TDR Targets

Basic information

Technical information

TDR Targets ID: 1406073
Name: N-[(2-chlorophenyl)methyl]-1-(7,8,9,10-tetrah ydro-6H-purino[9,8-a]azepin-4-yl)piperidine-3 -carboxamide
MW: 438.953 | Formula: C23H27ClN6O
H donors: 1 H acceptors: 4 LogP: 3.48 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCN(C1)c1ncnc2c1nc1n2CCCCC1)NCc1ccccc1Cl
InChi: 1S/C23H27ClN6O/c24-18-9-4-3-7-16(18)13-25-23(31)17-8-6-11-29(14-17)21-20-22(27-15-26-21)30-12-5-1-2-10-19(30)28-20/h3-4,7,9,15,17H,1-2,5-6,8,10-14H2,(H,25,31)
InChiKey: VILFHJDSMWNWMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-chlorophenyl)methyl]-1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)-3-piperidinecarboxamide
N-(2-chlorobenzyl)-1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)nipecotamide
ChemDiv3_016226

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0038	0.0291	0.0133
Loa Loa (eye worm)	melatonin receptor type 1A	0.0093	0.1899	0.174
Echinococcus granulosus	somatostatin receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0057	0.0845	0.0666
Brugia malayi	Dopamine receptor protein 2	0.0093	0.1899	0.2303
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0038	0.0291	0.0101
Echinococcus granulosus	g protein coupled receptor	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0093	0.1899	0.2303
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0038	0.0291	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Echinococcus multilocularis	geminin	0.0205	0.5135	0.504
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Treponema pallidum	catabolite gene activator	0.0038	0.0291	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Brugia malayi	RNA, U transporter 1	0.0099	0.2061	0.2522
Schistosoma mansoni	opsin-like receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.1899	0.174
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0289	0.7603	0.7557
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Brugia malayi	G protein-coupled receptor F59B2.13	0.0093	0.1899	0.2303
Onchocerca volvulus		0.0093	0.1899	1
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0291	0.0101
Onchocerca volvulus		0.0093	0.1899	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0093	0.1899	1
Brugia malayi	neuropeptide F receptor	0.0093	0.1899	0.2303
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0057	0.0845	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0291	0.0101
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0038	0.0291	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0289	0.7603	0.7557
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0093	0.1899	0.2303
Onchocerca volvulus		0.0093	0.1899	1
Schistosoma mansoni	amine GPCR	0.0093	0.1899	0.174
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0038	0.0291	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0093	0.1899	0.2303
Echinococcus granulosus	neuropeptide receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.1899	0.174
Schistosoma mansoni	hypothetical protein	0.0093	0.1899	0.174
Mycobacterium ulcerans	regulatory protein	0.0038	0.0291	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0084	0.1619	0.1455
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0038	0.0291	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0038	0.0291	0.5
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0084	0.1619	0.1926
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	voltage gated potassium channel	0.0084	0.1619	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0093	0.1899	0.174
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0093	0.1899	0.174
Leishmania major	protein kinase A regulatory subunit, putative	0.0038	0.0291	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.1899	0.174
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.0845	0.1199
Brugia malayi	AKH receptor	0.0093	0.1899	0.2303
Echinococcus granulosus	neuropeptide FF receptor 2	0.0093	0.1899	0.174
Brugia malayi	sulfakinin receptor protein	0.0093	0.1899	0.2303
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.0845	0.1199
Echinococcus granulosus	hypothetical protein	0.0093	0.1899	0.174
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0038	0.0291	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0093	0.1899	0.174
Schistosoma mansoni	voltage-gated potassium channel	0.0057	0.0845	0.0666
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0038	0.0291	0.0101
Schistosoma mansoni	histamine h1 receptor	0.0093	0.1899	0.174
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.1899	0.174
Schistosoma mansoni	growth hormone secretagogue receptor	0.0093	0.1899	0.174
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0443	0.0256
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0038	0.0291	0.0412
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.1899	0.174
Echinococcus granulosus	neuropeptide receptor	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0057	0.0845	0.0666
Echinococcus granulosus	neuropeptide receptor A26	0.0093	0.1899	0.174
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.1899	0.174
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Onchocerca volvulus		0.0093	0.1899	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0057	0.0845	0.0666
Brugia malayi	Serotonin receptor	0.0093	0.1899	0.2303
Brugia malayi	GnHR receptor homolog	0.0093	0.1899	0.2303
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0038	0.0291	0.0101
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0038	0.0291	0.0101
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0038	0.0291	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0093	0.1899	0.174
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0093	0.1899	0.174
Schistosoma mansoni	voltage-gated potassium channel	0.0316	0.8377	0.8346
Echinococcus multilocularis	neuropeptide s receptor	0.0093	0.1899	0.174
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0376	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	TYRA-2 protein	0.0093	0.1899	0.174
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.1899	0.174
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.1899	0.174
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.1899	0.174
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.1899	0.174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	hypothetical protein	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0291	0.0101
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0057	0.0845	0.0666
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	dro:myosuppressin receptor	0.0093	0.1899	0.174
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0057	0.0845	0.0666
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0038	0.0291	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0093	0.1899	0.174
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0038	0.0291	0.0101
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0038	0.0291	0.0101
Echinococcus granulosus	orexin receptor type 2	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus granulosus	neuropeptide s receptor	0.0093	0.1899	0.174
Treponema pallidum	cyclic nucleotide binding protein	0.0038	0.0291	0.5
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1619	0.1455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0038	0.0291	0.0101
Echinococcus granulosus	sex peptide receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.027	0.7049	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.1899	0.174
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0038	0.0291	1
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0057	0.0845	0.0666
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0093	0.1899	0.2303
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0038	0.0291	1
Brugia malayi	Serotonin receptor	0.0093	0.1899	0.2303
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0038	0.0291	0.0101
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0291	0.5
Echinococcus multilocularis	somatostatin receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0038	0.0291	0.0412
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0251	0.6491	0.6422
Onchocerca volvulus		0.0093	0.1899	1
Brugia malayi	larval opioid receptor	0.0093	0.1899	0.2303
Trypanosoma brucei	cAMP response protein 1, putative	0.0038	0.0291	1
Echinococcus multilocularis	voltage gated potassium channel	0.0084	0.1619	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Leishmania major	protein kinase, putative	0.0038	0.0291	1
Trypanosoma cruzi	cAMP response protein 1	0.0038	0.0291	1
Schistosoma mansoni	neuropeptide receptor	0.0093	0.1899	0.174
Schistosoma mansoni	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	biogenic amine receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0291	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0093	0.1899	0.174
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Treponema pallidum	catabolite gene activator (Crp)	0.0038	0.0291	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0093	0.1899	0.174
Trypanosoma cruzi	cAMP binding protein, putative	0.0038	0.0291	1
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0291	0.5
Echinococcus multilocularis	expressed conserved protein	0.0038	0.0291	0.0101
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.1899	0.174
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0057	0.0845	0.0666
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0038	0.0291	0.0101
Schistosoma mansoni	amine GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0093	0.1899	0.174
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0291	0.0101
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0291	0.5
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0038	0.0291	0.0101
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0093	0.1899	0.174
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0443	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0291	0.0101
Schistosoma mansoni	neuropeptide f receptor 76f	0.0093	0.1899	0.174
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0289	0.7603	0.7557
Echinococcus granulosus	cGMP dependent protein kinase	0.0038	0.0291	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	follicle stimulating hormone receptor	0.0093	0.1899	0.2303
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.1899	0.174
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0291	0.0101
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0057	0.0845	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0038	0.0291	0.0101
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0093	0.1899	0.174
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.1899	0.174
Mycobacterium ulcerans	transcriptional regulatory protein	0.0038	0.0291	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0093	0.1899	0.2303
Echinococcus multilocularis	orexin receptor type 2	0.0093	0.1899	0.174
Brugia malayi	Melatonin receptor type 1A	0.0093	0.1899	0.2303
Onchocerca volvulus		0.0093	0.1899	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0038	0.0291	0.0101
Brugia malayi	putative neuropeptide receptor	0.0093	0.1899	0.2303
Brugia malayi	G protein-coupled receptor	0.0093	0.1899	0.2303
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.1899	0.174
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0931	0.0997
Treponema pallidum	cyclic nucleotide binding protein	0.0038	0.0291	0.5
Brugia malayi	ORL1-like opioid receptor	0.0093	0.1899	0.2303
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0038	0.0291	1
Schistosoma mansoni	hypothetical protein	0.0093	0.1899	0.174
Brugia malayi	N-terminal motif family protein	0.0038	0.0291	0.0133
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Schistosoma mansoni	opsin-like receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	serotonin receptor	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0038	0.0291	1
Echinococcus multilocularis	g-protein coupled receptor	0.0093	0.1899	0.174
Echinococcus granulosus	serotonin receptor	0.0093	0.1899	0.174
Echinococcus granulosus	7TM GPCR rhodopsin	0.0093	0.1899	0.174
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0093	0.1899	0.174
Trypanosoma brucei	cAMP binding protein, putative	0.0038	0.0291	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0038	0.0291	0.0133
Echinococcus granulosus	hyperpolarization activated cyclic	0.0057	0.0845	0.0666
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.1899	0.174
Leishmania major	hypothetical protein, conserved	0.0038	0.0291	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	allatostatin A receptor	0.0093	0.1899	0.174
Brugia malayi	putative neuropeptide receptor NPR1	0.0093	0.1899	0.2303
Leishmania major	hypothetical protein, conserved	0.0038	0.0291	1
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0093	0.1899	0.174
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0038	0.0291	0.0101
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1619	0.1455
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0931	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0291	0.0101
Schistosoma mansoni	opsin-like receptor	0.0093	0.1899	0.174
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0093	0.1899	0.2303
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0057	0.0845	0.0666
Echinococcus multilocularis	G protein coupled receptor 139	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus granulosus	g-protein coupled receptor	0.0093	0.1899	0.174
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0289	0.7603	1
Schistosoma mansoni	hypothetical protein	0.0205	0.5135	0.504
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0291	0.0412
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0057	0.0845	0.0666
Mycobacterium leprae	Conserved hypothetical protein	0.0038	0.0291	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	G protein coupled receptor 139	0.0093	0.1899	0.174
Brugia malayi	neuropeptide F receptor	0.0093	0.1899	0.2303
Trypanosoma cruzi	cAMP response protein 1, putative	0.0038	0.0291	1
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0038	0.0291	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0093	0.1899	0.174
Schistosoma mansoni	hypothetical protein	0.0041	0.0376	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Echinococcus multilocularis	sex peptide receptor	0.0093	0.1899	0.174
Echinococcus granulosus	g protein coupled receptor	0.0093	0.1899	0.174
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0093	0.1899	0.174
Brugia malayi	Dopamine receptor protein 1	0.0093	0.1899	0.2303
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0038	0.0291	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0043	0.0443	0.0339
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0291	0.5
Echinococcus granulosus	hyperpolarization activated cyclic	0.0057	0.0845	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	neuropeptide receptor	0.0093	0.1899	0.174
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0038	0.0291	0.0133
Leishmania major	hypothetical protein, conserved	0.0038	0.0291	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0057	0.0845	0.0666
Echinococcus granulosus	dro:myosuppressin receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.1899	0.174
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0291	0.0412
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0038	0.0291	1
Mycobacterium ulcerans	transmembrane transport protein	0.0038	0.0291	0.5
Schistosoma mansoni	60S ribosomal protein L21	0.0046	0.0506	0.0321
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.1899	0.174
Echinococcus granulosus	g protein coupled receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.1899	0.174
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0038	0.0291	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0038	0.0291	1
Brugia malayi	Dopamine receptor	0.0093	0.1899	0.2303
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0376	0.0188
Schistosoma mansoni	hypothetical protein	0.0043	0.0443	0.0256
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.1899	0.174
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0038	0.0291	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Leishmania major	hypothetical protein, unknown function	0.0038	0.0291	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	biogenic amine receptor	0.0093	0.1899	0.174
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0291	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0057	0.0845	0.0666
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0038	0.0291	0.0101
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0038	0.0291	1
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0038	0.0291	1
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.1899	0.174
Schistosoma mansoni	voltage-gated potassium channel	0.0316	0.8377	0.8346
Schistosoma mansoni	adenoreceptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0093	0.1899	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus granulosus	7tm_1 domain containing protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0845	0.0666
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.1899	0.174
Schistosoma mansoni	hypothetical protein	0.0205	0.5135	0.504
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0291	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0291	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0057	0.0845	0.0881
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0057	0.0845	0.0666
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0291	0.5
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0038	0.0291	0.0101
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0038	0.0291	0.0101
Echinococcus granulosus	fmrfamide receptor	0.0093	0.1899	0.174
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0038	0.0291	0.0101
Leishmania major	protein kinase, putative	0.0038	0.0291	1
Schistosoma mansoni	biogenic amine receptor	0.0093	0.1899	0.174
Plasmodium falciparum	cGMP-dependent protein kinase	0.0038	0.0291	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0084	0.1619	0.1455
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0038	0.0291	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0093	0.1899	0.174
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.1899	0.174
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.1899	0.174
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0038	0.0291	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0506	0.0321
Schistosoma mansoni	myosin xvIII	0.0093	0.1899	0.174
Brugia malayi	G-protein coupled receptor	0.0093	0.1899	0.2303
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	Egg laying defective protein 4	0.0038	0.0291	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Trypanosoma brucei	Flagellar Member 6	0.0038	0.0291	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.027	0.7049	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0093	0.1899	0.174
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0057	0.0845	0.0666
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0443	0.0256
Onchocerca volvulus		0.0093	0.1899	1
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0038	0.0291	0.0101
Brugia malayi	RE15519p	0.0093	0.1899	0.2303
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0931	0.0753
Onchocerca volvulus		0.0093	0.1899	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.1899	0.174
Schistosoma mansoni	amine GPCR	0.0093	0.1899	0.174
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0093	0.1899	0.174
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0038	0.0291	1
Trypanosoma cruzi	Flagellar Member 6	0.0038	0.0291	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0093	0.1899	0.174
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.1899	0.174
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0291	0.0412
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0093	0.1899	0.174
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1619	0.1455
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0038	0.0291	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	geminin	0.0205	0.5135	0.504
Schistosoma mansoni	amine GPCR	0.0093	0.1899	0.174
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0057	0.0845	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0038	0.0291	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.1899	0.174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.1899	0.174
Brugia malayi	G-protein coupled receptor	0.0093	0.1899	0.2303
Schistosoma mansoni	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.1899	0.174
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0038	0.0291	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0038	0.0291	0.5
Schistosoma mansoni	amine GPCR	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Echinococcus multilocularis	serotonin receptor	0.0093	0.1899	0.174
Brugia malayi	hypothetical protein	0.0093	0.1899	0.2303
Echinococcus granulosus	allatostatin A receptor	0.0093	0.1899	0.174
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1899	0.174
Trypanosoma brucei	protein kinase A regulatory subunit	0.0038	0.0291	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0931	0.0753

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	9.2 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	23.0999 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1562628

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1406073