Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.9845 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.9845 | 0.9845 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.2842 | 0.2887 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.9845 | 0.9845 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.9845 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7041 | 0.7152 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.9845 | 0.9845 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.9845 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.314 | 0.3189 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0925 | 0.0925 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.468 | 0.4754 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.9845 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.7686 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.