Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.2733 | 0.2733 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.2733 | 0.2733 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.2733 | 0.2733 |
Brugia malayi | hypothetical protein | 0.0137 | 0.2538 | 0.2538 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0179 | 0.3685 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0238 | 0.5278 | 0.5278 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0238 | 0.5278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.156 | 0.156 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0238 | 0.5278 | 0.5278 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0238 | 0.5278 | 0.5278 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0238 | 0.5278 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.636 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0238 | 0.5278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2538 | 0.2538 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0238 | 0.5278 | 0.5278 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0238 | 0.5278 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0238 | 0.5278 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.