Detailed information for compound 1406917

Basic information

Technical information
  • TDR Targets ID: 1406917
  • Name: 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-p yridin-3-ylbenzamide
  • MW: 343.422 | Formula: C22H21N3O
  • H donors: 1 H acceptors: 2 LogP: 3.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)CN1CCc2c(C1)cccc2)Nc1cccnc1
  • InChi: 1S/C22H21N3O/c26-22(24-21-6-3-12-23-14-21)19-9-7-17(8-10-19)15-25-13-11-18-4-1-2-5-20(18)16-25/h1-10,12,14H,11,13,15-16H2,(H,24,26)
  • InChiKey: RVULDOSZJYLBSA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(3-pyridyl)benzamide
  • 4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-pyridin-3-yl-benzamide
  • BAS 02903282
  • Oprea1_521804
  • MLS000110465
  • SMR000106394
  • Oprea1_498843

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0027 0.0027
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0177 0.0182 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Trichomonas vaginalis centrin, putative 0.0393 0.0427 0.1288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0029 0.0088
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.003 0.0376
Plasmodium vivax hypothetical protein, conserved 0.0042 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Brugia malayi MAP kinase sur-1 0.0052 0.0041 0.0041
Trypanosoma brucei hypothetical protein 0.072 0.0796 0.2422
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.257 0.2886 0.8778
Echinococcus multilocularis calmodulin 0.0393 0.0427 0.0427
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Leishmania major calpain family cysteine protease-like protein 0.072 0.0796 0.2422
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.0005
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0397 0.0431 0.0431
Trypanosoma brucei hypothetical protein, conserved 0.0393 0.0427 0.1298
Toxoplasma gondii cathepsin CPL 0.0266 0.0283 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0005
Brugia malayi cathepsin L-like cysteine proteinase 0.0266 0.0283 0.0283
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0031 0.0031
Brugia malayi Cathepsin L-like cysteine proteinase 0.0266 0.0283 0.0283
Trichomonas vaginalis calcineurin B subunit, putative 0.0397 0.0431 0.1302
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Onchocerca volvulus 0.0266 0.0283 0.0565
Echinococcus multilocularis EF hand domain containing family member A2 0.0397 0.0431 0.0431
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.7329 0.8264 0.8264
Brugia malayi Probable myosin regulatory light chain 0.0075 0.0067 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Echinococcus multilocularis programmed cell death protein 0.0464 0.0507 0.0507
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0033 0.0032
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Mycobacterium ulcerans oxidoreductase 0.0042 0.003 0.04
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.005 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0005
Loa Loa (eye worm) calpain family protein 1 0.6935 0.7819 0.7819
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0283 0.0283
Toxoplasma gondii cathepsin B 0.2925 0.3288 1
Echinococcus granulosus programmed cell death protein 0.0464 0.0507 0.0507
Plasmodium vivax unspecified product 0.0266 0.0283 0.0979
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0029 0.0078
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.7329 0.8264 0.8264
Trichomonas vaginalis conserved hypothetical protein 0.0393 0.0427 0.1288
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0031 0.0084
Mycobacterium tuberculosis Conserved protein 0.0043 0.0031 0.0451
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.257 0.2886 0.2886
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0033 0.0088
Loa Loa (eye worm) calpain family protein 1 0.5086 0.573 0.573
Leishmania major protein kinase, putative 0.0394 0.0428 0.13
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0041 0.0113
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0031 0.0451
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0031 0.0716
Toxoplasma gondii calcium binding protein precursor, putative 0.0071 0.0062 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0018
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0033 0.0033
Trypanosoma brucei centrin-3 0.0464 0.0507 0.1541
Entamoeba histolytica cysteine proteinase 1, putative 0.0266 0.0283 0.1348
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0071 0.0062 0.0116
Trichomonas vaginalis myosin light chain 1, putative 0.0393 0.0427 0.1288
Entamoeba histolytica grainin 2 0.0071 0.0062 0.0282
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.072 0.0796 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0031 0.0084
Toxoplasma gondii calmodulin CAM2 0.0071 0.0062 0.0189
Trichomonas vaginalis hypothetical protein 0.072 0.0796 0.2413
Echinococcus multilocularis calpain 5 0.257 0.2886 0.2886
Giardia lamblia Hypothetical protein 0.0266 0.0283 0.0849
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Mycobacterium ulcerans monoamine oxidase 0.0042 0.003 0.04
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.003 0.003
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0283 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0042 0.003 0.0104
Schistosoma mansoni calmodulin-related 0.0071 0.0062 0.0062
Schistosoma mansoni ef hand domain family member A2 0.0393 0.0427 0.0427
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.0005
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0074
Entamoeba histolytica calpain family cysteine protease, putative 0.072 0.0796 0.3831
Leishmania major calmodulin, putative 0.0393 0.0427 0.1298
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0041 0.0124
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Brugia malayi hypothetical protein 0.0286 0.0305 0.0305
Loa Loa (eye worm) programmed cell death protein 6 0.0397 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Leishmania major calmodulin, putative 0.0393 0.0427 0.1298
Loa Loa (eye worm) hypothetical protein 0.005 0.0039 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.0283 0.0283
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Echinococcus granulosus neuronal calcium sensor 0.0393 0.0427 0.0427
Brugia malayi nuclear receptor NHR-88 0.0021 0.0005 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0031 0.0031
Trichomonas vaginalis calcium binding protein, putative 0.0393 0.0427 0.1288
Plasmodium falciparum serine repeat antigen 2 0.0266 0.0283 0.3549
Loa Loa (eye worm) ctsf protein 0.0266 0.0283 0.0283
Echinococcus multilocularis calpain A 0.7333 0.8268 0.8268
Echinococcus granulosus EF HAND 1 calcium binding site 0.0393 0.0427 0.0427
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Giardia lamblia Hypothetical protein 0.0397 0.0431 0.1302
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0266 0.0283 0.0283
Giardia lamblia Cysteine protease 0.0266 0.0283 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2925 0.3288 0.3288
Trypanosoma cruzi calmodulin, putative 0.0393 0.0427 0.0427
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.002 0.0267
Trichomonas vaginalis calcium binding proteins, putative 0.0393 0.0427 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0393 0.0427 0.1288
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.2886
Giardia lamblia Cysteine protease 0.0266 0.0283 0.0849
Echinococcus multilocularis calcium uptake protein 1 0.0397 0.0431 0.0431
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0052 0.0729
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0031 0.0031
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.0004
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.072 0.0796 0.0796
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Onchocerca volvulus 0.0266 0.0283 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1089 0.1089
Loa Loa (eye worm) calpain D 0.072 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0071 0.0062 0.0062
Trypanosoma brucei cysteine peptidase C (CPC) 0.2925 0.3288 1
Schistosoma mansoni amine oxidase 0.0042 0.003 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0052 0.0738
Schistosoma mansoni survival motor neuron protein 0.0058 0.0048 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0019 0.0019
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0005 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0048 0.0048
Echinococcus multilocularis EF hand domain containing family member A2 0.0393 0.0427 0.0427
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0031 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.8778
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Echinococcus granulosus neurocalcin 0.0393 0.0427 0.0427
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.0283 0.0283
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.0005
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Plasmodium falciparum serine repeat antigen 6 0.0266 0.0283 0.3549
Trichomonas vaginalis calcium binding protein, putative 0.0464 0.0507 0.1532
Onchocerca volvulus 0.004 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Brugia malayi RasGEF domain containing protein 0.0071 0.0062 0.0062
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Entamoeba histolytica grainin, putative 0.0397 0.0431 0.2066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Toxoplasma gondii RNA-directed DNA polymerase 0.0177 0.0182 0.0554
Brugia malayi EF hand family protein 0.0393 0.0427 0.0427
Brugia malayi calpain family protein 1 0.6935 0.7819 0.7819
Giardia lamblia Cathepsin B precursor 0.0266 0.0283 0.0849
Echinococcus multilocularis neurocalcin 0.0393 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0071 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0062 0.0178
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.257 0.2886 0.2886
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0602 0.0663 1
Trypanosoma cruzi centrin-3 0.0464 0.0507 0.0507
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Schistosoma mansoni myosin light chain 0.0071 0.0062 0.0062
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.072 0.0796 0.2422
Loa Loa (eye worm) hypothetical protein 0.5086 0.573 0.573
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0266 0.0283 0.3549
Echinococcus multilocularis Calcium binding protein 0.0071 0.0062 0.0062
Brugia malayi Myosin regulatory light chain 1 0.0071 0.0062 0.0062
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Brugia malayi calpain D 0.072 0.0796 0.0796
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Brugia malayi ecdysteroid receptor 0.0021 0.0005 0.0005
Trypanosoma cruzi I/6 autoantigen, putative 0.0393 0.0427 0.0427
Giardia lamblia Cathepsin B precursor 0.0266 0.0283 0.0849
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Brugia malayi SWIRM domain containing protein 0.0042 0.003 0.003
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Echinococcus granulosus cathepsin L 0.0266 0.0283 0.0283
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0024
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Echinococcus granulosus calpain 7 C02 family 0.257 0.2886 0.2886
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0025 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0005 0.0005
Plasmodium falciparum centrin-1 0.0393 0.0427 0.5358
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0393 0.0427 0.0427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0393 0.0427 0.2045
Mycobacterium ulcerans beta-lactamase 0.0043 0.0031 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0006 0.0019
Schistosoma mansoni rab6-interacting 0.004 0.0027 0.0027
Toxoplasma gondii calmodulin, putative 0.0071 0.0062 0.0189
Schistosoma mansoni calmodulin related calcium binding protein 0.0393 0.0427 0.0427
Brugia malayi Telomerase reverse transcriptase 0.0471 0.0515 0.0515
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trypanosoma brucei calpain, putative 0.072 0.0796 0.2422
Echinococcus granulosus RUN 0.004 0.0027 0.0027
Trypanosoma brucei centrin, putative 0.0393 0.0427 0.1298
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.2886
Echinococcus multilocularis 0.0042 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0266 0.0283 0.1348
Trypanosoma brucei kinesin, putative 0.1849 0.2072 0.6301
Leishmania major centrin, putative 0.0393 0.0427 0.1298
Onchocerca volvulus 0.0042 0.003 0.005
Trichomonas vaginalis esterase, putative 0.0043 0.0031 0.0084
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.072 0.0796 0.2413
Schistosoma mansoni jumonji domain containing protein 0.006 0.005 0.0049
Onchocerca volvulus 0.0033 0.0019 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0031 0.0084
Toxoplasma gondii EFHC1, putative 0.0393 0.0427 0.1298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.0005
Echinococcus multilocularis Myosin regulatory light chain 0.0071 0.0062 0.0062
Schistosoma mansoni calmodulin 0.0393 0.0427 0.0427
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Loa Loa (eye worm) fibroinase 0.0266 0.0283 0.0283
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0283 0.1348
Echinococcus multilocularis programmed cell death protein 6 0.0075 0.0067 0.0067
Trypanosoma brucei calpain, putative 0.072 0.0796 0.2422
Trichomonas vaginalis centrin, putative 0.0071 0.0062 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0266 0.0283 0.0979
Giardia lamblia Cathepsin B precursor 0.0266 0.0283 0.0849
Leishmania major cysteine peptidase A (CPA) 0.0266 0.0283 0.0859
Trypanosoma brucei I/6 autoantigen 0.0393 0.0427 0.1298
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0045
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0027 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Loa Loa (eye worm) cathepsin B 0.2925 0.3288 0.3288
Loa Loa (eye worm) hypothetical protein 0.6215 0.7005 0.7005
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0393 0.0427 0.1288
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trichomonas vaginalis centrin, putative 0.0071 0.0062 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0005
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0033 0.0033
Onchocerca volvulus 0.0071 0.0062 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.0005
Onchocerca volvulus 0.4366 0.4915 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0011
Schistosoma mansoni reticulocalbin 0.0397 0.0431 0.0431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0033 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0019 0.0019
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0266 0.0283 0.0849
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.8778
Trypanosoma brucei caltractin, putative 0.0464 0.0507 0.1541
Toxoplasma gondii centrin family protein 0.0071 0.0062 0.0189
Echinococcus granulosus EF hand domain containing family member A2 0.0393 0.0427 0.0427
Onchocerca volvulus 0.0033 0.0019 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0005
Loa Loa (eye worm) calpain 5 0.1849 0.2072 0.2072
Brugia malayi fibroinase precursor 0.0266 0.0283 0.0283
Schistosoma mansoni amine oxidase 0.0042 0.003 0.003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0025 0.0063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0004
Schistosoma mansoni centrin-related 0.0393 0.0427 0.0427
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0283 0.1348
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0052 0.0052
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0027 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0071 0.0062 0.0178
Toxoplasma gondii hypothetical protein 0.072 0.0796 0.2422
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.003 0.0104
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0071 0.0062 0.0116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0041 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0033 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Mycobacterium ulcerans hypothetical protein 0.0043 0.0031 0.0418
Leishmania major centrin, putative 0.0393 0.0427 0.1298
Brugia malayi intermediate filament protein 0.0033 0.0019 0.0019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0266 0.0283 0.3549
Leishmania major hypothetical protein, conserved 0.0393 0.0427 0.1298
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0041 0.0041
Plasmodium falciparum serine repeat antigen 4 0.0266 0.0283 0.3549
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0025 0.0063
Entamoeba histolytica calmodulin, putative 0.0393 0.0427 0.2045
Schistosoma mansoni cathepsin B (C01 family) 0.0266 0.0283 0.0283
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0025 0.0025
Trypanosoma brucei antigen, putative 0.257 0.2886 0.8778
Entamoeba histolytica hypothetical protein, conserved 0.0397 0.0431 0.2066
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.0283 0.0283
Loa Loa (eye worm) cysteine protease 0.0266 0.0283 0.0283
Echinococcus granulosus programmed cell death protein 6 0.0075 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0133
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0298 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0031 0.0451
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0041 0.0041
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0266 0.0283 0.3549
Trypanosoma cruzi calpain cysteine peptidase, putative 0.072 0.0796 0.0796
Brugia malayi Doublecortin family protein 0.004 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Echinococcus granulosus cysteine protease 0.0266 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.0283 0.0283
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.257 0.2886 0.2886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Toxoplasma gondii preprocathepsin c precursor, putative 0.0266 0.0283 0.0859
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0266 0.0283 0.0283
Brugia malayi calpain 5 0.1849 0.2072 0.2072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0381 0.1149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Echinococcus granulosus cathepsin l cysteine peptidase 0.0266 0.0283 0.0283
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0041 0.0124
Toxoplasma gondii centrin 0.0393 0.0427 0.1298
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0648 0.0715 0.1445
Mycobacterium ulcerans lipase LipD 0.0043 0.0031 0.0418
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0283 0.0283
Schistosoma mansoni neuronal calcium sensor 0.0393 0.0427 0.0427
Trypanosoma cruzi cysteine proteinase, putative 0.0266 0.0283 0.0283
Echinococcus granulosus intermediate filament protein 0.0033 0.0019 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0052 0.0738
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Echinococcus granulosus calpain A 0.257 0.2886 0.2886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Schistosoma mansoni calmodulin 0.0393 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Giardia lamblia Cathepsin L-like protease 0.0266 0.0283 0.0849
Onchocerca volvulus 0.0266 0.0283 0.0565
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0033 0.0088
Plasmodium falciparum serine repeat antigen 5 0.0266 0.0283 0.3549
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0266 0.0283 0.0849
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0031 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0005
Onchocerca volvulus 0.004 0.0027 0.0045
Plasmodium vivax vivapain-3 0.0266 0.0283 0.0979
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Plasmodium falciparum serine repeat antigen 1 0.0266 0.0283 0.3549
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0029 0.0088
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0029 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.003 0.003
Brugia malayi programmed cell death protein 6 0.0393 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0283 0.0283
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0041 0.0041
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0052 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0031 0.0108
Echinococcus granulosus calmodulin 0.0393 0.0427 0.0427
Brugia malayi hypothetical protein 0.0042 0.003 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.005 0.005
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2925 0.3288 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Onchocerca volvulus 0.0058 0.0048 0.0087
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0006 0.0019
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0283 0.0979
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0381 1
Trypanosoma cruzi kinesin, putative 0.1849 0.2072 0.2072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.0283 0.0849
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0033 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Echinococcus multilocularis cysteine protease 0.0266 0.0283 0.0283
Toxoplasma gondii cathepsin CPC1 0.0266 0.0283 0.0859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Giardia lamblia Telomerase catalytic subunit 0.0177 0.0182 0.0544
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0266 0.0283 0.0979
Leishmania major hypothetical protein, unknown function 0.072 0.0796 0.2422
Trichomonas vaginalis calcineurin B subunit, putative 0.0393 0.0427 0.1288
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0019 0.0019
Echinococcus granulosus calpain A 0.7333 0.8268 0.8268
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0266 0.0283 0.0283
Trichomonas vaginalis calmodulin, putative 0.0071 0.0062 0.0178
Loa Loa (eye worm) calpain 0.257 0.2886 0.2886
Leishmania major kinesin, putative 0.1849 0.2072 0.6301
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.003 0.003
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.003 0.064
Giardia lamblia Programmed cell death protein-like protein 0.0071 0.0062 0.0178
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0283 0.0565
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.003 0.0376
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Echinococcus granulosus cathepsin l1 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.4366 0.4915 0.4915
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0018
Brugia malayi Inositol-1 0.0037 0.0025 0.0024
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0393 0.0427 0.0427
Trypanosoma brucei cysteine peptidase, putative 0.072 0.0796 0.2422
Giardia lamblia Calmodulin 0.0071 0.0062 0.0178
Schistosoma mansoni hypothetical protein 0.0393 0.0427 0.0427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Trypanosoma brucei centrin, putative 0.0393 0.0427 0.1298
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0283 0.0849
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0052 0.0052
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Leishmania major hypothetical protein, conserved 0.0043 0.0031 0.0095
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0041 0.0113
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0074
Toxoplasma gondii ABC1 family protein 0.0043 0.0031 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0005 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0283 0.0979
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Loa Loa (eye worm) hypothetical protein 0.0393 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.072 0.0796 0.0796
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0266 0.0283 0.0979
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0071 0.0062 0.0215
Echinococcus granulosus calpain 5 0.257 0.2886 0.2886
Echinococcus granulosus calumenin 0.0397 0.0431 0.0431
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0005 0.0005
Echinococcus multilocularis lamin dm0 0.0033 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0283 0.0849
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0031 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0005
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0029 0.0387
Entamoeba histolytica calpain large subunit domain III containing protein 0.1849 0.2072 0.9996
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.0283 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.6935 0.7819 0.7819
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.0283 0.0849
Mycobacterium tuberculosis Conserved protein 0.0043 0.0031 0.0451
Plasmodium vivax centrin-1, putative 0.0393 0.0427 0.1478
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Echinococcus granulosus calcyphosin protein 0.0071 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0033 0.0099
Loa Loa (eye worm) calmodulin-like protein 0.0393 0.0427 0.0427
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0394 0.0428 0.1481
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0052 0.0052
Onchocerca volvulus 0.005 0.0039 0.0068
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Leishmania major calcineurin B subunit, putative 0.0393 0.0427 0.1298
Schistosoma mansoni lamin 0.0033 0.0019 0.0019
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trypanosoma brucei Component of motile flagella 41 0.0393 0.0427 0.1298
Onchocerca volvulus 0.0266 0.0283 0.0565
Trypanosoma brucei calpain-like protein, putative 0.257 0.2886 0.8778
Plasmodium falciparum calpain 0.072 0.0796 1
Echinococcus multilocularis calpain 0.257 0.2886 0.2886
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Schistosoma mansoni mitochondrial solute carrier 0.0393 0.0427 0.0427
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.2573 0.289 0.289
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0018 0.0054
Schistosoma mansoni calpain-2 (C02 family) 0.072 0.0796 0.0796
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0266 0.0283 0.0283
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0393 0.0427 0.0427
Leishmania major hypothetical protein, conserved 0.0397 0.0431 0.1311
Echinococcus multilocularis calbindin 32 0.0397 0.0431 0.0431
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0394 0.0428 0.0428
Echinococcus granulosus lamin 0.0033 0.0019 0.0019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0033 0.0032
Trypanosoma cruzi kinesin, putative 0.1849 0.2072 0.2072
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0397 0.0431 0.0431
Onchocerca volvulus 0.0266 0.0283 0.0565
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0283 0.0849
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0041 0.0124
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0021 0.0005 0.0005
Giardia lamblia Cysteine protease 0.0266 0.0283 0.0849
Echinococcus granulosus centrin 2 0.0393 0.0427 0.0427
Schistosoma mansoni calpain-7 (C02 family) 0.2573 0.289 0.289
Echinococcus granulosus Calcium binding protein 0.0071 0.0062 0.0062
Leishmania major telomerase reverse transcriptase, putative 0.0177 0.0182 0.0554
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0019
Schistosoma mansoni reticulocalbin 0.0393 0.0427 0.0427
Schistosoma mansoni intermediate filament proteins 0.0033 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0043 0.0031 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Loa Loa (eye worm) hypothetical protein 0.0045 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Schistosoma mansoni hypothetical protein 0.0393 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Schistosoma mansoni hypothetical protein 0.072 0.0796 0.0796
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0043 0.0031 0.0053
Brugia malayi calcium-binding protein 0.0393 0.0427 0.0427
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0305 0.0305
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Loa Loa (eye worm) hypothetical protein 0.004 0.0027 0.0027
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Giardia lamblia Cathepsin B precursor 0.0266 0.0283 0.0849
Loa Loa (eye worm) myosin Light Chain family member 0.0075 0.0067 0.0067
Leishmania major programmed cell death 6 protein-like protein 0.0393 0.0427 0.1298
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Trypanosoma cruzi conserved protein 0.072 0.0796 0.0796
Brugia malayi calpain 5 0.072 0.0796 0.0796
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0031 0.0451
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Brugia malayi beta-lactamase family protein 0.0043 0.0031 0.0031
Schistosoma mansoni lamin 0.0033 0.0019 0.0019
Loa Loa (eye worm) inositol-1 0.0037 0.0025 0.0025
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0602 0.0663 1
Leishmania major calmodulin-like protein 0.0393 0.0427 0.1298
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0031 0.0031
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Plasmodium falciparum telomerase reverse transcriptase 0.0177 0.0182 0.2288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Giardia lamblia Cysteine protease 0.0266 0.0283 0.0849
Trichomonas vaginalis caltractin, putative 0.0071 0.0062 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0005
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0052 0.0157
Schistosoma mansoni centrin 0.0393 0.0427 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2925 0.3288 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0041 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0283 0.0283
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0283 0.0283
Trypanosoma brucei Calpain-like protein 2 0.072 0.0796 0.2422
Trypanosoma brucei mitochondrial calcium uptake 1 0.0393 0.0427 0.1298
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0133
Schistosoma mansoni loxhd1 0.004 0.0027 0.0027
Entamoeba histolytica calmodulin, putative 0.0393 0.0427 0.2045
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0033 0.0033
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.003 0.003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0283 0.0283
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.003 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.072 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Schistosoma mansoni hypothetical protein 0.0058 0.0048 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.0005
Giardia lamblia Cathepsin B precursor 0.2925 0.3288 1
Trichomonas vaginalis centrin, putative 0.0071 0.0062 0.0178
Plasmodium falciparum serine repeat antigen 7 0.0266 0.0283 0.3549
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0031 0.0095
Brugia malayi beta-lactamase 0.0043 0.0031 0.0031
Leishmania major phospholipase c-like protein 0.0393 0.0427 0.1298
Echinococcus granulosus cathepsin L 0.0266 0.0283 0.0283
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0266 0.0283 0.0283
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0003 0.0002
Echinococcus multilocularis calumenin 0.0397 0.0431 0.0431
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Echinococcus granulosus tumor protein p63 0.0343 0.037 0.037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0031 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0031 0.0084
Plasmodium vivax vivapain-1 0.0266 0.0283 0.0979
Echinococcus granulosus calcium uptake protein 1 0.0397 0.0431 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0033 0.0033
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0393 0.0427 0.0427
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.003 0.003
Giardia lamblia Hypothetical protein 0.0266 0.0283 0.0849
Brugia malayi steroid hormone receptor 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0393 0.0427 0.0858
Entamoeba histolytica protein kinase, putative 0.185 0.2073 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0052 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0029
Brugia malayi cathepsin L-like precursor 0.0266 0.0283 0.0283
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0041 0.0113
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0266 0.0283 0.0979
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0393 0.0427 0.0427
Echinococcus multilocularis cathepsin L 0.0266 0.0283 0.0283
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.006 0.005 0.0049
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0266 0.0283 0.0979
Plasmodium vivax vivapain-2 0.0266 0.0283 0.0979
Echinococcus granulosus EF hand domain containing family member A2 0.0397 0.0431 0.0431
Onchocerca volvulus Cathepsin F homolog 0.0266 0.0283 0.0565
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.0283 0.0283
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0025 0.0315
Schistosoma mansoni polycystin 1-related 0.004 0.0027 0.0027
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0041 0.0041
Trypanosoma brucei calpain-like protein, putative 0.257 0.2886 0.8778
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0033 0.0088
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0177 0.0182 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0266 0.0283 0.0849
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0041 0.0041
Onchocerca volvulus 0.0043 0.0031 0.0053
Trichomonas vaginalis calcium binding protein, putative 0.0393 0.0427 0.1288
Schistosoma mansoni inositol monophosphatase 0.0037 0.0025 0.0024
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0041 0.0124
Brugia malayi calpain family protein 1 0.6935 0.7819 0.7819
Trypanosoma brucei calpain-like protein, putative 0.257 0.2886 0.8778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Giardia lamblia Cathepsin B precursor 0.2925 0.3288 1
Trypanosoma cruzi cruzipain precursor, putative 0.0266 0.0283 0.0283
Brugia malayi hypothetical protein 0.004 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0005
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0266 0.0283 0.0979
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Plasmodium falciparum cysteine proteinase falcipain 1 0.0266 0.0283 0.3549
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.257 0.2886 0.2886
Giardia lamblia Cathepsin B precursor 0.0266 0.0283 0.0849
Brugia malayi cathepsin F-like cysteine proteinase 0.0266 0.0283 0.0283
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0005
Echinococcus multilocularis cysteine protease 0.0266 0.0283 0.0283
Onchocerca volvulus 0.0043 0.0031 0.0053
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0177 0.2835
Plasmodium vivax hypothetical protein, conserved 0.0397 0.0431 0.1494
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.005 0.005
Toxoplasma gondii EF hand domain-containing protein 0.0071 0.0062 0.0189
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.003 0.003
Echinococcus multilocularis calcyphosin protein 0.0071 0.0062 0.0062
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.004 0.0027 0.0027
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.072 0.0796 0.2422
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Trichomonas vaginalis calcium binding protein, putative 0.0393 0.0427 0.1288
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0266 0.0283 0.0979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0283 0.0979
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0283 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus multilocularis lamin 0.0033 0.0019 0.0019
Trypanosoma brucei calmodulin, putative 0.0397 0.0431 0.1311
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0025 0.0024
Plasmodium falciparum centrin-4 0.0071 0.0062 0.0779
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0033 0.0099
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Brugia malayi EF hand family protein 0.0397 0.0431 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0088
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0283 0.0849
Giardia lamblia Cathepsin L precursor 0.0266 0.0283 0.0849
Onchocerca volvulus 0.0397 0.0431 0.0867
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0052 0.0052
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0052 0.0157
Toxoplasma gondii calcium-dependent protein kinase 0.0398 0.0432 0.1314
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0266 0.0283 0.0849
Leishmania major UDP-galactopyranose mutase 0.0042 0.003 0.0091
Trypanosoma cruzi calmodulin, putative 0.0393 0.0427 0.0427
Schistosoma mansoni calpain C (C02 family) 0.257 0.2886 0.2886
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.8778
Trypanosoma cruzi calmodulin, putative 0.0393 0.0427 0.0427
Trypanosoma brucei Calpain-like protein CALP1.3 0.072 0.0796 0.2422
Onchocerca volvulus 0.0266 0.0283 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0283 0.0849
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.003 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0031 0.0031
Leishmania major calmodulin-like protein 0.0393 0.0427 0.1298
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0283 0.0849
Brugia malayi polk-prov protein 0.0032 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0266 0.0283 0.0283
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.072 0.0796 0.0796
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.0005
Schistosoma mansoni cathepsin C 0.0266 0.0283 0.0283
Trypanosoma brucei telomerase reverse transcriptase 0.0177 0.0182 0.0554
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.7329 0.8264 0.8264
Toxoplasma gondii cathepsin CPC2 0.0266 0.0283 0.0859
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0071 0.0062 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0041 0.0113
Leishmania major i/6 autoantigen-like protein 0.0393 0.0427 0.1298
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0039 0.0039
Plasmodium falciparum serine repeat antigen 8 0.0266 0.0283 0.3549
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0044 0.0044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Plasmodium vivax calpain, putative 0.257 0.2886 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0031 0.0031
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.2886
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0025 0.0025
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0266 0.0283 0.0283
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0052 0.0786
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.0005
Entamoeba histolytica calmodulin, putative 0.0071 0.0062 0.0282
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0381 0.1823
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0283 0.0283
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trichomonas vaginalis calmodulin-2, putative 0.0393 0.0427 0.1288
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.7329 0.8264 0.8264
Toxoplasma gondii centrin, putative 0.0393 0.0427 0.1298
Echinococcus multilocularis programmed cell death protein 0.0464 0.0507 0.0507
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.8778
Echinococcus granulosus Myosin regulatory light chain 0.0071 0.0062 0.0062
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0283 0.0283
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Brugia malayi cathepsin L precursor 0.0266 0.0283 0.0283
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0025 0.01
Mycobacterium ulcerans dehydrogenase 0.0042 0.003 0.04
Leishmania major hypothetical protein, conserved 0.072 0.0796 0.2422
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0005
Trypanosoma cruzi I/6 autoantigen, putative 0.0393 0.0427 0.0427
Echinococcus multilocularis calpain 7 (C02 family) 0.257 0.2886 0.2886
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0025 0.0074
Trypanosoma brucei protein kinase, putative 0.0052 0.0041 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.0283 0.0283
Onchocerca volvulus 0.0393 0.0427 0.0858
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0266 0.0283 0.0283
Plasmodium falciparum serine repeat antigen 3 0.0266 0.0283 0.3549
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) EF hand family protein 0.0393 0.0427 0.0427
Schistosoma mansoni lipoxygenase 0.0104 0.0099 0.0099
Trypanosoma cruzi cysteine proteinase, putative 0.0266 0.0283 0.0283
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.005 0.005
Leishmania major centrin, putative,caltractin, putative 0.0393 0.0427 0.1298
Schistosoma mansoni myosin regulatory light chain 0.0071 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0031 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0041 0.0113
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0033 0.0032
Brugia malayi calpain 7 0.257 0.2886 0.2886
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Echinococcus multilocularis cathepsin L 0.0266 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0027 0.0027
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0018 0.0003 0.0003
Giardia lamblia Cathepsin B precursor 0.2925 0.3288 1
Schistosoma mansoni neuronal calcium sensor 0.0393 0.0427 0.0427
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Echinococcus granulosus cathepsin L cysteine protease 0.0266 0.0283 0.0283
Trypanosoma brucei unspecified product 0.0035 0.0022 0.0065
Plasmodium falciparum serine repeat antigen 9 0.0266 0.0283 0.3549
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0266 0.0283 0.3549
Brugia malayi Calmodulin-like protein 0.0393 0.0427 0.0427
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.005 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.257 0.2886 0.2886
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.056 0.0615 1
Loa Loa (eye worm) myosin regulatory light chain 1 0.0071 0.0062 0.0062
Echinococcus granulosus calbindin 32 0.0397 0.0431 0.0431
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0266 0.0283 0.0283
Echinococcus multilocularis centrin 2 0.0393 0.0427 0.0427
Onchocerca volvulus 0.0266 0.0283 0.0565
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0177 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.003 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Echinococcus multilocularis hypothetical protein 0.257 0.2886 0.2886
Brugia malayi Neuronal calcium sensor family protein 1 0.0071 0.0062 0.0062
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0394 0.0428 0.13
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Brugia malayi hypothetical protein 0.0043 0.0031 0.0031
Giardia lamblia DINP protein human, muc B family 0.0021 0.0006 0.0008
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0394 0.0428 0.0428
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0033 0.0032
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0296 0.4783
Trichomonas vaginalis calmodulin, putative 0.0464 0.0507 0.1532
Schistosoma mansoni lipoxygenase 0.0176 0.0181 0.0181
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0041 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0041 0.0041
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0266 0.0283 0.3549
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0393 0.0427 0.0427
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0029 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Echinococcus multilocularis musashi 0.0033 0.0019 0.0019
Schistosoma mansoni calpain (C02 family) 0.257 0.2886 0.2886
Entamoeba histolytica calcium-binding protein, putative 0.0393 0.0427 0.2045
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.0181 0.0181
Trichomonas vaginalis centrin, putative 0.0393 0.0427 0.1288
Echinococcus granulosus dna polymerase kappa 0.0042 0.0029 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0031 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0031 0.0451
Leishmania major calpain protease-like protein 0.072 0.0796 0.2422
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.003 0.003
Trichomonas vaginalis calpain, putative 0.072 0.0796 0.2413
Brugia malayi hypothetical protein 0.004 0.0027 0.0027
Toxoplasma gondii EF hand domain-containing protein 0.0393 0.0427 0.1298
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0393 0.0427 0.1298
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0062 0.0062
Echinococcus multilocularis tumor protein p63 0.0343 0.037 0.037
Echinococcus multilocularis RUN 0.004 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0029 0.0088
Plasmodium vivax unspecified product 0.0266 0.0283 0.0979
Schistosoma mansoni myosin regulatory light chain 0.0071 0.0062 0.0062
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0027 0.0027
Leishmania major DNA polymerase kappa, putative 0.0021 0.0006 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0029
Schistosoma mansoni cathepsin S (C01 family) 0.0266 0.0283 0.0283
Brugia malayi follicle stimulating hormone receptor 0.028 0.0298 0.0298
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0031 0.0031
Entamoeba histolytica cysteine proteinase 2 0.0266 0.0283 0.1348
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Toxoplasma gondii troponin c, isotype gamma, putative 0.0393 0.0427 0.1298
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0001 0.0003
Trypanosoma brucei Calpain-like protein 1.2 0.072 0.0796 0.2422
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trichomonas vaginalis calcium binding protein, putative 0.0071 0.0062 0.0178
Schistosoma mansoni neuronal calcium sensor 0.0393 0.0427 0.0427
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2925 0.3288 0.3288
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.0283 0.0283
Schistosoma mansoni rab 0.0393 0.0427 0.0427
Mycobacterium leprae Probable lipase LipE 0.0043 0.0031 0.0716
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.003
Echinococcus multilocularis calmodulin 0.0393 0.0427 0.0427
Trypanosoma brucei calmodulin, putative 0.0393 0.0427 0.1298
Entamoeba histolytica grainin 2 0.0464 0.0507 0.2431
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0011
Echinococcus multilocularis calpain family protein 1, d 0.5086 0.573 0.573
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.072 0.0796 0.2422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0052 0.0729
Entamoeba histolytica cysteine protease, putative 0.0266 0.0283 0.1348
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0283 0.0849
Trypanosoma cruzi caltractin, putative 0.0393 0.0427 0.0427
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0177 0.2629
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.072 0.0796 0.2413
Schistosoma mansoni rab6-interacting 0.004 0.0027 0.0027
Loa Loa (eye worm) beta-lactamase 0.0043 0.0031 0.0031
Leishmania major cathepsin L-like protease 0.0266 0.0283 0.0859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.257 0.2886 0.2886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.005 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0052 0.0729
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0283 0.0565
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0005 0.0005
Giardia lamblia Cathepsin L-like protease 0.0266 0.0283 0.0849
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.0283 0.0283
Schistosoma mansoni inositol monophosphatase 0.0037 0.0025 0.0024
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.003 0.003
Trypanosoma cruzi cysteine protease, putative 0.0266 0.0283 0.0283
Trypanosoma cruzi calpain cysteine peptidase, putative 0.257 0.2886 0.2886
Schistosoma mansoni neuronal calcium sensor 0.0393 0.0427 0.0427
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.003 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0006 0.0042
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0027 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.0005
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0266 0.0283 0.3549
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.005 0.005
Toxoplasma gondii calmodulin CAM1 0.0397 0.0431 0.1311
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0283 0.0283
Trypanosoma brucei Calpain-like protein 1.1 0.072 0.0796 0.2422
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0393 0.0427 0.2045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0381 0.1823
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0031 0.0451
Entamoeba histolytica calcium binding family protein 0.0393 0.0427 0.2045
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.003 0.0091
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0031 0.0451
Onchocerca volvulus 0.0071 0.0062 0.0116
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.003 0.0432
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0266 0.0283 0.0849
Trichomonas vaginalis calpain, putative 0.072 0.0796 0.2413
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0266 0.0283 0.0859
Brugia malayi beta-lactamase family protein 0.0043 0.0031 0.0031
Onchocerca volvulus 0.0266 0.0283 0.0565
Loa Loa (eye worm) doublecortin family protein 0.004 0.0027 0.0027
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0027 0.0027
Plasmodium vivax telomerase reverse transcriptase, putative 0.0177 0.0182 0.0631
Echinococcus granulosus cathepsin L cysteine proteinase 0.0266 0.0283 0.0283
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.0005
Echinococcus multilocularis neuronal calcium sensor 0.0393 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0283 0.0849
Echinococcus granulosus lamin dm0 0.0033 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0011
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.006 0.005 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0005
Echinococcus granulosus calpain 0.257 0.2886 0.2886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0283 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0018 0.0054
Plasmodium vivax vivapain-2 0.0266 0.0283 0.0979
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.003 0.04
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0266 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0266 0.0283 0.0283
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0393 0.0427 0.1288
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0022 0.0065
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0393 0.0427 0.0427
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0027 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.0796
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.072 0.0796 0.2422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0004
Trichomonas vaginalis calmodulin, putative 0.0393 0.0427 0.1288
Trypanosoma brucei calpain-like protein, putative 0.257 0.2886 0.8778
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0029 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.0283 0.1348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Trichomonas vaginalis kakapo, putative 0.0071 0.0062 0.0178
Schistosoma mansoni Mername-AA248 (C02 family) 0.257 0.2886 0.2886
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.003 0.003
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0393 0.0427 0.0427
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0029 0.0029
Trypanosoma brucei protein I/6 0.0393 0.0427 0.1298
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0283 0.0979
Loa Loa (eye worm) hypothetical protein 0.0286 0.0305 0.0305
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0133
Giardia lamblia Encystation-specific protease 0.0266 0.0283 0.0849
Trichomonas vaginalis caltractin, putative 0.0071 0.0062 0.0178
Trichomonas vaginalis calpain, putative 0.072 0.0796 0.2413
Loa Loa (eye worm) hypothetical protein 0.6935 0.7819 0.7819
Onchocerca volvulus 0.0266 0.0283 0.0565
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0266 0.0283 0.0979
Trypanosoma cruzi centrin, putative 0.0464 0.0507 0.0507
Trypanosoma cruzi centrin, putative 0.0464 0.0507 0.0507
Echinococcus granulosus cathepsin l1 0.0266 0.0283 0.0283
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0031 0.0031
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.072 0.0796 0.2422
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.0005
Trichomonas vaginalis calmodulin, putative 0.0397 0.0431 0.1302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0381 0.1149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0283 0.0849
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0031 0.0451

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 120 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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