Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA gyrase subunit B | 0.0247 | 0.4121 | 0.3378 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0111 | 0.1123 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0111 | 0.1123 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0196 | 0.2998 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0247 | 0.4121 | 0.3378 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0111 | 0.1123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3182 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0111 | 0.1123 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0143 | 0.1822 | 0.0788 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0111 | 0.1123 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0111 | 0.1123 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0247 | 0.4121 | 0.2419 |
Echinococcus granulosus | geminin | 0.0205 | 0.3182 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0196 | 0.2998 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0245 | 0.4073 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0103 | 0.0952 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0111 | 0.1123 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.3182 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0196 | 0.2998 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0111 | 0.1123 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3182 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0196 | 0.2998 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0111 | 0.1123 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0037 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.3264 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.