Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Mycobacterium tuberculosis | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0081 | 0.0027 |
Echinococcus granulosus | geminin | 0.0205 | 0.088 | 0.2149 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.0728 | 0.0664 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.3835 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0122 | 0.0136 |
Mycobacterium tuberculosis | Probable reductase | 0.0234 | 0.102 | 0.0943 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.0728 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0026 | 0.0041 | 0.0373 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0087 | 0.0064 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0122 | 0.0136 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.0728 | 0.0649 |
Trypanosoma cruzi | DNA repair protein, putative | 0.004 | 0.0107 | 0.067 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0087 | 0.0043 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0087 | 0.0043 |
Trypanosoma cruzi | DNA repair protein, putative | 0.004 | 0.0107 | 0.067 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0103 | 0.0404 | 0.0884 |
Loa Loa (eye worm) | glutathione reductase | 0.0103 | 0.0401 | 0.3649 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0103 | 0.0401 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0234 | 0.102 | 0.0943 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0071 | 0.0646 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0036 | 0.0085 | 0.0038 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0103 | 0.0401 | 0.3649 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0261 | 0.1143 | 0.2055 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0087 | 0.0795 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0766 | 0.1846 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0234 | 0.102 | 0.0943 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0103 | 0.0404 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0766 | 0.6967 |
Onchocerca volvulus | 0.0286 | 0.1263 | 1 | |
Leishmania major | trypanothione reductase | 0.0103 | 0.0401 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0036 | 0.0085 | 0.0038 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.2014 | 0.9387 | 0.9382 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.088 | 0.2149 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0068 | 0.0621 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0036 | 0.0085 | 0.0777 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0766 | 0.6967 |
Treponema pallidum | recombinase A | 0.013 | 0.0531 | 0.2984 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0103 | 0.0401 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0103 | 0.0401 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Mycobacterium ulcerans | recombinase A | 0.013 | 0.0531 | 0.6922 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0087 | 0.0043 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0071 | 0.0646 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0087 | 0.0043 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.3835 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0103 | 0.0401 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0234 | 0.102 | 0.1642 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Onchocerca volvulus | 0.0036 | 0.0087 | 0.0137 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0261 | 0.1143 | 0.1067 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.1099 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0103 | 0.0401 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0261 | 0.1143 | 0.1067 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0087 | 0.0795 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0234 | 0.102 | 0.0943 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0071 | 0.0646 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0071 | 0.0646 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0122 | 0.0136 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.013 | 0.0531 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0026 | 0.0041 | 0.0373 |
Chlamydia trachomatis | recombinase RecA | 0.013 | 0.0531 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0234 | 0.102 | 0.0943 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0087 | 0.0043 |
Brugia malayi | glutathione reductase | 0.0103 | 0.0401 | 0.3649 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0087 | 0.0043 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0103 | 0.0401 | 0.0318 |
Toxoplasma gondii | thioredoxin reductase | 0.0103 | 0.0401 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.1099 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0087 | 0.0064 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0234 | 0.102 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0766 | 0.6967 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.1577 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.088 | 0.2149 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0764 | 0.3511 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.088 | 0.2149 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.1263 | 0.7892 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.1577 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.3835 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0036 | 0.0085 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0122 | 0.1112 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0122 | 0.0136 |
Plasmodium falciparum | thioredoxin reductase | 0.0103 | 0.0401 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0071 | 0.0646 |
Trypanosoma brucei | recA bacterial DNA recombination protein, putative | 0.004 | 0.0107 | 0.067 |
Brugia malayi | Thioredoxin reductase | 0.0103 | 0.0401 | 0.3649 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0766 | 0.1846 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1577 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0766 | 0.1846 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0087 | 0.0043 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0261 | 0.1143 | 0.1067 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 25.79 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] | ChEMBL. | No reference |
AC50 (functional) | > 380 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] | ChEMBL. | No reference |
EC50 (functional) | = 9.8 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] | ChEMBL. | No reference |
IC50 (functional) | 26.45 uM | PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 3.2643 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (binding) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9054 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.