Detailed information for compound 1408016

Basic information

Technical information
  • TDR Targets ID: 1408016
  • Name: 4,8-dimethyl-3-(3-oxobutyl)-1H-quinolin-2-one
  • MW: 243.301 | Formula: C15H17NO2
  • H donors: 1 H acceptors: 3 LogP: 2.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)CCc1c(O)nc2c(c1C)cccc2C
  • InChi: 1S/C15H17NO2/c1-9-5-4-6-12-11(3)13(8-7-10(2)17)15(18)16-14(9)12/h4-6H,7-8H2,1-3H3,(H,16,18)
  • InChiKey: ZBQQMRRWZNQLOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-ketobutyl)-4,8-dimethyl-carbostyril
  • MLS000107912
  • SMR000103876

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0121 0.0672
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0101 0.9885
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0047 0.0665
Echinococcus multilocularis geminin 0.0205 0.1094 0.2417
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0081
Echinococcus granulosus pyruvate kinase 0.0033 0.0102 0.0595
Schistosoma mansoni hypothetical protein 0.0205 0.1094 0.6569
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0047 0.0322
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0102 0.045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.008
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0076 0.5996
Leishmania major importin beta-1 subunit, putative 0.0023 0.0045 0.1779
Schistosoma mansoni hypothetical protein 0.004 0.0144 0.0812
Plasmodium vivax importin-beta 2, putative 0.0028 0.0076 0.5996
Brugia malayi RNA binding protein 0.0062 0.0272 0.1756
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0047 0.0665
Schistosoma mansoni importin beta-1 0.0028 0.0076 0.0403
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0013 0.0365
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0272 0.1756
Echinococcus multilocularis pyruvate kinase 0.0033 0.0102 0.0219
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.4518 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0153 0.0919
Echinococcus granulosus snurportin 1 0.0303 0.1661 1
Echinococcus granulosus muscleblind protein 0.0147 0.0761 0.4571
Schistosoma mansoni patched 1 0.0042 0.0153 0.0864
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1565 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0121 0.0672
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0047 0.0277
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0121 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0153 0.078
Echinococcus granulosus expressed conserved protein 0.0091 0.0438 0.2621
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0056 0.4139
Schistosoma mansoni pyruvate kinase 0.0033 0.0102 0.0559
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1364 0.8213
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0033 0.018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0101 0.0607
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0102 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0117 0.0685
Echinococcus multilocularis muscleblind protein 0.0147 0.0761 0.1678
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0013 0.0304
Leishmania major pyruvate kinase 0.0033 0.0102 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0272 0.159
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0014
Brugia malayi TAR-binding protein 0.0062 0.0272 0.1756
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.4979
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0712 0.4274
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0106 0.0526 0.1382
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0047 0.0665
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0045 0.0265
Echinococcus granulosus importin subunit beta 1 0.0028 0.0076 0.044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0045 0.027
Loa Loa (eye worm) RNA binding protein 0.0062 0.0272 0.164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.02
Mycobacterium ulcerans recombinase A 0.0106 0.0526 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0336
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.3283
Schistosoma mansoni intermediate filament proteins 0.0033 0.0101 0.055
Onchocerca volvulus 0.0286 0.1565 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0102 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0117 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0272 0.159
Schistosoma mansoni hypothetical protein 0.0303 0.1661 1
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0039
Brugia malayi follicle stimulating hormone receptor 0.028 0.1528 1
Schistosoma mansoni hypothetical protein 0.004 0.0144 0.0812
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0272 0.159
Chlamydia trachomatis pyruvate kinase 0.0033 0.0102 0.1734
Schistosoma mansoni hypothetical protein 0.004 0.0144 0.0812
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0272 0.159
Entamoeba histolytica hypothetical protein 0.0035 0.0117 0.1911
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0121 0.0672
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0102 0.0361
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0047 0.2049
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0153 0.033
Loa Loa (eye worm) hypothetical protein 0.0051 0.0207 0.1244
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0033 0.2099
Entamoeba histolytica hypothetical protein 0.0035 0.0117 0.1911
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0102 0.0361
Echinococcus multilocularis pyruvate kinase 0.0026 0.0062 0.013
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0472 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0102 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0121 0.0672
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0272 0.159
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.6273
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0102 0.8312
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0047 0.004
Schistosoma mansoni hypothetical protein 0.0035 0.0117 0.0649
Brugia malayi CHE-14 protein 0.0042 0.0153 0.0969
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0102 0.1734
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0047 0.0665
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0013 0.0005
Giardia lamblia Pyruvate kinase 0.0033 0.0102 1
Onchocerca volvulus 0.0036 0.0121 0.0485
Schistosoma mansoni lamin 0.0033 0.0101 0.055
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0076 0.0162
Onchocerca volvulus 0.0033 0.0101 0.0352
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.008
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0047 0.0277
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0102 0.0615
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0472 0.2826
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0047 0.0277
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0285
Leishmania major hypothetical protein, conserved 0.0025 0.0056 0.3283
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.046
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0047 0.0665
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0101 0.9885
Echinococcus multilocularis musashi 0.0033 0.0101 0.0216
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0102 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.2525
Echinococcus multilocularis protein dispatched 1 0.0047 0.0187 0.0406
Echinococcus granulosus tar DNA binding protein 0.0062 0.0272 0.1623
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0097 0.0586
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.028
Entamoeba histolytica hypothetical protein 0.0035 0.0117 0.1911
Brugia malayi Pre-SET motif family protein 0.0036 0.0121 0.076
Echinococcus multilocularis snurportin 1 0.0303 0.1661 0.3671
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0047 0.0322
Echinococcus granulosus geminin 0.0205 0.1094 0.6582
Plasmodium falciparum importin beta, putative 0.0028 0.0076 0.7214
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.1528 0.9199
Chlamydia trachomatis recombinase RecA 0.0106 0.0526 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.2525
Plasmodium vivax SET domain protein, putative 0.0036 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0615
Brugia malayi hypothetical protein 0.0025 0.0056 0.0333
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0033 0.0066
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0712 0.1569
Loa Loa (eye worm) hypothetical protein 0.0147 0.0761 0.4582
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0056 0.3283
Mycobacterium leprae Conserved hypothetical protein 0.0622 0.3508 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0102 0.0559
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0047 0.0665
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0121 0.026
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0047 0.2049
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.3283
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0121 0.0708
Loa Loa (eye worm) hypothetical protein 0.0042 0.0153 0.0919
Onchocerca volvulus 0.0033 0.0101 0.0352
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0102 0.0615
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0047 0.004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.008
Schistosoma mansoni hypothetical protein 0.0205 0.1094 0.6569
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0045 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0047 0.0665
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0272 0.164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0285
Echinococcus granulosus intermediate filament protein 0.0033 0.0101 0.0587
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0102 0.045
Brugia malayi Importin beta-1 subunit 0.0028 0.0076 0.0468
Brugia malayi intermediate filament protein 0.0033 0.0101 0.0628
Treponema pallidum recombinase A 0.0106 0.0526 0.5
Brugia malayi hypothetical protein 0.0035 0.0117 0.0735
Entamoeba histolytica hypothetical protein 0.0035 0.0117 0.1911
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0153 0.09
Echinococcus granulosus lamin dm0 0.0033 0.0101 0.0587
Echinococcus multilocularis protein patched 0.0042 0.0153 0.033
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0113 0.0662
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.008
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0101 0.9885
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0021
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0056 0.4139
Schistosoma mansoni ran 0.0021 0.0033 0.0141
Loa Loa (eye worm) hypothetical protein 0.0097 0.0472 0.2841
Brugia malayi Pre-SET motif family protein 0.0251 0.1364 0.8924
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0102 0.0637
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0272 0.0596
Loa Loa (eye worm) hypothetical protein 0.0147 0.0761 0.4582
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0472 0.1037
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1661 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0121 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0153 0.09
Schistosoma mansoni hypothetical protein 0.004 0.0144 0.0812
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0101 0.0628
Echinococcus granulosus pyruvate kinase 0.0033 0.0102 0.0595
Echinococcus granulosus lamin 0.0033 0.0101 0.0587
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.6273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0607
Mycobacterium ulcerans hypothetical protein 0.0023 0.0047 0.0665
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0185
Echinococcus multilocularis lamin 0.0033 0.0101 0.0216
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0045 0.027
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0472 0.3065
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0102 0.0615
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0047 0.0322
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0106 0.0526 0.5
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0045 0.1779
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0102 0.0361
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0117 0.0649
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0728
Echinococcus multilocularis expressed conserved protein 0.0091 0.0438 0.0962
Brugia malayi Muscleblind-like protein 0.0147 0.0761 0.4964
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.164 0.9387 0.9387
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0102 0.8312
Schistosoma mansoni ran 0.0021 0.0033 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0101 0.0607
Echinococcus multilocularis pyruvate kinase 0.0033 0.0102 0.0219
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0102 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0102 0.0637
Leishmania major pyruvate kinase 0.0033 0.0102 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0047 0.2049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0272 0.164
Echinococcus multilocularis lamin dm0 0.0033 0.0101 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0033 0.2099
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0761 0.1678
Brugia malayi RNA, U transporter 1 0.0081 0.0378 0.2451
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0481 0.285
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.4979
Schistosoma mansoni lamin 0.0033 0.0101 0.055
Plasmodium falciparum pyruvate kinase 0.0033 0.0102 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0102 0.0158

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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