Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0631 | 0.1843 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0631 | 0.1403 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0175 | 0.0461 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0346 | 0.3424 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0175 | 0.0511 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0175 | 0.0511 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.274 | 0.8002 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0346 | 0.3424 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0175 | 0.0461 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0631 | 0.1403 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0631 | 0.1403 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0346 | 0.3424 | 1 |
Onchocerca volvulus | 0.0033 | 0.0175 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0.0175 | 0.5 | |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0346 | 0.3424 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0346 | 0.3424 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0346 | 0.3424 | 0.3424 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0346 | 0.3424 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0631 | 0.1843 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0631 | 0.1843 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0175 | 0.0175 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0631 | 0.1403 |
Echinococcus granulosus | transcription factor Dp 1 | 0.02 | 0.1913 | 0.5588 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0631 | 0.18 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0175 | 0.0511 |
Echinococcus granulosus | lamin | 0.0033 | 0.0175 | 0.0511 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0346 | 0.3424 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0346 | 0.3424 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0631 | 0.1403 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0175 | 0.0511 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0175 | 0.0511 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0631 | 0.1843 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0631 | 0.0631 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.02 | 0.1913 | 0.1913 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0631 | 0.18 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0018 | 0.0052 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.274 | 0.7992 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0346 | 0.3424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0493 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0631 | 0.18 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.