TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.381 | Formula: C21H20O5
H donors: 0 H acceptors: 1 LogP: 3.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1OC)C1=CC(=O)C[C@@H](C1)c1ccc2c(c1)OCO2
InChi: 1S/C21H20O5/c1-23-19-5-3-4-17(21(19)24-2)15-8-14(9-16(22)10-15)13-6-7-18-20(11-13)26-12-25-18/h3-7,10-11,14H,8-9,12H2,1-2H3/t14-/m1/s1
InChiKey: NKBRGZMUHHBEFC-CQSZACIVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references
Photinus pyralis	Luciferin 4-monooxygenase	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania braziliensis	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium falciparum	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium vivax	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium knowlesi	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Entamoeba histolytica	acyl-coA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium yoelii	peroxisomal-coenzyme a synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium berghei	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	21.5 %
Trypanosoma congolense	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	500 aa	22.4 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	480 aa	22.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	478 aa	21.1 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	524 aa	24.0 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	529 aa	22.3 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	442 aa	23.5 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	526 aa	22.4 %
Cryptosporidium hominis	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	26.1 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	550 aa	20.9 %
Leishmania mexicana	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	559 aa	20.6 %
Echinococcus granulosus	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	23.9 %
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	509 aa	21.8 %
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	Luciferin 4-monooxygenase	550 aa	493 aa	22.1 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	443 aa	26.4 %
Leishmania braziliensis	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	496 aa	22.8 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	459 aa	27.0 %
Onchocerca volvulus	Matrilysin homolog	Luciferin 4-monooxygenase	550 aa	466 aa	24.2 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	526 aa	21.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	558 aa	20.4 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	560 aa	21.4 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	617 aa	22.2 %
Babesia bovis	fatty acyl-CoA synthetase family protein	Luciferin 4-monooxygenase	550 aa	461 aa	23.4 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 4, putative	Luciferin 4-monooxygenase	550 aa	497 aa	23.7 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %
Echinococcus multilocularis	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.5 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	484 aa	20.5 %
Mycobacterium leprae	Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	484 aa	23.3 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.	Luciferin 4-monooxygenase	550 aa	487 aa	22.4 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	482 aa	24.3 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	25.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	22.9 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	452 aa	26.1 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	527 aa	25.0 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	23.5 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	462 aa	23.8 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	22.6 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	596 aa	21.1 %
Cryptosporidium parvum	acetyl-coenzyme A synthetase	Luciferin 4-monooxygenase	550 aa	545 aa	22.8 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	531 aa	19.0 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	542 aa	23.8 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	466 aa	27.3 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	24.3 %
Trichomonas vaginalis	AMP dependent ligase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	26.1 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	545 aa	24.9 %
Cryptosporidium parvum	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	25.7 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	530 aa	23.8 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	466 aa	21.7 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Dictyostelium discoideum	acetyl-CoA ligase	Luciferin 4-monooxygenase	550 aa	549 aa	22.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	Luciferin 4-monooxygenase	550 aa	558 aa	20.1 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Leishmania infantum	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	Luciferin 4-monooxygenase	550 aa	502 aa	22.5 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	593 aa	22.1 %
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	509 aa	22.6 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Leishmania mexicana	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	483 aa	23.8 %
Leishmania donovani	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	505 aa	28.1 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	487 aa	23.8 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	Luciferin 4-monooxygenase	550 aa	463 aa	21.8 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	544 aa	21.5 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	497 aa	19.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Loa Loa (eye worm)	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	489 aa	23.3 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	497 aa	24.7 %
Toxoplasma gondii	type I fatty acid synthase, putative	Luciferin 4-monooxygenase	550 aa	514 aa	19.8 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	475 aa	21.1 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	576 aa	19.8 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	484 aa	26.0 %
Trypanosoma brucei	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Mycobacterium leprae	PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	565 aa	22.8 %
Toxoplasma gondii	propionate-CoA ligase	Luciferin 4-monooxygenase	550 aa	550 aa	21.1 %
Neospora caninum	acetyl-coenzyme a synthetase, putative	Luciferin 4-monooxygenase	550 aa	549 aa	20.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	507 aa	20.9 %
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Luciferin 4-monooxygenase	550 aa	518 aa	19.1 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	537 aa	20.9 %
Entamoeba histolytica	acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	446 aa	22.0 %
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	Luciferin 4-monooxygenase	550 aa	476 aa	22.5 %
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	461 aa	22.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	21.7 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	577 aa	22.2 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	20.8 %
Mycobacterium tuberculosis	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)	Luciferin 4-monooxygenase	550 aa	592 aa	20.4 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	603 aa	22.6 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	24.7 %
Theileria parva	long-chain fatty acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	507 aa	23.5 %
Schistosoma japonicum	ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative	Luciferin 4-monooxygenase	550 aa	501 aa	24.6 %
Cryptosporidium hominis	acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme)	Luciferin 4-monooxygenase	550 aa	549 aa	22.6 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	601 aa	22.5 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	24.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Leishmania braziliensis	long-chain-fatty-acid-CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	504 aa	25.6 %
Cryptosporidium parvum	putative long chain fatty acyl CoA synthetase having a signal peptide	Luciferin 4-monooxygenase	550 aa	472 aa	24.8 %
Leishmania major	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	23.2 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	582 aa	22.3 %
Schistosoma mansoni	FAA1 Long-chain-fatty-acid--CoA ligase 1	Luciferin 4-monooxygenase	550 aa	494 aa	26.3 %
Onchocerca volvulus	Lysine-specific histone demethylase 1A homolog	Luciferin 4-monooxygenase	550 aa	550 aa	22.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Trypanosoma cruzi	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	495 aa	22.6 %
Mycobacterium ulcerans	putative fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	576 aa	20.8 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	517 aa	24.8 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	581 aa	21.2 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	493 aa	20.7 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	586 aa	24.4 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	502 aa	24.9 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase, FadD11	Luciferin 4-monooxygenase	550 aa	492 aa	24.6 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.8 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	504 aa	22.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	463 aa	23.5 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD11	Luciferin 4-monooxygenase	550 aa	498 aa	23.5 %
Candida albicans	similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase	Luciferin 4-monooxygenase	550 aa	478 aa	23.4 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	501 aa	24.4 %
Babesia bovis	long-chain acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	21.8 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	492 aa	23.6 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	490 aa	23.3 %
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	Luciferin 4-monooxygenase	550 aa	536 aa	24.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Mycobacterium leprae	FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	533 aa	22.7 %
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	535 aa	23.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	499 aa	19.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	voltage-gated potassium channel	0.0204	0.1289	0.3603
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.047	0.3312	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0116	0.0616	0.186
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0166	0.0997	0.2787
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0237	0.1537	0.464
Leishmania major	hypothetical protein, unknown function	0.0116	0.0616	0.0506
Schistosoma mansoni	two-pore calcium channel	0.0116	0.0616	0.1722
Trypanosoma brucei	protein kinase A regulatory subunit	0.005	0.0116	0.1883
Echinococcus granulosus	potassium voltage gated channel protein	0.012	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0166	0.0997	0.2757
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.005	0.0116	0.0324
Echinococcus granulosus	potassium voltage gated channel protein	0.0204	0.1289	0.1289
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.005	0.0116	0.0324
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0116	0.0616	0.1722
Echinococcus multilocularis	sodium leak channel non selective protein	0.0116	0.0616	0.0506
Loa Loa (eye worm)	voltage-gated potassium channel	0.0121	0.0656	0.1689
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0116	0.0616	1
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0116	0.0324
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.005	0.0116	0.0477
Loa Loa (eye worm)	voltage-gated potassium channel	0.012	0.0647	0.166
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0201	0.1262	0.3811
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.005	0.0116	0.0116
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Trypanosoma brucei	Flagellar Member 6	0.005	0.0116	0.1883
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0116	0.0616	0.0616
Brugia malayi	hypothetical protein	0.0116	0.0616	0.186
Schistosoma mansoni	60S ribosomal protein L21	0.0151	0.0881	0.2463
Mycobacterium leprae	Conserved hypothetical protein	0.005	0.0116	1
Schistosoma mansoni	transient receptor potential channel	0.0116	0.0616	0.1722
Echinococcus granulosus	cGMP dependent protein kinase 1	0.005	0.0116	0.0116
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.005	0.0116	0.0116
Echinococcus granulosus	ryanodine receptor 44f	0.0116	0.0616	0.0616
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0116	0.0616	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0166	0.0997	0.2787
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0317	0.0887
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0116	0.0616	0.186
Schistosoma mansoni	voltage-gated cation channel	0.0116	0.0616	0.1722
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0166	0.0997	0.4102
Mycobacterium ulcerans	transcriptional regulatory protein	0.005	0.0116	0.5
Echinococcus granulosus	hyperpolarization activated cyclic	0.0166	0.0997	0.0997
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0317	0.063
Echinococcus multilocularis	ryanodine receptor 44f	0.0116	0.0616	0.0506
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Echinococcus multilocularis	two pore calcium channel protein 1	0.0116	0.0616	0.0506
Echinococcus granulosus	potassium voltage gated channel subfamily KQT	0.0055	0.0156	0.0156
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0166	0.0997	0.0891
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Echinococcus granulosus	short transient receptor potential channel 6	0.0116	0.0616	0.0616
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0055	0.0156	0.0126
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.005	0.0116	0.5
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.005	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0156	0.0126
Echinococcus granulosus	voltage dependent calcium channel	0.0116	0.0616	0.0616
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0116	0.0616	1
Loa Loa (eye worm)	ryanodine receptor	0.0116	0.0616	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Loa Loa (eye worm)	calcium channel	0.0116	0.0616	0.1564
Brugia malayi	N-terminal motif family protein	0.005	0.0116	0.035
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0116	0.0616	0.1722
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.012	0.0647	0.0537
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0055	0.0156	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0201	0.1262	0.3586
Schistosoma mansoni	voltage-dependent calcium channel	0.0116	0.0616	0.1722
Mycobacterium ulcerans	transmembrane transport protein	0.005	0.0116	0.5
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.005	0.0116	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0317	0.063
Schistosoma mansoni	voltage-gated potassium channel	0.0116	0.0616	0.1722
Echinococcus multilocularis	voltage gated potassium channel	0.0201	0.1262	0.116
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.005	0.0116	0.035
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.0616	0.0506
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Echinococcus granulosus	sodium leak channel non selective protein	0.0116	0.0616	0.0616
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0237	0.1537	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0997	0.2757
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.012	0.0647	0.0647
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.005	0.0116	0.0477
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.005	0.0116	0.0324
Schistosoma mansoni	voltage-gated potassium channel	0.0505	0.3577	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0317	0.0887
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Brugia malayi	voltage-dependent calcium channel	0.0116	0.0616	0.186
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0166	0.0997	0.0997
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Brugia malayi	olfactory channel protein osm-9	0.0116	0.0616	0.186
Brugia malayi	ion channel NompC	0.0116	0.0616	0.186
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Brugia malayi	Egg laying defective protein 4	0.005	0.0116	0.035
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0204	0.1289	0.3891
Echinococcus multilocularis	voltage gated potassium channel	0.012	0.0647	0.0537
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Echinococcus multilocularis	potassium large conductance calcium activated	0.0116	0.0616	0.0506
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.0616	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0116	0.0616	1
Brugia malayi	TAR-binding protein	0.0076	0.0317	0.0958
Echinococcus multilocularis	potassium voltage gated channel protein	0.0116	0.0616	0.0506
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.005	0.0116	0.5
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.005	0.0116	0.0324
Echinococcus granulosus	transient receptor potential gamma protein	0.0116	0.0616	0.0616
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.0616	0.0506
Treponema pallidum	cyclic nucleotide binding protein	0.005	0.0116	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.012	0.0647	0.0537
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0166	0.0997	0.0997
Echinococcus granulosus	voltage gated potassium channel	0.012	0.0647	0.0647
Schistosoma mansoni	hypothetical protein	0.0116	0.0616	0.1722
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0116	0.0616	0.0616
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.012	0.0647	0.1952
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0317	0.0317
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0166	0.0997	0.0891
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.005	0.0116	0.0324
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0317	0.0887
Treponema pallidum	cyclic nucleotide binding protein	0.005	0.0116	0.5
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.005	0.0116	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0354	0.2431	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0166	0.0997	0.0997
Echinococcus granulosus	hypothetical protein	0.0116	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.042	0.2931	0.8808
Schistosoma mansoni	calcium-activated potassium channel	0.0116	0.0616	0.1722
Schistosoma mansoni	ryanodine receptor related	0.0116	0.0616	0.1722
Toxoplasma gondii	transporter, cation channel family protein	0.0116	0.0616	1
Toxoplasma gondii	transporter, cation channel family protein	0.0116	0.0616	1
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.005	0.0116	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0116	0.0324
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0116	0.0616	0.0616
Schistosoma mansoni	voltage-gated potassium channel	0.0166	0.0997	0.2787
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.0616	0.0506
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0166	0.0997	0.4102
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0317	0.0204
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.005	0.0116	0.0324
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.012	0.0647	0.1952
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.005	0.0116	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Schistosoma mansoni	hypothetical protein	0.005	0.0116	0.0324
Mycobacterium ulcerans	hypothetical protein	0.005	0.0116	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.012	0.0647	0.0647
Schistosoma mansoni	vesicular amine transporter	0.012	0.0647	0.1807
Echinococcus multilocularis	potassium voltage gated channel protein	0.012	0.0647	0.0537
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.005	0.0116	0.0324
Schistosoma mansoni	voltage-gated potassium channel	0.0201	0.1262	0.3529
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0116	0.0616	0.1564
Echinococcus multilocularis	conserved hypothetical protein	0.0116	0.0616	0.0506
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0116	0.0616	1
Toxoplasma gondii	hypothetical protein	0.0116	0.0616	1
Brugia malayi	Transient-receptor-potential like protein	0.0116	0.0616	0.186
Echinococcus granulosus	patatin phospholipase domain containing protein	0.005	0.0116	0.0116
Toxoplasma gondii	hypothetical protein	0.0116	0.0616	1
Echinococcus granulosus	TRP transient receptor potential channel	0.0116	0.0616	0.0616
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0116	0.0616	0.1722
Echinococcus granulosus	potassium voltage gated channel protein	0.012	0.0647	0.0647
Schistosoma mansoni	voltage-gated potassium channel	0.0116	0.0616	0.1722
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0116	0.0616	0.1722
Loa Loa (eye worm)	voltage-gated calcium channel	0.0116	0.0616	0.1564
Schistosoma mansoni	voltage-gated potassium channel	0.0505	0.3577	1
Schistosoma mansoni	voltage-gated potassium channel	0.0201	0.1262	0.3529
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0317	0.0887
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0116	0.0616	0.186
Schistosoma mansoni	voltage-gated potassium channel	0.0116	0.0616	0.1722
Echinococcus multilocularis	shaker cognate	0.012	0.0647	0.0537
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0116	0.0616	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0201	0.1262	0.1262
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0237	0.1537	0.1537
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0237	0.1537	0.4296
Echinococcus granulosus	short transient receptor potential channel 6	0.0116	0.0616	0.0616
Brugia malayi	RNA binding protein	0.0076	0.0317	0.0958
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.047	0.3312	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.012	0.0647	0.0647
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0116	0.0616	0.0506
Echinococcus granulosus	voltage dependent calcium channel	0.0116	0.0616	0.0616
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0166	0.0997	0.0891
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0116	0.0616	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0116	0.0616	0.0506
Echinococcus multilocularis	short transient receptor potential channel 6	0.0116	0.0616	0.0506
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Mycobacterium ulcerans	hypothetical protein	0.005	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Schistosoma mansoni	transient receptor potential channel 4	0.0116	0.0616	0.1722
Trypanosoma brucei	cAMP response protein 1, putative	0.005	0.0116	0.1883
Echinococcus multilocularis	transient receptor potential gamma protein	0.0116	0.0616	0.0506
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0116	0.0616	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0166	0.0997	0.2787
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0116	0.0477
Leishmania major	hypothetical protein, conserved	0.0116	0.0616	0.0506
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0204	0.1289	0.1289
Echinococcus granulosus	cGMP dependent protein kinase	0.005	0.0116	0.0116
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0116	0.0616	0.1722
Plasmodium falciparum	cGMP-dependent protein kinase	0.005	0.0116	0.5
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.0616	0.0506
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0116	0.0616	0.186
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Treponema pallidum	catabolite gene activator (Crp)	0.005	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0116	0.0324
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.005	0.0116	0.0324
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.005	0.0116	0.035
Schistosoma mansoni	transient receptor potential channel	0.0116	0.0616	0.1722
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.005	0.0116	0.5
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.719	0.7157
Onchocerca volvulus		0.0116	0.0616	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0204	0.1289	0.1186
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.005	0.0116	0.0324
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0317	0.063
Trypanosoma brucei	cAMP binding protein, putative	0.005	0.0116	0.1883
Toxoplasma gondii	transporter, cation channel family protein	0.0116	0.0616	1
Mycobacterium tuberculosis	Conserved protein	0.005	0.0116	0.5
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0116	0.0616	0.186
Echinococcus granulosus	voltage gated potassium channel	0.0201	0.1262	0.1262
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0116	0.0616	0.0506
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0166	0.0997	0.0997
Schistosoma mansoni	voltage-gated potassium channel	0.0116	0.0616	0.1722
Echinococcus multilocularis	calcium activated potassium channel	0.0116	0.0616	0.0506
Mycobacterium tuberculosis	Conserved hypothetical protein	0.005	0.0116	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0116	0.0616	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.005	0.0116	0.0477
Echinococcus multilocularis	potassium voltage gated channel protein	0.012	0.0647	0.0537
Loa Loa (eye worm)	hypothetical protein	0.012	0.0647	0.166
Brugia malayi	cation channel family protein	0.0116	0.0616	0.186
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0201	0.1262	0.116
Mycobacterium ulcerans	hypothetical protein	0.005	0.0116	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0166	0.0997	0.3011
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0317	0.0958
Echinococcus granulosus	cGMP dependent protein kinase 1	0.005	0.0116	0.0116
Echinococcus granulosus	hyperpolarization activated cyclic	0.0166	0.0997	0.0997
Echinococcus multilocularis	two pore calcium channel protein 2	0.0116	0.0616	0.0506
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0116	0.0616	0.1722
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.005	0.0116	0.0324
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0116	0.0616	1
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.0647	0.1807
Brugia malayi	cation channel family protein	0.0116	0.0616	0.186
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0116	0.0616	0.1722
Echinococcus multilocularis	transfer RNA-Gly	0.012	0.0647	0.0537
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0354	0.2431	1
Mycobacterium ulcerans	regulatory protein	0.005	0.0116	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0151	0.0881	0.2463
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1289	0.3669
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.047	0.3312	0.3234
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0116	0.0616	0.186
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0166	0.0997	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0116	0.0616	0.186
Treponema pallidum	catabolite gene activator	0.005	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.005	0.0116	0.0116
Schistosoma mansoni	voltage-gated potassium channel	0.0204	0.1289	0.3603
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0116	0.0616	0.1722
Echinococcus granulosus	potassium voltage gated channel protein	0.0116	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0616	0.1564
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0116	0.0616	0.186
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0116	0.0616	0.186
Echinococcus granulosus	two pore calcium channel protein 2	0.0116	0.0616	0.0616
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.005	0.0116	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0116	0.0616	0.1722
Loa Loa (eye worm)	voltage-gated potassium channel	0.0116	0.0616	0.1564
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.012	0.0647	0.0537
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0116	0.0616	0.1722
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.005	0.0116	0.0324
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.005	0.0116	0.5
Echinococcus granulosus	shaker cognate	0.012	0.0647	0.0647
Schistosoma mansoni	voltage-gated ion channel	0.0116	0.0616	0.1722
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0166	0.0997	0.2787
Loa Loa (eye worm)	ion channel NompC	0.0116	0.0616	0.1564
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.005	0.0116	0.0116
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.005	0.0116	0.035
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0116	0.0616	0.0616
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0166	0.0997	0.2787
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0317	0.0887
Echinococcus granulosus	calcium activated potassium channel	0.0116	0.0616	0.0616
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0116	0.0616	0.0616
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.0616	0.0506
Echinococcus granulosus	two pore calcium channel protein 1	0.0116	0.0616	0.0616
Mycobacterium tuberculosis	Conserved hypothetical protein	0.005	0.0116	0.5
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.005	0.0116	0.1883
Echinococcus granulosus	potassium large conductance calcium activated	0.0116	0.0616	0.0616
Echinococcus granulosus	potassium voltage gated channel protein	0.0116	0.0616	0.0616
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.005	0.0116	0.1883
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0166	0.0997	0.2757
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.012	0.0647	0.0647
Schistosoma mansoni	transient receptor potential channel	0.0116	0.0616	0.1722
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.047	0.3312	0.3312
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0156	0.0126
Echinococcus granulosus	transient receptor potential cation channel	0.0116	0.0616	0.0616
Echinococcus multilocularis	transient receptor potential cation channel	0.0116	0.0616	0.0506
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.02	0.1258	0.1156
Mycobacterium ulcerans	hypothetical protein	0.005	0.0116	0.5
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0166	0.0997	0.0891
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.005	0.0116	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0026 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.5918 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	11.9955 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1563737

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1403085