Detailed information for compound 1403174

Basic information

Technical information
  • TDR Targets ID: 1403174
  • Name: N-[(E)-1-furan-2-yl-3-[2-(1H-indol-3-yl)ethyl amino]-3-oxoprop-1-en-2-yl]-3,4-dimethylbenza mide
  • MW: 427.495 | Formula: C26H25N3O3
  • H donors: 3 H acceptors: 2 LogP: 4.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C(=C\c1ccco1)/NC(=O)c1ccc(c(c1)C)C)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C26H25N3O3/c1-17-9-10-19(14-18(17)2)25(30)29-24(15-21-6-5-13-32-21)26(31)27-12-11-20-16-28-23-8-4-3-7-22(20)23/h3-10,13-16,28H,11-12H2,1-2H3,(H,27,31)(H,29,30)/b24-15+
  • InChiKey: WMBRJOZBZRKLMT-BUVRLJJBSA-N  


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Synonyms

  • N-[(E)-2-(2-furyl)-1-[2-(1H-indol-3-yl)ethylcarbamoyl]vinyl]-3,4-dimethyl-benzamide
  • N-[(E)-2-(2-furyl)-1-[[2-(1H-indol-3-yl)ethylamino]-oxomethyl]vinyl]-3,4-dimethylbenzamide
  • N-[(E)-1-furan-2-yl-3-[2-(1H-indol-3-yl)ethylamino]-3-oxo-prop-1-en-2-yl]-3,4-dimethyl-benzamide
  • ZINC02152227
  • AN-919/15527142
  • MLS000325407
  • N-[2-(2-furyl)-1-({[2-(1H-indol-3-yl)ethyl]amino}carbonyl)vinyl]-3,4-dimethylbenzamide
  • SMR000161044

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cathepsin CPC1 0.0101 0.0868 0.1719
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.2306 0.5124
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.009 0.0991
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0413 0.0326
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0477 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.4415 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Brugia malayi RNA binding protein 0.0065 0.0477 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0868 0.161
Echinococcus granulosus neuropeptide s receptor 0.0477 0.4899 0.4802
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.0868 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0432 0.4415 1
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0101 0.0868 0.1944
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0059 0.0413 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Loa Loa (eye worm) cathepsin B 0.0365 0.3693 0.3685
Plasmodium vivax vivapain-3 0.0235 0.2306 0.521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0868 0.161
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.009 0.0991
Schistosoma mansoni cathepsin F (C01 family) 0.0432 0.4415 0.4327
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.2306 0.5124
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0868 0.0723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0868 0.0694
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 0.1778
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.0868 0.0723
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0868 0.0785
Brugia malayi Papain family cysteine protease containing protein 0.0235 0.2306 0.2236
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.1221 0.1053
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0447 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1221 0.121
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Plasmodium falciparum serine repeat antigen 1 0.0101 0.0868 0.1944
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.1656 0.1581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.0868 0.1944
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.0868 0.1944
Entamoeba histolytica cysteine proteinase 1, putative 0.0235 0.2306 0.5124
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1155 0.1014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Toxoplasma gondii cathepsin B 0.0365 0.3693 0.8312
Onchocerca volvulus 0.0101 0.0868 0.1799
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0059 0.0413 0.0261
Trypanosoma cruzi cysteine proteinase, putative 0.0235 0.2306 0.2159
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0432 0.4415 0.4309
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Onchocerca volvulus 0.0432 0.4415 1
Toxoplasma gondii cathepsin CPC2 0.0101 0.0868 0.1719
Trypanosoma cruzi cysteine peptidase, putative 0.0432 0.4415 0.4309
Onchocerca volvulus 0.0432 0.4415 1
Plasmodium falciparum serine repeat antigen 2 0.0101 0.0868 0.1944
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Onchocerca volvulus 0.0432 0.4415 1
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Loa Loa (eye worm) hypothetical protein 0.0128 0.1155 0.1144
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0059 0.0413 0.0747
Schistosoma mansoni cathepsin B (C01 family) 0.0101 0.0868 0.0723
Onchocerca volvulus 0.0432 0.4415 1
Trypanosoma cruzi cysteine proteinase, putative 0.0235 0.2306 0.2159
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.009 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Plasmodium falciparum serine repeat antigen 7 0.0101 0.0868 0.1944
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0868 0.0785
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0188 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.2977 0.6599
Plasmodium vivax vivapain-2 0.0432 0.4415 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0175 0.1656 0.1497
Loa Loa (eye worm) hypothetical protein 0.0045 0.0265 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.2306 0.5011
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0432 0.4415 0.4408
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0078
Plasmodium falciparum cysteine proteinase falcipain 3 0.0432 0.4415 1
Plasmodium vivax unspecified product 0.0101 0.0868 0.1944
Loa Loa (eye worm) hypothetical protein 0.0298 0.2977 0.2969
Brugia malayi cathepsin F-like cysteine proteinase 0.0134 0.1221 0.1141
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0569 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.2977 0.6599
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0432 0.4415 0.4309
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1221 0.1053
Plasmodium falciparum serine repeat antigen 3 0.0101 0.0868 0.1944
Brugia malayi cathepsin L-like cysteine proteinase 0.0101 0.0868 0.0785
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0477 0.039
Echinococcus granulosus cathepsin L cysteine proteinase 0.0432 0.4415 0.4309
Loa Loa (eye worm) hypothetical protein 0.0128 0.1155 0.1144
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0101 0.0868 0.1944
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0134 0.1221 0.121
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0013 0.022
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.0868 0.1944
Echinococcus granulosus Dipeptidyl peptidase 9 0.0059 0.0413 0.023
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0298 0.2977 0.2843
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0868 0.0723
Plasmodium falciparum serine repeat antigen 9 0.0101 0.0868 0.1944
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.8666 0.864
Echinococcus granulosus tar DNA binding protein 0.0065 0.0477 0.0295
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0868 0.0723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.2306 0.5011
Giardia lamblia Cathepsin B precursor 0.0365 0.3693 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0477 0.0465
Echinococcus multilocularis serotonin receptor 0.0128 0.1155 0.0985
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0796 0.0649
Schistosoma mansoni cathepsin S (C01 family) 0.0101 0.0868 0.0723
Entamoeba histolytica cysteine proteinase 2 0.0235 0.2306 0.5124
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Plasmodium falciparum serine repeat antigen 6 0.0101 0.0868 0.1944
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0317
Echinococcus granulosus cysteine protease 0.0235 0.2306 0.2159
Loa Loa (eye worm) cysteine protease 0.0432 0.4415 0.4408
Loa Loa (eye worm) hypothetical protein 0.0298 0.2977 0.2969
Trypanosoma brucei cysteine peptidase C (CPC) 0.0365 0.3693 0.829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0796 0.0619
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Trypanosoma cruzi cysteine protease, putative 0.0235 0.2306 0.2159
Brugia malayi cathepsin L precursor 0.0101 0.0868 0.0785
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0447 0.0264
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Entamoeba histolytica cysteine proteinase, putative 0.0298 0.2977 0.6675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0796 0.0619
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0101 0.0868 0.1944
Brugia malayi TAR-binding protein 0.0065 0.0477 0.039
Loa Loa (eye worm) RNA binding protein 0.0065 0.0477 0.0465
Echinococcus granulosus cathepsin l cysteine peptidase 0.0432 0.4415 0.4309
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0432 0.4415 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0101 0.0868 0.0857
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0101 0.0868 0.1944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0868 0.0785
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0868 0.161
Plasmodium falciparum cysteine proteinase falcipain 1 0.0235 0.2306 0.521
Trypanosoma cruzi cruzipain precursor, putative 0.0432 0.4415 0.4309
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.4415 1
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0059 0.0413 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.2306 0.5011
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.4899 0.4802
Brugia malayi Cathepsin L-like precursor 0.0134 0.1221 0.1141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1221 0.121
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0078
Loa Loa (eye worm) prolyl oligopeptidase 0.0175 0.1656 0.1646
Onchocerca volvulus Cathepsin L homolog 0.0101 0.0868 0.1799
Plasmodium vivax unspecified product 0.0134 0.1221 0.2745
Loa Loa (eye worm) hypothetical protein 0.0134 0.1221 0.121
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0175 0.1656 0.1497
Brugia malayi Probable ClpP-like protease 0.0094 0.0796 0.0712
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Onchocerca volvulus 0.0432 0.4415 1
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Loa Loa (eye worm) ctsf protein 0.0432 0.4415 0.4408
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0101 0.0868 0.1944
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.2306 0.5011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0298 0.2977 0.2914
Loa Loa (eye worm) inositol-1 0.0038 0.0188 0.0175
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0569 0.0419
Echinococcus multilocularis cysteine protease 0.0432 0.4415 0.4309
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0101 0.0868 0.161
Echinococcus granulosus cathepsin l1 0.0298 0.2977 0.2843
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.0868 0.1799
Echinococcus multilocularis cysteine protease 0.0432 0.4415 0.4309
Echinococcus granulosus cathepsin L 0.0235 0.2306 0.2159
Brugia malayi Papain family cysteine protease containing protein 0.0432 0.4415 0.4365
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0101 0.0868 0.1944
Brugia malayi Inositol-1 0.0038 0.0188 0.0099
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0059 0.0413 0.023
Onchocerca volvulus 0.0432 0.4415 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0796 0.1778
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0477 0.0326
Echinococcus multilocularis serotonin receptor 0.0128 0.1155 0.0985
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Loa Loa (eye worm) hypothetical protein 0.0094 0.0796 0.0784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0235 0.2306 0.2184
Brugia malayi Papain family cysteine protease containing protein 0.0235 0.2306 0.2236
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0059 0.0413 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0188 0.013
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0477 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Entamoeba histolytica hypothetical protein 0.0101 0.0868 0.1799
Plasmodium falciparum serine repeat antigen 8 0.0101 0.0868 0.1944
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0432 0.4415 0.4408
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0868 0.161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.009 0.0991
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.009 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Onchocerca volvulus Cathepsin L homolog 0.0432 0.4415 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0134 0.1221 0.1141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0796 1
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.0868 0.0723
Brugia malayi Cathepsin L-like precursor 0.0298 0.2977 0.2914
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.009 0.1583
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0101 0.0868 0.1944
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0868 0.161
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0365 0.3693 0.829
Brugia malayi Cathepsin L-like precursor 0.0298 0.2977 0.2914
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0447 0.7848
Giardia lamblia Cathepsin B precursor 0.0365 0.3693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0101 0.0868 0.161
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.009 0.0991
Onchocerca volvulus 0.0432 0.4415 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0101 0.0868 0.1944
Schistosoma mansoni inositol monophosphatase 0.0038 0.0188 0.0032
Onchocerca volvulus Cathepsin L homolog 0.0432 0.4415 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0569 0.0389
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1155 0.0985
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Loa Loa (eye worm) hypothetical protein 0.0101 0.0868 0.0857
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Schistosoma mansoni cathepsin F (C01 family) 0.0432 0.4415 0.4327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Schistosoma mansoni cathepsin C 0.0101 0.0868 0.0723
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.4899 0.4802
Brugia malayi cathepsin F-like cysteine proteinase 0.0101 0.0868 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.009 0.0991
Mycobacterium ulcerans hypothetical protein 0.0029 0.009 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0447 0.7848
Toxoplasma gondii cathepsin CPL 0.0432 0.4415 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0569 0.711
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0569 0.1021
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0365 0.3693 0.8329
Trypanosoma cruzi cysteine peptidase, putative 0.0432 0.4415 0.4309
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0796 1
Brugia malayi cathepsin L-like precursor 0.0298 0.2977 0.2914
Plasmodium vivax vivapain-2 0.0432 0.4415 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0868 0.161
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.2306 0.5124
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0101 0.0868 0.1944
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Plasmodium vivax vivapain-1 0.0235 0.2306 0.521
Plasmodium falciparum serine repeat antigen 5 0.0101 0.0868 0.1944
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0059 0.0413 0.0656
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0569 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0868 0.161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0329 0.0317
Trypanosoma cruzi cysteine peptidase, putative 0.0432 0.4415 0.4309
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0156 0.0067
Echinococcus multilocularis cathepsin L 0.0101 0.0868 0.0694
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.2306 0.5124
Plasmodium vivax unspecified product 0.0235 0.2306 0.521
Echinococcus granulosus cathepsin L 0.0101 0.0868 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0101 0.0868 0.161
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0132 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0868 0.0723
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0477 0.0326
Loa Loa (eye worm) hypothetical protein 0.0298 0.2977 0.2969
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Brugia malayi fibroinase precursor 0.0101 0.0868 0.0785
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0329 0.0241
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0145 0.0783
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0569 0.711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0477 0.0295
Loa Loa (eye worm) fibroinase 0.0432 0.4415 0.4408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0329 0.0241
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0796 0.1549
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0365 0.3693 0.3592
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0101 0.0868 0.1944
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0569 0.1108
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0235 0.2306 0.2184
Brugia malayi Cathepsin L-like precursor 0.0432 0.4415 0.4365
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0101 0.0868 0.0723
Schistosoma mansoni inositol monophosphatase 0.0038 0.0188 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0078
Onchocerca volvulus 0.0298 0.2977 0.6675
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0432 0.4415 0.4408
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0101 0.0868 0.0723
Schistosoma mansoni cathepsin F (C01 family) 0.0298 0.2977 0.2866
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0059 0.0413 0.023
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0477 0.0326
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0101 0.0868 0.0785
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0235 0.2306 0.2159
Schistosoma mansoni cathepsin s 0.0134 0.1221 0.1082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0477 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0101 0.0868 0.161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0868 0.161
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0132 0.0271
Echinococcus multilocularis cathepsin L cysteine protease 0.0432 0.4415 0.4309
Toxoplasma gondii preprocathepsin c precursor, putative 0.0101 0.0868 0.1719
Brugia malayi hypothetical protein 0.0045 0.0265 0.0176
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0101 0.0868 0.1944
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0175 0.1656 0.1524
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0569 0.711
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0188 0.2238
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0235 0.2306 0.2184
Plasmodium falciparum serine repeat antigen 4 0.0101 0.0868 0.1944
Onchocerca volvulus Cathepsin F homolog 0.0432 0.4415 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0132 0.0593
Leishmania major cathepsin L-like protease 0.0432 0.4415 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0868 0.0723
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0868 0.0857
Trypanosoma cruzi cysteine peptidase, putative 0.0432 0.4415 0.4309
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0145 0.2554
Giardia lamblia Cathepsin B precursor 0.0365 0.3693 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.0868 0.1944
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0447 0.5056
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0365 0.3693 0.3572
Leishmania major cysteine peptidase A (CPA) 0.0432 0.4415 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.009 0.1583
Echinococcus granulosus cathepsin l1 0.0432 0.4415 0.4309
Echinococcus multilocularis cathepsin L 0.0235 0.2306 0.2159
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0868 0.0857
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0796 0.1549
Entamoeba histolytica cysteine protease, putative 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.4415 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0175 0.1656 0.3621
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.0868 0.1799
Entamoeba histolytica cysteine protease, putative 0.0101 0.0868 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.4415 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.0868 0.0785
Echinococcus granulosus cathepsin L cysteine protease 0.0235 0.2306 0.2159
Entamoeba histolytica cysteine protease, putative 0.0235 0.2306 0.5124
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0868 0.0694
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.4899 0.4802
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0432 0.4415 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0432 0.4415 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0432 0.4415 0.4309
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.2306 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0868 0.161
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0868 0.161
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0569 0.0419
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0188 0.0226

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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