Detailed information for compound 1404997

Basic information

Technical information
  • TDR Targets ID: 1404997
  • Name: 2-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol -3-yl)sulfanyl]-N-(5-methyl-1,3,4-thiadiazol- 2-yl)acetamide
  • MW: 336.436 | Formula: C13H16N6OS2
  • H donors: 1 H acceptors: 5 LogP: 1.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(SCC(=O)Nc2nnc(s2)C)nnc1C1CC1
  • InChi: 1S/C13H16N6OS2/c1-3-6-19-11(9-4-5-9)16-18-13(19)21-7-10(20)14-12-17-15-8(2)22-12/h3,9H,1,4-7H2,2H3,(H,14,17,20)
  • InChiKey: HRJDPPRCZDUMBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-allyl-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-[(4-allyl-5-cyclopropyl-1,2,4-triazol-3-yl)thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)ethanamide
  • IVK/0012446

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sex peptide receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni amine GPCR 0.0126 0.2579 0.2579
Schistosoma mansoni neuropeptide F-like receptor 0.0126 0.2579 0.2579
Echinococcus granulosus peptide allatostatin:somatostatin 0.0126 0.2579 0.2875
Brugia malayi G protein-coupled receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0126 0.2579 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0294 0.8972 1
Echinococcus granulosus hypothetical protein 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Schistosoma mansoni neuropeptide receptor 0.0126 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis serotonin receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus g protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus granulosus neuropeptide FF receptor 2 0.0126 0.2579 0.2875
Echinococcus granulosus sex peptide receptor 0.0126 0.2579 0.2875
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0126 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus biogenic amine 5HT receptor 0.0126 0.2579 0.2875
Brugia malayi Dopamine receptor 0.0126 0.2579 0.2875
Schistosoma mansoni opsin-like receptor 0.0126 0.2579 0.2579
Brugia malayi G-protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus granulosus tm gpcr rhodopsin 0.0126 0.2579 0.2875
Schistosoma mansoni neuropeptide receptor 0.0126 0.2579 0.2579
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0126 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.1028 0.1028
Echinococcus granulosus somatostatin receptor 0.0126 0.2579 0.2875
Schistosoma mansoni amine GPCR 0.0126 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus tm gpcr rhodopsin 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis orexin receptor type 2 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Brugia malayi neuropeptide F receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptide s receptor 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Schistosoma mansoni adenoreceptor 0.0126 0.2579 0.2579
Echinococcus multilocularis allatostatin A receptor 0.0126 0.2579 0.2875
Echinococcus granulosus dro:myosuppressin receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptides capa receptor 0.0126 0.2579 0.2875
Schistosoma mansoni neuropeptide receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis dro:myosuppressin receptor 0.0126 0.2579 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Echinococcus multilocularis g protein coupled receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi Tachykinin-like peptides receptor 99D 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus neuropeptides capa receptor 0.0126 0.2579 0.2875
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0085 0.1028 0.1145
Brugia malayi Melatonin receptor type 1A 0.0126 0.2579 0.2875
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus 7TM GPCR rhodopsin 0.0126 0.2579 0.2875
Schistosoma mansoni biogenic amine (5HT) receptor 0.0126 0.2579 0.2579
Onchocerca volvulus 0.0126 0.2579 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0126 0.2579 0.2579
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis somatostatin receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Onchocerca volvulus Neuropeptide F receptor homolog 0.0126 0.2579 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Schistosoma mansoni biogenic amine receptor 0.0126 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptide Y receptor 0.0126 0.2579 0.2875
Brugia malayi AKH receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis G protein coupled receptor 139 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0085 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus orexin receptor type 2 0.0126 0.2579 0.2875
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) neuropeptide F receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni biogenic amine receptor 0.0126 0.2579 0.2579
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0126 0.2579 0.2875
Loa Loa (eye worm) G-protein coupled receptor 0.0126 0.2579 0.2875
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0275 0.8236 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus tachykinin peptides receptor 99D 0.0126 0.2579 0.2875
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0126 0.2579 0.2875
Schistosoma mansoni hypothetical protein 0.0126 0.2579 0.2579
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0126 0.2579 0.2579
Brugia malayi Serotonin receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus neuropeptide Y receptor 0.0126 0.2579 0.2875
Echinococcus granulosus neuropeptide s receptor 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Onchocerca volvulus 0.0126 0.2579 0.5
Echinococcus multilocularis neuropeptide receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus allatostatin A receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptides capa receptor 0.0126 0.2579 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Echinococcus multilocularis voltage gated potassium channel 0.0085 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi ORL1-like opioid receptor 0.0126 0.2579 0.2875
Schistosoma mansoni neuropeptide F-like receptor 0.0126 0.2579 0.2579
Echinococcus granulosus neuropeptide receptor 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Onchocerca volvulus 0.0126 0.2579 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0126 0.2579 0.2875
Schistosoma mansoni opsin-like receptor 0.0126 0.2579 0.2579
Schistosoma mansoni amine GPCR 0.0126 0.2579 0.2579
Schistosoma mansoni neuropeptide f receptor 76f 0.0126 0.2579 0.2579
Brugia malayi Serotonin receptor 0.0126 0.2579 0.2875
Echinococcus granulosus G protein coupled receptor 139 0.0126 0.2579 0.2875
Echinococcus granulosus serotonin receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0256 0.7495 0.8354
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0085 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Brugia malayi G protein-coupled receptor F59B2.13 0.0126 0.2579 0.2875
Echinococcus granulosus fmrfamide receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni hypothetical protein 0.0126 0.2579 0.2579
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0126 0.2579 0.2875
Echinococcus granulosus tm gpcr rhodopsin 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptide receptor 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Loa Loa (eye worm) melatonin receptor type 1A 0.0126 0.2579 0.2875
Echinococcus granulosus biogenic amine 5HT receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni amine GPCR 0.0126 0.2579 0.2579
Schistosoma mansoni amine GPCR 0.0126 0.2579 0.2579
Echinococcus granulosus alpha 1A adrenergic receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis G-protein coupled receptor, putative 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Echinococcus granulosus g protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0294 0.8972 1
Echinococcus granulosus neuropeptide receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0126 0.2579 0.2875
Echinococcus granulosus voltage gated potassium channel 0.0085 0.1028 0.1145
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0126 0.2579 0.5
Onchocerca volvulus 0.0126 0.2579 0.5
Schistosoma mansoni opsin-like receptor 0.0126 0.2579 0.2579
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0126 0.2579 0.2579
Brugia malayi sulfakinin receptor protein 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0126 0.2579 0.2579
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Loa Loa (eye worm) TYRA-2 protein 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni growth hormone secretagogue receptor 0.0126 0.2579 0.2579
Schistosoma mansoni biogenic amine (5HT) receptor 0.0126 0.2579 0.2579
Brugia malayi RE15519p 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni histamine h1 receptor 0.0126 0.2579 0.2579
Schistosoma mansoni alpha-1 adrenergic receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0126 0.2579 0.2579
Schistosoma mansoni myosin xvIII 0.0126 0.2579 0.2579
Brugia malayi putative neuropeptide receptor NPR1 0.0126 0.2579 0.2875
Echinococcus multilocularis serotonin receptor 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Onchocerca volvulus 0.0126 0.2579 0.5
Schistosoma mansoni biogenic amine receptor 0.0126 0.2579 0.2579
Echinococcus granulosus rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Brugia malayi Dopamine receptor protein 2 0.0126 0.2579 0.2875
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0126 0.2579 0.2875
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0275 0.8236 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0126 0.2579 0.2875
Brugia malayi GnHR receptor homolog 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptide Y receptor 0.0126 0.2579 0.2875
Brugia malayi larval opioid receptor 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Echinococcus granulosus neuropeptides capa receptor 0.0126 0.2579 0.2875
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0126 0.2579 0.2579
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0126 0.2579 0.2875
Echinococcus multilocularis g protein coupled receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0294 0.8972 1
Brugia malayi putative neuropeptide receptor 0.0126 0.2579 0.2875
Brugia malayi follicle stimulating hormone receptor 0.0126 0.2579 0.2875
Echinococcus granulosus neuropeptide Y receptor 0.0126 0.2579 0.2875
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0126 0.2579 0.2875
Onchocerca volvulus 0.0126 0.2579 0.5
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni hypothetical protein 0.0126 0.2579 0.2579
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0126 0.2579 0.2875
Brugia malayi Dopamine receptor protein 1 0.0126 0.2579 0.2875
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Loa Loa (eye worm) G-protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis g-protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.1028 0.1028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis fmrfamide receptor 0.0126 0.2579 0.2875
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis neuropeptide receptor A26 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) neuropeptide F receptor 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus granulosus g-protein coupled receptor 0.0126 0.2579 0.2875
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0126 0.2579 0.2875
Echinococcus granulosus 7tm_1 domain containing protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0126 0.2579 0.2875
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0126 0.2579 0.2875
Brugia malayi G-protein coupled receptor 0.0126 0.2579 0.2875
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0085 0.1028 0.1145
Echinococcus granulosus g protein coupled receptor 0.0126 0.2579 0.2875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0126 0.2579 0.2875
Schistosoma mansoni hypothetical protein 0.0126 0.2579 0.2579
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0294 0.8972 1
Echinococcus granulosus neuropeptide receptor A26 0.0126 0.2579 0.2875
Echinococcus multilocularis fmrfamide receptor 0.0126 0.2579 0.2875
Schistosoma mansoni neuropeptide receptor 0.0126 0.2579 0.2579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0126 0.2579 0.2579
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0126 0.2579 0.2579
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0126 0.2579 0.2875
Brugia malayi hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0126 0.2579 0.2875
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0126 0.2579 0.2875
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0126 0.2579 0.2579
Brugia malayi neuropeptide F receptor 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Loa Loa (eye worm) hypothetical protein 0.0126 0.2579 0.2875
Echinococcus multilocularis rhodopsin orphan GPCR 0.0126 0.2579 0.2875
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0126 0.2579 0.2875
Echinococcus multilocularis g protein coupled receptor 0.0126 0.2579 0.2875

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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