Detailed information for compound 1405573

Basic information

Technical information
  • TDR Targets ID: 1405573
  • Name: 3-(4-methoxyphenyl)-1-(7-nitro-6-oxoheptyl)th iourea
  • MW: 339.41 | Formula: C15H21N3O4S
  • H donors: 1 H acceptors: 3 LogP: 2.49 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=NCCCCCC(=O)C[N+](=O)[O-])S
  • InChi: 1S/C15H21N3O4S/c1-22-14-8-6-12(7-9-14)17-15(23)16-10-4-2-3-5-13(19)11-18(20)21/h6-9H,2-5,10-11H2,1H3,(H2,16,17,23)
  • InChiKey: FMYFZHCSZMEVTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxyphenyl)-1-(7-nitro-6-oxo-heptyl)thiourea
  • 1-(6-keto-7-nitro-heptyl)-3-(4-methoxyphenyl)thiourea
  • MLS001017975
  • SMR000354260
  • T0507-8592
  • ZINC03226993

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.018 0.6078 0.6721
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi neuropeptide F receptor 0.0096 0.2575 0.2847
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.2575 0.2847
Brugia malayi G-protein coupled receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis neuropeptide s receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi G protein-coupled receptor 0.0096 0.2575 0.2847
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Mycobacterium tuberculosis Probable reductase 0.0104 0.293 0.8591
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2575 0.2575
Plasmodium falciparum glutathione reductase 0.0046 0.0512 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0096 0.2575 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0252 0.9043 1
Brugia malayi Serotonin receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.2575 0.2847
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0252 0.9043 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0096 0.2575 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.2575 0.2847
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis orexin receptor type 2 0.0096 0.2575 0.2847
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0573 0.0685
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus multilocularis voltage gated potassium channel 0.0073 0.1643 0.1816
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.2575 0.2847
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Brugia malayi chromobox protein homolog 3 0.0047 0.0573 0.0633
Echinococcus multilocularis fmrfamide receptor 0.0096 0.2575 0.2847
Brugia malayi Cyclic-nucleotide gated cation channel 0.005 0.0686 0.0758
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.2575 0.2847
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.341 1
Brugia malayi Muscleblind-like protein 0.018 0.6078 0.6721
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni adenoreceptor 0.0096 0.2575 0.2575
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.005 0.0686 0.0758
Echinococcus granulosus hyperpolarization activated cyclic 0.005 0.0686 0.0758
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi Dopamine receptor protein 2 0.0096 0.2575 0.2847
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.1643 0.1816
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.2575 0.2575
Onchocerca volvulus 0.0096 0.2575 1
Brugia malayi RE15519p 0.0096 0.2575 0.2847
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.2575 0.2575
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0236 0.8357 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.21 0.2323
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptide s receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Plasmodium vivax glutathione reductase, putative 0.0046 0.0512 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.2575 0.2847
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.005 0.0686 0.0758
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.2575 0.2847
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.2575 0.2575
Schistosoma mansoni 60S ribosomal protein L21 0.004 0.0267 0.0267
Onchocerca volvulus 0.0096 0.2575 1
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.005 0.0686 0.0758
Schistosoma mansoni histamine h1 receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptide receptor A26 0.0096 0.2575 0.2847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Echinococcus multilocularis chromobox protein 1 0.0084 0.21 0.2323
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0721 0.2799
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.2575 0.2575
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.341 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0512 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.6078 0.6721
Echinococcus granulosus cyclic nucleotide gated cation channel 0.005 0.0686 0.0758
Brugia malayi Melatonin receptor type 1A 0.0096 0.2575 0.2847
Brugia malayi ORL1-like opioid receptor 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.2575 0.2847
Schistosoma mansoni biogenic amine receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.2575 0.2847
Echinococcus granulosus g protein coupled receptor 0.0096 0.2575 0.2847
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.2575 0.2847
Schistosoma mansoni neuropeptide receptor 0.0096 0.2575 0.2575
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.293 0.8591
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus fmrfamide receptor 0.0096 0.2575 0.2847
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.2575 0.2847
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.2575 0.2847
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.2575 0.2575
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.2575 0.2847
Brugia malayi AKH receptor 0.0096 0.2575 0.2847
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0573 0.0685
Echinococcus multilocularis neuropeptide receptor A26 0.0096 0.2575 0.2847
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.2575 0.2847
Brugia malayi sulfakinin receptor protein 0.0096 0.2575 0.2847
Schistosoma mansoni myosin xvIII 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni opsin-like receptor 0.0096 0.2575 0.2575
Schistosoma mansoni hypothetical protein 0.0096 0.2575 0.2575
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.005 0.0686 0.0758
Onchocerca volvulus 0.0096 0.2575 1
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.005 0.0686 0.0758
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.293 0.8591
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.005 0.0686 0.0758
Leishmania major trypanothione reductase 0.0046 0.0512 0.3093
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.2575 0.2575
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.2575 0.2847
Echinococcus granulosus orexin receptor type 2 0.0096 0.2575 0.2847
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.2575 0.2575
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0037 0.0152 0.059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1654 1
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1654 0.1829
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1654 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.2575 0.2575
Schistosoma mansoni neuropeptide receptor 0.0096 0.2575 0.2575
Schistosoma mansoni biogenic amine receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0252 0.9043 1
Echinococcus multilocularis neuropeptide receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.005 0.0686 0.0758
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.2575 0.2847
Toxoplasma gondii thioredoxin reductase 0.0046 0.0512 0.3093
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2575 0.2847
Echinococcus multilocularis hyperpolarization activated cyclic 0.005 0.0686 0.0758
Echinococcus multilocularis serotonin receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.018 0.6078 0.6721
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis hyperpolarization activated cyclic 0.005 0.0686 0.0758
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0721 0.0862
Echinococcus multilocularis serotonin receptor 0.0096 0.2575 0.2847
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.2575 0.2847
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.2575 0.2847
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.2575 0.2847
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.005 0.0686 0.0686
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.2575 0.2847
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.2575 0.2575
Brugia malayi G-protein coupled receptor 0.0096 0.2575 0.2847
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0512 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.2575 0.2847
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.2575 0.2847
Echinococcus granulosus g-protein coupled receptor 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.2575 0.2847
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.005 0.0686 0.0686
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.293 0.8591
Schistosoma mansoni amine GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.2575 0.2847
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Schistosoma mansoni hypothetical protein 0.0096 0.2575 0.2575
Echinococcus granulosus hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.0047 0.0573 0.0633
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.2575 0.2847
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1654 0.1829
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0686 0.082
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2575 0.2847
Brugia malayi Dopamine receptor 0.0096 0.2575 0.2847
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0252 0.9043 1
Schistosoma mansoni neuropeptide receptor 0.0096 0.2575 0.2575
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Schistosoma mansoni hypothetical protein 0.0096 0.2575 0.2575
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1654 0.1654
Brugia malayi glutathione reductase 0.0046 0.0512 0.0566
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.293 0.8591
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0686 0.082
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni amine GPCR 0.0096 0.2575 0.2575
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1654 1
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.2575 0.2847
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.005 0.0686 0.0758
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis somatostatin receptor 0.0096 0.2575 0.2847
Brugia malayi GnHR receptor homolog 0.0096 0.2575 0.2847
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.2575 0.2575
Echinococcus granulosus chromobox protein 1 0.0084 0.21 0.2323
Trichomonas vaginalis chromobox protein, putative 0.0084 0.21 0.2513
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Onchocerca volvulus 0.0096 0.2575 1
Brugia malayi follicle stimulating hormone receptor 0.0096 0.2575 0.2847
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0267 0.0267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0512 0.15
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus muscleblind protein 0.018 0.6078 0.6721
Brugia malayi larval opioid receptor 0.0096 0.2575 0.2847
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.2575 0.2847
Echinococcus granulosus serotonin receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0512 0.0566
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0073 0.1643 0.1816
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.005 0.0686 0.0686
Brugia malayi neuropeptide F receptor 0.0096 0.2575 0.2847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1654 1
Schistosoma mansoni amine GPCR 0.0096 0.2575 0.2575
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0073 0.1643 0.1816
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.2575 0.2847
Schistosoma mansoni amine GPCR 0.0096 0.2575 0.2575
Echinococcus multilocularis fmrfamide receptor 0.0096 0.2575 0.2847
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0537 0.0594
Schistosoma mansoni chromobox protein 0.0084 0.21 0.21
Schistosoma mansoni biogenic amine receptor 0.0096 0.2575 0.2575
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.293 0.8591
Brugia malayi Serotonin receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2575 0.2847
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0573 0.2225
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1654 1
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0686 0.0686
Echinococcus granulosus neuropeptide receptor 0.0096 0.2575 0.2847
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptide receptor 0.0096 0.2575 0.2847
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus somatostatin receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0168
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus hyperpolarization activated cyclic 0.005 0.0686 0.0758
Trichomonas vaginalis chromobox protein, putative 0.0084 0.21 0.2513
Echinococcus granulosus g protein coupled receptor 0.0096 0.2575 0.2847
Echinococcus granulosus voltage gated potassium channel 0.0073 0.1643 0.1816
Schistosoma mansoni opsin-like receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0537 0.0594
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.2575 0.2847
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0219 0.7667 0.8478
Echinococcus granulosus allatostatin A receptor 0.0096 0.2575 0.2847
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2575 0.2847
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.005 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.2575 0.2847
Loa Loa (eye worm) glutathione reductase 0.0046 0.0512 0.0566
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.2575 0.2847
Echinococcus granulosus chromobox protein 1 0.0084 0.21 0.2323
Schistosoma mansoni hypothetical protein 0.0096 0.2575 0.2575
Echinococcus granulosus sex peptide receptor 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2575 0.2847
Plasmodium falciparum thioredoxin reductase 0.0046 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.2575 0.2847
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.2575 0.2847
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0236 0.8357 1
Brugia malayi putative neuropeptide receptor 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0721 0.0862
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis neuropeptide receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni chromobox protein 0.0084 0.21 0.21
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Echinococcus granulosus g protein coupled receptor 0.0096 0.2575 0.2847
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.2575 0.2847
Schistosoma mansoni amine GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis chromobox protein 1 0.0084 0.21 0.2323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.2575 0.2847
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi hypothetical protein 0.0096 0.2575 0.2847
Echinococcus multilocularis allatostatin A receptor 0.0096 0.2575 0.2847
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.341 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0004 0.0005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1654 0.485
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.2575 0.2847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.2575 0.2847
Onchocerca volvulus 0.0096 0.2575 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.2575 0.2847
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2575 0.2847
Schistosoma mansoni neuropeptide receptor 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.293 0.8591
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0512 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.005 0.0686 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2575 0.2575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Brugia malayi Thioredoxin reductase 0.0046 0.0512 0.0566
Echinococcus multilocularis muscleblind protein 0.018 0.6078 0.6721
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.005 0.0686 0.0686
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.1643 0.1816
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.2575 0.2847
Loa Loa (eye worm) hypothetical protein 0.0096 0.2575 0.2847
Schistosoma mansoni opsin-like receptor 0.0096 0.2575 0.2575
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2575 0.2847
Brugia malayi Dopamine receptor protein 1 0.0096 0.2575 0.2847
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.2575 0.2575
Echinococcus multilocularis sex peptide receptor 0.0096 0.2575 0.2847
Brugia malayi Heterochromatin protein 1 0.0084 0.21 0.2323

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.631 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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