TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.467 | Formula: C19H21N5O2S
H donors: 1 H acceptors: 5 LogP: 2.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCCCCC1)CSc1nc2nncc2c(n1c1ccccc1)O
InChi: 1S/C19H21N5O2S/c25-16(23-10-6-1-2-7-11-23)13-27-19-21-17-15(12-20-22-17)18(26)24(19)14-8-4-3-5-9-14/h3-5,8-9,12,26H,1-2,6-7,10-11,13H2
InChiKey: WMNLKOZWZSNZST-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.5199	1
Schistosoma mansoni	amine GPCR	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	opsin-like receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0023	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	hypothetical protein	0.0018	0.0193	0.0193
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0193	0.0214
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0109	0.8357	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0034	0.1643	0.1816
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.5199	0.5199
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0023	0.0686	0.0686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus granulosus	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.0193	0.0214
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	somatostatin receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0023	0.0686	0.0758
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0193	0.0193
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0193	0.0214
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0034	0.1643	0.1816
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0193	0.0193
Brugia malayi	G-protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Schistosoma mansoni	amine GPCR	0.0018	0.0193	0.0193
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0023	0.0686	0.0758
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	hyperpolarization activated cyclic	0.0023	0.0686	0.0758
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0023	0.0686	0.0758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Brugia malayi	GnHR receptor homolog	0.0018	0.0193	0.0214
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0193	0.0214
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0193	0.0193
Brugia malayi	larval opioid receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0018	0.0193	0.0214
Brugia malayi	putative neuropeptide receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0193	0.0214
Schistosoma mansoni	opsin-like receptor	0.0018	0.0193	0.0193
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0193	0.0214
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.5199	1
Schistosoma mansoni	myosin xvIII	0.0018	0.0193	0.0193
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0193	0.0214
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0193	0.0214
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0034	0.1643	0.1816
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0193	0.0214
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	sex peptide receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0023	0.0686	0.0758
Echinococcus granulosus	voltage gated potassium channel	0.0034	0.1643	0.1816
Brugia malayi	neuropeptide F receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0193	0.0214
Brugia malayi	Dopamine receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	hypothetical protein	0.0018	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0193	0.0214
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0023	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0193	0.0193
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.5199	0.5749
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0193	0.0214
Brugia malayi	follicle stimulating hormone receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0116	0.9043	1
Brugia malayi	sulfakinin receptor protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0018	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0193	0.0214
Brugia malayi	G-protein coupled receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0193	0.0214
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0193	0.0193
Echinococcus granulosus	serotonin receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0193	0.0214
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0193	0.0214
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.5199	0.5199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Schistosoma mansoni	voltage-gated potassium channel	0.0018	0.0267	0.0267
Schistosoma mansoni	hypothetical protein	0.0018	0.0193	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Schistosoma mansoni	amine GPCR	0.0018	0.0193	0.0193
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0193	0.0214
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0193	0.0214
Brugia malayi	G protein-coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0023	0.0686	0.082
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0018	0.0193	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0193	0.0214
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.5199	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0023	0.0686	0.0758
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0193	0.0193
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0193	0.0214
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0193	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0193	0.0193
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0116	0.9043	1
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0023	0.0686	0.0758
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0023	0.0686	0.0758
Onchocerca volvulus		0.0018	0.0193	1
Onchocerca volvulus		0.0018	0.0193	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0023	0.0686	0.0686
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	60S ribosomal protein L21	0.0018	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0023	0.0686	0.0758
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.5199	0.5749
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0193	0.0193
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0193	0.0214
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0193	0.0214
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.1643	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0109	0.8357	1
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0193	0.0193
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0193	0.0193
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.5199	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0193	0.0214
Echinococcus multilocularis	serotonin receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Echinococcus multilocularis	serotonin receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	amine GPCR	0.0018	0.0193	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.1643	0.1643
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0193	0.0214
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0116	0.9043	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0193	0.0214
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	hypothetical protein	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1643	0.1816
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0193	0.0214
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0023	0.0686	0.082
Onchocerca volvulus		0.0018	0.0193	1
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0193	0.0193
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0193	0.0214
Brugia malayi	Serotonin receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0023	0.0686	0.0758
Schistosoma mansoni	opsin-like receptor	0.0018	0.0193	0.0193
Brugia malayi	AKH receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0023	0.0686	0.0758
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0193	0.0193
Onchocerca volvulus		0.0018	0.0193	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0193	0.0214
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0193	0.0214
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.5199	1
Brugia malayi	Serotonin receptor	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	hyperpolarization activated cyclic	0.0023	0.0686	0.0758
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0193	0.0214
Brugia malayi	RE15519p	0.0018	0.0193	0.0214
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0023	0.0686	0.0686
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0193	0.0214
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.5199	1
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	adenoreceptor	0.0018	0.0193	0.0193
Brugia malayi	neuropeptide F receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	voltage gated potassium channel	0.0034	0.1643	0.1816
Loa Loa (eye worm)	hypothetical protein	0.0101	0.7667	0.8478
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0193	0.0214
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0193	0.0214
Schistosoma mansoni	amine GPCR	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0023	0.0686	0.0758
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	voltage-gated potassium channel	0.0023	0.0686	0.0686
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0193	0.0214
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0193	0.0193
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0193	0.0214
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0193	0.0214
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0193	0.0193
Onchocerca volvulus		0.0018	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0686	0.0758
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0193	0.0214
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0023	0.0686	0.0686
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0193	0.0214
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0193	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0193	0.0214
Brugia malayi	hypothetical protein	0.0018	0.0193	0.0214
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0193	0.0214
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0193	0.0214
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0116	0.9043	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1543105

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1403052