Detailed information for compound 1404996

Basic information

Technical information
  • TDR Targets ID: 1404996
  • Name: ethyl 4-[[furan-2-ylmethyl-[3-(3-methylpiperi din-1-yl)propyl]carbamothioyl]amino]benzoate
  • MW: 443.602 | Formula: C24H33N3O3S
  • H donors: 1 H acceptors: 1 LogP: 4.2 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=S)N(Cc1ccco1)CCCN1CCCC(C1)C
  • InChi: 1S/C24H33N3O3S/c1-3-29-23(28)20-9-11-21(12-10-20)25-24(31)27(18-22-8-5-16-30-22)15-6-14-26-13-4-7-19(2)17-26/h5,8-12,16,19H,3-4,6-7,13-15,17-18H2,1-2H3,(H,25,31)
  • InChiKey: NQTKVLVVQBKXOK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 4-[[2-furylmethyl-[3-(3-methyl-1-piperidyl)propyl]carbamothioyl]amino]benzoate
  • 4-[[[2-furylmethyl-[3-(3-methyl-1-piperidinyl)propyl]amino]-thioxomethyl]amino]benzoic acid ethyl ester
  • 4-[[2-furylmethyl-[3-(3-methyl-1-piperidyl)propyl]thiocarbamoyl]amino]benzoic acid ethyl ester
  • ethyl 4-[({(2-furylmethyl)[3-(3-methylpiperidin-1-yl)propyl]amino}carbonothioyl)amino]benzoate
  • MLS000586285
  • SMR000204648

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0709 0.2097
Loa Loa (eye worm) cathepsin B 0.0328 0.1275 0.3763
Schistosoma mansoni glutaminase 0.0278 0.1069 0.316
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0231 0.0625
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0118 0.0482
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.01 0.01
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0063 0.0185
Schistosoma mansoni hypothetical protein 0.0295 0.1139 0.3367
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.01 0.0332 0.1599
Entamoeba histolytica hypothetical protein 0.01 0.0332 0.1731
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.016 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Plasmodium falciparum serine repeat antigen 7 0.01 0.0332 0.1873
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.016 0.0474
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0036 0.0282
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0118 0.035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0169 0.05
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0063 0.0172
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0332 0.1599
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0328 0.1275 0.7266
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0118 0.035
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi cathepsin L-like precursor 0.0304 0.1173 0.3428
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni hypothetical protein 0.0076 0.0231 0.0684
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0012 0.0037
Brugia malayi Bromodomain containing protein 0.0076 0.0233 0.0631
Toxoplasma gondii cathepsin CPC2 0.01 0.0332 0.18
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Trypanosoma cruzi cysteine protease, putative 0.0239 0.0906 0.2632
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.01 0.0332 0.1873
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0332 0.1599
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus cathepsin L cysteine protease 0.0239 0.0906 0.2678
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0118 0.035
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Brugia malayi jmjC domain containing protein 0.0071 0.0211 0.0565
Brugia malayi mbt repeat family protein 0.0049 0.0118 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi hypothetical protein 0.018 0.066 0.1901
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Onchocerca volvulus 0.0035 0.0063 0.0156
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni cathepsin s 0.0139 0.0491 0.1452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Mycobacterium ulcerans glutaminase 0.0278 0.1069 1
Loa Loa (eye worm) MBCTL1 0.0055 0.0146 0.042
Brugia malayi cathepsin Z-like cysteine proteinase 0.01 0.0332 0.0925
Plasmodium vivax serine-repeat antigen (SERA), putative 0.01 0.0332 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.01 0.0332 0.1873
Plasmodium vivax unspecified product 0.0239 0.0906 0.5168
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0063 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.01 0.0332 0.1873
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Echinococcus multilocularis cysteine protease 0.0442 0.1747 0.1747
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.1747 0.5166
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0123
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0118 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.01 0.0332 0.1731
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.042
Brugia malayi Bromodomain containing protein 0.0039 0.0079 0.0171
Loa Loa (eye worm) hypothetical protein 0.0111 0.0376 0.1102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0173
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Echinococcus granulosus cathepsin b 0.0838 0.3382 1
Schistosoma mansoni hypothetical protein 0.0731 0.294 0.8693
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Onchocerca volvulus 0.018 0.066 0.3649
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0509 1
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0304 0.1173 0.3428
Loa Loa (eye worm) ctsf protein 0.0442 0.1747 0.516
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0509 0.6024
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.01 0.0332 0.1873
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0146 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0239 0.0906 0.5125
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0239 0.0906 0.2678
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0211 0.0625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.01 0.0332 0.1873
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0063 0.0173
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0251
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.1747 0.1747
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Brugia malayi Papain family cysteine protease containing protein 0.0442 0.1747 0.5135
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.1747 0.1747
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0338
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0118 0.035
Brugia malayi cathepsin B-like cysteine proteinase 0.0838 0.3382 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0442 0.1747 0.516
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Plasmodium falciparum serine repeat antigen 2 0.01 0.0332 0.1873
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0063 0.0123
Brugia malayi Cathepsin L-like cysteine proteinase 0.0304 0.1173 0.3428
Plasmodium vivax serine-repeat antigen (SERA) 0.01 0.0332 0.1873
Entamoeba histolytica cysteine protease, putative 0.0442 0.1747 1
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0442 0.1747 0.516
Plasmodium vivax vivapain-2 0.0442 0.1747 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0063 0.0565
Plasmodium vivax vivapain-1 0.0239 0.0906 0.5168
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0012 0.0037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1129 0.6388
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0649
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0376 0.1102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Brugia malayi Cathepsin L-like precursor 0.0304 0.1173 0.3428
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0491 0.1441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.01 0.0235
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.01 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Brugia malayi mbt repeat family protein 0.0049 0.0118 0.0289
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0063 0.0729
Loa Loa (eye worm) cysteine protease 0.0442 0.1747 0.516
Echinococcus granulosus cathepsin l1 0.0442 0.1747 0.5166
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0098 0.0228
Echinococcus granulosus cathepsin L 0.0239 0.0906 0.2678
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0509 0.4736
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Brugia malayi cathepsin L precursor 0.01 0.0332 0.0925
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0146 0.0432
Onchocerca volvulus 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.01 0.0284
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Mycobacterium leprae Probable lipase LipE 0.0035 0.0063 0.0565
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0063 0.0123
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Echinococcus granulosus dna polymerase eta 0.0044 0.0098 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0036 0.0412
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0063 0.0729
Schistosoma mansoni DNA polymerase eta 0.0044 0.0098 0.029
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.0491 0.1398
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.01 0.0332 0.1599
Echinococcus multilocularis cathepsin b 0.0838 0.3382 0.3382
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Schistosoma mansoni hypothetical protein 0.0731 0.294 0.8693
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0514 0.1508
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0123
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1129 0.6388
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0036 0.0412
Brugia malayi Cathepsin L-like precursor 0.0304 0.1173 0.3428
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0332 0.0925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0063 0.0729
Plasmodium falciparum serine repeat antigen 6 0.01 0.0332 0.1873
Schistosoma mansoni cathepsin C 0.01 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Plasmodium vivax vivapain-2 0.0442 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0625
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0146 0.0432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0063 0.0063
Loa Loa (eye worm) fibroinase 0.0442 0.1747 0.516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0098 0.0444
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Echinococcus multilocularis GPCR, family 2 0.0035 0.0063 0.0063
Schistosoma mansoni cathepsin S (C01 family) 0.01 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0239 0.0906 0.2632
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0169 0.0169
Entamoeba histolytica papain family cysteine protease domain containing protein 0.01 0.0332 0.1731
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Leishmania major DNA polymerase eta, putative 0.0031 0.0044 0.0133
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0186
Entamoeba histolytica cysteine proteinase 1, putative 0.0239 0.0906 0.5083
Plasmodium falciparum serine repeat antigen 5 0.01 0.0332 0.1873
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0328 0.1275 0.3771
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0185
Brugia malayi cathepsin F-like cysteine proteinase 0.01 0.0332 0.0925
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.1747 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.01 0.0297
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0063 0.0533
Onchocerca volvulus 0.0442 0.1747 1
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1129 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0036 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0057
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0006 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Toxoplasma gondii cathepsin CPL 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.01 0.0332 0.1599
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0069 0.0204
Toxoplasma gondii preprocathepsin c precursor, putative 0.01 0.0332 0.18
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0332 0.097
Plasmodium falciparum serine repeat antigen 3 0.01 0.0332 0.1873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Toxoplasma gondii cathepsin B 0.0328 0.1275 0.7266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0332 0.0925
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.01 0.0332 0.097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.1747 0.1747
Brugia malayi cahepsin L-like non-peptiedase homolog 0.01 0.0332 0.0925
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0332 0.0925
Mycobacterium ulcerans hypothetical protein 0.0029 0.0036 0.0282
Onchocerca volvulus 0.0304 0.1173 0.6648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0649
Plasmodium falciparum serine repeat antigen 8 0.01 0.0332 0.1873
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0211 0.0625
Entamoeba histolytica cysteine protease, putative 0.01 0.0332 0.1731
Brugia malayi MH2 domain containing protein 0.0144 0.0514 0.1465
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0838 0.3382 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0328 0.1275 0.7266
Echinococcus multilocularis dna polymerase eta 0.0044 0.0098 0.0098
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0063 0.0729
Onchocerca volvulus 0.0035 0.0063 0.0156
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0044 0.0133
Brugia malayi PHD-finger family protein 0.0025 0.0022 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0063 0.0533
Brugia malayi fibroinase precursor 0.01 0.0332 0.0925
Brugia malayi Cathepsin L-like precursor 0.0442 0.1747 0.5135
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0845 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1173 0.6594
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0063 0.0186
Plasmodium vivax serine-repeat antigen (SERA), putative 0.01 0.0332 0.1873
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Onchocerca volvulus Cathepsin L homolog 0.01 0.0332 0.1731
Trypanosoma cruzi cruzipain precursor, putative 0.0139 0.0491 0.1398
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0063 0.0325
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0093
Echinococcus granulosus GPCR family 2 0.0035 0.0063 0.0186
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.01 0.0332 0.1873
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0328 0.1275 0.7199
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Brugia malayi jmjC domain containing protein 0.0073 0.0219 0.0589
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0044 0.0068
Loa Loa (eye worm) glutaminase 2 0.0278 0.1069 0.3151
Echinococcus granulosus cysteine protease 0.0239 0.0906 0.2678
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.01 0.0332 0.1873
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0906 0.2632
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0709 0.0709
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0838 0.3382 1
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.1747 0.5166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0063 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Onchocerca volvulus 0.0035 0.0063 0.0156
Echinococcus granulosus cathepsin L cysteine proteinase 0.0442 0.1747 0.5166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0332 0.1599
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1129 0.845
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0906 0.5005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0514 0.1508
Echinococcus granulosus geminin 0.0731 0.294 0.8693
Loa Loa (eye worm) hypothetical protein 0.0076 0.0231 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0906 0.5005
Plasmodium falciparum serine repeat antigen 4 0.01 0.0332 0.1873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0063 0.0063
Trypanosoma cruzi cysteine proteinase, putative 0.0239 0.0906 0.2632
Plasmodium falciparum cysteine proteinase falcipain 1 0.0239 0.0906 0.5168
Schistosoma mansoni cathepsin B (C01 family) 0.01 0.0332 0.0982
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Leishmania major hypothetical protein, conserved 0.0035 0.0063 0.0239
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0906 0.2632
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Echinococcus multilocularis cysteine protease 0.0442 0.1747 0.1747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Entamoeba histolytica cysteine proteinase, putative 0.0239 0.0906 0.5083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0211 0.0211
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1173 0.6648
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0838 0.3382 1
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0036 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0063 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.016 0.1884
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.1747 1
Plasmodium vivax serine-repeat antigen (SERA) 0.01 0.0332 0.1873
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0376 0.1057
Giardia lamblia Cathepsin B precursor 0.0328 0.1275 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Onchocerca volvulus 0.01 0.0332 0.1731
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.016 0.0474
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1747 0.5135
Brugia malayi cathepsin L-like cysteine proteinase 0.01 0.0332 0.0925
Loa Loa (eye worm) hypothetical protein 0.0304 0.1173 0.3461
Schistosoma mansoni cathepsin F (C01 family) 0.0304 0.1173 0.347
Echinococcus granulosus cathepsin l1 0.0304 0.1173 0.347
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0332 0.0982
Brugia malayi cathepsin Z-like cysteine proteinase 0.01 0.0332 0.0925
Onchocerca volvulus Cathepsin L homolog 0.0442 0.1747 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0442 0.1747 0.5166
Onchocerca volvulus 0.0442 0.1747 1
Plasmodium falciparum serine repeat antigen 9 0.01 0.0332 0.1873
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0063 0.0729
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0219 0.0636
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0118 0.0338
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0211 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1173 0.6594
Mycobacterium ulcerans hypothetical protein 0.0035 0.0063 0.0533
Trypanosoma cruzi cruzipain precursor, putative 0.0442 0.1747 0.5135
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0123
Echinococcus multilocularis cathepsin L 0.01 0.0332 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.01 0.0332 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0277
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.1747 0.1747
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.01 0.0332 0.1873
Onchocerca volvulus 0.0442 0.1747 1
Plasmodium vivax unspecified product 0.0139 0.0491 0.2787
Echinococcus multilocularis cathepsin b 0.0838 0.3382 0.3382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0098 0.0228
Plasmodium vivax unspecified product 0.01 0.0332 0.1873
Leishmania major cysteine peptidase A (CPA) 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Echinococcus granulosus cathepsin L 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.1747 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0332 0.1599
Leishmania major DNA polymerase eta, putative 0.0044 0.0098 0.0444
Loa Loa (eye worm) hypothetical protein 0.018 0.066 0.1942
Loa Loa (eye worm) beta-lactamase 0.0035 0.0063 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0332 0.097
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0013
Toxoplasma gondii ABC1 family protein 0.0035 0.0063 0.0239
Loa Loa (eye worm) glutaminase 0.0278 0.1069 0.3151
Schistosoma mansoni bromodomain containing protein 0.0064 0.0184 0.0544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0442 0.1747 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.01 0.0297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Onchocerca volvulus Cathepsin F homolog 0.0442 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0219 0.0649
Onchocerca volvulus 0.0442 0.1747 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0239 0.0906 0.5125
Loa Loa (eye worm) hypothetical protein 0.0043 0.0097 0.0275
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0012 0.0012
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.01 0.0332 0.0982
Echinococcus multilocularis cathepsin L 0.0239 0.0906 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0332 0.1599
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0036 0.0282
Echinococcus multilocularis geminin 0.0731 0.294 0.294
Plasmodium vivax vivapain-3 0.0239 0.0906 0.5168
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1129 0.6331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Brugia malayi glutaminase DH11.1 0.0278 0.1069 0.3117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.01 0.01
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.01 0.0297
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0063 0.0239
Leishmania major cathepsin L-like protease 0.0442 0.1747 1
Plasmodium falciparum serine repeat antigen 1 0.01 0.0332 0.1873
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0172
Mycobacterium ulcerans lipase LipD 0.0035 0.0063 0.0533
Loa Loa (eye worm) hypothetical protein 0.0139 0.0491 0.1441
Entamoeba histolytica cysteine proteinase 2 0.0239 0.0906 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0063 0.0186
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0838 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0069 0.0069
Toxoplasma gondii cathepsin CPC1 0.01 0.0332 0.18
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0442 0.1747 0.516
Trichomonas vaginalis glutaminase, putative 0.0278 0.1069 0.5973
Trypanosoma cruzi cysteine peptidase, putative 0.0239 0.0906 0.2632
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.01 0.0332 0.1873
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.016 0.0474
Brugia malayi Cathepsin L-like precursor 0.0139 0.0491 0.1398
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0063 0.0729
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Onchocerca volvulus Cathepsin L homolog 0.0442 0.1747 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.016 0.145
Loa Loa (eye worm) hypothetical protein 0.01 0.0332 0.097
Entamoeba histolytica cysteine protease, putative 0.0239 0.0906 0.5083
Plasmodium falciparum cysteine proteinase falcipain 3 0.0442 0.1747 1
Echinococcus granulosus cathepsin b 0.0838 0.3382 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0063 0.0533
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0442 0.1747 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.0491 0.1398
Brugia malayi beta-lactamase 0.0035 0.0063 0.0123
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.01 0.0332 0.0982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0118 0.0118
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.016 0.0804
Trypanosoma cruzi cysteine proteinase, putative 0.0239 0.0906 0.2632
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0146 0.0432
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.01 0.0332 0.1873
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0328 0.1275 0.3731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0139 0.0491 0.1398
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0036 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.1747 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0376 0.1057
Onchocerca volvulus 0.0049 0.0118 0.0482

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0067 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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