Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.2554 | 0.2554 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.2554 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.2554 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2554 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0131 | 0.0511 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.2554 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.2554 | 0.2554 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.2554 | 0.2554 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0131 | 0.0131 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0131 | 0.0511 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.2554 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.2554 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Schistosoma mansoni | kinase | 0.0058 | 0.0119 | 0.0465 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.2554 | 0.2554 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.2554 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2554 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2554 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2909 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.3714 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.