Detailed information for compound 1404761

Basic information

Technical information
  • TDR Targets ID: 1404761
  • Name: Z81973146
  • MW: 387.473 | Formula: C21H29N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1(CC)NC(=O)N(C1=O)CC(=O)NC1CCCCC1C
  • InChi: 1S/C21H29N3O4/c1-4-21(15-9-11-16(28-3)12-10-15)19(26)24(20(27)23-21)13-18(25)22-17-8-6-5-7-14(17)2/h9-12,14,17H,4-8,13H2,1-3H3,(H,22,25)(H,23,27)
  • InChiKey: VTNGLMQBTUROSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis sex peptide receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0102 0.1313 0.1463
Echinococcus granulosus peptide allatostatin:somatostatin 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.1313 0.1313
Brugia malayi G protein-coupled receptor 0.0102 0.1313 0.1463
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0324 0.8972 1
Echinococcus granulosus hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus multilocularis serotonin receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptide FF receptor 2 0.0102 0.1313 0.1463
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0102 0.1313 0.1313
Echinococcus granulosus sex peptide receptor 0.0102 0.1313 0.1463
Echinococcus granulosus g protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi G-protein coupled receptor 0.0102 0.1313 0.1463
Brugia malayi Dopamine receptor 0.0102 0.1313 0.1463
Schistosoma mansoni opsin-like receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Schistosoma mansoni neuropeptide receptor 0.0102 0.1313 0.1313
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0102 0.1313 0.1313
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.1313 0.1463
Schistosoma mansoni voltage-gated potassium channel 0.0094 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis orexin receptor type 2 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni amine GPCR 0.0102 0.1313 0.1313
Echinococcus granulosus somatostatin receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi neuropeptide F receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide s receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0102 0.1313 0.1463
Echinococcus multilocularis allatostatin A receptor 0.0102 0.1313 0.1463
Schistosoma mansoni adenoreceptor 0.0102 0.1313 0.1313
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus multilocularis g protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis dro:myosuppressin receptor 0.0102 0.1313 0.1463
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide receptor 0.0102 0.1313 0.1313
Echinococcus granulosus dro:myosuppressin receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi Tachykinin-like peptides receptor 99D 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.1313 0.1463
Brugia malayi Melatonin receptor type 1A 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.1313 0.1463
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0094 0.1028 0.1145
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0102 0.1313 0.1313
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.1313 0.1313
Onchocerca volvulus 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus 7TM GPCR rhodopsin 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0102 0.1313 0.1313
Echinococcus multilocularis somatostatin receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Schistosoma mansoni biogenic amine receptor 0.0102 0.1313 0.1313
Onchocerca volvulus Neuropeptide F receptor homolog 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi AKH receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0094 0.1028 0.1145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Echinococcus multilocularis G protein coupled receptor 139 0.0102 0.1313 0.1463
Schistosoma mansoni biogenic amine receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.1313 0.1463
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0102 0.1313 0.1463
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0303 0.8236 1
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0102 0.1313 0.1463
Echinococcus granulosus orexin receptor type 2 0.0102 0.1313 0.1463
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0102 0.1313 0.1463
Schistosoma mansoni hypothetical protein 0.0102 0.1313 0.1313
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0102 0.1313 0.1313
Echinococcus granulosus tachykinin peptides receptor 99D 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi Serotonin receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus multilocularis neuropeptide receptor 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptide s receptor 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0102 0.1313 0.1463
Echinococcus granulosus allatostatin A receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis voltage gated potassium channel 0.0094 0.1028 0.1145
Echinococcus granulosus neuropeptide receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi ORL1-like opioid receptor 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.1313 0.1313
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Schistosoma mansoni amine GPCR 0.0102 0.1313 0.1313
Schistosoma mansoni opsin-like receptor 0.0102 0.1313 0.1313
Onchocerca volvulus 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Echinococcus granulosus serotonin receptor 0.0102 0.1313 0.1463
Brugia malayi Serotonin receptor 0.0102 0.1313 0.1463
Echinococcus granulosus G protein coupled receptor 139 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide f receptor 76f 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0094 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0281 0.7495 0.8354
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus granulosus fmrfamide receptor 0.0102 0.1313 0.1463
Brugia malayi G protein-coupled receptor F59B2.13 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0102 0.1313 0.1463
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0102 0.1313 0.1313
Schistosoma mansoni hypothetical protein 0.0102 0.1313 0.1313
Loa Loa (eye worm) melatonin receptor type 1A 0.0102 0.1313 0.1463
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.1313 0.1463
Schistosoma mansoni amine GPCR 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni amine GPCR 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis G-protein coupled receptor, putative 0.0102 0.1313 0.1463
Echinococcus granulosus alpha 1A adrenergic receptor 0.0102 0.1313 0.1463
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0324 0.8972 1
Echinococcus granulosus neuropeptide receptor 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus granulosus g protein coupled receptor 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Schistosoma mansoni opsin-like receptor 0.0102 0.1313 0.1313
Echinococcus granulosus voltage gated potassium channel 0.0094 0.1028 0.1145
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0102 0.1313 0.1463
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0102 0.1313 0.1313
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.1313 0.1313
Brugia malayi sulfakinin receptor protein 0.0102 0.1313 0.1463
Schistosoma mansoni growth hormone secretagogue receptor 0.0102 0.1313 0.1313
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) TYRA-2 protein 0.0102 0.1313 0.1463
Schistosoma mansoni alpha-1 adrenergic receptor 0.0102 0.1313 0.1313
Schistosoma mansoni histamine h1 receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi RE15519p 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0102 0.1313 0.1463
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0102 0.1313 0.1313
Schistosoma mansoni myosin xvIII 0.0102 0.1313 0.1313
Brugia malayi putative neuropeptide receptor NPR1 0.0102 0.1313 0.1463
Echinococcus multilocularis serotonin receptor 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Onchocerca volvulus 0.0102 0.1313 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi GnHR receptor homolog 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Brugia malayi Dopamine receptor protein 2 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide FF receptor 2 0.0102 0.1313 0.1463
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0102 0.1313 0.1463
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0303 0.8236 1
Schistosoma mansoni biogenic amine receptor 0.0102 0.1313 0.1313
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0102 0.1313 0.1463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.1313 0.1313
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.1313 0.1463
Brugia malayi larval opioid receptor 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Onchocerca volvulus 0.0102 0.1313 0.5
Brugia malayi follicle stimulating hormone receptor 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.1313 0.1463
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0102 0.1313 0.1463
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0324 0.8972 1
Echinococcus multilocularis g protein coupled receptor 0.0102 0.1313 0.1463
Brugia malayi putative neuropeptide receptor 0.0102 0.1313 0.1463
Brugia malayi Dopamine receptor protein 1 0.0102 0.1313 0.1463
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0102 0.1313 0.1463
Schistosoma mansoni hypothetical protein 0.0102 0.1313 0.1313
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Echinococcus multilocularis g-protein coupled receptor 0.0102 0.1313 0.1463
Schistosoma mansoni voltage-gated potassium channel 0.0094 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.1313 0.1313
Echinococcus multilocularis fmrfamide receptor 0.0102 0.1313 0.1463
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis neuropeptide receptor A26 0.0102 0.1313 0.1463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.1313 0.1463
Echinococcus granulosus g-protein coupled receptor 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.1313 0.1463
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0094 0.1028 0.1145
Echinococcus granulosus g protein coupled receptor 0.0102 0.1313 0.1463
Brugia malayi G-protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus granulosus 7tm_1 domain containing protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0102 0.1313 0.1463
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0102 0.1313 0.1463
Echinococcus granulosus neuropeptide receptor A26 0.0102 0.1313 0.1463
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0324 0.8972 1
Schistosoma mansoni hypothetical protein 0.0102 0.1313 0.1313
Echinococcus multilocularis fmrfamide receptor 0.0102 0.1313 0.1463
Schistosoma mansoni neuropeptide receptor 0.0102 0.1313 0.1313
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0102 0.1313 0.1463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Brugia malayi hypothetical protein 0.0102 0.1313 0.1463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.1313 0.1463
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0102 0.1313 0.1463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.1313 0.1313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.1313 0.1313
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.1313 0.1463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.1313 0.1313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.1313 0.1463
Echinococcus multilocularis g protein coupled receptor 0.0102 0.1313 0.1463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Loa Loa (eye worm) hypothetical protein 0.0102 0.1313 0.1463
Brugia malayi neuropeptide F receptor 0.0102 0.1313 0.1463

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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