Detailed information for compound 1403857

Basic information

Technical information
  • TDR Targets ID: 1403857
  • Name: N-cyclopentyl-2-[(2-ethyl-[1]benzoxolo[2,3-e] pyrimidin-4-yl)sulfanyl]acetamide
  • MW: 355.454 | Formula: C19H21N3O2S
  • H donors: 1 H acceptors: 3 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc(SCC(=O)NC2CCCC2)c2c(n1)c1ccccc1o2
  • InChi: 1S/C19H21N3O2S/c1-2-15-21-17-13-9-5-6-10-14(13)24-18(17)19(22-15)25-11-16(23)20-12-7-3-4-8-12/h5-6,9-10,12H,2-4,7-8,11H2,1H3,(H,20,23)
  • InChiKey: YHFOJNCITIXQJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclopentyl-2-(2-ethylbenzofurano[2,3-e]pyrimidin-4-yl)sulfanyl-acetamide
  • N-cyclopentyl-2-[(2-ethyl-4-benzofurano[2,3-e]pyrimidinyl)thio]acetamide
  • N-cyclopentyl-2-[(2-ethylbenzofurano[2,3-e]pyrimidin-4-yl)thio]acetamide
  • N-cyclopentyl-2-[(2-ethyl-[1]benzoxolo[2,3-e]pyrimidin-4-yl)sulfanyl]ethanamide
  • ZINC02419489

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) voltage-dependent calcium channel 0.0181 0.0452 0.1179
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0181 0.0452 0.1179
Echinococcus granulosus potassium voltage gated channel protein 0.0186 0.0474 0.0474
Loa Loa (eye worm) ion channel NompC 0.0181 0.0452 0.1179
Leishmania major hypothetical protein, unknown function 0.0181 0.0452 0.0452
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0186 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus granulosus geminin 0.0172 0.0403 0.0403
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated ion channel 0.0181 0.0452 0.1085
Echinococcus granulosus short transient receptor potential channel 6 0.0181 0.0452 0.0452
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0181 0.0452 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0181 0.0452 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0181 0.0452 0.0452
Echinococcus granulosus voltage gated potassium channel 0.0186 0.0474 0.0474
Brugia malayi olfactory channel protein osm-9 0.0181 0.0452 0.1179
Echinococcus granulosus voltage dependent calcium channel 0.0181 0.0452 0.0452
Schistosoma mansoni 60S ribosomal protein L21 0.0246 0.0784 0.1883
Loa Loa (eye worm) voltage-gated calcium channel 0.0181 0.0452 0.1179
Loa Loa (eye worm) calcium channel 0.0181 0.0452 0.1179
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0181 0.0452 0.1085
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0275 0.0929 0.2232
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.0452 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0275 0.0929 0.2232
Echinococcus multilocularis short transient receptor potential channel 6 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus granulosus ryanodine receptor 44f 0.0181 0.0452 0.0452
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.034 0.1262 0.1262
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0841 0.3831 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0275 0.0929 0.2426
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0275 0.0929 0.2426
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0186 0.0474 0.1237
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Loa Loa (eye worm) hypothetical protein 0.0275 0.0929 0.2426
Echinococcus multilocularis voltage gated potassium channel 0.0186 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0181 0.0452 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0181 0.0452 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0181 0.0452 0.0452
Echinococcus granulosus calcium activated potassium channel 0.0181 0.0452 0.0452
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0275 0.0929 0.0929
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0181 0.0452 0.1085
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0181 0.0452 1
Schistosoma mansoni transient receptor potential channel 0.0181 0.0452 0.1085
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0275 0.0929 0.2232
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0181 0.0452 0.0452
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.066 0.2902 1
Schistosoma mansoni ryanodine receptor related 0.0181 0.0452 0.1085
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.0452 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0181 0.0452 0.0452
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0275 0.0929 0.3202
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.0452 0.1085
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0273 0.0921 0.0921
Schistosoma mansoni hypothetical protein 0.0172 0.0403 0.0969
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0277 0.0943 0.2461
Loa Loa (eye worm) hypothetical protein 0.0277 0.0943 0.2461
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0181 0.0452 0.1179
Echinococcus multilocularis potassium voltage gated channel protein 0.0186 0.0474 0.0474
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.066 0.2902 1
Echinococcus granulosus sodium leak channel non selective protein 0.0181 0.0452 0.0452
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0186 0.0474 0.0474
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0181 0.0452 0.1085
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0275 0.0929 0.3202
Loa Loa (eye worm) voltage-gated potassium channel 0.0186 0.0474 0.1237
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0181 0.0452 0.1179
Schistosoma mansoni two-pore calcium channel 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated potassium channel 0.034 0.1262 0.303
Schistosoma mansoni transient receptor potential channel 0.0181 0.0452 0.1085
Echinococcus multilocularis conserved hypothetical protein 0.0181 0.0452 0.0452
Schistosoma mansoni voltage-gated potassium channel 0.0277 0.0943 0.2265
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0181 0.0452 0.0452
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452
Leishmania major hypothetical protein, conserved 0.0181 0.0452 0.0452
Schistosoma mansoni transient receptor potential channel 4 0.0181 0.0452 0.1085
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0275 0.0929 0.0929
Echinococcus multilocularis two pore calcium channel protein 1 0.0181 0.0452 0.0452
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated potassium channel 0.0906 0.4163 1
Echinococcus granulosus potassium voltage gated channel protein 0.0186 0.0474 0.0474
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0313 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0748 0.3353 0.8753
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0186 0.0474 0.0474
Echinococcus multilocularis potassium voltage gated channel protein 0.0186 0.0474 0.0474
Echinococcus multilocularis two pore calcium channel protein 2 0.0181 0.0452 0.0452
Schistosoma mansoni transient receptor potential channel 0.0181 0.0452 0.1085
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0181 0.0452 0.1179
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.034 0.1262 0.3293
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0452 0.1085
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0181 0.0452 0.0452
Echinococcus multilocularis transient receptor potential gamma protein 0.0181 0.0452 0.0452
Echinococcus multilocularis voltage gated potassium channel 0.034 0.1262 0.1262
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0181 0.0452 0.1085
Toxoplasma gondii transporter, cation channel family protein 0.0181 0.0452 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0275 0.0929 0.0929
Schistosoma mansoni vesicular amine transporter 0.0186 0.0474 0.1138
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.0452 0.1085
Echinococcus granulosus voltage dependent calcium channel 0.0181 0.0452 0.0452
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0313 0.1124 0.1124
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Brugia malayi cation channel family protein 0.0181 0.0452 0.1179
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0275 0.0929 0.0929
Schistosoma mansoni voltage-gated potassium channel 0.0275 0.0929 0.2232
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus multilocularis hyperpolarization activated cyclic 0.0275 0.0929 0.0929
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0313 0.1124 0.2935
Schistosoma mansoni voltage-gated potassium channel 0.0906 0.4163 1
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0452 0.1085
Loa Loa (eye worm) voltage-gated potassium channel 0.0181 0.0452 0.1179
Toxoplasma gondii hypothetical protein 0.0181 0.0452 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0181 0.0452 0.0452
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0275 0.0929 0.0929
Loa Loa (eye worm) ryanodine receptor 0.0181 0.0452 0.1179
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0275 0.0929 0.2426
Brugia malayi voltage-dependent calcium channel 0.0181 0.0452 0.1179
Echinococcus multilocularis potassium large conductance calcium activated 0.0181 0.0452 0.0452
Echinococcus granulosus two pore calcium channel protein 1 0.0181 0.0452 0.0452
Echinococcus multilocularis potassium voltage gated channel protein 0.0277 0.0943 0.0943
Echinococcus granulosus potassium large conductance calcium activated 0.0181 0.0452 0.0452
Brugia malayi cation channel family protein 0.0181 0.0452 0.1179
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Loa Loa (eye worm) hypothetical protein 0.0186 0.0474 0.1237
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0186 0.0474 0.0474
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0181 0.0452 0.0452
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0186 0.0474 0.0474
Echinococcus multilocularis voltage dependent calcium channel 0.0181 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.0181 0.0452 0.1085
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0181 0.0452 0.1179
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0452 0.1085
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0181 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0181 0.0452 0.0452
Schistosoma mansoni calcium-activated potassium channel 0.0181 0.0452 0.1085
Echinococcus multilocularis hyperpolarization activated cyclic 0.0275 0.0929 0.0929
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0186 0.0474 0.0474
Echinococcus multilocularis shaker cognate 0.0186 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0186 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus multilocularis geminin 0.0172 0.0403 0.0403
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Loa Loa (eye worm) voltage-gated potassium channel 0.0131 0.0195 0.0509
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0181 0.0452 0.1085
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0275 0.0929 0.2232
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0313 0.1124 0.27
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0841 0.3831 0.3831
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0275 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus granulosus transient receptor potential cation channel 0.0181 0.0452 0.0452
Brugia malayi ion channel NompC 0.0181 0.0452 0.1179
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0275 0.0929 0.2232
Echinococcus granulosus voltage gated potassium channel 0.034 0.1262 0.1262
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0841 0.3831 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0181 0.0452 0.0452
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0181 0.0452 0.1179
Echinococcus multilocularis transfer RNA-Gly 0.0186 0.0474 0.0474
Schistosoma mansoni voltage-dependent calcium channel 0.0181 0.0452 0.1085
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0181 0.0452 0.1179
Brugia malayi Transient-receptor-potential like protein 0.0181 0.0452 0.1179
Echinococcus multilocularis potassium voltage gated channel protein 0.0181 0.0452 0.0452
Echinococcus multilocularis voltage dependent calcium channel 0.0181 0.0452 0.0452
Echinococcus granulosus shaker cognate 0.0186 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.034 0.1262 0.3293
Echinococcus granulosus short transient receptor potential channel 6 0.0181 0.0452 0.0452
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0181 0.0452 0.1179
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.0452 0.0452
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0181 0.0452 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0275 0.0929 0.0929
Echinococcus granulosus two pore calcium channel protein 2 0.0181 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.0172 0.0403 0.0969
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0275 0.0929 0.0929
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated potassium channel 0.0246 0.0784 0.1883
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0841 0.3831 0.3831
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0186 0.0474 0.1237
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.1179
Echinococcus granulosus hypothetical protein 0.0181 0.0452 0.0452
Toxoplasma gondii hypothetical protein 0.0181 0.0452 1
Echinococcus granulosus potassium voltage gated channel protein 0.0181 0.0452 0.0452
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0181 0.0452 0.1085
Schistosoma mansoni voltage-gated potassium channel 0.034 0.1262 0.303
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0277 0.0943 0.0943
Echinococcus granulosus potassium voltage gated channel subfamily H 0.034 0.1262 0.1262
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0181 0.0452 1
Echinococcus multilocularis ryanodine receptor 44f 0.0181 0.0452 0.0452
Echinococcus granulosus voltage gated hydrogen channel 1 0.0181 0.0452 0.0452
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0474 0.1138
Echinococcus granulosus transient receptor potential gamma protein 0.0181 0.0452 0.0452
Echinococcus granulosus potassium voltage gated channel protein 0.0277 0.0943 0.0943
Schistosoma mansoni voltage-gated potassium channel 0.0277 0.0943 0.2265
Brugia malayi hypothetical protein 0.0181 0.0452 0.1179
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0275 0.0929 0.0929
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0181 0.0452 0.0452
Schistosoma mansoni voltage-gated cation channel 0.0181 0.0452 0.1085
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0181 0.0452 1
Echinococcus granulosus TRP transient receptor potential channel 0.0181 0.0452 0.0452
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0181 0.0452 0.1179
Onchocerca volvulus 0.0181 0.0452 1
Echinococcus multilocularis calcium activated potassium channel 0.0181 0.0452 0.0452
Echinococcus multilocularis transient receptor potential cation channel 0.0181 0.0452 0.0452

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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