TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.552 | Formula: C21H21N5O5S2
H donors: 2 H acceptors: 5 LogP: 1.36 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)N1CC(CC1=O)C(=O)Nc1nnc(s1)SCC(=O)NCc1ccco1
InChi: 1S/C21H21N5O5S2/c1-30-15-5-2-4-14(9-15)26-11-13(8-18(26)28)19(29)23-20-24-25-21(33-20)32-12-17(27)22-10-16-6-3-7-31-16/h2-7,9,13H,8,10-12H2,1H3,(H,22,27)(H,23,24,29)
InChiKey: DGUWYTDXVUFTEG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	helicase, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Echinococcus granulosus	zinc finger protein	0.0006	0.012	0.0119
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.1784	0.178
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Echinococcus granulosus	cpg binding protein	0.0037	0.1899	0.1952
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.012	0.0116
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.2766	0.4302
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.6431	0.643
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.0004	0.0004	0.0007
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0258	0.0253
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0373	0.0369
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.6431	0.662
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.6431	0.643
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0381	0.0377
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0005	0.0041	0.0063
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0006	0.012	0.0119
Trichomonas vaginalis	lymphoid specific helicase, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0381	0.0388
Trichomonas vaginalis	bromodomain-containing protein 3, brd3, putative	0.0004	0.0004	0.0007
Brugia malayi	PHD-finger family protein	0.0006	0.012	0.0116
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Schistosoma mansoni	cpg binding protein	0.0037	0.1899	0.1896
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Schistosoma mansoni	bromodomain containing protein	0.0006	0.012	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Plasmodium vivax	SET domain containing protein	0.0005	0.0049	0.0161
Toxoplasma gondii	histone lysine methyltransferase SET1	0.007	0.3851	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0381	0.0377
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.3059	0.4756
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.2766	0.7181
Giardia lamblia	Kinase, PLK	0.0114	0.6431	1
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Echinococcus multilocularis	zinc finger protein	0.0006	0.012	0.0116
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0004	0.0004	0.0007
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0258	0.0253
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.6431	1
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0258	0.0253
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.406	0.4057
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.9713	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Echinococcus multilocularis	cpg binding protein	0.0037	0.1899	0.1896
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0258	0.0261
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	hypothetical protein	0.0004	0.0004	0.0007
Onchocerca volvulus		0.0035	0.1784	0.2768
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.2766	0.4302
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Brugia malayi	Bromodomain containing protein	0.0006	0.012	0.0116
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.2515	0.3907
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Schistosoma mansoni	bromodomain containing protein	0.0006	0.012	0.0116
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.2766	0.7181
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0004	0.0004	0.0007
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.6431	0.643
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Brugia malayi	CXXC zinc finger family protein	0.0035	0.1784	0.178
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.6431	0.643
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0044	0.004
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0005	0.0041	0.0063
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0213	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.2766	0.2845
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.2515	1
Schistosoma mansoni	cpg binding protein	0.0035	0.1784	0.178
Trypanosoma brucei	polo-like protein kinase	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Schistosoma mansoni	cpg binding protein	0.0037	0.1899	0.1896
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.012	0.0116
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain containing protein, putative	0.0004	0.0004	0.0007
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.2515	0.3907
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.6431	1
Trichomonas vaginalis	bromodomain and PHD finger-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0213	0.0331
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0258	0.0261
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0006	0.012	0.0116
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.3059	0.4756
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Schistosoma mansoni	kinase	0.0058	0.3147	0.3144
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.6431	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.2766	1
Schistosoma mansoni	zinc finger protein	0.0006	0.012	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0004	0.0004	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.8876 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1544048

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1405927