TDR Targets

Basic information

Technical information

TDR Targets ID: 1403737
Name: [2-oxo-2-[(3-sulfamoylphenyl)amino]ethyl] 2-( 1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)a cetate
MW: 421.424 | Formula: C18H19N3O7S
H donors: 2 H acceptors: 6 LogP: -0.24 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN1C(=O)C2C(C1=O)CC=CC2)OCC(=O)Nc1cccc(c1)S(=O)(=O)N
InChi: 1S/C18H19N3O7S/c19-29(26,27)12-5-3-4-11(8-12)20-15(22)10-28-16(23)9-21-17(24)13-6-1-2-7-14(13)18(21)25/h1-5,8,13-14H,6-7,9-10H2,(H,20,22)(H2,19,26,27)
InChiKey: BRQZNRQWXXFQPN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)acetic acid [2-oxo-2-[(3-sulfamoylphenyl)amino]ethyl] ester
2-(1,3-diketo-3a,4,7,7a-tetrahydroisoindol-2-yl)acetic acid [2-keto-2-[(3-sulfamoylphenyl)amino]ethyl] ester
[2-oxo-2-[(3-sulfamoylphenyl)amino]ethyl] 2-(1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)ethanoate
MLS001002778
SMR000370745
T5273154

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	aldose reductase, putative	0.0048	0.2221	0.3904
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0305	0.0421
Echinococcus granulosus	hypothetical protein	0.0048	0.2221	0.2216
Schistosoma mansoni	aldo-keto reductase	0.0048	0.2221	0.2057
Toxoplasma gondii	aldose reductase, putative	0.0048	0.2221	0.8535
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.1068	0.3633
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.1219	0.1956
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.2402	0.4257
Schistosoma mansoni	hypothetical protein	0.0013	0.0213	0.0006
Onchocerca volvulus		0.0048	0.2221	0.2918
Echinococcus granulosus	chromobox protein 1	0.0077	0.3821	0.3817
Brugia malayi	hypothetical protein	0.0135	0.7093	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Leishmania major	prostaglandin f synthase, putative	0.0048	0.2221	0.2689
Loa Loa (eye worm)	oxidoreductase	0.0048	0.2221	0.3125
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0048	0.2221	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1925	0.3329
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Echinococcus granulosus	aldo keto reductase	0.0048	0.2221	0.2216
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.2931	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Loa Loa (eye worm)	oxidoreductase	0.0048	0.2221	0.3125
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.5356	0.7551
Mycobacterium ulcerans	hypothetical protein	0.0048	0.2221	0.5
Brugia malayi	Heterochromatin protein 1	0.0077	0.3821	0.5387
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0207	0.0201
Onchocerca volvulus		0.0048	0.2221	0.2918
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0409	0.0382
Schistosoma mansoni	chromobox protein	0.0013	0.0213	0.0006
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.0409	0.0382
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1925	0.3329
Echinococcus multilocularis	Chromo domain	0.0013	0.0213	0.0207
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Loa Loa (eye worm)	oxidoreductase	0.0048	0.2221	0.3125
Schistosoma mansoni	chromobox protein	0.0077	0.3821	0.3691
Leishmania major	aldo-keto reductase-like protein	0.0048	0.2221	0.2689
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0048	0.2221	0.3131
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0048	0.2221	0.2689
Entamoeba histolytica	aldose reductase, putative	0.0048	0.2221	0.3904
Trypanosoma brucei	aldo-keto reductase, putative	0.0048	0.2221	0.2689
Trypanosoma brucei	polo-like protein kinase	0.0104	0.5356	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Trypanosoma cruzi	aldo/keto reductase, putative	0.0048	0.2221	0.2689
Schistosoma mansoni	chromobox protein	0.0077	0.3821	0.3691
Echinococcus granulosus	voltage gated potassium channel subunit	0.0048	0.2221	0.2216
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.1068	0.4257
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0013	0.0213	0.03
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0048	0.2221	0.3131
Trichomonas vaginalis	aldo/keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Schistosoma mansoni	chromobox protein	0.0013	0.0213	0.0006
Mycobacterium ulcerans	oxidoreductase	0.0048	0.2221	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Onchocerca volvulus		0.0048	0.2221	0.2918
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.2109	0.3686
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0305	0.01
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0305	0.0299
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.1925	0.2489
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.1121	0.1573
Brugia malayi	Protein cec-1.	0.0013	0.0213	0.03
Entamoeba histolytica	aldose reductase, putative	0.0048	0.2221	0.3904
Mycobacterium tuberculosis	Conserved protein	0.0048	0.2221	0.5
Loa Loa (eye worm)	heterochromatin protein 1	0.0077	0.3821	0.5383
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.1068	0.4257
Onchocerca volvulus		0.0013	0.0248	0.0051
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.2566	1
Schistosoma mansoni	potassium channel beta	0.0048	0.2221	0.2057
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1925	0.2708
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0048	0.2221	0.3904
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Onchocerca volvulus		0.0048	0.2221	0.2918
Brugia malayi	Associated with TFs and helicases family protein	0.0013	0.0213	0.03
Schistosoma mansoni	aldo-keto reductase	0.0048	0.2221	0.2057
Trypanosoma brucei	prostaglandin f synthase	0.0048	0.2221	0.2689
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.2221	0.3904
Onchocerca volvulus		0.0048	0.2221	0.2918
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0048	0.2221	0.3131
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0048	0.2221	0.3131
Echinococcus multilocularis	aldo keto reductase	0.0048	0.2221	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.5356	0.5258
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Schistosoma mansoni	pol-related	0.0048	0.2221	0.2057
Brugia malayi	hypothetical protein	0.0018	0.0515	0.0725
Brugia malayi	hypothetical protein	0.0028	0.1068	0.1505
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0048	0.2221	0.3904
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.5356	1
Schistosoma mansoni	kinase	0.0053	0.248	0.2321
Loa Loa (eye worm)	hypothetical protein	0.0135	0.7093	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.3821	0.7015
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Brugia malayi	SET domain containing protein	0.0013	0.0248	0.035
Onchocerca volvulus	Huntingtin homolog	0.0135	0.7093	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0048	0.2221	0.3904
Echinococcus multilocularis	chromobox protein 1	0.0077	0.3821	0.3817
Brugia malayi	Valyl-tRNA synthetase	0.0013	0.0213	0.03
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.2109	0.2756
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.2109	0.3686
Brugia malayi	hypothetical protein	0.0013	0.0213	0.03
Echinococcus granulosus	cpg binding protein	0.003	0.1213	0.1208
Trypanosoma brucei	aldo/keto reductase, putative	0.0048	0.2221	0.2689
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0013	0.0213	0.0006
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0013	0.0213	0.0207
Loa Loa (eye worm)	oxidoreductase	0.0048	0.2221	0.3125
Toxoplasma gondii	aldo-keto reductase	0.0048	0.2221	0.8535
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0305	0.0299
Trichomonas vaginalis	aldo/keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	aldo/keto reductase, putative	0.0048	0.2221	0.3904
Echinococcus multilocularis	chromobox protein 2	0.0013	0.0213	0.0207
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0048	0.2221	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Echinococcus multilocularis	aldo keto reductase	0.0048	0.2221	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0213	0.0292
Echinococcus granulosus	aldo keto reductase	0.0048	0.2221	0.2216
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.1219	0.1956
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0013	0.0213	0.0006
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.3821	0.7015
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1403	0.197
Plasmodium vivax	aldehyde reductase, putative	0.0048	0.2221	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Brugia malayi	M-phase phosphoprotein, mpp8	0.0013	0.0213	0.03
Trypanosoma cruzi	aldo-keto reductase	0.0048	0.2221	0.2689
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Trypanosoma cruzi	aldo/keto reductase, putative	0.0048	0.2221	0.2689
Brugia malayi	CXXC zinc finger family protein	0.0029	0.1121	0.1581
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.5356	0.5353
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1068	0.1498
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0579	0.0711
Brugia malayi	CHD4 protein	0.0014	0.0305	0.043
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.5356	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0248	0.0042
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0048	0.2221	0.8535
Onchocerca volvulus		0.0048	0.2221	0.2918
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Giardia lamblia	Kinase, PLK	0.0104	0.5356	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Echinococcus multilocularis	aldo keto reductase	0.0048	0.2221	0.2216
Plasmodium falciparum	aldo-keto reductase, putative	0.0048	0.2221	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0048	0.2221	0.3125
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.5356	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0213	0.0006
Echinococcus multilocularis	cpg binding protein	0.003	0.1213	0.1208
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0207	0.0201
Echinococcus granulosus	Chromobox protein 3	0.0013	0.0213	0.0207
Schistosoma mansoni	cpg binding protein	0.003	0.1213	0.1028
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.5356	0.7549
Brugia malayi	chromobox protein homolog 3	0.0043	0.1925	0.2714
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.5356	0.5353
Mycobacterium tuberculosis	Probable oxidoreductase	0.0048	0.2221	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0048	0.2221	0.3904
Echinococcus multilocularis	aldo keto reductase	0.0048	0.2221	0.2216
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0048	0.2221	0.2689
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.7093	1
Loa Loa (eye worm)	helicase	0.0013	0.0213	0.0292
Schistosoma mansoni	cpg binding protein	0.003	0.1213	0.1028
Echinococcus multilocularis	chromobox protein 1	0.0077	0.3821	0.3817
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.5356	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Brugia malayi	NADH-dependent xylose reductase	0.0048	0.2221	0.3131
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0048	0.2221	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0048	0.2221	0.8535
Mycobacterium leprae	Possible oxidoreductase	0.0048	0.2221	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.1068	0.4257
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Loa Loa (eye worm)	oxidoreductase	0.0048	0.2221	0.3125
Echinococcus granulosus	chromobox protein 2	0.0013	0.0213	0.0207
Echinococcus granulosus	Chromo domain	0.0013	0.0213	0.0207
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Onchocerca volvulus		0.0029	0.1121	0.132
Echinococcus granulosus	chromobox protein 1	0.0077	0.3821	0.3817
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0013	0.0213	0.0207
Plasmodium falciparum	aldehyde reductase, putative	0.0048	0.2221	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2221	0.3125
Onchocerca volvulus		0.0048	0.2221	0.2918
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Onchocerca volvulus		0.0034	0.1403	0.1729
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.2402	0.4257
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.5356	0.7475
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0048	0.2221	0.3131
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0048	0.2221	0.2689
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0016	0.0383	0.033
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0579	0.0711
Onchocerca volvulus	Huntingtin homolog	0.0135	0.7093	1
Echinococcus multilocularis	Chromobox protein 3	0.0013	0.0213	0.0207
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.5356	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0048	0.2221	0.2216
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Schistosoma mansoni	cpg binding protein	0.0029	0.1121	0.0934
Echinococcus granulosus	aldo keto reductase	0.0048	0.2221	0.2216
Trichomonas vaginalis	aldo-keto reductase, putative	0.0048	0.2221	0.3904
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0579	0.0711
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0048	0.2221	0.2216

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0657 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	1.4125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	20.7865 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1565574

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1403737