Detailed information for compound 1406601

Basic information

Technical information
  • TDR Targets ID: 1406601
  • Name: 4-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2- oxoethyl]-1,4-benzoxazin-3-one
  • MW: 332.351 | Formula: C17H20N2O5
  • H donors: 0 H acceptors: 2 LogP: 0.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC2(CC1)OCCO2)CN1C(=O)COc2c1cccc2
  • InChi: 1S/C17H20N2O5/c20-15(18-7-5-17(6-8-18)23-9-10-24-17)11-19-13-3-1-2-4-14(13)22-12-16(19)21/h1-4H,5-12H2
  • InChiKey: VRBDHBXNDZOTMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxo-ethyl]-1,4-benzoxazin-3-one
  • 4-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-keto-ethyl]-1,4-benzoxazin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide receptor A26 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptide receptor 0.0079 0.1455 0.1194
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.1455 0.1194
Brugia malayi GnHR receptor homolog 0.0079 0.1455 0.1194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0499 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0499 0.008
Schistosoma mansoni adenoreceptor 0.0079 0.1455 0.1455
Brugia malayi Serotonin receptor 0.0079 0.1455 0.1194
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.1455 0.1194
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.1455 0.1194
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.1455 0.1194
Schistosoma mansoni hypothetical protein 0.0079 0.1455 0.1455
Echinococcus multilocularis neuropeptide receptor 0.0079 0.1455 0.1194
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.027 0.9017 1
Echinococcus multilocularis g protein coupled receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi AKH receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0499 0.008
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.1455 0.1194
Brugia malayi Dopamine receptor 0.0079 0.1455 0.1194
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis orexin receptor type 2 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni neuropeptide receptor 0.0079 0.1455 0.1455
Schistosoma mansoni opsin-like receptor 0.0079 0.1455 0.1455
Schistosoma mansoni hypothetical protein 0.0079 0.1455 0.1455
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.1455 0.1194
Brugia malayi sulfakinin receptor protein 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine receptor 0.0079 0.1455 0.1455
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni opsin-like receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.1455 0.1455
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.1455 0.1194
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.1455 0.1194
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide s receptor 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.1455 0.1194
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.1455 0.1455
Schistosoma mansoni amine GPCR 0.0079 0.1455 0.1455
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni myosin xvIII 0.0079 0.1455 0.1455
Echinococcus multilocularis serotonin receptor 0.0079 0.1455 0.1194
Brugia malayi follicle stimulating hormone receptor 0.0079 0.1455 0.1194
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0253 0.8312 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0499
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.1455 0.1194
Schistosoma mansoni hypothetical protein 0.0079 0.1455 0.1455
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus voltage gated potassium channel 0.0078 0.1414 0.1145
Brugia malayi Serotonin receptor 0.0079 0.1455 0.1194
Schistosoma mansoni hypothetical protein 0.0079 0.1455 0.1455
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.1455 0.1194
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.1455 0.1455
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus granulosus serotonin receptor 0.0079 0.1455 0.1194
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0054 0.043 0.043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Schistosoma mansoni neuropeptide receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine receptor 0.0079 0.1455 0.1455
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.1455 0.1194
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis fmrfamide receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.1455 0.1194
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.1455 0.1194
Echinococcus granulosus fmrfamide receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus g-protein coupled receptor 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.1455 0.1194
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.1455 0.1194
Brugia malayi larval opioid receptor 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide receptor 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide receptor 0.0079 0.1455 0.1194
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi Dopamine receptor protein 2 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.1414 0.1145
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus multilocularis serotonin receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.027 0.9017 1
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus granulosus g protein coupled receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.1455 0.1455
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.1455 0.1194
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.1455 0.1194
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus multilocularis fmrfamide receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.027 0.9017 1
Onchocerca volvulus 0.0079 0.1455 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.1455 0.1194
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptide s receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0078 0.1414 0.1145
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis somatostatin receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.1455 0.1194
Schistosoma mansoni amine GPCR 0.0079 0.1455 0.1455
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.1414 0.1145
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.043 0.043
Echinococcus multilocularis g protein coupled receptor 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.1455 0.5
Brugia malayi RE15519p 0.0079 0.1455 0.1194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0499
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0078 0.1414 0.1145
Echinococcus granulosus sex peptide receptor 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.1455 0.1455
Echinococcus granulosus hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.1455 0.1194
Brugia malayi G-protein coupled receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptide receptor A26 0.0079 0.1455 0.1194
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.1455 0.1455
Onchocerca volvulus 0.0079 0.1455 0.5
Brugia malayi G-protein coupled receptor 0.0079 0.1455 0.1194
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.1455 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.1455 0.1194
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.043 0.043
Schistosoma mansoni biogenic amine receptor 0.0079 0.1455 0.1455
Onchocerca volvulus 0.0079 0.1455 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.1455 0.1455
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.1455 0.1194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0499 0.008
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0499 0.008
Echinococcus multilocularis sex peptide receptor 0.0079 0.1455 0.1194
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.1455 0.1455
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0054 0.043 0.043
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Loa Loa (eye worm) hypothetical protein 0.0235 0.7603 0.8354
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Schistosoma mansoni histamine h1 receptor 0.0079 0.1455 0.1455
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.1455 0.1455
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0253 0.8312 1
Schistosoma mansoni amine GPCR 0.0079 0.1455 0.1455
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.1455 0.1455
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0078 0.1414 0.1145
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.1455 0.1455
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.1455 0.1455
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.1455 0.1194
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.1455 0.1194
Echinococcus multilocularis allatostatin A receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.1455 0.1194
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.1455 0.1194
Echinococcus granulosus g protein coupled receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.1455 0.1194
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.1455 0.1455
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus orexin receptor type 2 0.0079 0.1455 0.1194
Brugia malayi neuropeptide F receptor 0.0079 0.1455 0.1194
Brugia malayi G protein-coupled receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.1455 0.1194
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.1455 0.1194
Schistosoma mansoni voltage-gated potassium channel 0.0078 0.1414 0.1414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni voltage-gated potassium channel 0.0078 0.1414 0.1414
Schistosoma mansoni neuropeptide receptor 0.0079 0.1455 0.1455
Echinococcus granulosus allatostatin A receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Echinococcus granulosus g protein coupled receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi ORL1-like opioid receptor 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni opsin-like receptor 0.0079 0.1455 0.1455
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.1455 0.1194
Brugia malayi neuropeptide F receptor 0.0079 0.1455 0.1194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0499 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.1455 0.1455
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.1455 0.1455
Brugia malayi putative neuropeptide receptor 0.0079 0.1455 0.1194
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.1455 0.1455
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Onchocerca volvulus 0.0079 0.1455 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.027 0.9017 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0499 0.0499
Schistosoma mansoni amine GPCR 0.0079 0.1455 0.1455
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.1455 0.1194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.1455 0.1194
Echinococcus multilocularis g protein coupled receptor 0.0079 0.1455 0.1194
Brugia malayi Melatonin receptor type 1A 0.0079 0.1455 0.1194
Echinococcus granulosus somatostatin receptor 0.0079 0.1455 0.1194
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.1455 0.1194
Schistosoma mansoni neuropeptide receptor 0.0079 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.043 0.043
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0054 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi hypothetical protein 0.0079 0.1455 0.1194
Brugia malayi Dopamine receptor protein 1 0.0079 0.1455 0.1194
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.1455 0.1194
Schistosoma mansoni amine GPCR 0.0079 0.1455 0.1455
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.1455 0.1455

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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