Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.3888 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.3888 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5919 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3888 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.3888 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5919 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.3888 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.3888 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.3888 | 0.3825 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3888 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3888 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5919 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.8336 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 707.9458 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.