Detailed information for compound 1405960

Basic information

Technical information
  • TDR Targets ID: 1405960
  • Name: 1-(phenylmethyl)-3-[4-[4-(pyridine-4-carbonyl )phenyl]piperazin-1-yl]pyrrolidine-2,5-dione
  • MW: 454.52 | Formula: C27H26N4O3
  • H donors: 0 H acceptors: 4 LogP: 2.67 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1)c1ccc(cc1)N1CCN(CC1)C1CC(=O)N(C1=O)Cc1ccccc1
  • InChi: 1S/C27H26N4O3/c32-25-18-24(27(34)31(25)19-20-4-2-1-3-5-20)30-16-14-29(15-17-30)23-8-6-21(7-9-23)26(33)22-10-12-28-13-11-22/h1-13,24H,14-19H2
  • InChiKey: HKEMFKDTHGLJSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[4-[4-[oxo-(4-pyridyl)methyl]phenyl]-1-piperazinyl]-1-(phenylmethyl)pyrrolidine-2,5-dione
  • 1-(benzyl)-3-[4-[4-(pyridine-4-carbonyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-quinone
  • 1-(phenylmethyl)-3-[4-(4-pyridin-4-ylcarbonylphenyl)piperazin-1-yl]pyrrolidine-2,5-dione
  • A3719/0157556
  • 1-benzyl-3-[4-(4-isonicotinoylphenyl)-1-piperazinyl]-2,5-pyrrolidinedione
  • MLS000052706
  • SMR000082446

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis short transient receptor potential channel 6 0.0098 0.0591 0.0586
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.004 0.0071 0.0066
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0591 0.0586
Trypanosoma brucei protein kinase, putative 0.0062 0.0264 0.3724
Schistosoma mansoni hypothetical protein 0.0041 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0017
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0138 0.0948 0.0943
Loa Loa (eye worm) voltage-gated potassium channel 0.0118 0.0766 0.2459
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0098 0.0591 1
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.1359 0.189
Echinococcus multilocularis potassium voltage gated channel protein 0.0098 0.0591 0.0586
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0253 0.0795
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.004 0.0071 0.0066
Brugia malayi cation channel family protein 0.0098 0.0591 0.1883
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0054 0.0195 0.0628
Loa Loa (eye worm) hypothetical protein 0.018 0.1328 0.4263
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus voltage dependent calcium channel 0.0098 0.0591 0.0586
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0082 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0264 0.0894
Leishmania major protein kinase, putative 0.004 0.0076 0.0005
Loa Loa (eye worm) voltage-gated potassium channel 0.0098 0.0591 0.1897
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0098 0.0591 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0103 0.0136
Echinococcus granulosus sodium leak channel non selective protein 0.0098 0.0591 0.0586
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0216 0.1643 0.1638
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.004 0.0071 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0264 0.0195
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0264 0.3724
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.004 0.0071 0.5
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.8474 0.8473
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0264 0.0894
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0264
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0216 0.1643 0.2286
Schistosoma mansoni ryanodine receptor related 0.0098 0.0591 0.0817
Echinococcus granulosus TRP transient receptor potential channel 0.0098 0.0591 0.0586
Echinococcus granulosus potassium voltage gated channel protein 0.0098 0.0591 0.0586
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus granulosus muscleblind protein 0.018 0.1328 0.1323
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0113 0.0108
Schistosoma mansoni hypothetical protein 0.004 0.0071 0.0091
Brugia malayi MAP kinase sur-1 0.0062 0.0264 0.0833
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0591 0.0817
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0821
Echinococcus granulosus voltage gated potassium channel 0.0102 0.0626 0.0621
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0102 0.0626 0.0621
Echinococcus granulosus short transient receptor potential channel 6 0.0098 0.0591 0.0586
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0071 0.5
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0098 0.0591 0.1883
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0098 0.0591 0.1883
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0235 0.0739
Brugia malayi olfactory channel protein osm-9 0.0098 0.0591 0.1883
Schistosoma mansoni voltage-dependent calcium channel 0.0098 0.0591 0.0817
Echinococcus multilocularis voltage gated potassium channel 0.0102 0.0626 0.0621
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.1359 0.1355
Loa Loa (eye worm) hypothetical protein 0.034 0.2758 0.8855
Schistosoma mansoni hypothetical protein 0.0098 0.0591 0.0817
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0184 0.1359 0.4354
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Schistosoma mansoni voltage-gated potassium channel 0.0408 0.3363 0.4687
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0102 0.0626 0.2009
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Schistosoma mansoni voltage-gated potassium channel 0.0138 0.0948 0.1315
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0591 0.0817
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.004 0.0071 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2269 0.2264
Echinococcus multilocularis two pore calcium channel protein 1 0.0098 0.0591 0.0586
Treponema pallidum catabolite gene activator 0.004 0.0071 0.5
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0098 0.0591 0.1883
Schistosoma mansoni hypothetical protein 0.0043 0.0103 0.0136
Onchocerca volvulus 0.0098 0.0591 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0098 0.0591 0.0586
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0138 0.0948 0.0943
Echinococcus multilocularis ryanodine receptor 44f 0.0098 0.0591 0.0586
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0005 0.0017
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0591 0.0817
Treponema pallidum catabolite gene activator (Crp) 0.004 0.0071 0.5
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7169 0.7167
Echinococcus granulosus two pore calcium channel protein 1 0.0098 0.0591 0.0586
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0098 0.0591 1
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Echinococcus granulosus shaker cognate 0.0102 0.0626 0.0621
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.004 0.0071 0.0091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0113 0.0348
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.004 0.0071 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0166 0.1196 0.1662
Echinococcus granulosus potassium voltage gated channel protein 0.0098 0.0591 0.0586
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.018 0.1324 0.132
Echinococcus granulosus ryanodine receptor 44f 0.0098 0.0591 0.0586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0098 0.0591 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0264 0.0894
Mycobacterium ulcerans hypothetical protein 0.004 0.0071 0.5
Echinococcus multilocularis muscleblind protein 0.018 0.1328 0.1323
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0227
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) voltage-dependent calcium channel 0.0098 0.0591 0.1897
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0113 0.0151
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0113 0.0108
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0102 0.0626 0.0621
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0138 0.0948 0.1315
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0821
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.004 0.0071 0.1118
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0138 0.0948 0.3042
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.004 0.0071 0.0066
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.004 0.0071 0.0091
Echinococcus granulosus voltage dependent calcium channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) hypothetical protein 0.018 0.1328 0.4263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0253 0.0811
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0102 0.0626 0.0621
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0054 0.0195 0.019
Echinococcus granulosus voltage gated potassium channel 0.0166 0.1196 0.1191
Echinococcus multilocularis hyperpolarization activated cyclic 0.0138 0.0948 0.0943
Schistosoma mansoni hypothetical protein 0.0058 0.0235 0.0321
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0102 0.0626 0.0621
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0098 0.0591 0.0586
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7169 0.7167
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0264 0.0259
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0102 0.0626 0.0621
Echinococcus granulosus cyclic nucleotide gated cation channel 0.004 0.0071 0.0066
Echinococcus multilocularis shaker cognate 0.0102 0.0626 0.0621
Onchocerca volvulus 0.004 0.0071 0.1118
Brugia malayi Muscleblind-like protein 0.018 0.1328 0.4253
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0098 0.0591 0.1883
Loa Loa (eye worm) hypothetical protein 0.0166 0.1196 0.3839
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0264 0.0362
Echinococcus granulosus two pore calcium channel protein 2 0.0098 0.0591 0.0586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0005 0.0017
Schistosoma mansoni voltage-gated cation channel 0.0098 0.0591 0.0817
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0264 0.0259
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0098 0.0591 0.1883
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.004 0.0071 0.0211
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Schistosoma mansoni vesicular amine transporter 0.0102 0.0626 0.0866
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0591 0.0586
Mycobacterium leprae Conserved hypothetical protein 0.004 0.0071 0.5
Echinococcus granulosus hyperpolarization activated cyclic 0.0138 0.0948 0.0943
Leishmania major hypothetical protein, unknown function 0.0098 0.0591 0.0524
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0113 0.0197
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) hypothetical protein 0.006 0.0253 0.0811
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Brugia malayi hypothetical protein 0.0286 0.2269 0.7278
Loa Loa (eye worm) calcium channel 0.0098 0.0591 0.1897
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0264 0.3724
Echinococcus multilocularis transfer RNA-Gly 0.0102 0.0626 0.0621
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0113 0.0043
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0098 0.0591 0.1883
Loa Loa (eye worm) ion channel NompC 0.0098 0.0591 0.1897
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0216 0.1643 0.5266
Echinococcus granulosus potassium voltage gated channel subfamily H 0.038 0.3115 0.3111
Loa Loa (eye worm) hypothetical protein 0.0045 0.0113 0.0364
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0138 0.0948 0.0943
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0138 0.0948 0.0943
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0591 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.0591 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0113 0.0197
Schistosoma mansoni similar to Protein C20orf152 homolog 0.004 0.0071 0.0091
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Brugia malayi hypothetical protein 0.0098 0.0591 0.1883
Echinococcus granulosus potassium voltage gated channel protein 0.0102 0.0626 0.0621
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.004 0.0071 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0264 0.0894
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0098 0.0591 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0102 0.0626 0.1995
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.038 0.3115 0.3111
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0138 0.0948 0.0943
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0098 0.0591 0.0586
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.1359 0.189
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0821
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.004 0.0071 0.0066
Mycobacterium ulcerans hypothetical protein 0.004 0.0071 0.5
Brugia malayi Transient-receptor-potential like protein 0.0098 0.0591 0.1883
Onchocerca volvulus 0.0058 0.0235 0.3924
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0076 0.0098
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1004 0.3222
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0098 0.0591 0.0817
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0591 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0138 0.0948 0.303
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.004 0.0071 0.0091
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0098 0.0591 0.0586
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.004 0.0071 0.5
Echinococcus multilocularis cGMP dependent protein kinase 1 0.004 0.0076 0.007
Schistosoma mansoni transient receptor potential channel 0.0098 0.0591 0.0817
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0098 0.0591 0.0817
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0138 0.0948 0.3042
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Loa Loa (eye worm) voltage-gated calcium channel 0.0098 0.0591 0.1897
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0264 0.3724
Echinococcus granulosus calcium activated potassium channel 0.0099 0.0596 0.0591
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0264 0.0259
Brugia malayi hypothetical protein 0.0043 0.0103 0.0313
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.004 0.0071 0.0091
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.004 0.0071 0.0091
Schistosoma mansoni 60S ribosomal protein L21 0.0126 0.0839 0.1164
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0102 0.0626 0.1995
Echinococcus multilocularis cGMP dependent protein kinase 1 0.004 0.0076 0.007
Loa Loa (eye worm) AGC/PKG protein kinase 0.004 0.0076 0.0243
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.004 0.0071 0.0211
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.004 0.0071 0.0211
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0138 0.0948 0.1315
Echinococcus multilocularis short transient receptor potential channel 6 0.0098 0.0591 0.0586
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0098 0.0591 0.0586
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0098 0.0591 0.0817
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.004 0.0071 0.5
Mycobacterium ulcerans hypothetical protein 0.004 0.0071 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0166 0.1196 0.3828
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0098 0.0591 0.0586
Treponema pallidum cyclic nucleotide binding protein 0.004 0.0071 0.5
Schistosoma mansoni voltage-gated ion channel 0.0098 0.0591 0.0817
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.004 0.0071 0.5
Brugia malayi ion channel NompC 0.0098 0.0591 0.1883
Echinococcus multilocularis conserved hypothetical protein 0.0098 0.0591 0.0586
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0166 0.1196 0.1191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0113 0.0197
Onchocerca volvulus 0.004 0.0071 0.1118
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0098 0.0591 0.1883
Loa Loa (eye worm) hypothetical protein 0.0054 0.0195 0.0628
Schistosoma mansoni survival motor neuron protein 0.0058 0.0235 0.0321
Mycobacterium ulcerans transmembrane transport protein 0.004 0.0071 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0264 0.3724
Echinococcus multilocularis muscleblind protein 1 0.018 0.1328 0.1323
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0098 0.0591 0.0817
Echinococcus granulosus cGMP dependent protein kinase 1 0.004 0.0076 0.007
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0098 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0264 0.0849
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.004 0.0071 0.0227
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.004 0.0076 0.0096
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0184 0.1359 0.1355
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0591 0.0817
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0264 0.3724
Echinococcus multilocularis potassium voltage gated channel protein 0.0102 0.0626 0.0621
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0071 0.0091
Toxoplasma gondii hypothetical protein 0.0098 0.0591 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0138 0.0948 0.0943
Mycobacterium ulcerans hypothetical protein 0.004 0.0071 0.5
Echinococcus multilocularis sodium leak channel non selective protein 0.0098 0.0591 0.0586
Echinococcus multilocularis expressed conserved protein 0.004 0.0076 0.007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0113 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0282 0.2238 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0113 0.0108
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0098 0.0591 0.1883
Echinococcus multilocularis voltage gated potassium channel 0.0166 0.1196 0.1191
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.0591 0.0586
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0264 0.3724
Treponema pallidum cyclic nucleotide binding protein 0.004 0.0071 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0138 0.0948 0.1315
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.004 0.0071 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0138 0.0948 0.4045
Echinococcus granulosus cGMP dependent protein kinase 0.004 0.0076 0.007
Mycobacterium ulcerans transcriptional regulatory protein 0.004 0.0071 0.5
Toxoplasma gondii hypothetical protein 0.0098 0.0591 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0216 0.1643 0.1638
Schistosoma mansoni voltage-gated potassium channel 0.0408 0.3363 0.4687
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0286 0.2269 0.7283
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0166 0.1196 0.1191
Brugia malayi voltage-dependent calcium channel 0.0098 0.0591 0.1883
Schistosoma mansoni two-pore calcium channel 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus potassium large conductance calcium activated 0.0098 0.0591 0.0586
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0138 0.0948 0.4045
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0054 0.0195 0.019
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0098 0.0591 0.0817
Leishmania major protein kinase, putative 0.004 0.0076 0.0005
Echinococcus multilocularis potassium voltage gated channel protein 0.0102 0.0626 0.0621
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.038 0.3115 1
Mycobacterium ulcerans regulatory protein 0.004 0.0071 0.5
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0098 0.0591 0.1883
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.0591 0.0586
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.004 0.0071 0.0091
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0113 0.0108
Leishmania major hypothetical protein, conserved 0.0098 0.0591 0.0524
Brugia malayi N-terminal motif family protein 0.004 0.0071 0.0211
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0103 0.0097
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0264 0.0195
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0098 0.0591 0.0817
Echinococcus granulosus potassium voltage gated channel protein 0.0102 0.0626 0.0621
Loa Loa (eye worm) voltage-gated potassium channel 0.0102 0.0626 0.2009
Brugia malayi MH2 domain containing protein 0.0144 0.1004 0.3211
Schistosoma mansoni calcium-activated potassium channel 0.0098 0.0591 0.0817
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0138 0.0948 0.1315
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.004 0.0071 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0076 0.0098
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.038 0.3115 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1004 0.3222
Loa Loa (eye worm) hypothetical protein 0.0054 0.0195 0.0628
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0113 0.0151
Echinococcus granulosus transient receptor potential cation channel 0.0098 0.0591 0.0586
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0113 0.0108
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Echinococcus granulosus hyperpolarization activated cyclic 0.0138 0.0948 0.0943
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0138 0.0948 0.0943
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0098 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0071 0.5
Toxoplasma gondii transporter, cation channel family protein 0.0098 0.0591 1
Echinococcus multilocularis calcium activated potassium channel 0.0099 0.0596 0.0591
Echinococcus granulosus voltage gated hydrogen channel 1 0.0098 0.0591 0.0586
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0113 0.2204
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.0626 0.0866
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.004 0.0071 0.0091
Echinococcus granulosus short transient receptor potential channel 6 0.0098 0.0591 0.0586
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0264 0.0259
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0138 0.0948 0.1315
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0138 0.0948 0.0943
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0098 0.0591 0.0586
Schistosoma mansoni transient receptor potential channel 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus patatin phospholipase domain containing protein 0.004 0.0071 0.0066
Plasmodium falciparum cGMP-dependent protein kinase 0.004 0.0076 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0102 0.0626 0.0621
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0264 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0282 0.2238 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.004 0.0071 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0076 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0227
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0591 0.0817
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0102 0.0626 0.0621
Loa Loa (eye worm) hypothetical protein 0.0138 0.0948 0.3042
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7169 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0098 0.0591 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2269 0.2264
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.0591 0.0586
Loa Loa (eye worm) ryanodine receptor 0.0098 0.0591 0.1897
Echinococcus multilocularis potassium voltage gated channel protein 0.0184 0.1359 0.1355
Echinococcus granulosus hypothetical protein 0.0098 0.0591 0.0586
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0103 0.0097
Loa Loa (eye worm) hypothetical protein 0.0098 0.0591 0.1897
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.004 0.0071 0.0066
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.004 0.0071 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0166 0.1196 0.1662
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0839 0.1164
Mycobacterium tuberculosis Conserved protein 0.004 0.0071 0.5
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.004 0.0071 0.0091
Schistosoma mansoni transient receptor potential channel 0.0098 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0184 0.1359 0.4364
Echinococcus multilocularis patatin phospholipase domain containing protein 0.004 0.0071 0.0066
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.0591 0.0586
Echinococcus granulosus cGMP dependent protein kinase 1 0.004 0.0076 0.007
Brugia malayi cation channel family protein 0.0098 0.0591 0.1883
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0253 0.0795
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0113 0.0108
Echinococcus multilocularis potassium large conductance calcium activated 0.0098 0.0591 0.0586
Brugia malayi Egg laying defective protein 4 0.004 0.0076 0.0227

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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