Detailed information for compound 1401324

Basic information

Technical information
  • TDR Targets ID: 1401324
  • Name: 1-(4-fluorobenzoyl)-N-(4-fluorophenyl)piperid ine-4-carboxamide
  • MW: 344.355 | Formula: C19H18F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)F
  • InChi: 1S/C19H18F2N2O2/c20-15-3-1-14(2-4-15)19(25)23-11-9-13(10-12-23)18(24)22-17-7-5-16(21)6-8-17/h1-8,13H,9-12H2,(H,22,24)
  • InChiKey: NKZUMAJMIIODQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-1-[(4-fluorophenyl)-oxomethyl]-4-piperidinecarboxamide
  • 1-(4-fluorobenzoyl)-N-(4-fluorophenyl)isonipecotamide
  • N-(4-fluorophenyl)-1-(4-fluorophenyl)carbonyl-piperidine-4-carboxamide
  • T5546398
  • ZINC05558731

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0004 0.0007
Brugia malayi Cytochrome P450 family protein 0.0037 0.0245 0.0379
Onchocerca volvulus 0.0031 0.0182 0.0607
Leishmania major beta tubulin 0.0612 0.6451 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0182 0.0281
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.1443 0.2199
Echinococcus multilocularis tubulin epsilon chain 0.0333 0.3437 0.5328
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0333 0.0515
Schistosoma mansoni tyrosine kinase 0.0204 0.2047 0.3174
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0318 0.0493
Plasmodium falciparum tubulin gamma chain 0.0333 0.3437 0.5306
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0031 0.0047
Mycobacterium tuberculosis Cell division protein FtsZ 0.0148 0.1443 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0027
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.053 0.5573 0.5573
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Toxoplasma gondii beta-tubulin, putative 0.0612 0.6451 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni hypothetical protein 0.0352 0.3645 0.565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Loa Loa (eye worm) hypothetical protein 0.008 0.0713 0.0713
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0318 0.0448
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Leishmania major beta tubulin 0.0612 0.6451 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0377 0.054
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0124 0.0145
Entamoeba histolytica hypothetical protein 0.0041 0.0292 0.0381
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Trypanosoma cruzi beta tubulin, putative 0.0612 0.6451 1
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Trypanosoma cruzi epsilon tubulin, putative 0.0333 0.3437 0.5306
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0041 0.0292 0.0381
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis tubulin alpha 3 chain 0.0448 0.4685 0.7263
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Brugia malayi tubulin alpha-2 chain 0.0448 0.4685 0.7263
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0333 0.0515
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Tyrosine-protein kinase abl-1 0.0093 0.0853 0.1322
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0443 0.0687
Loa Loa (eye worm) DNA topoisomerase I 0.0182 0.1808 0.1808
Brugia malayi Protein kinase domain containing protein 0.0049 0.0377 0.0584
Trypanosoma brucei beta tubulin 0.0333 0.3437 0.5306
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0063 0.0051
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.053 0.5573 0.8633
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0031
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0318 0.0494
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Brugia malayi hypothetical protein 0.0037 0.0244 0.0377
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Schistosoma mansoni tubulin subunit delta 0.0148 0.1443 0.2237
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.041 0.2684
Loa Loa (eye worm) tubulin gamma chain 0.0333 0.3437 0.3437
Schistosoma mansoni cytochrome P450 0.0028 0.0153 0.0238
Trichomonas vaginalis tubulin epsilon chain, putative 0.0448 0.4685 0.725
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0027 0.0042
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0041 0.0292 0.0381
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.5573 0.8639
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0124 0.0192
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0717 0.1112
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Schistosoma mansoni tyrosine kinase 0.0017 0.0027 0.0042
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Trichomonas vaginalis tubulin, putative 0.0185 0.1841 0.282
Entamoeba histolytica protein kinase, putative 0.0032 0.0192 0.0225
Echinococcus multilocularis tyrosine protein kinase ABL1 0.021 0.2118 0.3284
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0063 0.0098
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0153 0.0868
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.053 0.5573 0.8639
Leishmania major gamma-tubulin 0.0333 0.3437 0.5306
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Echinococcus multilocularis tubulin delta chain 0.0148 0.1443 0.2237
Trichomonas vaginalis tubulin epsilon chain, putative 0.0448 0.4685 0.725
Echinococcus granulosus tubulin gamma 1 chain 0.0333 0.3437 0.5328
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.041 0.2684
Schistosoma mansoni survival motor neuron protein 0.0051 0.0399 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1443 0.2199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.1056 0.7026
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.144 0.2232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0377 0.0585
Loa Loa (eye worm) TK/ABL protein kinase 0.021 0.2118 0.2118
Leishmania major hypothetical protein, conserved 0.0044 0.0318 0.0448
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0074
Leishmania major epsilon tubulin, putative 0.0333 0.3437 0.5306
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.041 0.0635
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0048 0.0122
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0133 0.0409
Echinococcus granulosus beta tubulin 0.0612 0.6451 1
Echinococcus multilocularis carbonic anhydrase II 0.053 0.5573 0.8639
Brugia malayi Tubulin beta chain 0.0185 0.1841 0.2854
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.053 0.5573 0.8633
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0048 0.0122
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0182 0.0282
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Tubulin beta chain 0.0148 0.1443 0.2236
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0362 0.3754 0.5819
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Plasmodium falciparum alpha tubulin 1 0.0448 0.4685 0.725
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni lipoxygenase 0.0056 0.0453 0.0702
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0192 0.0298
Leishmania major beta tubulin 0.0612 0.6451 1
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0046 0.034 0.0482
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0124 0.0145
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0153 0.0868
Brugia malayi Putative carbonic anhydrase 5 precursor 0.053 0.5573 0.8639
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Leishmania major beta tubulin 0.0612 0.6451 1
Leishmania major beta tubulin 0.0612 0.6451 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium leprae Conserved hypothetical protein 0.0028 0.0153 0.0081
Brugia malayi hypothetical protein 0.0026 0.0133 0.0205
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Plasmodium falciparum carbonic anhydrase 0.0339 0.3507 0.5415
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0153 0.0868
Toxoplasma gondii beta tubulin 0.0612 0.6451 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0153 0.0868
Toxoplasma gondii thioredoxin reductase 0.0049 0.0377 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Toxoplasma gondii hypothetical protein 0.0027 0.0143 0.0175
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Loa Loa (eye worm) cytochrome P450 0.0028 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0028 0.0153 0.0238
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Plasmodium falciparum glutathione reductase 0.0049 0.0377 0.054
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0333 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0377 0.0585
Plasmodium vivax tubulin alpha chain, putative 0.0448 0.4685 0.725
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0143 0.0794
Entamoeba histolytica tubulin alpha-1 chain 0.0448 0.4685 0.7242
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Leishmania major zeta tubulin, putative 0.0148 0.1443 0.2199
Brugia malayi hypothetical protein 0.002 0.0063 0.0098
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0315 0.3249 0.5035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.002 0.0031
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0124 0.0145
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0153 0.0868
Loa Loa (eye worm) tubulin alpha-3 chain 0.0263 0.2691 0.2691
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0153 0.0868
Mycobacterium ulcerans cell division protein FtsZ 0.0148 0.1443 1
Toxoplasma gondii hypothetical protein 0.0339 0.3507 0.5415
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0153 0.0868
Trichomonas vaginalis tubulin epsilon chain, putative 0.0148 0.1443 0.2199
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.03 0.3089 0.4764
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0318 0.0448
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0443 0.0687
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0148 0.1443 1
Loa Loa (eye worm) tubulin alpha 2 0.03 0.3089 0.3089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0339 0.3507 0.3507
Echinococcus granulosus peroxisome assembly protein 26 0.0448 0.4685 0.7263
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Echinococcus granulosus tyrosine protein kinase ABL1 0.021 0.2118 0.3284
Brugia malayi Tubulin beta-1 chain 0.0612 0.6451 1
Brugia malayi Probable ClpP-like protease 0.008 0.0705 0.1093
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0015 0.0009 0.0009
Echinococcus granulosus tubulin alpha 0.0333 0.3437 0.5328
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0185 0.1841 0.282
Trichomonas vaginalis tubulin beta chain, putative 0.0612 0.6451 1
Echinococcus multilocularis 0.0045 0.0331 0.0512
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0153 0.0868
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0245 0.0245
Echinococcus granulosus tubulin alpha 1C chain 0.0448 0.4685 0.7263
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Plasmodium vivax glutathione reductase, putative 0.0049 0.0377 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Echinococcus granulosus tubulin alpha 1C chain 0.0448 0.4685 0.7263
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 1
Echinococcus granulosus beta tubulin 0.0612 0.6451 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0099 0.092 0.1425
Echinococcus granulosus tyrosine kinase 0.0039 0.0263 0.0408
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0153 0.0868
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Echinococcus granulosus RUN 0.002 0.0063 0.0098
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0153 0.0868
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1191 0.8217
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0153 0.0868
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.144 0.2233
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0124 0.0191
Schistosoma mansoni peroxidasin 0.0026 0.0133 0.0206
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Peroxidasin 0.0029 0.0164 0.0253
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0244 0.0378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Onchocerca volvulus 0.0026 0.0133 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0443 0.0687
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trichomonas vaginalis tubulin gamma chain, putative 0.0333 0.3437 0.5306
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0339 0.3507 0.3507
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0124 0.0124
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii beta-1 tubulin, putative 0.0612 0.6451 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0223 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.041 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Plasmodium vivax tubulin beta chain, putative 0.0612 0.6451 1
Brugia malayi glutathione reductase 0.0049 0.0377 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0153 0.0868
Loa Loa (eye worm) glutathione reductase 0.0049 0.0377 0.0377
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0333 0.0515
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.0951 0.1473
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Entamoeba histolytica tubulin family protein 0.0612 0.6451 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.0263 0.0408
Schistosoma mansoni lipoxygenase 0.002 0.0063 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Leishmania major beta tubulin 0.0612 0.6451 1
Plasmodium falciparum tubulin beta chain 0.0612 0.6451 1
Schistosoma mansoni tyrosine kinase 0.0081 0.0717 0.1112
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.0263 0.0408
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1191 0.8217
Leishmania major carbonic anhydrase-like protein 0.053 0.5573 0.8633
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0099 0.092 0.1425
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0031
Trichomonas vaginalis tubulin gamma chain, putative 0.0333 0.3437 0.5306
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Trypanosoma brucei tubulin gamma chain 0.0333 0.3437 0.5306
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0318 0.0494
Loa Loa (eye worm) tubulin alpha-2 chain 0.0448 0.4685 0.4685
Brugia malayi alpha-tubulin 0.0448 0.4685 0.7263
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0153 0.0238
Brugia malayi Cytochrome P450 family protein 0.0037 0.0245 0.0379
Echinococcus multilocularis DNA topoisomerase 1 0.0182 0.1808 0.2803
Brugia malayi Thioredoxin reductase 0.0049 0.0377 0.0584
Echinococcus multilocularis Ankyrin 0.0015 0.0004 0.0007
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0182 0.0282
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0124 0.0191
Trypanosoma brucei carbonic anhydrase-like protein 0.053 0.5573 0.8633
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0377 0.054
Brugia malayi Tubulin alpha-2 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0362 0.3754 0.5799
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.0263 0.0408
Echinococcus multilocularis beta tubulin 0.0612 0.6451 1
Schistosoma mansoni peroxidasin 0.0026 0.0133 0.0206
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0705 0.1051
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0153 0.0868
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Loa Loa (eye worm) TK protein kinase 0.0102 0.0951 0.0951
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0098
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0318 0.0494
Loa Loa (eye worm) beta-tubulin 0.0612 0.6451 0.6451
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0143 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Leishmania major DNA topoisomerase type IB small subunit 0.0046 0.034 0.0482
Schistosoma mansoni hypothetical protein 0.0339 0.3507 0.5437
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0153 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0063 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0153 0.0868
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Trypanosoma brucei trypanothione reductase 0.0049 0.0377 0.054
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0027
Echinococcus granulosus insulin receptor 0.0049 0.0377 0.0585
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0136 0.1316 0.2001
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Loa Loa (eye worm) hypothetical protein 0.0448 0.4685 0.4685
Echinococcus multilocularis insulin receptor 0.0049 0.0377 0.0585
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0153 0.0868
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0153 0.0868
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) tubulin beta-1 chain 0.0612 0.6451 0.6451
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0453 0.0702
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus granulosus tubulin beta 1 chain 0.0612 0.6451 1
Echinococcus multilocularis hypothetical protein 0.0448 0.4685 0.7263
Loa Loa (eye worm) alpha-tubulin isotype 2 0.03 0.3089 0.3089
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.002 0.002
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0399 0.0617
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0037 0.0244 0.0378
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0245 0.0333
Plasmodium vivax tubulin epsilon chain, putative 0.0333 0.3437 0.5306
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.1443 0.2199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0027
Echinococcus granulosus carbonic anhydrase II 0.053 0.5573 0.8639
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0443 0.0687
Loa Loa (eye worm) hypothetical protein 0.025 0.2551 0.2551
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) doublecortin family protein 0.002 0.0063 0.0063
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Schistosoma mansoni tubulin subunit beta 0.0148 0.1443 0.2237
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0153 0.0868
Schistosoma mansoni DNA topoisomerase type I 0.0136 0.1316 0.2039
Plasmodium vivax SET domain protein, putative 0.0031 0.0182 0.0235
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0153 0.0191
Trypanosoma brucei alpha tubulin, putative 0.0185 0.1841 0.282
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0164 0.0164
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2502 0.385
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.1095 0.1095
Brugia malayi Latrophilin receptor protein 2 0.0016 0.002 0.0031
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Entamoeba histolytica tubulin gamma chain 0.0333 0.3437 0.5293
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0318
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Trichomonas vaginalis tubulin, putative 0.0148 0.1443 0.2199
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0705 0.1094
Brugia malayi Cytochrome P450 family protein 0.0028 0.0153 0.0237
Plasmodium vivax delta tubulin, putative 0.0148 0.1443 0.2199
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0164 0.0164
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Trichomonas vaginalis tubulin alpha chain, putative 0.0612 0.6451 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1056 0.7262
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0136 0.1316 0.2001
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus tubulin delta chain 0.0148 0.1443 0.2237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0448 0.4685 0.725
Trypanosoma cruzi tubulin delta chain 0.0148 0.1443 0.2199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0182 0.0235
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1191 0.8217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Echinococcus multilocularis transient receptor potential cation channel 0.0159 0.1559 0.2416
Toxoplasma gondii alpha tubulin TUBA1 0.0448 0.4685 0.725
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0153 0.0868
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Plasmodium vivax tubulin gamma chain, putative 0.0333 0.3437 0.5306
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0318 0.0494
Schistosoma mansoni loxhd1 0.002 0.0063 0.0098
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0245 0.0333
Brugia malayi Cytochrome P450 family protein 0.0028 0.0153 0.0237
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Loa Loa (eye worm) tubulin alpha 2 0.03 0.3089 0.3089
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0717 0.1112
Schistosoma mansoni hypothetical protein 0.0035 0.0221 0.0343
Plasmodium vivax topoisomerase I, putative 0.0182 0.1808 0.2769
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1191 0.8064
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis peroxisome assembly protein 26 0.0448 0.4685 0.7263
Echinococcus multilocularis peroxidasin 0.0029 0.0164 0.0254
Brugia malayi Cell division protein ftsZ 0.0148 0.1443 0.2236
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0318 0.0493
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.0074
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1056 0.7262
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0453 0.0702
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.0263 0.2691 0.2691
Echinococcus granulosus peroxidasin 0.0029 0.0164 0.0254
Leishmania major beta tubulin 0.0612 0.6451 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0182 0.0282
Echinococcus granulosus GPCR family 2 0.0016 0.002 0.0031
Onchocerca volvulus 0.0051 0.0399 0.1483
Echinococcus granulosus tubulin beta 4A class IVa 0.0612 0.6451 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0705 0.1094
Echinococcus multilocularis tubulin subunit beta 0.0612 0.6451 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0027
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0318 0.0448
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0333 0.0515
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Tubulin alpha chain 0.0148 0.1443 0.2236
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Brugia malayi protein-tyrosine kinase 0.0039 0.0263 0.0408
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0244 0.0378
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus multilocularis geminin 0.0352 0.3645 0.565
Leishmania major cytochrome p450-like protein 0.0028 0.0153 0.0191
Schistosoma mansoni tyrosine kinase 0.0081 0.0717 0.1112
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0315 0.3249 0.5036
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0027 0.0042
Loa Loa (eye worm) tubulin alpha chain 0.0448 0.4685 0.4685
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.1051
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0153 0.0868
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0031
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0359 0.372 0.5746
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0153 0.0868
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0333 0.0515
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0362 0.3754 0.5819
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.218 0.218
Onchocerca volvulus 0.002 0.0063 0.0129
Leishmania major cytochrome p450-like protein 0.0037 0.0245 0.0333
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0705 0.4328
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0245 0.0245
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0333 0.0515
Loa Loa (eye worm) tubulin beta-2A chain 0.0612 0.6451 0.6451
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0099 0.092 0.1425
Echinococcus multilocularis tubulin alpha 1C chain 0.0448 0.4685 0.7263
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0263 0.2691 0.4143
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.002 0.0063 0.0098
Brugia malayi hypothetical protein 0.025 0.2551 0.3954
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0153 0.0868
Trypanosoma cruzi tubulin delta chain 0.0148 0.1443 0.2199
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0394 0.0394
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0717 0.1112
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0164 0.0534
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0333 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0182 0.0182
Loa Loa (eye worm) tubulin beta chain 0.0612 0.6451 0.6451
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0153 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Loa Loa (eye worm) hypothetical protein 0.008 0.0705 0.0705
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0153 0.0868
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0031
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0245 0.0333
Brugia malayi DNA topoisomerase I 0.0182 0.1808 0.2803
Leishmania major DNA topoisomerase IB, large subunit 0.0136 0.1316 0.2001
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.1443 0.2199
Loa Loa (eye worm) carbonic anhydrase 3 0.053 0.5573 0.5573
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0315 0.3249 0.3249
Trichomonas vaginalis tubulin epsilon chain, putative 0.0612 0.6451 1
Brugia malayi Tubulin alpha-2 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis tubulin epsilon chain, putative 0.0612 0.6451 1
Brugia malayi Tubulin alpha chain 0.0448 0.4685 0.7263
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Giardia lamblia Hypothetical protein 0.0044 0.0318 0.0448
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0245 0.1515
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.1443 0.2199
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0155 0.1521 0.2357
Loa Loa (eye worm) BEN-1 protein 0.0612 0.6451 0.6451
Leishmania major cytochrome p450-like protein 0.0028 0.0153 0.0191
Echinococcus granulosus DNA topoisomerase 1 0.0182 0.1808 0.2803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0359 0.372 0.5766
Plasmodium falciparum alpha tubulin 2 0.0448 0.4685 0.725
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Echinococcus granulosus alpha tubulin 0.0448 0.4685 0.7263
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.0359 0.372 0.372
Schistosoma mansoni tyrosine kinase 0.0099 0.092 0.1425
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0377 0.2453
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0182 0.0282
Schistosoma mansoni tyrosine kinase 0.0045 0.0333 0.0515
Trichomonas vaginalis tubulin gamma chain, putative 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0153 0.0868
Trypanosoma cruzi epsilon tubulin, putative 0.0333 0.3437 0.5306
Loa Loa (eye worm) hypothetical protein 0.0051 0.0394 0.0394
Mycobacterium leprae putative cytochrome p450 0.0028 0.0153 0.0081
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis tubulin alpha 0.0333 0.3437 0.5328
Echinococcus multilocularis tubulin subunit TubB 0.0448 0.4685 0.7263
Treponema pallidum cell division protein FtsZ 0.0148 0.1443 1
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0074
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Giardia lamblia Delta tubulin 0.0148 0.1443 0.2199
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Schistosoma mansoni tyrosine kinase 0.0049 0.0377 0.0585
Schistosoma mansoni tyrosine kinase 0.0045 0.0333 0.0515
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Trypanosoma brucei zeta tubulin, putative 0.0148 0.1443 0.2199
Plasmodium vivax tubulin alpha chain, putative 0.0448 0.4685 0.725
Brugia malayi tubulin alpha chain - mouse 0.0448 0.4685 0.7263
Schistosoma mansoni vesicular amine transporter 0.0014 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0153 0.0868
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Trichomonas vaginalis tubulin, putative 0.0185 0.1841 0.282
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis beta tubulin 0.0612 0.6451 1
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0443 0.0443
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0705 0.1094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0047 0.0353 0.0501
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Leishmania major hypothetical protein, conserved 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0153 0.0868
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0164 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Trichomonas vaginalis chaperonin, putative 0.0026 0.0124 0.0145
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0153 0.0868
Echinococcus multilocularis tubulin gamma 1 chain 0.0333 0.3437 0.5328
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0027 0.0042
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0098
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Doublecortin family protein 0.002 0.0063 0.0098
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0333 0.0515
Giardia lamblia Alpha-tubulin 0.0448 0.4685 0.725
Echinococcus granulosus tubulin alpha 3 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Echinococcus multilocularis tyrosine protein kinase Abl 0.0093 0.0853 0.1323
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2551 0.3954
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0153 0.0191
Onchocerca volvulus Peroxidase homolog 0.0026 0.0133 0.0409
Echinococcus granulosus geminin 0.0352 0.3645 0.565
Brugia malayi SRC-1 0.0045 0.0333 0.0515
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0318 0.0493
Loa Loa (eye worm) tubulin beta chain 0.0148 0.1443 0.1443
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0153 0.0191
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis tubulin alpha 1C chain 0.0448 0.4685 0.7263
Echinococcus granulosus ankyrin repeat protein 0.0155 0.1521 0.2357
Schistosoma mansoni tyrosine kinase 0.0049 0.0377 0.0585
Brugia malayi Blistered cuticle protein 3 0.0026 0.0133 0.0205
Onchocerca volvulus 0.0246 0.2506 1
Plasmodium falciparum thioredoxin reductase 0.0049 0.0377 0.054
Echinococcus multilocularis RUN 0.002 0.0063 0.0098
Echinococcus multilocularis 0.0028 0.0153 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0153 0.0868
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0048 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.144 0.144
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0098
Trypanosoma cruzi tubulin gamma chain 0.0333 0.3437 0.5306
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Plasmodium falciparum topoisomerase I 0.0182 0.1808 0.2769
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Brugia malayi Pre-SET motif family protein 0.0216 0.218 0.3379
Mycobacterium leprae cell division protein FtsZ 0.0148 0.1443 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0245 0.0245
Loa Loa (eye worm) BEN-1 protein 0.0612 0.6451 0.6451
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0394 0.0611
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus tubulin alpha 3 chain 0.0448 0.4685 0.7263
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0046 0.034 0.0482
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0153 0.0153
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.1555 0.241
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0048 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0244 0.0378
Plasmodium falciparum tubulin delta chain, putative 0.0148 0.1443 0.2199
Loa Loa (eye worm) tubulin beta-4 chain 0.0612 0.6451 0.6451
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0223 0.0346
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0333 0.0515
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0099 0.092 0.1425
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Giardia lamblia hypothetical protein 0.0044 0.0318 0.0448
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0063
Echinococcus granulosus tubulin subunit beta 0.0612 0.6451 1
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.0027
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0063 0.0051
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0192 0.0298
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0318 0.0494
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Loa Loa (eye worm) alpha-tubulin 0.0448 0.4685 0.4685
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni carbonic anhydrase 0.0339 0.3507 0.5437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0443 0.0687
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.1443 0.2199
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0048 0.0027
Brugia malayi cytochrome P450 0.0028 0.0153 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0153 0.0868
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0315 0.3249 0.5036
Schistosoma mansoni tyrosine kinase 0.0148 0.144 0.2233
Trypanosoma cruzi alpha tubulin, putative 0.0448 0.4685 0.725
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0705 0.1051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1056 0.7262
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2551 0.3954
Leishmania major trypanothione reductase 0.0049 0.0377 0.054
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0027 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0221 0.0342
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0394 0.0611
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0377 0.0585
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Schistosoma mansoni tubulin subunit epsilon 0.0333 0.3437 0.5328
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0027 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.03 0.3089 0.3089
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0333 0.3437 0.5306
Mycobacterium tuberculosis Probable reductase 0.0112 0.1056 0.7262
Echinococcus granulosus tubulin subunit TubB 0.0448 0.4685 0.7263
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.053 0.5573 0.8639
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.0263 0.0408
Leishmania major beta tubulin 0.0612 0.6451 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.0074
Schistosoma mansoni DNA topoisomerase type I 0.0182 0.1808 0.2803
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.144 0.2233
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0124 0.0145
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0333 0.0515
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Trypanosoma brucei zeta tubulin 0.0148 0.1443 0.2199
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0318 0.0494
Schistosoma mansoni DNA topoisomerase type I 0.0136 0.1316 0.2039
Loa Loa (eye worm) alpha-tubulin 0.0448 0.4685 0.4685
Onchocerca volvulus Peroxidase homolog 0.0026 0.0133 0.0409
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0153 0.0868
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0148 0.1443 0.2199
Schistosoma mansoni hypothetical protein 0.0352 0.3645 0.565
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0618
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0098
Echinococcus granulosus tubulin epsilon chain 0.0333 0.3437 0.5328
Echinococcus multilocularis ankyrin repeat protein 0.0155 0.1521 0.2357
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0318 0.0494
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Entamoeba histolytica tubulin family protein 0.0612 0.6451 1
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Leishmania major beta tubulin 0.0612 0.6451 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0339 0.3507 0.5437
Echinococcus multilocularis GPCR, family 2 0.0016 0.002 0.0031
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0133 0.0409
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0153 0.0868
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) PDE1B protein 0.0044 0.0318 0.0318
Toxoplasma gondii DNA topoisomerase I, putative 0.0182 0.1808 0.2769
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Loa Loa (eye worm) TK protein kinase 0.0032 0.0192 0.0192
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0153 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0612 0.6451 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1056 0.7262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0169 0.0263
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0153 0.0868
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.1181 0.1831
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Entamoeba histolytica tubulin alpha chain, putative 0.0448 0.4685 0.7242
Leishmania major beta tubulin 0.0612 0.6451 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0339 0.3507 0.5437
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0377 0.0377
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.0048
Plasmodium falciparum tubulin epsilon chain, putative 0.0333 0.3437 0.5306
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0318 0.0448
Echinococcus granulosus Ankyrin 0.0015 0.0004 0.0007
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0318 0.0494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0221
Echinococcus multilocularis tubulin beta 1 chain 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.1182 0.1794
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0263 0.0408
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.1841 0.282
Loa Loa (eye worm) SRC-1 0.0045 0.0333 0.0333
Echinococcus multilocularis tubulin alpha 3 chain 0.0448 0.4685 0.7263
Leishmania major delta tubulin, putative 0.0148 0.1443 0.2199
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0124 0.0192
Trichomonas vaginalis tubulin, putative 0.0612 0.6451 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni polycystin 1-related 0.002 0.0063 0.0098
Onchocerca volvulus 0.0026 0.0133 0.0409
Onchocerca volvulus 0.0026 0.0133 0.0409
Loa Loa (eye worm) hypothetical protein 0.0339 0.3507 0.3507
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0153 0.0868
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) tubulin alpha chain 0.0448 0.4685 0.4685
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0164 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0153 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1443 0.2199
Onchocerca volvulus 0.002 0.0063 0.0129
Onchocerca volvulus 0.0185 0.1841 0.7313
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Toxoplasma gondii alpha-tubulin I, putative 0.0448 0.4685 0.725
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.041 0.2053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Brugia malayi beta-tubulin, identical 0.0612 0.6451 1
Brugia malayi Tubulin gamma chain 0.0333 0.3437 0.5328
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0143 0.0175
Giardia lamblia Gamma tubulin 0.0333 0.3437 0.5306
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0098
Giardia lamblia Alpha-tubulin 0.0448 0.4685 0.725
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0124 0.0118
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0153 0.0868
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0027
Trichomonas vaginalis tubulin alpha chain, putative 0.0333 0.3437 0.5306
Schistosoma mansoni tubulin subunit alpha 0.0148 0.1443 0.2237
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0027
Trypanosoma brucei tubulin delta chain 0.0148 0.1443 0.2199
Loa Loa (eye worm) TK protein kinase 0.0039 0.0263 0.0263
Schistosoma mansoni tyrosine kinase 0.0017 0.0027 0.0042
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1056 0.7262
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0705 0.1051
Schistosoma mansoni tubulin subunit gamma 0.0333 0.3437 0.5328
Brugia malayi hypothetical protein 0.002 0.0063 0.0098
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0124 0.0145
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Giardia lamblia Epsilon tubulin 0.0148 0.1443 0.2199
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0377 0.0585
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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