Detailed information for compound 1405906

Basic information

Technical information
  • TDR Targets ID: 1405906
  • Name: N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-(2,5 -dioxopyrrolidin-1-yl)benzamide
  • MW: 379.432 | Formula: C20H17N3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=O)N1c1ccc(cc1)C(=O)Nc1nc2c(s1)c(C)ccc2C
  • InChi: 1S/C20H17N3O3S/c1-11-3-4-12(2)18-17(11)21-20(27-18)22-19(26)13-5-7-14(8-6-13)23-15(24)9-10-16(23)25/h3-8H,9-10H2,1-2H3,(H,21,22,26)
  • InChiKey: MESADALDHZDWFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-(2,5-dioxo-1-pyrrolidinyl)benzamide
  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-succinimido-benzamide
  • MLS000696928
  • SMR000237361
  • ZINC04292212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0104 0.0225 0.0663
Plasmodium falciparum serine repeat antigen 3 0.0239 0.0728 0.1588
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0102 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.1809 0.5018
Loa Loa (eye worm) hypothetical protein 0.0121 0.029 0.029
Brugia malayi Cathepsin L-like precursor 0.0666 0.2313 0.2313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Trypanosoma cruzi cruzipain precursor, putative 0.1013 0.3604 0.3604
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1011 0.3596 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0268 0.0268
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax vivapain-1 0.053 0.1809 0.533
Echinococcus multilocularis c4b binding protein beta chain 0.0104 0.0225 0.0225
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0956 0.3393 1
Brugia malayi Papain family cysteine protease containing protein 0.053 0.1809 0.1809
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0239 0.0728 0.1588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Echinococcus multilocularis muscleblind protein 1 0.018 0.0509 0.0509
Onchocerca volvulus 0.0956 0.3393 1
Brugia malayi fibroinase precursor 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi pregnancy-associated plasma protein-A 0.0104 0.0225 0.0225
Echinococcus multilocularis cysteine protease 0.0956 0.3393 0.3393
Trypanosoma cruzi cysteine peptidase, putative 0.0291 0.0919 0.0919
Loa Loa (eye worm) cysteine protease 0.0956 0.3393 0.3393
Onchocerca volvulus 0.0104 0.0225 0.0663
Toxoplasma gondii preprocathepsin c precursor, putative 0.0239 0.0728 0.2025
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0102 0.0102
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1011 0.3596 0.3596
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0239 0.0728 0.0728
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0239 0.0728 0.0728
Schistosoma mansoni cathepsin F (C01 family) 0.0956 0.3393 0.3393
Echinococcus granulosus cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.2313 0.6432
Entamoeba histolytica cysteine protease, putative 0.0956 0.3393 1
Onchocerca volvulus 0.0104 0.0225 0.0663
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Toxoplasma gondii rhoptry neck protein RON9 0.0104 0.0225 0.0626
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0871 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0956 0.3393 0.3393
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0239 0.0728 0.0728
Plasmodium vivax vivapain-2 0.0956 0.3393 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0956 0.3393 0.3393
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0956 0.3393 1
Entamoeba histolytica cysteine proteinase 1, putative 0.053 0.1809 0.4054
Plasmodium vivax serine-repeat antigen (SERA) 0.0239 0.0728 0.2146
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0102 0.0102
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0239 0.0728 0.2146
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.0728 0.2025
Brugia malayi Muscleblind-like protein 0.018 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Echinococcus granulosus cathepsin L 0.0239 0.0728 0.0728
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0104 0.0225 0.0225
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Echinococcus granulosus C type lectin domian containing protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax apical sushi protein, putative 0.0104 0.0225 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Toxoplasma gondii rhoptry neck protein RON1 0.0104 0.0225 0.0626
Echinococcus multilocularis muscleblind protein 0.018 0.0509 0.0509
Plasmodium falciparum serine repeat antigen 8 0.0239 0.0728 0.1588
Echinococcus granulosus c4b binding protein beta chain 0.0104 0.0225 0.0225
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.1809 0.1809
Trypanosoma cruzi major cysteine proteinase, putative 0.0239 0.0728 0.0728
Brugia malayi Cathepsin L-like cysteine proteinase 0.0666 0.2313 0.2313
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Entamoeba histolytica cysteine proteinase, putative 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0956 0.3393 0.9436
Loa Loa (eye worm) fibroinase 0.0956 0.3393 0.3393
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Echinococcus multilocularis C type lectin domian containing protein 0.0104 0.0225 0.0225
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Brugia malayi Sushi domain 0.0104 0.0225 0.0225
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Echinococcus multilocularis cysteine protease 0.0956 0.3393 0.3393
Onchocerca volvulus 0.0104 0.0225 0.0663
Leishmania major cysteine peptidase A (CPA) 0.0956 0.3393 0.9414
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0956 0.3393 0.3393
Onchocerca volvulus 0.0104 0.0225 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0239 0.0728 0.0728
Onchocerca volvulus Cathepsin L homolog 0.0239 0.0728 0.2146
Brugia malayi cathepsin F-like cysteine proteinase 0.0291 0.0919 0.0919
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Onchocerca volvulus Cathepsin L homolog 0.0956 0.3393 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0239 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium falciparum serine repeat antigen 5 0.0239 0.0728 0.1588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0956 0.3393 0.3393
Plasmodium vivax vivapain-3 0.053 0.1809 0.533
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.2313 0.6432
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0239 0.0728 0.2025
Brugia malayi cathepsin F-like cysteine proteinase 0.0239 0.0728 0.0728
Brugia malayi Cathepsin L-like precursor 0.0291 0.0919 0.0919
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Onchocerca volvulus 0.0104 0.0225 0.0663
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1011 0.3596 0.3596
Echinococcus multilocularis cathepsin L 0.053 0.1809 0.1809
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0239 0.0728 0.1588
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Onchocerca volvulus 0.0104 0.0225 0.0663
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.053 0.1809 0.1809
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.018 0.0509 0.0509
Echinococcus granulosus cathepsin L 0.053 0.1809 0.1809
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0239 0.0728 0.1588
Entamoeba histolytica cysteine proteinase, putative 0.0956 0.3393 1
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0102 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Brugia malayi cathepsin L precursor 0.0239 0.0728 0.0728
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Onchocerca volvulus 0.0104 0.0225 0.0663
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0239 0.0728 0.0728
Schistosoma mansoni c4b-binding protein beta chain 0.0104 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.018 0.0509 0.0509
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0722 0.2524 0.2524
Entamoeba histolytica cysteine proteinase 2 0.053 0.1809 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0956 0.3393 0.3393
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0956 0.3393 0.3393
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1011 0.3596 0.9977
Schistosoma mansoni cathepsin F (C01 family) 0.0956 0.3393 0.3393
Trypanosoma cruzi cysteine protease, putative 0.053 0.1809 0.1809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Brugia malayi Papain family cysteine protease containing protein 0.053 0.1809 0.1809
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Echinococcus granulosus cathepsin l1 0.0956 0.3393 0.3393
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trypanosoma cruzi cysteine peptidase, putative 0.053 0.1809 0.1809
Plasmodium vivax serine-repeat antigen (SERA) 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Loa Loa (eye worm) ctsf protein 0.0956 0.3393 0.3393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.1809 0.5018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.1809 0.1809
Brugia malayi jmjC domain containing protein 0.0071 0.0102 0.0102
Plasmodium vivax vivapain-2 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0291 0.0919 0.0919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Trypanosoma brucei cysteine peptidase C (CPC) 0.1011 0.3596 0.9977
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Loa Loa (eye worm) cathepsin B 0.1011 0.3596 0.3596
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0291 0.0919 0.0919
Echinococcus granulosus muscleblind protein 0.018 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.1809 0.503
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Echinococcus granulosus cathepsin l1 0.0666 0.2313 0.2313
Plasmodium falciparum cysteine proteinase falcipain 1 0.053 0.1809 0.4999
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Plasmodium falciparum serine repeat antigen 4 0.0239 0.0728 0.1588
Plasmodium falciparum serine repeat antigen 6 0.0239 0.0728 0.1588
Onchocerca volvulus 0.0956 0.3393 1
Schistosoma mansoni cathepsin s 0.0291 0.0919 0.0919
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium falciparum serine repeat antigen 9 0.0239 0.0728 0.1588
Plasmodium falciparum serine repeat antigen 2 0.0239 0.0728 0.1588
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Plasmodium vivax unspecified product 0.0239 0.0728 0.2146
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0239 0.0728 0.0728
Plasmodium vivax unspecified product 0.053 0.1809 0.533
Schistosoma mansoni cathepsin C 0.0239 0.0728 0.0728
Toxoplasma gondii cathepsin CPC1 0.0239 0.0728 0.2025
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Echinococcus granulosus cysteine protease 0.053 0.1809 0.1809
Onchocerca volvulus Cathepsin L homolog 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0239 0.0728 0.2146
Brugia malayi Cathepsin L-like precursor 0.0666 0.2313 0.2313
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0291 0.0919 0.0919
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0104 0.0225 0.0663
Toxoplasma gondii cathepsin CPL 0.0956 0.3393 0.9436
Schistosoma mansoni cathepsin S (C01 family) 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0956 0.3393 1
Brugia malayi jmjC domain containing protein 0.0071 0.0102 0.0102
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0239 0.0728 0.2146
Echinococcus granulosus cathepsin L cysteine protease 0.053 0.1809 0.1809
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.0728 0.2025
Trypanosoma cruzi major cysteine proteinase, putative 0.0296 0.0939 0.0939
Brugia malayi cathepsin L-like precursor 0.0666 0.2313 0.2313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium falciparum serine repeat antigen 7 0.0239 0.0728 0.1588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium falciparum serine repeat antigen 1 0.0239 0.0728 0.1588
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Schistosoma mansoni cathepsin B (C01 family) 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.1809 0.503
Onchocerca volvulus 0.0104 0.0225 0.0663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax unspecified product 0.0291 0.0919 0.2708
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Schistosoma mansoni cathepsin F (C01 family) 0.0666 0.2313 0.2313
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Toxoplasma gondii cathepsin B 0.1011 0.3596 1
Echinococcus multilocularis cathepsin L 0.0239 0.0728 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Entamoeba histolytica cysteine proteinase, putative 0.0666 0.2313 0.5946
Plasmodium falciparum cysteine proteinase falcipain 3 0.0956 0.3393 1
Onchocerca volvulus 0.0956 0.3393 1
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0239 0.0728 0.2146
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0239 0.0728 0.2146
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Brugia malayi cathepsin L-like cysteine proteinase 0.0239 0.0728 0.0728
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0239 0.0728 0.2146
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0239 0.0728 0.2146
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Toxoplasma gondii cathepsin CPC2 0.0239 0.0728 0.2025
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0956 0.3393 0.3393
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Brugia malayi GCC2 and GCC3 family protein 0.0121 0.029 0.029
Onchocerca volvulus 0.0666 0.2313 0.6816
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0102 0.0102
Onchocerca volvulus 0.0239 0.0728 0.2146
Echinococcus multilocularis cathepsin L cysteine protease 0.0956 0.3393 0.3393
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Onchocerca volvulus Cathepsin F homolog 0.0956 0.3393 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0239 0.0728 0.0728
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1995 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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