Detailed information for compound 1404738

Basic information

Technical information
  • TDR Targets ID: 1404738
  • Name: 1-[2-(4-chlorophenyl)-2-oxoethyl]-3-(2,4-dime thoxyphenyl)-N,N-diethyl-5-methyl-2,4-dioxoth ieno[4,5-e]pyrimidine-6-carboxamide
  • MW: 570.056 | Formula: C28H28ClN3O6S
  • H donors: 0 H acceptors: 4 LogP: 5.25 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(C(=O)c1sc2c(c1C)c(=O)n(c(=O)n2CC(=O)c1ccc(cc1)Cl)c1ccc(cc1OC)OC)CC
  • InChi: 1S/C28H28ClN3O6S/c1-6-30(7-2)26(35)24-16(3)23-25(34)32(20-13-12-19(37-4)14-22(20)38-5)28(36)31(27(23)39-24)15-21(33)17-8-10-18(29)11-9-17/h8-14H,6-7,15H2,1-5H3
  • InChiKey: TWYZMGCQUURZNI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[2-(4-chlorophenyl)-2-oxo-ethyl]-3-(2,4-dimethoxyphenyl)-N,N-diethyl-5-methyl-2,4-dioxo-thieno[4,5-e]pyrimidine-6-carboxamide
  • 1-[2-(4-chlorophenyl)-2-oxoethyl]-3-(2,4-dimethoxyphenyl)-N,N-diethyl-5-methyl-2,4-dioxo-6-thieno[4,5-e]pyrimidinecarboxamide
  • 1-[2-(4-chlorophenyl)-2-keto-ethyl]-3-(2,4-dimethoxyphenyl)-N,N-diethyl-2,4-diketo-5-methyl-thieno[4,5-e]pyrimidine-6-carboxamide
  • K305-0293
  • NCGC00138630-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0065 0.0477 0.0779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0477 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0125 0.0129
Schistosoma mansoni hypothetical protein 0.0195 0.1878 0.2113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0125 0.0108
Echinococcus granulosus ubiquitin specific protease 41 0.0049 0.0302 0.031
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.022 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.022 0.0572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Entamoeba histolytica hypothetical protein 0.008 0.0636 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0125 0.0108
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.042 0.2642
Onchocerca volvulus 0.0148 0.1371 0.2428
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0125 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0056
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0302 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.1961 0.3515
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0463 0.0753
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0125 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1285 0.1434
Loa Loa (eye worm) hypothetical protein 0.0053 0.0344 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0125 0.0129
Brugia malayi beta-lactamase 0.0148 0.1371 0.2504
Loa Loa (eye worm) hypothetical protein 0.0141 0.1294 0.2286
Loa Loa (eye worm) beta-lactamase 0.0148 0.1371 0.2427
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0302 0.0856
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0202 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1797 0.202
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0083 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.022 0.0258
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2936 1
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.022 0.0572
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.022 0.0258
Trichomonas vaginalis esterase, putative 0.0148 0.1371 0.2431
Entamoeba histolytica hypothetical protein 0.008 0.0636 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0679 0.0741
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0463 0.0846
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0463 0.0846
Echinococcus multilocularis tumor protein p63 0.0363 0.3695 0.4191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1797 0.202
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.252 0.4546
Brugia malayi hypothetical protein 0.0528 0.5477 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.042 0.2642
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0125 0.0108
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0125 0.0229
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0049 0.0302 0.031
Echinococcus granulosus lamin 0.0029 0.0085 0.0062
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0674 0.1141
Plasmodium vivax glutathione reductase, putative 0.0084 0.0674 0.4584
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.1371 0.952
Schistosoma mansoni hypothetical protein 0.0064 0.0463 0.0494
Loa Loa (eye worm) hypothetical protein 0.0054 0.0352 0.0548
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0083 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0125 0.0229
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0125 0.0108
Brugia malayi hypothetical protein 0.008 0.0636 0.116
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1268 0.4211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0477 0.051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0125 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0202 0.0509
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.1371 0.1299
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Brugia malayi nuclear receptor NHR-88 0.0033 0.0125 0.0229
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0125 0.0229
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0202 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0352 0.4557
Onchocerca volvulus Huntingtin homolog 0.0141 0.1294 0.2283
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0125 0.0229
Onchocerca volvulus 0.0109 0.0942 0.1618
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.1831 0.8792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0125 0.0129
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0125 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0352 0.4557
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1268 0.4211
Brugia malayi hypothetical protein 0.0054 0.0352 0.0643
Schistosoma mansoni alpha-glucosidase 0.0161 0.1515 0.1697
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1285 0.1434
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0125 0.0108
Schistosoma mansoni intermediate filament proteins 0.0029 0.0085 0.0062
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.022 0.1061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0125 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0506 0.0543
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.1831 0.1763
Leishmania major cathepsin L-like protease 0.0077 0.0602 0.1899
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0125 0.0108
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0352 0.2089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0125 0.0229
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2936 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0313 0.0894
Mycobacterium tuberculosis Conserved protein 0.0148 0.1371 0.1299
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0125 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0125 0.0229
Schistosoma mansoni hypothetical protein 0.0064 0.0463 0.0494
Brugia malayi glutathione reductase 0.0084 0.0674 0.123
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0477 0.051
Mycobacterium ulcerans hypothetical protein 0.0148 0.1371 0.952
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Echinococcus multilocularis musashi 0.0029 0.0085 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0168 0.1588 0.178
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8773 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.042 0.0445
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0463 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1371 0.2431
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0125 0.0229
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0083 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0125 0.0129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0125 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.1371 0.2504
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.1831 0.1763
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0202 0.0509
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0202 0.0224
Schistosoma mansoni lamin 0.0029 0.0085 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1285 0.1434
Schistosoma mansoni hypothetical protein 0.0135 0.1232 0.1374
Loa Loa (eye worm) inositol-1 0.004 0.0202 0.0271
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.2061 0.1994
Brugia malayi Thioredoxin reductase 0.0084 0.0674 0.123
Echinococcus granulosus tumor protein p63 0.0363 0.3695 0.4191
Loa Loa (eye worm) hypothetical protein 0.0064 0.0463 0.0753
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0083 0.0097
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0125 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0352 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0049 0.0302 0.0856
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.022 0.0415
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0125 0.0229
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0424 0.1281
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.2061 0.1994
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Leishmania major hypothetical protein, conserved 0.0054 0.0352 0.1031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0125 0.0108
Brugia malayi Inositol-1 0.004 0.0202 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0506 0.0543
Brugia malayi nuclear hormone receptor 0.0033 0.0125 0.0229
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0215 0.0556
Plasmodium vivax SET domain protein, putative 0.0065 0.0477 0.306
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0636 0.0691
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0125 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Leishmania major cathepsin L-like protease 0.0077 0.0602 0.1899
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0125 0.0108
Onchocerca volvulus 0.0519 0.5382 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1371 0.2431
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0125 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0463 0.0494
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.022 0.0415
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.022 0.0258
Echinococcus multilocularis lamin 0.0029 0.0085 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0168 0.1588 0.178
Brugia malayi Pre-SET motif family protein 0.0456 0.4701 0.8583
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0125 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0125 0.0229
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1797 0.3213
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0352 0.1031
Mycobacterium leprae conserved hypothetical protein 0.0148 0.1371 0.6378
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1371 0.1533
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.1371 0.1299
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0059
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0352 0.1031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0049 0.0302 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0506 0.0543
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1371 0.4568
Mycobacterium ulcerans lipase LipD 0.0148 0.1371 0.952
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0202 0.0509
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1371 0.1533
Schistosoma mansoni hypothetical protein 0.0108 0.0934 0.1033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0049 0.0302 0.0551
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1285 0.2268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0125 0.0229
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.1371 0.1299
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.022 0.0258
Onchocerca volvulus Huntingtin homolog 0.0141 0.1294 0.2283
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0085 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0421 0.0675
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.1232 0.1374
Brugia malayi Cytochrome P450 family protein 0.006 0.0421 0.0769
Brugia malayi hypothetical protein 0.0141 0.1294 0.2363
Onchocerca volvulus 0.0033 0.0125 0.0076
Loa Loa (eye worm) glutathione reductase 0.0084 0.0674 0.1141
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.022 0.0401
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0636 0.0691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Brugia malayi ecdysteroid receptor 0.0033 0.0125 0.0229
Plasmodium vivax hypothetical protein, conserved 0.0148 0.1371 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1285 0.1434
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.1371 0.1299
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0202 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0125 0.0229
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0085 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0477 0.051
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2936 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0125 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0463 0.0494
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1438 0.1366
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0477 0.051
Trypanosoma brucei trypanothione reductase 0.0084 0.0674 0.2147
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1371 0.2431
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.042 0.2619
Echinococcus multilocularis survival motor neuron protein 1 0.0528 0.5477 0.6229
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0083 0.0202
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0602 0.1899
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0352 0.1031
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.2061 0.1994
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0456 0.4701 0.8569
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.1961 0.358
Leishmania major hypothetical protein, conserved 0.0148 0.1371 0.4568
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0477 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1371 0.2431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0083 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0506 0.0543
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0674 0.4584
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8773 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0125 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0125 0.0229
Mycobacterium leprae Probable lipase LipE 0.0148 0.1371 0.6378
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0506 0.0543
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0477 0.306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0506 0.0924
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0202 0.0922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Loa Loa (eye worm) RNA binding protein 0.0068 0.0506 0.0831
Mycobacterium tuberculosis Conserved protein 0.0148 0.1371 0.1299
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.022 0.0572
Mycobacterium ulcerans beta-lactamase 0.0148 0.1371 0.952
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.1371 0.1299
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.022 0.0258
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0934 0.1705
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.1232 0.1374
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0674 0.2147
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0157 0.0074
Schistosoma mansoni hypothetical protein 0.0195 0.1878 0.2113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0125 0.0108
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0344 0.0358
Brugia malayi Cytochrome P450 family protein 0.0026 0.0055 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1285 0.1434
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.042 0.1268
Schistosoma mansoni survival motor neuron protein 0.0108 0.0934 0.1033
Mycobacterium tuberculosis Probable reductase 0.0191 0.1831 0.1763
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.1831 0.1763
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0125 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.022 0.0258
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.1371 0.1299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0125 0.0129
Toxoplasma gondii thioredoxin reductase 0.0084 0.0674 0.4584
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Echinococcus granulosus intermediate filament protein 0.0029 0.0085 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0125 0.0229
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0202 0.0509
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0302 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1285 0.1434
Brugia malayi hypothetical protein 0.0035 0.0146 0.0266
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.053 0.1649
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1268 0.4211
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0506 0.0543
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.1831 0.1763
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.022 0.0258
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.042 0.034
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0125 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0083 0.0097
Loa Loa (eye worm) hypothetical protein 0.0203 0.1961 0.3515
Onchocerca volvulus 0.0065 0.0477 0.074
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0302 0.0856
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0506 0.0831
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Brugia malayi steroid hormone receptor 0.0033 0.0125 0.0229
Loa Loa (eye worm) hypothetical protein 0.0049 0.0302 0.0455
Echinococcus multilocularis GPCR, family 2 0.0064 0.0463 0.0494
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8773 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1268 0.2236
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0302 0.0413
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0125 0.0108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0125 0.0108
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0302 0.0413
Brugia malayi MH2 domain containing protein 0.0255 0.252 0.4601
Plasmodium falciparum glutathione reductase 0.0084 0.0674 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0202 0.1061
Brugia malayi Pre-SET motif family protein 0.0065 0.0477 0.0871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0125 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1285 0.1434
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0302 0.031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0202 0.0224
Leishmania major trypanothione reductase 0.0084 0.0674 0.2147
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.042 0.2642
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0302 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0125 0.0129
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0215 0.0556
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0679 0.0741
Echinococcus multilocularis geminin 0.0195 0.1878 0.2113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1285 0.2346
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1268 0.2315
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0477 0.051
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.252 0.4546
Schistosoma mansoni inositol monophosphatase 0.004 0.0202 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0602 0.1899
Schistosoma mansoni hypothetical protein 0.0064 0.0463 0.0494
Echinococcus multilocularis lamin dm0 0.0029 0.0085 0.0062
Schistosoma mansoni alpha glucosidase 0.0042 0.022 0.0216
Toxoplasma gondii ABC1 family protein 0.0148 0.1371 1
Treponema pallidum NADH oxidase 0.0029 0.0083 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0085 0.0056
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0049 0.0302 0.2304
Entamoeba histolytica hypothetical protein 0.008 0.0636 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0083 0.0097
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0674 0.0595
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2936 1
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1371 0.2431
Brugia malayi TAR-binding protein 0.0068 0.0506 0.0924
Echinococcus granulosus GPCR family 2 0.0064 0.0463 0.0494
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Schistosoma mansoni inositol monophosphatase 0.004 0.0202 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0602 0.1899
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0636 0.0691
Schistosoma mansoni alpha-glucosidase 0.0161 0.1515 0.1697
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.1371 0.952
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.022 0.0216
Schistosoma mansoni lamin 0.0029 0.0085 0.0062
Echinococcus granulosus survival motor neuron protein 1 0.0528 0.5477 0.6229
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.2061 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0451 0.0481
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.1371 0.2427
Echinococcus granulosus lamin dm0 0.0029 0.0085 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0519 0.5382 1
Onchocerca volvulus 0.0148 0.1371 0.2428
Brugia malayi RNA binding protein 0.0068 0.0506 0.0924
Echinococcus multilocularis ubiquitin specific protease 41 0.0049 0.0302 0.031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.1371 0.1533
Leishmania major cathepsin L-like protease 0.0077 0.0602 0.1899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0125 0.0229
Brugia malayi beta-lactamase family protein 0.0148 0.1371 0.2504
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.042 0.0445
Schistosoma mansoni hypothetical protein 0.0064 0.0463 0.0494
Schistosoma mansoni hypothetical protein 0.0139 0.1268 0.1414
Schistosoma mansoni thyroid hormone receptor 0.0168 0.1588 0.178
Schistosoma mansoni coup transcription factor 0.0033 0.0125 0.0108
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.022 0.0258
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0602 0.1899
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0125 0.0108
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0125 0.0108
Trypanosoma brucei glucosidase, putative 0.0042 0.022 0.0572
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.1961 0.358
Toxoplasma gondii hypothetical protein 0.0047 0.0281 0.1534
Echinococcus granulosus geminin 0.0195 0.1878 0.2113
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0083 0.0202
Onchocerca volvulus 0.0108 0.0934 0.1602
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0125 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0125 0.0108
Mycobacterium ulcerans hypothetical protein 0.0154 0.1438 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0202
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0215 0.0556
Brugia malayi Cytochrome P450 family protein 0.0026 0.0055 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1371 0.4568
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0083 0.0152
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0125 0.0076
Onchocerca volvulus 0.0053 0.0344 0.0489
Loa Loa (eye worm) hypothetical protein 0.0528 0.5477 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.042 0.0445
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.1371 0.4568
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.022 0.0304
Loa Loa (eye worm) hypothetical protein 0.0148 0.1371 0.2427
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0083 0.0097
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1797 0.202
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.022 0.0216
Onchocerca volvulus 0.0148 0.1371 0.2428
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.1371 0.1299
Loa Loa (eye worm) hypothetical protein 0.0141 0.1294 0.2286
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0125 0.0108
Schistosoma mansoni hypothetical protein 0.008 0.0636 0.0691
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0302 0.031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0463 0.0494
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0129
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0302 0.031
Plasmodium falciparum thioredoxin reductase 0.0084 0.0674 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1797 0.3281
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.042 0.0445
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0083 0.0097
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.1831 0.1763
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0202 0.0195
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.1371 0.1533
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0049 0.0302 0.031
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0602 0.1899
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0215 0.0556
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0083 0.0059
Echinococcus granulosus tar DNA binding protein 0.0068 0.0506 0.0543
Brugia malayi beta-lactamase family protein 0.0148 0.1371 0.2504
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0125 0.0229
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0506 0.0831
Mycobacterium tuberculosis Conserved protein 0.0148 0.1371 0.1299
Brugia malayi intermediate filament protein 0.0029 0.0085 0.0156
Entamoeba histolytica hypothetical protein 0.008 0.0636 1

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 1.122 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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