Detailed information for compound 1405243

Basic information

Technical information
  • TDR Targets ID: 1405243
  • Name: [4-(6-amino-3-tert-butyl-5-cyano-2,4-dihydrop yrano[6,5-c]pyrazol-4-yl)phenyl] furan-2-carb oxylate
  • MW: 404.419 | Formula: C22H20N4O4
  • H donors: 2 H acceptors: 3 LogP: 4.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1ccc(cc1)OC(=O)c1ccco1)c([nH]n2)C(C)(C)C
  • InChi: 1S/C22H20N4O4/c1-22(2,3)18-17-16(14(11-23)19(24)30-20(17)26-25-18)12-6-8-13(9-7-12)29-21(27)15-5-4-10-28-15/h4-10,16H,24H2,1-3H3,(H,25,26)
  • InChiKey: FARLAARCGKMBHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-furancarboxylic acid [4-(6-amino-3-tert-butyl-5-cyano-2,4-dihydropyrano[6,5-c]pyrazol-4-yl)phenyl] ester
  • furan-2-carboxylic acid [4-(6-amino-3-tert-butyl-5-cyano-2,4-dihydropyrano[6,5-c]pyrazol-4-yl)phenyl] ester
  • A2311/0097470
  • 4-(6-amino-3-tert-butyl-5-cyano-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl 2-furoate
  • MLS000089684
  • SMR000024302

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0044 0.1681
Echinococcus multilocularis titin 0.0025 0.0016 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0039 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0017 0.0017
Loa Loa (eye worm) glutathione reductase 0.0106 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0145 0.03 0.03
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0049 0.0049
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0044 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0039 0.0039
Brugia malayi Pre-SET motif family protein 0.022 0.0477 0.0477
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Onchocerca volvulus 0.0032 0.0033 0.0169
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0028 0.0023 0.0023
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Schistosoma mansoni coup transcription factor 0.0035 0.0039 0.0039
Trichomonas vaginalis set domain proteins, putative 0.025 0.0548 0.0538
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Schistosoma mansoni titin 0.0053 0.0082 0.0082
Echinococcus granulosus peroxidasin 0.0053 0.0082 0.0082
Brugia malayi jmjC domain containing protein 0.0054 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.018 0.0383 0.0383
Echinococcus granulosus roundabout 2 0.015 0.0312 0.0312
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0033
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0084 0.0073
Schistosoma mansoni ets-related 0.0261 0.0573 0.0573
Loa Loa (eye worm) thioredoxin reductase 0.0106 0.0207 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0039 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.013 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0075 0.0065
Brugia malayi Doublecortin family protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0035 0.0025
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0071 0.0071
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0028 0.0023 0.0023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0044
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0696 0.1602 0.1659
Loa Loa (eye worm) hypothetical protein 0.015 0.0312 0.0312
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0049 0.0038
Echinococcus granulosus Immunoglobulin 0.0097 0.0187 0.0187
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0097 0.0187 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0085 0.0085
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0049 0.0038
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0097 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Brugia malayi Prion-like- 0.0053 0.0082 0.0082
Echinococcus multilocularis lysine specific demethylase 6a 0.0054 0.0084 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0105
Echinococcus granulosus dnaJ subfamily B 0.0431 0.0976 0.0976
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0042 0.0042
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase otk 0.0053 0.0082 0.0082
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0006 0.0006
Echinococcus multilocularis twitchin 0.0025 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0033 0.0035 0.0025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0268 0.0592 0.061
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0049 0.0038
Echinococcus granulosus titin 0.0025 0.0017 0.0017
Brugia malayi Thioredoxin reductase 0.0106 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0039 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.0516 0.1178 0.1178
Echinococcus granulosus nephrin 0.0025 0.0016 0.0016
Brugia malayi Peroxidasin 0.0053 0.0082 0.0082
Brugia malayi basement membrane proteoglycan 0.0028 0.0023 0.0023
Echinococcus multilocularis down syndrome cell adhesion 0.0025 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0039 0.0039
Chlamydia trachomatis recombinase RecA 0.013 0.0265 0.2453
Echinococcus granulosus basement membrane specific heparan sulfate 0.0028 0.0023 0.0023
Echinococcus granulosus fibroblast growth factor receptor 4 0.0208 0.0448 0.0448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0085 0.0085
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0033 0.0035 0.0025
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0044 0.0044
Echinococcus multilocularis protein patched 0.005 0.0075 0.0075
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0054 0.0084 0.3728
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Schistosoma mansoni loxhd1 0.0021 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0039 0.0039
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0033 0.0033
Schistosoma mansoni phd/f-box containing protein 0.0054 0.0084 0.0084
Leishmania major trypanothione reductase 0.0106 0.0207 0.0197
Brugia malayi Heparan sulfate 0.0028 0.0023 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0097 0.0097
Loa Loa (eye worm) disorganized muscle protein 1 0.0025 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0083 0.0083
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.002 0.002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.002 0.002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.001 0.0025
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0052 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0097 0.0187 0.0187
Schistosoma mansoni cell adhesion molecule 0.0025 0.0016 0.0016
Brugia malayi jmjC domain containing protein 0.0054 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0001 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Schistosoma mansoni cell adhesion molecule 0.0125 0.0253 0.0253
Brugia malayi jmjC domain containing protein 0.0054 0.0084 0.0084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0241 0.0528 0.1583
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0145 0.03 0.03
Onchocerca volvulus 0.0025 0.0016 0.0061
Echinococcus granulosus hemicentin 1 0.0053 0.0082 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0048 0.0071 0.0071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0039 0.0039
Plasmodium falciparum thioredoxin reductase 0.0106 0.0207 0.0201
Toxoplasma gondii thioredoxin reductase 0.0106 0.0207 1
Echinococcus multilocularis 0.0025 0.0016 0.0016
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0025 0.0016 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0052 0.0052
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0028 0.0023 0.0023
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0044 0.0352
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0084
Plasmodium falciparum glutathione reductase 0.0037 0.0044 0.0038
Echinococcus multilocularis titin 0.0025 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.003 0.0028 0.0028
Echinococcus multilocularis expressed conserved protein 0.011 0.0216 0.0216
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0208 0.0448 0.0448
Schistosoma mansoni roundabout 0.0053 0.0082 0.0082
Schistosoma mansoni nephrin related 0.0025 0.0016 0.0016
Schistosoma mansoni septate junction protein 0.0028 0.0023 0.0023
Echinococcus multilocularis sterol regulatory element binding protein 0.005 0.0075 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0039 0.0039
Loa Loa (eye worm) fli-1 protein 0.0261 0.0573 0.0573
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0092 0.0092
Brugia malayi Prion-like- 0.0025 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0962 0.2231 0.2231
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Echinococcus granulosus contactin 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi kettin 0.0025 0.0016 0.0016
Schistosoma mansoni ap endonuclease 0.0023 0.001 0.001
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0025 0.0016 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0477 0.0477
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0044 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Brugia malayi Immunoglobulin domain containing protein 0.0028 0.0023 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0013
Echinococcus granulosus tyrosine protein kinase otk 0.0053 0.0082 0.0082
Schistosoma mansoni cell adhesion molecule 0.0025 0.0016 0.0016
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0028 0.0023 0.0023
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0044 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) TK protein kinase 0.0233 0.0507 0.0507
Schistosoma mansoni cell adhesion molecule 0.0028 0.0023 0.0023
Echinococcus granulosus Immunoglobulin 0.0028 0.0023 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0085 0.0085
Echinococcus granulosus defective proboscis extension response 0.0097 0.0187 0.0187
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) twinkle helicase 0.0133 0.0272 0.0272
Schistosoma mansoni basigin related 0.0028 0.0023 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0044 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0039 0.0039
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0092 0.0092
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.0976 0.0976
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0025 0.0016 0.0016
Mycobacterium ulcerans glutaminase 0.0288 0.0638 0.3957
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0092 0.0538
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0095 0.4301
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0025
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0086 0.016 0.016
Schistosoma mansoni cell adhesion molecule 0.0053 0.0082 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0044 0.0033
Brugia malayi Ets-domain containing protein 0.0086 0.016 0.016
Entamoeba histolytica DNA repair and recombination protein, putative 0.0033 0.0035 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0039 0.0039
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Brugia malayi Fibronectin type III domain containing protein 0.0097 0.0187 0.0187
Brugia malayi Cytochrome P450 family protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0032 0.0032 0.0032
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0053 0.0082 0.0479
Schistosoma mansoni survival motor neuron protein 0.0105 0.0206 0.0206
Onchocerca volvulus 0.0025 0.0016 0.0061
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0023 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0012 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.013 0.6087
Echinococcus multilocularis RUN 0.0021 0.0006 0.0006
Echinococcus granulosus roundabout 2 0.0053 0.0082 0.0082
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0039 0.0039
Plasmodium vivax SET domain protein, putative 0.0032 0.0033 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0039 0.0039
Echinococcus multilocularis Immunoglobulin subtype 0.0028 0.0023 0.0023
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0025 0.0016 0.0016
Onchocerca volvulus Huntingtin homolog 0.0145 0.03 0.1854
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0049 0.0049
Loa Loa (eye worm) glutaminase 0.0288 0.0638 0.0638
Plasmodium vivax glutathione reductase, putative 0.0106 0.0207 0.0201
Mycobacterium tuberculosis Probable oxidoreductase 0.0268 0.0592 0.061
Echinococcus multilocularis hemicentin 1 0.0053 0.0082 0.0082
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0044 0.0038
Mycobacterium leprae Conserved hypothetical protein 0.1376 0.321 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Brugia malayi Immunoglobulin domain containing protein 0.0028 0.0023 0.0023
Schistosoma mansoni titin 0.0025 0.0017 0.0017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0023 0.0105
Onchocerca volvulus Putative titin 0.0025 0.0016 0.0061
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Echinococcus granulosus titin 0.0025 0.0016 0.0016
Echinococcus multilocularis titin 0.0025 0.0016 0.0016
Echinococcus granulosus lachesin 0.0053 0.0082 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0241 0.0528 0.0544
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0033 0.0035 0.0035
Brugia malayi glutaminase DH11.1 0.0288 0.0638 0.0638
Brugia malayi nuclear hormone receptor 0.0035 0.0039 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0006 0.0006
Brugia malayi Immunoglobulin domain containing protein 0.0028 0.0023 0.0023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0044 0.1681
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0241 0.0528 0.0544
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.001 0.001
Plasmodium falciparum thioredoxin reductase 0.0037 0.0044 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0053 0.0082 0.0082
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0025 0.0017 0.0017
Schistosoma mansoni lipoxygenase 0.0087 0.0162 0.0162
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0028 0.0023 0.0023
Echinococcus multilocularis Immunoglobulin 0.0028 0.0023 0.0023
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0696 0.1602 0.4953
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0208 0.0448 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Brugia malayi CXXC zinc finger family protein 0.003 0.0028 0.0028
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0053 0.0082 0.0082
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0006 0.0001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0049 0.0038
Echinococcus multilocularis cpg binding protein 0.0032 0.0032 0.0032
Chlamydia trachomatis replicative DNA helicase 0.0467 0.106 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0105
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0033 0.0035 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Echinococcus granulosus cpg binding protein 0.0032 0.0032 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0233 0.0507 0.0507
Onchocerca volvulus 0.0028 0.0023 0.0109
Echinococcus granulosus Immunoglobulin 0.0028 0.0023 0.0023
Loa Loa (eye worm) LAD-2 short isoform 0.0028 0.0023 0.0023
Brugia malayi Ets-domain containing protein 0.0086 0.016 0.016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0039 0.0039
Onchocerca volvulus 0.0025 0.0016 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.013 0.013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Echinococcus granulosus titin 0.0025 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0105 0.0206 0.0206
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0084 0.0084
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0044 0.0233
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0053 0.0082 0.0082
Schistosoma mansoni jumonji domain containing protein 0.0054 0.0084 0.0084
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0039 0.0039
Echinococcus multilocularis insulin growth factor binding 0.0025 0.0016 0.0016
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0033 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0039 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0039 0.0039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.106 1
Echinococcus granulosus titin 0.0025 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0028 0.0028
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.001 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Trypanosoma brucei trypanothione reductase 0.0106 0.0207 0.0197
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0028 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.106 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Brugia malayi hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Schistosoma mansoni cell adhesion molecule 0.0028 0.0023 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0233
Brugia malayi Pre-SET motif family protein 0.0032 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0039 0.0039
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0265 0.0758
Brugia malayi glutathione reductase 0.0106 0.0207 0.0207
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0034 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.0035 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0062 0.0103 0.0103
Brugia malayi CHE-14 protein 0.005 0.0075 0.0075
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0023 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0203 0.0437 0.0437
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0053 0.0082 0.0082
Echinococcus granulosus leucine rich repeat containing protein 4 0.0025 0.0016 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0006 0.0006
Schistosoma mansoni netrin receptor unc5 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0023 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0039 0.0039
Schistosoma mansoni patched 1 0.005 0.0075 0.0075
Echinococcus granulosus GA binding protein alpha chain 0.0086 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Leishmania major cytochrome p450-like protein 0.0023 0.0012 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0039 0.0039
Schistosoma mansoni cell adhesion molecule 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0379 0.0854 0.0854
Echinococcus multilocularis lachesin 0.0053 0.0082 0.0082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0044 0.0315
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0119 0.0237 0.0237
Echinococcus granulosus down syndrome cell adhesion 0.0025 0.0016 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0023 0.0013
Plasmodium vivax thioredoxin reductase, putative 0.0106 0.0207 0.0201
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0053 0.0082 0.0082
Brugia malayi Protein kinase domain containing protein 0.0172 0.0364 0.0364
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0044 0.0315
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Loa Loa (eye worm) glutaminase 2 0.0288 0.0638 0.0638
Brugia malayi Niemann-Pick C1 protein precursor 0.0117 0.0233 0.0233
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0287 0.0636 0.0636
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0084 0.0084
Wolbachia endosymbiont of Brugia malayi recombinase A 0.013 0.0265 0.2424
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0044 0.0233
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0201 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0073 0.013 0.013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0106 0.0207 0.0211
Schistosoma mansoni myosin-binding protein-related 0.0025 0.0016 0.0016
Loa Loa (eye worm) TK/ROR protein kinase 0.0034 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0039 0.0039
Echinococcus multilocularis Immunoglobulin 0.0097 0.0187 0.0187
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.013 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0097 0.0097
Plasmodium falciparum glutathione reductase 0.0106 0.0207 0.0201
Leishmania major hypothetical protein, conserved 0.0054 0.0084 0.0073
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0055 0.0088 0.0088
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0052 0.0052
Echinococcus granulosus insulin growth factor binding 0.0025 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0048 0.0071 0.0071
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0092 0.0538
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0025 0.0016 0.0016
Echinococcus multilocularis geminin 0.0379 0.0854 0.0854
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0084 0.0073
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0039 0.0039
Schistosoma mansoni nephrin 0.0053 0.0082 0.0082
Echinococcus multilocularis Immunoglobulin 0.0097 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0039 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.015 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0125 0.0253 0.0253
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0049 0.0049
Schistosoma mansoni polycystin 1-related 0.0021 0.0006 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0039 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0125 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Onchocerca volvulus Netrin receptor homolog 0.0025 0.0016 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0085 0.0085
Onchocerca volvulus 0.0025 0.0017 0.0068
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0233 0.0233
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0013
Brugia malayi hypothetical protein 0.0145 0.03 0.03
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0085 0.0085
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0241 0.0528 0.0544
Brugia malayi Prion-like- 0.0025 0.0016 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0117 0.0233 0.0233
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0028 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Echinococcus multilocularis muscleblind protein 1 0.018 0.0383 0.0383
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0053 0.0082 0.0082
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0696 0.1602 1
Schistosoma mansoni basigin related 0.0028 0.0023 0.0023
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0039 0.0206
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni rab6-interacting 0.0021 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0044 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0203 0.0437 0.0437
Echinococcus multilocularis neuroglian 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0097
Schistosoma mansoni ap endonuclease 0.0023 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) one IG domain family member 0.0025 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Brugia malayi Leucine Rich Repeat family protein 0.0025 0.0016 0.0016
Onchocerca volvulus 0.0025 0.0016 0.0061
Echinococcus granulosus Protein patched homolog 1 0.005 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0084
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0039 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0039 0.0206
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni titin 0.0025 0.0016 0.0016
Brugia malayi basement membrane proteoglycan precursor 0.0028 0.0023 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0039 0.0039
Schistosoma mansoni rab6-interacting 0.0021 0.0006 0.0006
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0028 0.0023 0.0023
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0028 0.0023 0.0023
Echinococcus granulosus RUN 0.0021 0.0006 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0201 0.0433 0.0433
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni nephrin 0.0122 0.0246 0.0246
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.106 0.6606
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0016 0.0016
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0033
Echinococcus multilocularis roundabout 2 0.015 0.0312 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0085 0.0085
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3756 0.8839 0.9174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0039 0.0039
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0039 0.0039
Schistosoma mansoni peroxidasin 0.0028 0.0023 0.0023
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0034 0.0037 0.0037
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0044 0.0033
Echinococcus granulosus Immunoglobulin subtype 0.0028 0.0023 0.0023
Onchocerca volvulus 0.0025 0.0016 0.0061
Brugia malayi ecdysteroid receptor 0.0035 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0364 0.0364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Brugia malayi protein unc-22 0.0025 0.0017 0.0017
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.106 0.3254
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0044 0.0041
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0203 0.0437 0.0437
Mycobacterium tuberculosis Probable dehydrogenase 0.0241 0.0528 0.0544
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni slit 0.0025 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.0028 0.0023 0.0105
Schistosoma mansoni cpg binding protein 0.0032 0.0032 0.0032
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0052 0.0041
Echinococcus multilocularis transfer RNA-Phe 0.0025 0.0016 0.0016
Echinococcus granulosus phd:f box containing protein 0.0054 0.0084 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.013 0.013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0268 0.0592 0.1783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0023 0.0105
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0044 0.0033
Brugia malayi follicle stimulating hormone receptor 0.0287 0.0636 0.0636
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.005 0.0075 0.0075
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0049 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0039 0.0039
Schistosoma mansoni netrin receptor unc5 0.0028 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0017 0.0017
Echinococcus multilocularis neuroglian 0.0122 0.0246 0.0246
Echinococcus multilocularis peroxidasin 0.0053 0.0082 0.0082
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0044 0.0038
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0033 0.0035 0.0025
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0028 0.0023 0.0023
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0049 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Echinococcus multilocularis lysine specific demethylase 5A 0.0201 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) projectin 0.0025 0.0016 0.0016
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0054 0.0084 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0023 0.0013
Schistosoma mansoni tyrosine kinase 0.0208 0.0448 0.0448
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Echinococcus multilocularis phd:f box containing protein 0.0054 0.0084 0.0084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Schistosoma mansoni hypothetical protein 0.0033 0.0035 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0001 0.0001
Echinococcus multilocularis protein dispatched 1 0.0057 0.0092 0.0092
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0251 0.0251
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0028 0.0023 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0039 0.0039
Onchocerca volvulus 0.0105 0.0206 0.126
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.001 0.001
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0044 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0039 0.0039
Onchocerca volvulus 0.0658 0.1513 0.9497
Schistosoma mansoni Replicative DNA helicase 0.0467 0.106 0.106
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Schistosoma mansoni phosphatidylserine receptor 0.0054 0.0084 0.0084
Echinococcus granulosus roundabout 2 0.0053 0.0082 0.0082
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0201 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0023 0.0105
Onchocerca volvulus 0.0025 0.0016 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0039 0.0039
Onchocerca volvulus Huntingtin homolog 0.0145 0.03 0.1854
Onchocerca volvulus 0.0025 0.0016 0.0061
Echinococcus multilocularis GA binding protein alpha chain 0.0086 0.016 0.016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0516 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0023 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0268 0.0592 0.061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Brugia malayi Disorganized muscle protein 1 0.0025 0.0016 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0039 0.0206
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0003
Echinococcus granulosus sterol regulatory element binding protein 0.005 0.0075 0.0075
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0049 0.0049
Echinococcus granulosus lysine specific demethylase 6a 0.0054 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0044 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Brugia malayi hypothetical protein 0.0028 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0053 0.0083 0.0083
Echinococcus multilocularis hemicentin 1 0.0053 0.0082 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0203 0.0437 0.0437
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0105
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0053 0.0082 0.0082
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0016 0.0016
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0028 0.0023 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0044 0.0033
Echinococcus granulosus muscleblind protein 0.018 0.0383 0.0383
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Echinococcus multilocularis jumonji domain containing 1A 0.0054 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0006 0.0006
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0028 0.0023 0.0023
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0025 0.0016 0.0016
Schistosoma mansoni protein phosphatase 2C 0.0054 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Brugia malayi jmjC domain containing protein 0.0054 0.0084 0.0084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0039 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0039 0.0039
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0082 0.0082
Giardia lamblia Fructose-bisphosphate aldolase 0.015 0.0312 0.0302
Echinococcus granulosus lysine specific demethylase 5A 0.0203 0.0437 0.0437
Brugia malayi Fli-1 protein 0.0261 0.0573 0.0573
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Brugia malayi hypothetical protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0082 0.0082
Loa Loa (eye worm) CAMK protein kinase 0.0025 0.0017 0.0017
Echinococcus multilocularis Immunoglobulin 0.0028 0.0023 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0023 0.0013
Schistosoma mansoni septate junction protein 0.0053 0.0082 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0039 0.0039
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.004 0.0052 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0044 0.0033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0049 0.0038
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0016 0.0061
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0117 0.0233 0.0223
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Echinococcus granulosus twitchin 0.0123 0.0247 0.0247
Onchocerca volvulus 0.025 0.0548 0.3418
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0082 0.0082
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0033 0.0035 0.0025
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0084
Echinococcus granulosus low density lipoprotein receptor ldl 0.0028 0.0023 0.0023
Plasmodium falciparum JmjC domain-containing protein, putative 0.0054 0.0084 0.0078
Echinococcus granulosus geminin 0.0379 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Treponema pallidum NADH oxidase 0.0037 0.0044 0.0315
Echinococcus granulosus titin 0.0025 0.0016 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0111 0.0111
Schistosoma mansoni basigin related 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.018 0.0383 0.0383
Schistosoma mansoni nephrin related 0.0028 0.0023 0.0023
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0039 0.0039
Schistosoma mansoni hemicentin 0.0025 0.0016 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0085 0.0085
Brugia malayi hypothetical protein 0.0097 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Echinococcus granulosus Niemann Pick C1 protein 0.0167 0.0351 0.0351
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0049 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0097 0.0187 0.0187
Mycobacterium tuberculosis Probable reductase 0.0241 0.0528 0.0544
Schistosoma mansoni cell adhesion molecule 0.0053 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Brugia malayi Prion-like- 0.0025 0.0016 0.0016
Echinococcus multilocularis JmjC domain containing protein 4 0.0054 0.0084 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0039 0.0039
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0793 0.1831 0.1831
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Echinococcus multilocularis roundabout 2 0.0053 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0039 0.0039
Plasmodium vivax JmjC domain containing protein 0.0054 0.0084 0.0078
Brugia malayi hypothetical protein 0.0516 0.1178 0.1178
Treponema pallidum fructose-bisphosphate aldolase 0.015 0.0312 0.2876
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0033 0.0035 0.0025
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.0207 0.0197
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0025 0.0016 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0044 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0033 0.0033
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0049 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Echinococcus granulosus JmjC domain containing protein 4 0.0054 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0053 0.0082 0.0082
Brugia malayi Myb-like DNA-binding domain containing protein 0.0025 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Mycobacterium ulcerans recombinase A 0.013 0.0265 0.162
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0001 0.0001
Echinococcus granulosus neuroglian 0.0122 0.0246 0.0246
Giardia lamblia Rrm3p helicase 0.0033 0.0035 0.0025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0039 0.0039
Trichomonas vaginalis glutaminase, putative 0.0288 0.0638 0.0628
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.004 0.0052 0.0052
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.4093 0.9635 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0055 0.0088 0.0088
Schistosoma mansoni lipoxygenase 0.0124 0.0251 0.0251
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0049 0.0038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0054 0.0084 0.3728
Schistosoma mansoni septate junction protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0039 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0106 0.0207 0.0207
Echinococcus granulosus neuroglian 0.0053 0.0082 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Echinococcus multilocularis roundabout 2 0.0053 0.0082 0.0082
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0048 0.0071 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0082 0.0082
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.013 0.012
Schistosoma mansoni glutaminase 0.0288 0.0638 0.0638
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0033 0.0035 0.0025
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0025 0.0016 0.0016
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0251 0.0251
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0776
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0379 0.0854 0.0854
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0033 0.0033
Schistosoma mansoni neuroglian 0.0053 0.0082 0.0082
Echinococcus granulosus jumonji domain containing 1A 0.0054 0.0084 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0044 0.0033
Brugia malayi jmjC domain containing protein 0.0201 0.0433 0.0433
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0039 0.0039
Echinococcus granulosus thioredoxin glutathione reductase 0.0106 0.0207 0.0207
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0039 0.0039
Treponema pallidum recombinase A 0.013 0.0265 0.2424
Onchocerca volvulus 0.0025 0.0016 0.0061
Schistosoma mansoni cell adhesion molecule 0.0025 0.0016 0.0016
Echinococcus granulosus expressed conserved protein 0.011 0.0216 0.0216
Echinococcus multilocularis Niemann Pick C1 protein 0.0167 0.0351 0.0351
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0172 0.0364 0.0364
Schistosoma mansoni septate junction protein 0.0053 0.0082 0.0082
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0208 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0023
Onchocerca volvulus 0.0035 0.0039 0.0206
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0054 0.0084 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0033 0.0033
Schistosoma mansoni gabp alpha 0.0086 0.016 0.016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0033 0.113
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0001 0.0001
Trichomonas vaginalis N-myristoyl transferase, putative 0.2791 0.6556 0.6552
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0776
Onchocerca volvulus 0.003 0.0028 0.0141
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0049 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Echinococcus multilocularis titin 0.0025 0.0017 0.0017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0053 0.0082 0.0082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0776
Brugia malayi nuclear receptor NHR-88 0.0035 0.0039 0.0039
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0092 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0793 0.1831 0.1831
Brugia malayi Muscleblind-like protein 0.018 0.0383 0.0383
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0241 0.0528 0.0544
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0516 0.1178 0.1178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0097 0.0097
Echinococcus multilocularis muscleblind protein 0.018 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0012 0.0036
Onchocerca volvulus Tyrosine kinase homolog 0.0692 0.1593 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0016 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0431 0.0976 0.0976
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0097 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0039 0.0039
Schistosoma mansoni vesicular amine transporter 0.0097 0.0187 0.0187
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.015 0.0312 0.0302
Echinococcus multilocularis GPCR, family 2 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0025 0.0016 0.0061
Echinococcus granulosus GPCR family 2 0.0019 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.238721139 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 4.466835922 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) 64 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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