Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | ATM serine/threonine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0142 | 0.0142 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0022 | 0.0041 | 0.0041 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.1688 | 0.1688 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0217 | 0.0217 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.3407 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0844 | 0.0844 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.003 | 0.0308 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1013 | 0.1013 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.017 | 0.0385 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0747 | 0.0747 |
Giardia lamblia | GTOR | 0.0022 | 0.0041 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.3407 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.1829 | 0.1829 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.3407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2124 | 0.2124 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2293 | 0.2261 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.0042 | 0.0004 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0125 | 0.3407 | 0.5 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.0042 | 0.0004 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.003 | 0.0308 | 0.0268 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.01 | 0.01 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.3407 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0024 | 0.0024 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.003 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0937 | 0.0937 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0142 | 0.0142 |
Toxoplasma gondii | FATC domain-containing protein | 0.003 | 0.0308 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.017 | 0.017 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0217 | 0.0217 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0022 | 0.0041 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0308 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0022 | 0.0041 | 0.0041 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.01 | 0.01 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0022 | 0.0041 | 0.0041 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0308 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0022 | 0.0041 | 0.0041 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.3407 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0841 | 0.0803 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0311 | 0.0271 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0747 | 0.0747 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0022 | 0.0041 | 0.0041 |
Echinococcus granulosus | serine protein kinase ATM | 0.003 | 0.0308 | 0.0308 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.01 | 0.01 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.003 | 0.0308 | 0.0794 |
Echinococcus multilocularis | serine protein kinase ATM | 0.003 | 0.0308 | 0.0308 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0217 | 0.0217 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.