Detailed information for compound 1402113

Basic information

Technical information
  • TDR Targets ID: 1402113
  • Name: (7R)-8-[(E)-but-2-enoyl]-3-[3-(2-methylprop-2 -enoylamino)phenyl]-1-oxa-2,8-diazaspiro[4.4] non-2-ene-7-carboxamide
  • MW: 396.44 | Formula: C21H24N4O4
  • H donors: 2 H acceptors: 3 LogP: 1.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/C(=O)N1CC2(C[C@@H]1C(=O)N)ON=C(C2)c1cccc(c1)NC(=O)C(=C)C
  • InChi: 1S/C21H24N4O4/c1-4-6-18(26)25-12-21(11-17(25)19(22)27)10-16(24-29-21)14-7-5-8-15(9-14)23-20(28)13(2)3/h4-9,17H,2,10-12H2,1,3H3,(H2,22,27)(H,23,28)/b6-4+/t17-,21?/m1/s1
  • InChiKey: CQMBETNXXRVNKZ-HFIKFMIISA-N  


Substructure search Similarity search

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Synonyms

  • (7R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-8-[(E)-1-oxobut-2-enyl]-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • (7R)-8-[(E)-but-2-enoyl]-3-(3-methacrylamidophenyl)-1-oxa-2,8-diazaspiro[4.4]non-2-ene-7-carboxamide
  • MLS000561975
  • SMR000390639

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens apoptotic peptidase activating factor 1 Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1223 0.336
Schistosoma mansoni bromodomain containing protein 0.0076 0.1073 0.2938
Schistosoma mansoni chromobox protein 0.0084 0.1223 0.336
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0038 0.0032
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0035 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0528 0.0528
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0483 0.0547
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0038 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0275 0.0697
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.3587 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0487 0.0487
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0483 0.0547
Onchocerca volvulus 0.0037 0.0311 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.183 0.2163
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.3587 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.3587 0.5345
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.3587 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0306 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.6686 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.183 0.2163
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0275 0.0697
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0573 0.1533
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0306 0.0419
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2141 0.3174
Schistosoma mansoni hypothetical protein 0.0037 0.0311 0.0799
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0306 0.0784
Entamoeba histolytica ubiquitin like protein 0.0037 0.0306 0.0784
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0459 0.1215
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0035 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0311 0.0311
Echinococcus granulosus chromobox protein 1 0.0084 0.1223 0.1435
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0306 0.0335
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.2141 0.3174
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0414 0.0465
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0035 0.001
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.6686 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.0637 0.1715
Leishmania major DNA polymerase eta, putative 0.0038 0.0324 0.0447
Brugia malayi hypothetical protein 0.0182 0.3138 0.3119
Echinococcus multilocularis Protein lozenge 0.0067 0.0891 0.1037
Mycobacterium ulcerans hypothetical protein 0.0192 0.3325 0.9266
Giardia lamblia PHD finger protein 15 0.0035 0.027 0.0683
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.1137 0.1113
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.023 0.0203
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.1532 0.1806
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0802 0.1163
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0035 0.0024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0038 0.0032
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2141 0.5938
Schistosoma mansoni hypothetical protein 0.01 0.1532 0.4228
Schistosoma mansoni apoptosis regulator bax 0.01 0.1532 0.4228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3587 0.5345
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0035 0.0024
Toxoplasma gondii hypothetical protein 0.0059 0.073 0.1975
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1 0.1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1137 0.1667
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0035 0.0024
Echinococcus multilocularis peregrin 0.0038 0.0326 0.0359
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0038 0.0032
Echinococcus multilocularis dna polymerase eta 0.0054 0.0637 0.0733
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2141 0.5938
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2141 0.3174
Brugia malayi hypothetical protein 0.0023 0.0035 0.0009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.027 0.0683
Echinococcus granulosus dna polymerase kappa 0.0023 0.0038 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0306 0.0784
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0035 0.001
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0306 0.0306
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.3587 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3325 0.9266
Echinococcus granulosus peregrin 0.0038 0.0326 0.0359
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0038 0.0012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1137 0.1667
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0306 0.0419
Loa Loa (eye worm) hypothetical protein 0.0054 0.0637 0.0637
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0035 0.001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0583 0.0835
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0038 0.0017
Schistosoma mansoni zinc finger protein 0.0024 0.0045 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0027 0.0027
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0115 0.0105
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0306 0.0419
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0035 0.001
Echinococcus granulosus expressed protein 0.0451 0.8362 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.3587 1
Brugia malayi hypothetical protein 0.0023 0.0035 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.007 0.007
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.1137 0.1332
Leishmania major DNA polymerase eta, putative 0.0054 0.0637 0.0917
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3587 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0038 0.0017
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0306 0.0784
Brugia malayi Phosphoglycerate kinase 0.0206 0.3587 0.3569
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0235 0.0584
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.027 0.0292
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0035 0.0024
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0035 0.001
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0539 0.0614
Brugia malayi PHD-finger family protein 0.003 0.017 0.0144
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1223 0.1223
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.0311 0.0341
Giardia lamblia Phosphoglycerate kinase 0.0206 0.3587 1
Echinococcus granulosus dna polymerase eta 0.0054 0.0637 0.0733
Brugia malayi jmjC domain containing protein 0.0045 0.0459 0.0434
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Echinococcus multilocularis chromobox protein 1 0.0084 0.1223 0.1435
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0035 0.001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0035 0.0024
Brugia malayi 6-phosphofructokinase 0.0131 0.2141 0.2119
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.3587 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3587 0.5345
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0035 0.001
Plasmodium falciparum phd finger protein, putative 0.0035 0.027 0.0683
Schistosoma mansoni hypothetical protein 0.0165 0.2792 0.7767
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0539 0.0614
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0459 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0024
Schistosoma mansoni hypothetical protein 0.01 0.1532 0.4228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Echinococcus multilocularis zinc finger protein 0.0024 0.0045 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0503 0.1337
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.2141 0.2536
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.027
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0306 0.028
Brugia malayi jmjC domain containing protein 0.0115 0.183 0.1808
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.3587 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0038 0.0014
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0459 0.0519
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0035 0.001
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3587 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0275 0.0697
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2141 0.5938
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0038 0.0032
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0035 0.0009
Schistosoma mansoni hypothetical protein 0.0165 0.2792 0.7767
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.1054 0.1542
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0035 0.0035
Loa Loa (eye worm) runx1 0.0067 0.0891 0.0891
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.3587 0.4271
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0035 0.001
Brugia malayi PXA domain containing protein 0.0023 0.0035 0.0009
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2141 0.5938
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0035 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.1532 0.1806
Echinococcus granulosus chromobox protein 1 0.0084 0.1223 0.1435
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2946 0.4383
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2141 0.2141
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.6686 1
Schistosoma mansoni hypothetical protein 0.0033 0.023 0.057
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0035 0.0009
Brugia malayi Bromodomain containing protein 0.0091 0.1348 0.1325
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0175 0.2983 0.8304
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0583 0.0835
Echinococcus granulosus zinc finger protein 0.0024 0.0045 0.0022
Echinococcus multilocularis chromobox protein 1 0.0084 0.1223 0.1435
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0182 0.3138 0.3138
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0275 0.0697
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0528 0.0503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.1532 0.1532
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.1137 0.1332
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0306 0.0784
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0324 0.0447
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0573 0.1533
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.1532 0.1806
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0035 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0459 0.1215
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0038 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0038 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2141 0.5938
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0324 0.0836
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0038 0.0032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.043 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0038 0.0032
Onchocerca volvulus 0.0037 0.0305 0.0035
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.0311 0.0042
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3587 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0311 0.0311
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3587 0.5345
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.1137 0.3118
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0235 0.0584
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0035 0.001
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0035 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0528 0.0503
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0035 0.0009
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.1532 0.1806
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Brugia malayi phosphofructokinase 0.0131 0.2141 0.2119
Echinococcus multilocularis ankyrin repeat protein 0.0175 0.2983 0.3547
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0035 0.0024
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.3587 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.043 0.0483
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0035 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1137 0.1667
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2141 0.5938
Brugia malayi chromobox protein homolog 3 0.0047 0.0503 0.0477
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0115 0.0247
Giardia lamblia DINP protein human, muc B family 0.0023 0.0038 0.0032
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2141 0.2141
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.6686 1
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3587 0.5345
Echinococcus granulosus ankyrin repeat protein 0.0175 0.2983 0.3547
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.3587 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.0311 0.0341
Brugia malayi Bromodomain containing protein 0.0046 0.0485 0.046
Leishmania major small ubiquitin protein, putative 0.0037 0.0306 0.0419
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0035 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0038 0.0014
Brugia malayi 6-phosphofructokinase 0.0131 0.2141 0.2119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0583 0.0835
Loa Loa (eye worm) hypothetical protein 0.006 0.076 0.076
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0024
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0275 0.0697
Echinococcus multilocularis caspase 2 0.0037 0.0311 0.0341
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Loa Loa (eye worm) hypothetical protein 0.0049 0.0543 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0637 0.0612
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0637 0.0917
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0115 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0275 0.0697
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2141 0.5938
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.2141 0.5938
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1368 0.3769
Schistosoma mansoni chromobox protein 0.0084 0.1223 0.336
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0275 0.0697
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0035 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0035 0.0035
Echinococcus granulosus geminin 0.0165 0.2792 0.3317
Schistosoma mansoni hypothetical protein 0.0035 0.027 0.0683
Brugia malayi Phosphoglycerate kinase 0.0075 0.1054 0.103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0988 0.1154
Brugia malayi PXA domain containing protein 0.0023 0.0035 0.0009
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0275 0.0697
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0035 0.001
Onchocerca volvulus 0.0182 0.3138 0.2947
Brugia malayi PHD-finger family protein 0.0035 0.027 0.0244
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0503 0.1337
Echinococcus granulosus transient receptor potential cation channel 0.018 0.3087 0.3671
Echinococcus granulosus caspase 2 0.0037 0.0311 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0035 0.001
Echinococcus multilocularis geminin 0.0165 0.2792 0.3317
Loa Loa (eye worm) phosphofructokinase 0.0131 0.2141 0.2141
Brugia malayi Cell death protein 3 precursor 0.0037 0.0311 0.0285
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0583 0.0835
Giardia lamblia Sentrin 0.0037 0.0306 0.0784
Loa Loa (eye worm) hypothetical protein 0.0033 0.023 0.023
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.3587 0.5345
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0035 0.0009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0035 0.0035
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.1532 0.1509
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2141 0.5938
Echinococcus multilocularis expressed protein 0.0451 0.8362 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.027 0.0683
Loa Loa (eye worm) hypothetical protein 0.0085 0.1248 0.1248
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0275 0.0697
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3587 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.1054 0.1542
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0038 0.0017
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.1137 0.1137
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.3587 0.4271
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0306 0.0784
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0637 0.0917
Echinococcus multilocularis transient receptor potential cation channel 0.018 0.3092 0.3677
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.2141 0.5938
Trypanosoma brucei unspecified product 0.0023 0.0038 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0038 0.0038
Leishmania major DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.027 0.0292
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.3587 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0503 0.0503
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0035 0.0024
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0035 0.001
Plasmodium vivax hypothetical protein, conserved 0.0035 0.027 0.0683
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.027 0.027
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0038 0.0032
Brugia malayi Heterochromatin protein 1 0.0084 0.1223 0.1199
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0035 0.001
Loa Loa (eye worm) hypothetical protein 0.0206 0.3587 0.3587
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0503 0.0239
Loa Loa (eye worm) hypothetical protein 0.0048 0.0528 0.0528
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0305
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0035 0.0009
Brugia malayi hypothetical protein 0.0037 0.0311 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0573 0.0311
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0038 0.0032
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.0311 0.0799
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1223 0.336
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.1532 0.4228
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0275 0.0697
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.2141 0.2536
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2946 0.4383
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.027 0.0683
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0035 0.001
Treponema pallidum phosphoglycerate kinase 0.0206 0.3587 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.2946 0.4383
Schistosoma mansoni lozenge 0.0067 0.0891 0.2428
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0035 0.0024
Schistosoma mansoni hypothetical protein 0.01 0.1532 0.4228
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.2141 0.5938
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2141 0.5938
Brugia malayi Bromodomain containing protein 0.0038 0.0326 0.03
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0988 0.1154
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0275 0.0697
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.1137 0.3118
Loa Loa (eye worm) hypothetical protein 0.0052 0.0587 0.0587
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0024
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.1137 0.1667
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0275 0.0697
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.1054 0.1542
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0038 0.0017
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0035 0.0024
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.1532 0.1532

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.71 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489031, AID492946] ChEMBL. No reference
EC50 (binding) = 21.28 uM PUBCHEM_BIOASSAY: Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488855] ChEMBL. No reference
EC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489031, AID492946] ChEMBL. No reference
IC50 (functional) = 1.614 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) 1.93 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 3.478132473 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (functional) = 6.14 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
IC50 (functional) 66.6 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
Potency (binding) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: Inhibitors of DNA Polymerase Beta: Hit validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485311] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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