Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1256 | 0.2505 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1256 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1256 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1256 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5014 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1256 | 0.2505 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1256 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1256 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Onchocerca volvulus | 0.0043 | 0.1256 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5014 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1256 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1256 | 0.2505 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1256 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.