Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1414 | 0.1145 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.1414 | 0.1145 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.4521 | 0.4764 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.043 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4521 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.1414 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.7603 | 0.8354 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.1414 | 0.1414 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4521 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4521 | 0.4521 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.043 | 0.043 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0015 | 0.043 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4521 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0075 | 0.9017 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.4521 | 0.4521 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.043 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.043 | 0.043 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0075 | 0.9017 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.1414 | 0.1145 |
Brugia malayi | hypothetical protein | 0.0043 | 0.4521 | 0.4764 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.1414 | 0.1145 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.4521 | 0.4764 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4521 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0075 | 0.9017 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0015 | 0.043 | 0.043 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.1414 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0075 | 0.9017 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.1414 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.8312 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.8312 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.