Detailed information for compound 1404036

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.352 | Formula: C14H14N4OS
  • H donors: 1 H acceptors: 4 LogP: 3.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc(O)c2c(n1)n(nc2)c1ccc(c(c1)C)C
  • InChi: 1S/C14H14N4OS/c1-8-4-5-10(6-9(8)2)18-12-11(7-15-18)13(19)17-14(16-12)20-3/h4-7H,1-3H3,(H,16,17,19)
  • InChiKey: NJTNBDBAOMVXIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0173 0.048 0.048
Echinococcus granulosus potassium voltage gated channel protein 0.0173 0.048 0.048
Schistosoma mansoni two-pore calcium channel 0.0169 0.0457 0.1114
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Echinococcus multilocularis voltage dependent calcium channel 0.0169 0.0457 0.0457
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0169 0.0457 0.1114
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0169 0.0457 0.1211
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0169 0.0457 0.1211
Echinococcus multilocularis hyperpolarization activated cyclic 0.0255 0.0925 0.0925
Echinococcus multilocularis potassium large conductance calcium activated 0.0169 0.0457 0.0457
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0261 0.0963 0.2552
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0169 0.0457 0.0457
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Loa Loa (eye worm) voltage-gated calcium channel 0.0169 0.0457 0.1211
Echinococcus multilocularis voltage gated potassium channel 0.0173 0.048 0.048
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0255 0.0925 0.0925
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0314 0.1251 0.3317
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis calcium activated potassium channel 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0834 0.4098 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0169 0.0457 0.1114
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0457 0.1114
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis sodium leak channel non selective protein 0.0169 0.0457 0.0457
Echinococcus granulosus calcium activated potassium channel 0.0169 0.0457 0.0457
Loa Loa (eye worm) calcium channel 0.0169 0.0457 0.1211
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0255 0.0925 0.0925
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0169 0.0457 0.0457
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0314 0.1251 0.3053
Echinococcus granulosus potassium voltage gated channel protein 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0255 0.0925 0.2258
Echinococcus granulosus potassium voltage gated channel protein 0.0261 0.0963 0.0963
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0169 0.0457 0.1211
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Loa Loa (eye worm) ion channel NompC 0.0169 0.0457 0.1211
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0257 0.094 0.094
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0169 0.0457 0.0457
Echinococcus granulosus TRP transient receptor potential channel 0.0169 0.0457 0.0457
Brugia malayi ion channel NompC 0.0169 0.0457 0.1211
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0169 0.0457 0.1114
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0169 0.0457 0.1211
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0169 0.0457 0.0457
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0169 0.0457 1
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0457 0.1114
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0255 0.0925 0.0925
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0255 0.0925 0.2258
Toxoplasma gondii transporter, cation channel family protein 0.0169 0.0457 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0169 0.0457 0.1114
Echinococcus granulosus hypothetical protein 0.0169 0.0457 0.0457
Schistosoma mansoni vesicular amine transporter 0.0173 0.048 0.117
Loa Loa (eye worm) ryanodine receptor 0.0169 0.0457 0.1211
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0775 0.3772 0.3772
Echinococcus granulosus potassium voltage gated channel protein 0.0169 0.0457 0.0457
Echinococcus multilocularis voltage gated potassium channel 0.0314 0.1251 0.1251
Schistosoma mansoni voltage-gated cation channel 0.0169 0.0457 0.1114
Echinococcus multilocularis X box binding protein 1 0.0348 0.1436 0.1436
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0261 0.0963 0.0963
Echinococcus multilocularis shaker cognate 0.0173 0.048 0.048
Echinococcus granulosus voltage gated hydrogen channel 1 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Brugia malayi hypothetical protein 0.0169 0.0457 0.1211
Echinococcus granulosus transient receptor potential gamma protein 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0261 0.0963 0.2552
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0296 0.1149 0.1149
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0169 0.0457 0.1211
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0775 0.3772 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0169 0.0457 0.0457
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0169 0.0457 0.1211
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0169 0.0457 0.1211
Brugia malayi voltage-dependent calcium channel 0.0169 0.0457 0.1211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0169 0.0457 1
Echinococcus granulosus shaker cognate 0.0173 0.048 0.048
Schistosoma mansoni voltage-gated potassium channel 0.0229 0.0783 0.191
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0169 0.0457 0.1211
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0169 0.0457 1
Echinococcus granulosus voltage gated potassium channel 0.0314 0.1251 0.1251
Echinococcus granulosus short transient receptor potential channel 6 0.0169 0.0457 0.0457
Leishmania major hypothetical protein, conserved 0.0169 0.0457 0.0457
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0255 0.0925 0.2258
Echinococcus granulosus two pore calcium channel protein 2 0.0169 0.0457 0.0457
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0169 0.0457 0.0457
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0169 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis short transient receptor potential channel 6 0.0169 0.0457 0.0457
Echinococcus multilocularis potassium voltage gated channel protein 0.0261 0.0963 0.0963
Echinococcus multilocularis potassium voltage gated channel protein 0.0173 0.048 0.048
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0173 0.048 0.1272
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0173 0.048 0.048
Echinococcus granulosus voltage gated potassium channel 0.0173 0.048 0.048
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0169 0.0457 0.1114
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Schistosoma mansoni transient receptor potential channel 4 0.0169 0.0457 0.1114
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0255 0.0925 0.0925
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0255 0.0925 0.2258
Echinococcus granulosus X box binding protein 1 0.0348 0.1436 0.1436
Echinococcus granulosus two pore calcium channel protein 1 0.0169 0.0457 0.0457
Brugia malayi cation channel family protein 0.0169 0.0457 0.1211
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0775 0.3772 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.1251 0.3317
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0255 0.0925 0.2258
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0169 0.0457 0.0457
Toxoplasma gondii transporter, cation channel family protein 0.0169 0.0457 1
Echinococcus granulosus potassium large conductance calcium activated 0.0169 0.0457 0.0457
Echinococcus granulosus hyperpolarization activated cyclic 0.0255 0.0925 0.0925
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0169 0.0457 0.1114
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.0963 0.2349
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0169 0.0457 0.1114
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0169 0.0457 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0169 0.0457 0.1114
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0606 0.2847 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0169 0.0457 0.0457
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0457 0.0457
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0775 0.3772 0.3772
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0255 0.0925 0.325
Schistosoma mansoni hypothetical protein 0.0348 0.1436 0.3505
Echinococcus granulosus short transient receptor potential channel 6 0.0169 0.0457 0.0457
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0173 0.048 0.048
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0255 0.0925 0.2453
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0255 0.0925 0.325
Loa Loa (eye worm) hypothetical protein 0.0173 0.048 0.1272
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0173 0.048 0.048
Onchocerca volvulus 0.0169 0.0457 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0169 0.0457 0.1211
Schistosoma mansoni 60S ribosomal protein L21 0.0229 0.0783 0.191
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0255 0.0925 0.0925
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Loa Loa (eye worm) voltage-dependent calcium channel 0.0169 0.0457 0.1211
Echinococcus multilocularis transient receptor potential gamma protein 0.0169 0.0457 0.0457
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0169 0.0457 0.1114
Echinococcus multilocularis hyperpolarization activated cyclic 0.0255 0.0925 0.0925
Echinococcus multilocularis conserved hypothetical protein 0.0169 0.0457 0.0457
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0173 0.048 0.1272
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0255 0.0925 0.2258
Toxoplasma gondii hypothetical protein 0.0169 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Brugia malayi Transient-receptor-potential like protein 0.0169 0.0457 0.1211
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0173 0.048 0.048
Loa Loa (eye worm) voltage-gated potassium channel 0.0169 0.0457 0.1211
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0169 0.0457 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0127 0.0224 0.0594
Echinococcus multilocularis ryanodine receptor 44f 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Schistosoma mansoni hypothetical protein 0.0169 0.0457 0.1114
Toxoplasma gondii transporter, cation channel family protein 0.0169 0.0457 1
Echinococcus multilocularis voltage dependent calcium channel 0.0169 0.0457 0.0457
Echinococcus granulosus ryanodine receptor 44f 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Brugia malayi olfactory channel protein osm-9 0.0169 0.0457 0.1211
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.048 0.117
Echinococcus multilocularis potassium voltage gated channel protein 0.0169 0.0457 0.0457
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0169 0.0457 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0314 0.1251 0.1251
Schistosoma mansoni transient receptor potential channel 0.0169 0.0457 0.1114
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0169 0.0457 0.1114
Brugia malayi cation channel family protein 0.0169 0.0457 0.1211
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0314 0.1251 0.1251
Echinococcus multilocularis two pore calcium channel protein 2 0.0169 0.0457 0.0457
Toxoplasma gondii hypothetical protein 0.0169 0.0457 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0169 0.0457 0.1114
Echinococcus granulosus sodium leak channel non selective protein 0.0169 0.0457 0.0457
Echinococcus granulosus potassium voltage gated channel protein 0.0173 0.048 0.048
Schistosoma mansoni voltage-gated ion channel 0.0169 0.0457 0.1114
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0255 0.0925 0.0925
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0169 0.0457 1
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0457 0.1114
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0255 0.0925 0.2453
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0457 0.1114
Schistosoma mansoni ryanodine receptor related 0.0169 0.0457 0.1114
Schistosoma mansoni voltage-gated potassium channel 0.0834 0.4098 1
Echinococcus multilocularis transfer RNA-Gly 0.0173 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0689 0.3303 0.8758
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0296 0.1149 0.2805
Echinococcus granulosus hyperpolarization activated cyclic 0.0255 0.0925 0.0925
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0606 0.2847 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0173 0.048 0.048
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Echinococcus granulosus voltage dependent calcium channel 0.0169 0.0457 0.0457
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0173 0.048 0.048
Loa Loa (eye worm) voltage-gated potassium channel 0.0173 0.048 0.1272
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0255 0.0925 0.0925
Schistosoma mansoni calcium-activated potassium channel 0.0169 0.0457 0.1114
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0169 0.0457 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0314 0.1251 0.3053
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0169 0.0457 0.1211
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0173 0.048 0.048
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0169 0.0457 0.0457
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0296 0.1149 0.1149
Schistosoma mansoni voltage-dependent calcium channel 0.0169 0.0457 0.1114
Brugia malayi Cyclic-nucleotide gated cation channel 0.0255 0.0925 0.2453
Echinococcus multilocularis short transient receptor potential channel 6 0.0169 0.0457 0.0457
Echinococcus granulosus voltage dependent calcium channel 0.0169 0.0457 0.0457
Schistosoma mansoni transient receptor potential channel 0.0169 0.0457 0.1114
Loa Loa (eye worm) hypothetical protein 0.0255 0.0925 0.2453
Schistosoma mansoni transient receptor potential channel 0.0169 0.0457 0.1114
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0296 0.1149 0.3047
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.0963 0.2349
Leishmania major hypothetical protein, unknown function 0.0169 0.0457 0.0457

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: BAP1 Enzyme inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 436 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) 0.1042 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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