TDR Targets

Basic information

Technical information

TDR Targets ID: 1405094
Name: (17'-acetyl-10',13'-dimethyl-1'-oxospiro[1,3- dioxolane-2,3'-4,5,6,7,8,9,11,12,14,15,16,17- dodecahydro-2H-cyclopenta[a]phenanthrene]-11' -yl) acetate
MW: 432.55 | Formula: C25H36O6
H donors: 0 H acceptors: 3 LogP: 2.88 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OC1CC2(C)C(C3C1C1(C)C(CC3)CC3(CC1=O)OCCO3)CCC2C(=O)C
InChi: 1S/C25H36O6/c1-14(26)18-7-8-19-17-6-5-16-11-25(29-9-10-30-25)13-21(28)24(16,4)22(17)20(31-15(2)27)12-23(18,19)3/h16-20,22H,5-13H2,1-4H3
InChiKey: RUQBPCMPFRJFIH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(17'-acetyl-10',13'-dimethyl-1'-oxo-spiro[1,3-dioxolane-2,3'-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene]-11'-yl) acetate
acetic acid (17'-acetyl-10',13'-dimethyl-1'-oxo-11'-spiro[1,3-dioxolane-2,3'-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene]yl) ester
acetic acid (17'-acetyl-1'-keto-10',13'-dimethyl-spiro[1,3-dioxolane-2,3'-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene]-11'-yl) ester
(17'-ethanoyl-10',13'-dimethyl-1'-oxo-spiro[1,3-dioxolane-2,3'-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene]-11'-yl) ethanoate
BAS 03655834
MLS000687186
SMR000284109

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Ras and Rab interactor 1		No references
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase		No references
Homo sapiens	tyrosyl-DNA phosphodiesterase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania major	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania braziliensis	tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania donovani	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Cryptosporidium parvum	tyrosyl-DNA phodphodiesterase 1 (tdp1)	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei gambiense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Leishmania infantum	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania mexicana	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0005	0.0022	0.0037
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.1666	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.0101	0.0103
Echinococcus multilocularis	serotonin receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	growth hormone secretagogue receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0022	0.0022
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.5989	1
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0007	0.0101	0.0101
Schistosoma mansoni	amine GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0008	0.0142	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0005	0.0022	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.3013	0.3013
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0008	0.0142	0.0144
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0022	0.0022
Brugia malayi	putative neuropeptide receptor NPR1	0.0005	0.0022	0.0037
Echinococcus granulosus	neuropeptide receptor	0.0005	0.0022	0.0022
Brugia malayi	G-protein coupled receptor	0.0005	0.0022	0.0037
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0022	0.0022
Echinococcus granulosus	biogenic amine 5HT receptor	0.0005	0.0022	0.0022
Brugia malayi	AKH receptor	0.0005	0.0022	0.0037
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0008	0.0142	0.0142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0005	0.0022	0.0022
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptide s receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	amine GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptides capa receptor	0.0005	0.0022	0.0022
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.3013	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	allatostatin A receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0008	0.0142	0.0144
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.3013	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0005	0.0022	0.0022
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0005	0.0022	0.0037
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0005	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	G-protein coupled receptor	0.0005	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0007	0.0101	0.0103
Echinococcus multilocularis	neuropeptides capa receptor	0.0005	0.0022	0.0022
Brugia malayi	Sex muscle abnormal protein 5	0.0007	0.0101	0.0169
Onchocerca volvulus		0.0005	0.0022	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide Y receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	somatostatin receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Brugia malayi	neuropeptide F receptor	0.0005	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0008	0.0142	0.0142
Schistosoma mansoni	amine GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	G protein coupled receptor 139	0.0005	0.0022	0.0022
Echinococcus granulosus	serotonin receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptide FF receptor 2	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	adapter molecule crk	0.0007	0.0101	0.0103
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Echinococcus multilocularis	serotonin receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Brugia malayi	GnHR receptor homolog	0.0005	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0008	0.0142	0.0144
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0101	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0005	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.1666	0.1666
Echinococcus multilocularis	c src tyrosine kinase	0.0008	0.0142	0.0142
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0101	0.0169
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Brugia malayi	RE15519p	0.0005	0.0022	0.0037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.3013	0.5
Echinococcus multilocularis	somatostatin receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0008	0.0142	0.0142
Brugia malayi	SRC-1	0.0008	0.0142	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0096	0.3678	0.3678
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	myosin xvIII	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	larval opioid receptor	0.0005	0.0022	0.0037
Onchocerca volvulus		0.0005	0.0022	1
Onchocerca volvulus		0.0005	0.0022	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	fmrfamide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0005	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Schistosoma mansoni	histamine h1 receptor	0.0005	0.0022	0.0022
Brugia malayi	G protein-coupled receptor	0.0005	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	sex peptide receptor	0.0005	0.0022	0.0022
Brugia malayi	Melatonin receptor type 1A	0.0005	0.0022	0.0037
Echinococcus granulosus	c src tyrosine kinase	0.0008	0.0142	0.0142
Echinococcus multilocularis	neuropeptides capa receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	7TM GPCR rhodopsin	0.0005	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Brugia malayi	sulfakinin receptor protein	0.0005	0.0022	0.0037
Echinococcus multilocularis	NCK adaptor protein	0.0007	0.0101	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0005	0.0022	0.0037
Loa Loa (eye worm)	SRC-1	0.0008	0.0142	0.0142
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	neuropeptide receptor A26	0.0005	0.0022	0.0022
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	neuropeptide f receptor 76f	0.0005	0.0022	0.0022
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.3013	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0005	0.0022	0.0022
Brugia malayi	Dopamine receptor protein 2	0.0005	0.0022	0.0037
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0101	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0022	0.0022
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.3013	0.5031
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0008	0.0142	0.0142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Echinococcus granulosus	growth factor receptor bound protein 2	0.0007	0.0101	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.3013	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	NCK adaptor protein	0.0007	0.0101	0.0101
Brugia malayi	Serotonin receptor	0.0005	0.0022	0.0037
Echinococcus multilocularis	fmrfamide receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	sex peptide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0007	0.0101	0.0101
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Brugia malayi	putative neuropeptide receptor	0.0005	0.0022	0.0037
Schistosoma mansoni	growth factor receptor-bound protein	0.0007	0.0101	0.0103
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0008	0.0142	0.0142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide s receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0022	0.0022
Schistosoma mansoni	amine GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0101	0.0101
Schistosoma mansoni	tyrosine kinase	0.0008	0.0142	0.0144
Onchocerca volvulus		0.0005	0.0022	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0103	0.3966	0.6621
Brugia malayi	follicle stimulating hormone receptor	0.0005	0.0022	0.0037
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0005	0.0022	0.0022
Brugia malayi	Dopamine receptor protein 1	0.0005	0.0022	0.0037
Echinococcus granulosus	neuropeptides capa receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0008	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0005	0.0022	0.0022
Echinococcus granulosus	allatostatin A receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0005	0.0022	0.0037
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Echinococcus granulosus	neuropeptide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	TYRA-2 protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0005	0.0022	0.0022
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0022	0.0022
Echinococcus granulosus	dro:myosuppressin receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	dro:myosuppressin receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	opsin-like receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Brugia malayi	Serotonin receptor	0.0005	0.0022	0.0037
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.3013	0.3013
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0005	0.0022	0.0022
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0005	0.0022	0.0037
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0005	0.0022	0.0022
Schistosoma mansoni	nck2/grb4	0.0007	0.0101	0.0103
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.3013	0.3058
Echinococcus granulosus	g-protein coupled receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	opsin-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide Y receptor	0.0005	0.0022	0.0022
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.3013	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0005	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0008	0.0142	0.0142
Brugia malayi	ORL1-like opioid receptor	0.0005	0.0022	0.0037
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0103	0.3966	0.3966
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	adenoreceptor	0.0005	0.0022	0.0022
Schistosoma mansoni	amine GPCR	0.0005	0.0022	0.0022
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0005	0.0022	0.0022
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Echinococcus granulosus	fmrfamide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	g-protein coupled receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus granulosus	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	G protein coupled receptor 139	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0008	0.0142	0.0142
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0008	0.0142	0.0142
Brugia malayi	Dopamine receptor	0.0005	0.0022	0.0037
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Echinococcus multilocularis	neuropeptide receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	melatonin receptor type 1A	0.0005	0.0022	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide receptor A26	0.0005	0.0022	0.0022
Echinococcus granulosus	biogenic amine 5HT receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	neuropeptide receptor	0.0005	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0142	0.0142
Echinococcus multilocularis	orexin receptor type 2	0.0005	0.0022	0.0022
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	orexin receptor type 2	0.0005	0.0022	0.0022
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0008	0.0142	0.0142
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	7tm_1 domain containing protein	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0008	0.0142	0.0142
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0005	0.0022	0.0022
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0005	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.025	0.9854	1
Brugia malayi	neuropeptide F receptor	0.0005	0.0022	0.0037
Onchocerca volvulus		0.0005	0.0022	1
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Schistosoma mansoni	opsin-like receptor	0.0005	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0022	0.0022
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0005	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0022
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0005	0.0022	0.0022
Brugia malayi	G protein-coupled receptor F59B2.13	0.0005	0.0022	0.0037
Brugia malayi	hypothetical protein	0.0005	0.0022	0.0037
Schistosoma mansoni	hypothetical protein	0.0005	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0008	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.0005	0.0022	0.0022
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0005	0.0022	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0022	0.0022
Onchocerca volvulus		0.0005	0.0022	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0008	0.0142	0.0142

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 15.953 uM	PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1562566

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1405094