi beta-lactamase 0.0042 0.0186 0.0567
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0108 0.0331
Onchocerca volvulus 0.0022 0.0072 0.0365
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0061 0.0061
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0006 0.0019
Loa Loa (eye worm) beta-lactamase 0.0042 0.0186 0.057
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0739 0.2266
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0539
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0072 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0363 0.5003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0072 0.0219

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.