Detailed information for compound 1407635

Basic information

Technical information
  • TDR Targets ID: 1407635
  • Name: N-(4-methylpiperazine-1-carbothioyl)-4-morpho lin-4-ylsulfonylbenzamide
  • MW: 412.527 | Formula: C17H24N4O4S2
  • H donors: 1 H acceptors: 3 LogP: 0.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=S)NC(=O)c1ccc(cc1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C17H24N4O4S2/c1-19-6-8-20(9-7-19)17(26)18-16(22)14-2-4-15(5-3-14)27(23,24)21-10-12-25-13-11-21/h2-5H,6-13H2,1H3,(H,18,22,26)
  • InChiKey: AXKBRGLGTKIITM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methylpiperazine-1-carbothioyl)-4-morpholinosulfonyl-benzamide
  • N-[(4-methyl-1-piperazinyl)-thioxomethyl]-4-morpholinosulfonylbenzamide
  • N-(4-methylpiperazin-1-yl)carbothioyl-4-morpholin-4-ylsulfonyl-benzamide
  • SMR000247541
  • T0510-1808
  • MLS000418672

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0854 0.1209
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0166 0.0535
Schistosoma mansoni coup transcription factor 0.0012 0.0166 0.0535
Trypanosoma brucei polo-like protein kinase 0.0114 0.3106 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0166 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0166 0.0535
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0166 0.0535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0166 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0166 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0166 0.0235
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.479 0.5
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0166 0.0535
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0166 0.0535
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8069 0.7744
Brugia malayi ecdysteroid receptor 0.0012 0.0166 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3106 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.193 0.6214
Brugia malayi nuclear receptor NHR-88 0.0012 0.0166 0.0235
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.479 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3106 0.372
Brugia malayi steroid hormone receptor 0.0012 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.193 0.6214
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3106 0.4395
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Brugia malayi Pre-SET motif family protein 0.0251 0.7067 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0166 0.0535
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0166 0.0235
Brugia malayi nuclear hormone receptor 0.0012 0.0166 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0166 0.0235
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0166 0.0535
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0166 0.0535
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0854 0.275
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0166 0.0535
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0854 0.275
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0166 0.0535
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3106 0.4395
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0166 0.0235
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.193 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0166 0.0535
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0166 0.0535
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0166 0.0535
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0166 0.0535
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0166 0.0235
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3106 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0166 0.0535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.193 0.6214
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0166 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0854 0.275
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3106 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0816 0.2627
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.479 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3106 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0854 0.275
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0166 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0166 0.0235
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0166 0.0235
Schistosoma mansoni kinase 0.0058 0.1487 0.4788
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0166 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0166 0.0235
Brugia malayi Pre-SET motif family protein 0.0036 0.0854 0.1209
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7067 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3106 0.1943
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.193 0.6214
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0166 0.0535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0166 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0166 0.0235
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0166 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0166 0.0235
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0166 0.0535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0166 0.0535
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0166 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0854 0.275
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0235
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3106 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0166 0.0535
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0166 0.0535
Onchocerca volvulus 0.0286 0.8069 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0854 0.275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0166 0.0235
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0166 0.0535
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0854 0.275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0166 0.0235
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0166 0.0535
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0166 0.0535
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0166 0.0535
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3106 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0166 0.0535
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0166 0.0535
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0166 0.0535
Onchocerca volvulus 0.0036 0.0854 0.0871
Plasmodium vivax SET domain protein, putative 0.0036 0.0854 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0166 0.0235

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 6.7016 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 9.4574 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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