Detailed information for compound 1404602

Basic information

Technical information
  • TDR Targets ID: 1404602
  • Name: 2-(5-nitropyridin-2-yl)sulfanyl-N-(1,3-thiazo l-2-yl)propanamide
  • MW: 310.352 | Formula: C11H10N4O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Sc1ccc(cn1)[N+](=O)[O-])C)Nc1nccs1
  • InChi: 1S/C11H10N4O3S2/c1-7(10(16)14-11-12-4-5-19-11)20-9-3-2-8(6-13-9)15(17)18/h2-7H,1H3,(H,12,14,16)
  • InChiKey: YOOJVNQYTXCBDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(5-nitro-2-pyridyl)sulfanyl]-N-thiazol-2-yl-propanamide
  • 2-[(5-nitro-2-pyridyl)thio]-N-(2-thiazolyl)propanamide
  • 2-[(5-nitro-2-pyridyl)thio]-N-thiazol-2-yl-propionamide
  • 2-(5-Nitro-pyridin-2-ylsulfanyl)-N-thiazol-2-yl-propionamide
  • ASN 15022330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Pyruvate kinase 0.004 0.0739 0.2099
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3519 0.4063
Loa Loa (eye worm) hexokinase 0.0157 0.5144 0.5783
Loa Loa (eye worm) pyruvate kinase 0.004 0.0739 0.0546
Echinococcus multilocularis muscleblind protein 0.018 0.6018 0.6948
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0739 0.0197
Echinococcus multilocularis hexokinase 0.0251 0.8663 1
Loa Loa (eye worm) hexokinase 0.0251 0.8663 0.9965
Onchocerca volvulus 0.0251 0.8663 0.858
Schistosoma mansoni pyruvate kinase 0.004 0.0739 0.0853
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Loa Loa (eye worm) hypothetical protein 0.0171 0.5661 0.6397
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3519 0.3509
Entamoeba histolytica hexokinase 1 0.0251 0.8663 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0579 0.0669
Echinococcus granulosus hexokinase 0.0251 0.8663 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3519 0.3121
Chlamydia trachomatis pyruvate kinase 0.004 0.0739 0.5
Trypanosoma brucei hexokinase, putative 0.0251 0.8663 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0579 0.0669
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0739 0.0853
Brugia malayi Hexokinase family protein 0.0157 0.5144 0.5627
Toxoplasma gondii hexokinase 0.0251 0.8663 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0739 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Trypanosoma cruzi hexokinase, putative 0.0251 0.8663 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0739 0.0197
Leishmania major hexokinase, putative 0.0251 0.8663 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3519 0.3865
Loa Loa (eye worm) pyruvate kinase 0.004 0.0739 0.0546
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8692 1
Brugia malayi Hexokinase family protein 0.0251 0.8663 0.9964
Echinococcus multilocularis pyruvate kinase 0.0032 0.0419 0.0484
Loa Loa (eye worm) hypothetical protein 0.008 0.2223 0.231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0579 0.0669
Trypanosoma cruzi hexokinase, putative 0.0251 0.8663 1
Brugia malayi Pre-SET motif family protein 0.0251 0.8692 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0579 0.0669
Mycobacterium ulcerans pyruvate kinase 0.004 0.0739 0.5
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3519 0.3624
Schistosoma mansoni pyruvate kinase 0.004 0.0739 0.0853
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3519 0.3509
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0579 0.0669
Echinococcus granulosus hexokinase 0.0251 0.8663 1
Plasmodium falciparum hexokinase 0.0251 0.8663 1
Trypanosoma brucei hexokinase 0.0251 0.8663 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.6018 0.6948
Echinococcus multilocularis hexokinase 0.0251 0.8663 1
Onchocerca volvulus 0.0157 0.5144 0.4846
Entamoeba histolytica hexokinase 2 0.0251 0.8663 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3519 0.4063
Brugia malayi hexokinase type II 0.008 0.2223 0.2026
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3519 0.4063
Loa Loa (eye worm) hexokinase 0.0078 0.2142 0.2214
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1349 0.0659
Echinococcus multilocularis hexokinase 0.0251 0.8663 1
Brugia malayi Muscleblind-like protein 0.018 0.6018 0.6705
Plasmodium vivax SET domain protein, putative 0.0036 0.0579 0.0669
Loa Loa (eye worm) hypothetical protein 0.0036 0.0579 0.0356
Echinococcus granulosus muscleblind protein 0.018 0.6018 0.6948
Echinococcus multilocularis hexokinase type 2 0.0251 0.8663 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3519 0.3851
Schistosoma mansoni kinase 0.0058 0.1405 0.1622
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1349 0.0659
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Schistosoma mansoni hexokinase 0.0251 0.8663 1
Onchocerca volvulus 0.0251 0.8663 0.858
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0739 0.0169
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0739 0.5
Onchocerca volvulus 0.0251 0.8663 0.858
Echinococcus granulosus hexokinase type 2 0.0251 0.8663 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0739 0.5
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3519 0.3509
Plasmodium falciparum pyruvate kinase 0.004 0.0739 0.0853
Trypanosoma brucei hexokinase 0.0251 0.8663 1
Loa Loa (eye worm) hexokinase type II 0.0251 0.8663 0.9965
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0739 0.0169
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0739 0.0169
Loa Loa (eye worm) hypothetical protein 0.018 0.6018 0.6822
Echinococcus multilocularis pyruvate kinase 0.004 0.0739 0.0853
Echinococcus multilocularis pyruvate kinase 0.004 0.0739 0.0853
Trypanosoma brucei polo-like protein kinase 0.0114 0.3519 0.3509
Loa Loa (eye worm) hypothetical protein 0.018 0.6018 0.6822
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Echinococcus granulosus hexokinase 0.0251 0.8663 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0579 0.0669
Loa Loa (eye worm) hexokinase 0.0251 0.8663 0.9965
Brugia malayi Hexokinase family protein 0.0078 0.2142 0.1927
Plasmodium vivax pyruvate kinase, putative 0.004 0.0739 0.0853
Brugia malayi hexokinase 0.0251 0.8663 0.9964
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0529 0.0611
Loa Loa (eye worm) pyruvate kinase 0.004 0.0739 0.0546
Plasmodium vivax hexokinase, putative 0.0251 0.8663 1
Onchocerca volvulus Hexokinase homolog 0.0157 0.5144 0.4846
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Echinococcus granulosus pyruvate kinase 0.004 0.0739 0.0853
Loa Loa (eye worm) hypothetical protein 0.008 0.2223 0.231
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0579 0.0669
Giardia lamblia Kinase, PLK 0.0114 0.3519 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Echinococcus granulosus pyruvate kinase 0.004 0.0739 0.0853
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3519 0.3002
Treponema pallidum hexokinase (hxk) 0.0251 0.8663 0.5
Leishmania major hexokinase, putative 0.0251 0.8663 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0579 0.0669

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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