Detailed information for compound 1403634

Basic information

Technical information
  • TDR Targets ID: 1403634
  • Name: 1-[(2-chlorophenyl)methyl]-3-(furan-2-ylmethy l)thiourea
  • MW: 280.773 | Formula: C13H13ClN2OS
  • H donors: 2 H acceptors: 0 LogP: 2.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NCc1ccccc1Cl)NCc1ccco1
  • InChi: 1S/C13H13ClN2OS/c14-12-6-2-1-4-10(12)8-15-13(18)16-9-11-5-3-7-17-11/h1-7H,8-9H2,(H2,15,16,18)
  • InChiKey: BAXJODVNZIANTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-chlorophenyl)methyl]-3-(2-furylmethyl)thiourea
  • 1-(2-chlorobenzyl)-3-(2-furylmethyl)thiourea
  • ZINC06332810

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0183 0.1567 0.1567
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0046 0.0317 0.0317
Echinococcus granulosus cGMP dependent protein kinase 1 0.0046 0.0317 0.0317
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0098 0.0796 0.1973
Echinococcus granulosus GPCR family 2 0.0019 0.0076 0.0076
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0056 0.0409 0.1096
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0046 0.0317 0.5
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0046 0.0317 0.0661
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0098 0.0796 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0098 0.0796 0.0796
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.022 0.1902 0.1902
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0317 0.0477
Loa Loa (eye worm) voltage-dependent calcium channel 0.0098 0.0796 0.2136
Echinococcus granulosus potassium voltage gated channel protein 0.0187 0.1604 0.1604
Treponema pallidum catabolite gene activator (Crp) 0.0046 0.0317 0.5
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0046 0.0317 0.0477
Echinococcus granulosus single minded 2 0.0032 0.0191 0.0191
Echinococcus multilocularis voltage gated potassium channel 0.0102 0.0833 0.0833
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0144 0.1211 0.2631
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0098 0.0796 0.1973
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus granulosus dnaJ subfamily B 0.0494 0.439 0.439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.05 0.3809
Loa Loa (eye worm) voltage-gated potassium channel 0.0122 0.1008 0.2705
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0098 0.0796 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0098 0.0796 0.1973
Schistosoma mansoni calcium-activated potassium channel 0.0098 0.0796 0.167
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0102 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0144 0.1211 0.3247
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0187 0.1604 0.4303
Loa Loa (eye worm) AGC/PKG protein kinase 0.0046 0.0317 0.085
Brugia malayi Transient-receptor-potential like protein 0.0098 0.0796 0.1973
Echinococcus multilocularis conserved hypothetical protein 0.0098 0.0796 0.0796
Brugia malayi CXXC zinc finger family protein 0.0035 0.0218 0.0389
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus granulosus calcium activated potassium channel 0.0098 0.0796 0.0796
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0098 0.0796 0.167
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0098 0.0796 1
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Trypanosoma brucei cAMP response protein 1, putative 0.0046 0.0317 0.2084
Mycobacterium ulcerans hypothetical protein 0.0046 0.0317 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0098 0.0796 0.0796
Schistosoma mansoni vesicular amine transporter 0.0102 0.0833 0.1755
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0046 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni voltage-gated ion channel 0.0098 0.0796 0.167
Schistosoma mansoni voltage-gated potassium channel 0.013 0.1085 0.2338
Echinococcus granulosus hyperpolarization activated cyclic 0.0144 0.1211 0.1211
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0056 0.0409 0.0409
Mycobacterium ulcerans hypothetical protein 0.0046 0.0317 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0102 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.006 0.0449 0.1206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.1211 0.3858
Echinococcus granulosus voltage gated potassium channel 0.0102 0.0833 0.0833
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.0796 0.0796
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0144 0.1211 0.3247
Loa Loa (eye worm) hypothetical protein 0.0375 0.3314 0.8888
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0046 0.0317 0.5
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0046 0.0317 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0276 0.055
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0098 0.0796 0.1973
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Loa Loa (eye worm) calcium channel 0.0098 0.0796 0.2136
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0421 0.3728 1
Echinococcus granulosus hypothetical protein 0.0098 0.0796 0.0796
Trypanosoma brucei cAMP binding protein, putative 0.0046 0.0317 0.2084
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0098 0.0796 0.0796
Leishmania major hypothetical protein, conserved 0.0098 0.0796 0.0495
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0317 0.0477
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Treponema pallidum cyclic nucleotide binding protein 0.0046 0.0317 0.5
Brugia malayi cation channel family protein 0.0098 0.0796 0.1973
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0317 0.0477
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0098 0.0796 0.1973
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0323 0.2834 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0098 0.0796 0.167
Schistosoma mansoni voltage-gated potassium channel 0.0144 0.1211 0.2631
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0187 0.1604 0.1604
Schistosoma mansoni voltage-gated potassium channel 0.0453 0.4016 0.9133
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0098 0.0796 0.0796
Loa Loa (eye worm) ryanodine receptor 0.0098 0.0796 0.2136
Loa Loa (eye worm) voltage-gated potassium channel 0.0102 0.0833 0.2234
Schistosoma mansoni hypothetical protein 0.0046 0.0317 0.0559
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.0796 0.0796
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0046 0.0317 0.2084
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.022 0.1902 0.1902
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0046 0.0317 0.2084
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0144 0.1211 0.1211
Echinococcus granulosus potassium voltage gated channel protein 0.0102 0.0833 0.0833
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0046 0.0317 0.0317
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0317 0.5
Schistosoma mansoni transient receptor potential channel 0.0098 0.0796 0.167
Schistosoma mansoni 60S ribosomal protein L21 0.013 0.1085 0.2338
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0796 0.167
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0032 0.0191 0.0316
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0098 0.0796 0.0796
Onchocerca volvulus 0.0046 0.0317 0.1717
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0176 0.1499 0.1499
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0098 0.0796 0.0796
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0144 0.1211 0.3247
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0796 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0046 0.0317 0.0317
Brugia malayi cation channel family protein 0.0098 0.0796 0.1973
Plasmodium falciparum cGMP-dependent protein kinase 0.0046 0.0317 0.5
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0098 0.0796 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0046 0.0317 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0317 0.0559
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0796 0.167
Mycobacterium ulcerans hypothetical protein 0.0046 0.0317 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0176 0.1499 0.1499
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0098 0.0796 0.167
Echinococcus granulosus ryanodine receptor 44f 0.0098 0.0796 0.0796
Echinococcus multilocularis potassium voltage gated channel protein 0.0098 0.0796 0.0796
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0144 0.1211 0.2631
Schistosoma mansoni voltage-gated cation channel 0.0098 0.0796 0.167
Schistosoma mansoni cpg binding protein 0.0037 0.0236 0.0371
Loa Loa (eye worm) hypothetical protein 0.0056 0.0409 0.1096
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0317 0.0559
Echinococcus multilocularis cpg binding protein 0.0037 0.0236 0.0236
Echinococcus multilocularis calcium activated potassium channel 0.0098 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0019 0.0076 0.0203
Echinococcus granulosus short transient receptor potential channel 6 0.0098 0.0796 0.0796
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0056 0.0409 0.0409
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.1211 0.3858
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0144 0.1211 0.2631
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0046 0.0317 0.0317
Echinococcus granulosus patatin phospholipase domain containing protein 0.0046 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0046 0.0317 0.0559
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0046 0.0317 0.0317
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0098 0.0796 0.1973
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0046 0.0317 0.5
Echinococcus multilocularis shaker cognate 0.0102 0.0833 0.0833
Treponema pallidum cyclic nucleotide binding protein 0.0046 0.0317 0.5
Echinococcus multilocularis two pore calcium channel protein 2 0.0098 0.0796 0.0796
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Mycobacterium leprae Conserved hypothetical protein 0.0046 0.0317 1
Schistosoma mansoni cpg binding protein 0.0037 0.0236 0.0371
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Schistosoma mansoni transient receptor potential channel 0.0098 0.0796 0.167
Loa Loa (eye worm) voltage-gated potassium channel 0.0098 0.0796 0.2136
Mycobacterium ulcerans regulatory protein 0.0046 0.0317 0.5
Loa Loa (eye worm) voltage-gated calcium channel 0.0098 0.0796 0.2136
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0046 0.0317 0.0661
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.1499 0.3299
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0098 0.0796 0.167
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0796 1
Echinococcus granulosus potassium voltage gated channel protein 0.0098 0.0796 0.0796
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0144 0.1211 0.1211
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0046 0.0317 0.0559
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0144 0.1211 0.1211
Echinococcus granulosus short transient receptor potential channel 6 0.0098 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0046 0.0317 0.0317
Echinococcus multilocularis potassium voltage gated channel protein 0.0102 0.0833 0.0833
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0421 0.3728 0.3728
Echinococcus multilocularis potassium voltage gated channel protein 0.0102 0.0833 0.0833
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0796 0.167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0098 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0833 0.2234
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0421 0.3728 0.3728
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0187 0.1604 0.4185
Echinococcus multilocularis hyperpolarization activated cyclic 0.0144 0.1211 0.1211
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0046 0.0317 0.0559
Brugia malayi Egg laying defective protein 4 0.0046 0.0317 0.0661
Echinococcus multilocularis sodium leak channel non selective protein 0.0098 0.0796 0.0796
Loa Loa (eye worm) ion channel NompC 0.0098 0.0796 0.2136
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0144 0.1211 0.1211
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0796 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0076 0.0203
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0796 0.167
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.022 0.1902 0.4233
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0098 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0317 0.085
Echinococcus multilocularis ryanodine receptor 44f 0.0098 0.0796 0.0796
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0046 0.0317 0.5
Echinococcus granulosus voltage gated hydrogen channel 1 0.0098 0.0796 0.0796
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0098 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0102 0.0833 0.0833
Leishmania major hypothetical protein, unknown function 0.0098 0.0796 0.0495
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0098 0.0796 0.167
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0796 0.167
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Schistosoma mansoni hypothetical protein 0.0032 0.0191 0.0267
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0046 0.0317 0.5
Trypanosoma brucei protein kinase A regulatory subunit 0.0046 0.0317 0.2084
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0796 0.167
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0449 0.1206
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0144 0.1211 0.1211
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0046 0.0317 0.0477
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0098 0.0796 0.0796
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0144 0.1211 0.2631
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0046 0.0317 0.0317
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0098 0.0796 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0317 0.5
Echinococcus multilocularis two pore calcium channel protein 1 0.0098 0.0796 0.0796
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0102 0.0833 0.2073
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus multilocularis transfer RNA-Gly 0.0102 0.0833 0.0833
Brugia malayi Cyclic-nucleotide gated cation channel 0.0144 0.1211 0.3108
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0046 0.0317 0.0559
Brugia malayi hypothetical protein 0.0098 0.0796 0.1973
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0317 0.0559
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0317 0.085
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0046 0.0317 0.0317
Schistosoma mansoni voltage-gated potassium channel 0.0453 0.4016 0.9133
Schistosoma mansoni transient receptor potential channel 0.0098 0.0796 0.167
Schistosoma mansoni cpg binding protein 0.0035 0.0218 0.0329
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0144 0.1211 0.1211
Brugia malayi N-terminal motif family protein 0.0046 0.0317 0.0661
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.1499 0.3299
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0076 0.0076
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0046 0.0317 0.0559
Mycobacterium tuberculosis Conserved protein 0.0046 0.0317 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Onchocerca volvulus 0.0046 0.0317 0.1717
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0571 0.1148
Brugia malayi voltage-dependent calcium channel 0.0098 0.0796 0.1973
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0144 0.1211 0.2631
Echinococcus multilocularis hyperpolarization activated cyclic 0.0144 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Onchocerca volvulus 0.0098 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1499 0.4021
Echinococcus granulosus cGMP dependent protein kinase 0.0046 0.0317 0.0317
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0102 0.0833 0.0833
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0833 0.1755
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0102 0.0833 0.2073
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0046 0.0317 0.5
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0046 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni hypothetical protein 0.0098 0.0796 0.167
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0317 0.0559
Schistosoma mansoni ryanodine receptor related 0.0098 0.0796 0.167
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0098 0.0796 0.167
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0796 0.167
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.439 0.439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0076 0.0076
Schistosoma mansoni two-pore calcium channel 0.0098 0.0796 0.167
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0102 0.0833 0.0833
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.0796 0.0796
Echinococcus granulosus TRP transient receptor potential channel 0.0098 0.0796 0.0796
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0323 0.2834 1
Echinococcus granulosus voltage gated potassium channel 0.0176 0.1499 0.1499
Echinococcus granulosus voltage dependent calcium channel 0.0098 0.0796 0.0796
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0102 0.0833 0.0833
Brugia malayi olfactory channel protein osm-9 0.0098 0.0796 0.1973
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0796 0.167
Echinococcus multilocularis potassium voltage gated channel protein 0.0187 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0056 0.0409 0.1096
Echinococcus granulosus two pore calcium channel protein 1 0.0098 0.0796 0.0796
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0144 0.1211 0.1211
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0796 0.0796
Echinococcus multilocularis short transient receptor potential channel 6 0.0098 0.0796 0.0796
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0421 0.3728 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0449 0.1024
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0102 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0741
Toxoplasma gondii hypothetical protein 0.0098 0.0796 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.022 0.1902 0.5001
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0465
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0046 0.0317 0.0661
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0218 0.0584
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus granulosus potassium voltage gated channel protein 0.0098 0.0796 0.0796
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.0796 0.0796
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0046 0.0317 0.0559
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0098 0.0796 0.0796
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.1604 0.3542
Echinococcus granulosus voltage dependent calcium channel 0.0098 0.0796 0.0796
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0046 0.0317 0.0317
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0098 0.0796 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0176 0.1499 0.3897
Echinococcus granulosus potassium large conductance calcium activated 0.0098 0.0796 0.0796
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.0796 0.0796
Trypanosoma brucei Flagellar Member 6 0.0046 0.0317 0.2084
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.0796 0.0796
Echinococcus multilocularis expressed conserved protein 0.0046 0.0317 0.0317
Mycobacterium ulcerans hypothetical protein 0.0046 0.0317 0.5
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0046 0.0317 0.0317
Brugia malayi ion channel NompC 0.0098 0.0796 0.1973
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0046 0.0317 0.0559
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0796 0.167
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0098 0.0796 0.1973
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0046 0.0317 0.5
Echinococcus granulosus cpg binding protein 0.0037 0.0236 0.0236
Mycobacterium ulcerans transcriptional regulatory protein 0.0046 0.0317 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.1604 0.3542
Echinococcus granulosus sodium leak channel non selective protein 0.0098 0.0796 0.0796
Echinococcus granulosus two pore calcium channel protein 2 0.0098 0.0796 0.0796
Schistosoma mansoni hypothetical protein 0.0494 0.439 1
Mycobacterium ulcerans transmembrane transport protein 0.0046 0.0317 0.5
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0046 0.0317 0.0317
Echinococcus multilocularis GPCR, family 2 0.0019 0.0076 0.0076
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0046 0.0317 0.0559
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0796 0.0796
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0176 0.1499 0.1499
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0796 0.167
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0046 0.0317 0.0559
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0449 0.1024
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0046 0.0317 0.085
Schistosoma mansoni voltage-dependent calcium channel 0.0098 0.0796 0.167
Echinococcus granulosus hyperpolarization activated cyclic 0.0144 0.1211 0.1211
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0098 0.0796 0.1973
Echinococcus granulosus cGMP dependent protein kinase 1 0.0046 0.0317 0.0317
Toxoplasma gondii hypothetical protein 0.0098 0.0796 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0046 0.0317 0.1717
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0098 0.0796 0.1973
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0102 0.0833 0.0833
Echinococcus granulosus shaker cognate 0.0102 0.0833 0.0833
Treponema pallidum catabolite gene activator 0.0046 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.0796 0.2136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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