Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0202 | 0.0752 | 0.0752 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0205 | 0.0775 | 0.0775 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0167 | 0.0442 | 0.1322 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0205 | 0.0775 | 0.2316 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0167 | 0.0442 | 0.1322 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.2867 | 0.8571 |
Schistosoma mansoni | voltage-gated potassium channel | 0.015 | 0.0297 | 0.0807 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0202 | 0.0752 | 0.0752 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0167 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0442 | 0.1322 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0167 | 0.0442 | 0.1202 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0202 | 0.0752 | 0.2044 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0537 | 0.3678 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0167 | 0.0442 | 0.0442 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0205 | 0.0775 | 0.0775 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0123 | 0.0061 | 0.0182 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0198 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0752 | 0.2247 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0167 | 0.0442 | 0.0442 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0236 | 0.1042 | 0.2834 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.015 | 0.0297 | 0.0807 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0236 | 0.1042 | 0.1042 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0167 | 0.0442 | 0.1202 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0202 | 0.0752 | 0.2044 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0202 | 0.0752 | 0.0752 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0167 | 0.0442 | 0.0442 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0167 | 0.0442 | 0.0442 |
Echinococcus granulosus | voltage gated potassium channel | 0.0205 | 0.0775 | 0.0775 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0499 | 0.3345 | 0.3345 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0205 | 0.0775 | 0.2106 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0205 | 0.0775 | 0.0775 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0167 | 0.0442 | 0.0442 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0236 | 0.1042 | 0.1042 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0167 | 0.0442 | 0.1322 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0167 | 0.0442 | 0.1202 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0167 | 0.0442 | 0.1202 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0167 | 0.0442 | 0.1202 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0167 | 0.0442 | 0.0442 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0387 | 0.2364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0775 | 0.2316 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0167 | 0.0442 | 0.1202 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0236 | 0.1042 | 0.3116 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0167 | 0.0442 | 0.0442 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0167 | 0.0442 | 0.0442 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0167 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0499 | 0.3345 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0202 | 0.0752 | 0.2247 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0167 | 0.0442 | 0.0442 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0387 | 0.2364 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0537 | 0.3678 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0205 | 0.0775 | 0.2106 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0499 | 0.3345 | 0.3345 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0499 | 0.3345 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.