Detailed information for compound 1408017

Basic information

Technical information
  • TDR Targets ID: 1408017
  • Name: N-[4-[(4-methylphenyl)sulfamoyl]phenyl]thioph ene-2-carboxamide
  • MW: 372.461 | Formula: C18H16N2O3S2
  • H donors: 2 H acceptors: 3 LogP: 3.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)NC(=O)c1cccs1
  • InChi: 1S/C18H16N2O3S2/c1-13-4-6-15(7-5-13)20-25(22,23)16-10-8-14(9-11-16)19-18(21)17-3-2-12-24-17/h2-12,20H,1H3,(H,19,21)
  • InChiKey: PVEOWTQKISAPJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(4-methylphenyl)sulfamoyl]phenyl]-2-thiophenecarboxamide
  • N-(4-{[(4-methylphenyl)amino]sulfonyl}phenyl)-2-thiophenecarboxamide
  • SMR000199570
  • STK128917
  • ZINC02734625
  • MLS000581079

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0079 0.0736 0.1777
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0134 0.1303 0.3145
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0024 0.0173 0.0165
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0079 0.0736 0.1777
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0121 0.117 0.2826
Schistosoma mansoni inositol monophosphatase 0.0021 0.0139 0.0163
Plasmodium falciparum acyl-CoA synthetase 0.0008 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Mycobacterium ulcerans hypothetical protein 0.0011 0.0032 0.0571
Entamoeba histolytica deoxycytidyl transferase, putative 0.0024 0.0173 0.0398
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0207 0.05
Leishmania major eukaryotic initiation factor 4a, putative 0.0011 0.0033 0.0081
Echinococcus granulosus cathepsin l cysteine peptidase 0.041 0.4142 0.4868
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0369 0.0361
Brugia malayi exodeoxyribonuclease III family protein 0.0008 0.0009 0.0021
Schistosoma mansoni cathepsin F (C01 family) 0.041 0.4142 0.4873
Echinococcus granulosus cathepsin L 0.0213 0.2117 0.2483
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.214 0.2518
Trypanosoma brucei unspecified product 0.0017 0.0095 0.023
Mycobacterium tuberculosis Probable lipase LipE 0.0017 0.01 0.0908
Giardia lamblia Hypothetical protein 0.0079 0.0736 0.629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Loa Loa (eye worm) inositol-1 0.0021 0.0139 0.0335
Giardia lamblia Cathepsin B precursor 0.0079 0.0736 0.629
Schistosoma mansoni terminal deoxycytidyl transferase 0.0024 0.0173 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.041 0.4142 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0276 0.2761 0.6666
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0077
Onchocerca volvulus 0.0079 0.0736 0.1713
Echinococcus granulosus survival motor neuron protein 1 0.0219 0.2178 0.2555
Brugia malayi MH1 domain containing protein 0.001 0.003 0.0072
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0736 0.1777
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0011 0.0033 0.0039
Brugia malayi Cathepsin L-like precursor 0.0276 0.2761 0.6666
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0009 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.049 0.1184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0011 0.0033 0.0081
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.001
Brugia malayi Papain family cysteine protease containing protein 0.041 0.4142 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.041 0.4142 0.4868
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0267 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.011 0.1059 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8498 1
Schistosoma mansoni DNA polymerase eta 0.0024 0.0173 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0024 0.0173 0.0419
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0115 0.0278
Entamoeba histolytica hypothetical protein 0.0043 0.0369 0.0872
Leishmania major hypothetical protein, conserved 0.0017 0.01 0.0241
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.001 0.0026 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Trypanosoma brucei importin beta-1 subunit, putative 0.0014 0.0063 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0736 0.0866
Trypanosoma brucei DNA polymerase IV, putative 0.0024 0.0173 0.0419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0121 0.117 0.2826
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.2328 0.5621
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.01 0.0241
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0011 0.0033 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0736 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Schistosoma mansoni cathepsin B (C01 family) 0.0079 0.0736 0.0866
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.01 0.022
Leishmania major DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.049 0.0567
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0011 0.0033 0.0081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0024 0.0173 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0095 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0032 0.0571
Schistosoma mansoni hypothetical protein 0.0081 0.076 0.0894
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0011 0.0032 0.0571
Leishmania major eukaryotic initiation factor 4a, putative 0.0011 0.0033 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0267 0.0645
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Echinococcus multilocularis GPCR, family 2 0.0019 0.0115 0.0106
Giardia lamblia Cathepsin B precursor 0.0121 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.2761 0.6666
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.2117 0.2491
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.01 0.022
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0736 0.1777
Schistosoma mansoni hypothetical protein 0.0019 0.0115 0.0135
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0382 0.0923
Onchocerca volvulus 0.0017 0.01 0.0165
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0561 0.1354
Trypanosoma brucei unspecified product 0.0017 0.0095 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.0577
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.01 0.0118
Brugia malayi hypothetical protein 0.0043 0.0369 0.0891
Trypanosoma cruzi cysteine peptidase, putative 0.041 0.4142 1
Giardia lamblia Cathepsin B precursor 0.0079 0.0736 0.629
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0561 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0207 0.05
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0011 0.0033 0.0081
Onchocerca volvulus 0.0266 0.2661 0.6396
Schistosoma mansoni smad1 5 8 and 0.001 0.003 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.01 0.0118
Brugia malayi beta-lactamase family protein 0.0017 0.01 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0736 0.176
Schistosoma mansoni cathepsin S (C01 family) 0.0079 0.0736 0.0866
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0011 0.0033 0.0081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.041 0.4142 0.4136
Echinococcus granulosus snurportin 1 0.0147 0.143 0.1674
Trypanosoma cruzi importin beta-1 subunit, putative 0.0011 0.0036 0.0088
Schistosoma mansoni survival motor neuron protein 0.0045 0.0382 0.045
Mycobacterium tuberculosis Probable lipase LipD 0.0017 0.01 0.0908
Plasmodium falciparum serine repeat antigen 1 0.0079 0.0736 0.1777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0036 0.0067
Plasmodium falciparum serine repeat antigen 6 0.0079 0.0736 0.1777
Trichomonas vaginalis DNA polymerase eta, putative 0.0024 0.0173 0.0398
Plasmodium falciparum cysteine proteinase falcipain 2b 0.041 0.4142 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0008 0.0009 0.0076
Giardia lamblia Cysteine protease 0.0079 0.0736 0.629
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.003 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.049 0.0567
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0736 0.1777
Schistosoma mansoni cathepsin C 0.0079 0.0736 0.0866
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.003 0.0072
Brugia malayi fibroinase precursor 0.0079 0.0736 0.1777
Onchocerca volvulus 0.041 0.4142 1
Mycobacterium tuberculosis Conserved protein 0.0017 0.01 0.0908
Brugia malayi cathepsin L-like precursor 0.0276 0.2761 0.6666
Echinococcus granulosus Smad4 0.001 0.003 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0173 0.0419
Plasmodium vivax acyl-CoA synthetase, putative 0.0008 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Echinococcus granulosus cathepsin L cysteine protease 0.0213 0.2117 0.2483
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0032 0.0077
Giardia lamblia DINP protein human, muc B family 0.0024 0.0173 0.1482
Loa Loa (eye worm) ctsf protein 0.041 0.4142 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0139 0.0335
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.2117 0.51
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.049 0.1184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Schistosoma mansoni hypothetical protein 0.0012 0.005 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Toxoplasma gondii cathepsin B 0.0121 0.117 0.2826
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.01 0.022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0139 0.0314
Echinococcus multilocularis cathepsin L 0.0079 0.0736 0.0728
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0011 0.0032 0.0264
Trypanosoma brucei DNA polymerase eta, putative 0.0024 0.0173 0.0419
Giardia lamblia Hypothetical protein 0.0079 0.0736 0.629
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0079 0.0736 0.1777
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0369 0.0434
Loa Loa (eye worm) Smad1 0.001 0.003 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0219 0.2178 0.2171
Entamoeba histolytica Ran family GTPase 0.001 0.0026 0.0041
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0079 0.0736 0.629
Giardia lamblia Cathepsin L-like protease 0.0079 0.0736 0.629
Brugia malayi MH2 domain containing protein 0.001 0.003 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0736 0.0866
Mycobacterium ulcerans DNA polymerase IV 0.0024 0.0173 0.3091
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0173 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Giardia lamblia Cysteine protease 0.0079 0.0736 0.629
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0267 0.0314
Toxoplasma gondii cathepsin CPL 0.041 0.4142 1
Entamoeba histolytica cysteine proteinase, putative 0.041 0.4142 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0079 0.0736 0.1777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Loa Loa (eye worm) cathepsin B 0.0121 0.117 0.2826
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.2117 0.5111
Schistosoma mansoni cathepsin F (C01 family) 0.041 0.4142 0.4873
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0017 0.01 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Plasmodium falciparum cysteine proteinase falcipain 3 0.041 0.4142 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0017 0.01 0.0908
Toxoplasma gondii preprocathepsin c precursor, putative 0.0079 0.0736 0.1777
Trypanosoma brucei DNA polymerase IV, putative 0.0024 0.0173 0.0419
Brugia malayi MH2 domain containing protein 0.001 0.003 0.0072
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0736 0.629
Plasmodium falciparum cysteine proteinase falcipain 2a 0.041 0.4142 1
Mycobacterium tuberculosis Probable esterase LipL 0.0017 0.01 0.0908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0736 0.1777
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0267 0.0304
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0011 0.0033 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0079 0.0736 0.1777
Echinococcus multilocularis inositol monophosphatase 1 0.0021 0.0139 0.013
Schistosoma mansoni hypothetical protein 0.0081 0.076 0.0894
Echinococcus multilocularis muscleblind protein 1 0.0344 0.346 0.3454
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0115 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Schistosoma mansoni smad 0.001 0.003 0.0035
Echinococcus granulosus GTP binding nuclear protein Ran 0.001 0.0026 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.2117 0.51
Brugia malayi beta-lactamase 0.0017 0.01 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0267 0.0314
Plasmodium vivax vivapain-2 0.041 0.4142 1
Plasmodium vivax vivapain-3 0.0213 0.2117 0.5111
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0079 0.0736 0.0866
Echinococcus granulosus geminin 0.0081 0.076 0.0884
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0008 0.0009 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Leishmania major cysteine peptidase A (CPA) 0.041 0.4142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Schistosoma mansoni ran 0.001 0.0026 0.003
Brugia malayi Smad1 0.001 0.003 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0032 0.0571
Echinococcus multilocularis snurportin 1 0.0147 0.143 0.1422
Onchocerca volvulus 0.041 0.4142 1
Brugia malayi Importin beta-1 subunit 0.0014 0.0063 0.0153
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0011 0.0033 0.0277
Brugia malayi hypothetical protein 0.0028 0.0207 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0079 0.0736 0.176
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0032 0.0077
Trypanosoma cruzi cysteine protease, putative 0.0213 0.2117 0.5111
Schistosoma mansoni ran 0.001 0.0026 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0561 1
Giardia lamblia Cathepsin L-like protease 0.0079 0.0736 0.629
Trichomonas vaginalis set domain proteins, putative 0.0266 0.2661 0.6416
Echinococcus multilocularis cathepsin L cysteine protease 0.041 0.4142 0.4136
Echinococcus multilocularis geminin 0.0081 0.076 0.0751
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0115 0.0106
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0033 0.0059
Plasmodium falciparum serine repeat antigen 4 0.0079 0.0736 0.1777
Loa Loa (eye worm) cysteine protease 0.041 0.4142 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0008 0.0004 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0532 0.1285
Brugia malayi RNA, U transporter 1 0.0039 0.0324 0.0781
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0207 0.05
Onchocerca volvulus Cathepsin L homolog 0.041 0.4142 1
Echinococcus granulosus cathepsin b 0.0216 0.214 0.251
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0008 0.0009 0.0158
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0139 0.0335
Brugia malayi Cathepsin L-like precursor 0.0276 0.2761 0.6666
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0032 0.0077
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0019 0.0116 1
Trypanosoma cruzi cruzipain precursor, putative 0.041 0.4142 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0011 0.0033 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0008 0.0009 0.0021
Echinococcus granulosus cathepsin l1 0.0276 0.2761 0.3242
Loa Loa (eye worm) MH2 domain-containing protein 0.0154 0.1503 0.3629
Mycobacterium ulcerans hypothetical protein 0.0017 0.01 0.1782
Mycobacterium leprae Probable lipase LipE 0.0017 0.01 0.8079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.05
Loa Loa (eye worm) hypothetical protein 0.041 0.4142 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0736 0.176
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0736 0.176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0077
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0079 0.0736 0.1777
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0736 0.1777
Plasmodium falciparum serine repeat antigen 7 0.0079 0.0736 0.1777
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0736 0.1777
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0032 0.0056
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8498 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.2761 0.6666
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0121 0.117 0.2826
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Plasmodium vivax unspecified product 0.0213 0.2117 0.5111
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0736 0.629
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0736 0.629
Schistosoma mansoni cathepsin s 0.0134 0.1303 0.1533
Giardia lamblia Cathepsin B precursor 0.0079 0.0736 0.629
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0532 0.1285
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.001 0.0026 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0736 0.176
Brugia malayi cathepsin L precursor 0.0079 0.0736 0.1777
Schistosoma mansoni ap endonuclease 0.0008 0.0009 0.001
Brugia malayi Pre-SET motif family protein 0.0234 0.2328 0.5621
Echinococcus multilocularis Smad4 0.001 0.003 0.0021
Schistosoma mansoni cathepsin F (C01 family) 0.0276 0.2761 0.3249
Trypanosoma cruzi cysteine peptidase, putative 0.041 0.4142 1
Echinococcus multilocularis dna polymerase kappa 0.0024 0.0173 0.0165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0115 0.0278
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Echinococcus granulosus inositol monophosphatase 1 0.0021 0.0139 0.0153
Toxoplasma gondii exonuclease III APE 0.0008 0.0009 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0024 0.0173 0.0204
Loa Loa (eye worm) hypothetical protein 0.0344 0.346 0.8355
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0008 0.0009 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.041 0.4142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.1303 0.3145
Loa Loa (eye worm) fibroinase 0.041 0.4142 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.041 0.4142 0.4136
Loa Loa (eye worm) hypothetical protein 0.0134 0.1303 0.3145
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0021 0.0139 1
Echinococcus multilocularis cysteine protease 0.041 0.4142 0.4136
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0017 0.01 0.1782
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.2117 0.51
Toxoplasma gondii ABC1 family protein 0.0017 0.01 0.0241
Plasmodium vivax hypothetical protein, conserved 0.0017 0.01 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.2117 0.5111
Mycobacterium ulcerans lipase LipD 0.0017 0.01 0.1782
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Mycobacterium ulcerans beta-lactamase 0.0017 0.01 0.1782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.2117 0.51
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8498 0.8497
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.001 0.0026 0.0063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0173 0.0419
Entamoeba histolytica cysteine proteinase, putative 0.041 0.4142 1
Loa Loa (eye worm) transcription factor SMAD2 0.0154 0.1503 0.3629
Giardia lamblia Cysteine protease 0.0079 0.0736 0.629
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Echinococcus granulosus cathepsin b 0.0216 0.214 0.251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0079 0.0736 0.1777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Leishmania major GTP-binding protein, putative 0.001 0.0026 0.0063
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0011 0.0033 0.0029
Giardia lamblia Cathepsin B precursor 0.0079 0.0736 0.629
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.2117 0.5111
Schistosoma mansoni hypothetical protein 0.0147 0.143 0.1682
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0736 0.0866
Mycobacterium ulcerans DNA polymerase IV 0.0024 0.0173 0.3091
Onchocerca volvulus 0.0017 0.01 0.0165
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Echinococcus granulosus GPCR family 2 0.0019 0.0115 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0008 0.0009 0.0021
Echinococcus multilocularis importin subunit beta 1 0.0014 0.0063 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.049 0.0482
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Entamoeba histolytica cysteine proteinase 2 0.0213 0.2117 0.51
Plasmodium vivax vivapain-1 0.0213 0.2117 0.5111
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0561 0.1354
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.001
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0079 0.0736 0.1777
Giardia lamblia Cysteine protease 0.0079 0.0736 0.629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Echinococcus granulosus muscleblind protein 0.0344 0.346 0.4065
Onchocerca volvulus 0.041 0.4142 1
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0369 0.0424
Onchocerca volvulus 0.041 0.4142 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0024 0.0173 0.0419
Schistosoma mansoni importin beta-1 0.0014 0.0063 0.0074
Brugia malayi beta-lactamase family protein 0.0017 0.01 0.0241
Trichomonas vaginalis penicillin-binding protein, putative 0.0017 0.01 0.022
Trypanosoma brucei unspecified product 0.0024 0.0173 0.0419
Entamoeba histolytica hypothetical protein 0.0043 0.0369 0.0872
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.003 0.0021
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0079 0.0736 0.176
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0024 0.0173 0.0398
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.001 0.0026 0.0063
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0079 0.0736 0.1777
Brugia malayi Muscleblind-like protein 0.0344 0.346 0.8355
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0011 0.0033 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0267 0.0258
Toxoplasma gondii cathepsin CPC2 0.0079 0.0736 0.1777
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0736 0.176
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0173 0.1604
Loa Loa (eye worm) hypothetical protein 0.0134 0.1303 0.3145
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0011 0.0032 0.0571
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0213 0.2117 0.5111
Giardia lamblia Cathepsin B precursor 0.0121 0.117 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0095 0.023
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0032 0.0077
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Echinococcus granulosus cathepsin l1 0.041 0.4142 0.4868
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0115 0.0125
Schistosoma mansoni hypothetical protein 0.0041 0.0339 0.0399
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0032 0.0056
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0079 0.0736 0.0866
Schistosoma mansoni hypothetical protein 0.0019 0.0115 0.0135
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Echinococcus granulosus dna polymerase kappa 0.0024 0.0173 0.0194
Loa Loa (eye worm) hypothetical protein 0.0216 0.214 0.5167
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Schistosoma mansoni inositol monophosphatase 0.0021 0.0139 0.0163
Leishmania major importin beta-1 subunit, putative 0.0011 0.0036 0.0088
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0736 0.1777
Echinococcus granulosus smad 0.001 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0276 0.2761 0.6666
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0079 0.0736 0.176
Echinococcus granulosus cathepsin L 0.0079 0.0736 0.0857
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0079 0.0736 0.1777
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0561 0.065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0736 0.0866
Loa Loa (eye worm) papain family cysteine protease containing protein 0.041 0.4142 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0095 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0561 0.066
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0267 0.0258
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.2117 0.2491
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.214 0.2518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.003 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0008 0.0009 0.0021
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Entamoeba histolytica hypothetical protein 0.0043 0.0369 0.0872
Onchocerca volvulus 0.0034 0.0267 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0344 0.346 0.8355
Plasmodium vivax unspecified product 0.0079 0.0736 0.1777
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0008 0.0009 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0736 0.176
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0736 0.0866
Brugia malayi hypothetical protein 0.0219 0.2178 0.5258
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Brugia malayi Cathepsin L-like cysteine proteinase 0.0276 0.2761 0.6666
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0736 0.1713
Echinococcus multilocularis GTP binding nuclear protein Ran 0.001 0.0026 0.0017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.005 0.0048
Plasmodium falciparum serine repeat antigen 5 0.0079 0.0736 0.1777
Plasmodium vivax RNA helicase-1, putative 0.0011 0.0033 0.0081
Brugia malayi eukaryotic initiation factor 4A 0.0011 0.0033 0.0081
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0079 0.0736 0.1777
Plasmodium falciparum cysteine proteinase falcipain 1 0.0213 0.2117 0.5111
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.003 0.0024
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.003 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.041 0.4142 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0134 0.1303 0.3145
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.003 0.0024
Brugia malayi cathepsin F-like cysteine proteinase 0.0134 0.1303 0.3145
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0115 0.0106
Plasmodium falciparum serine repeat antigen 3 0.0079 0.0736 0.1777
Loa Loa (eye worm) hypothetical protein 0.0059 0.0532 0.1285
Onchocerca volvulus 0.0045 0.0382 0.0852
Brugia malayi cathepsin F-like cysteine proteinase 0.0079 0.0736 0.1777
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0011 0.0033 0.0025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.005 0.0041
Entamoeba histolytica cysteine protease, putative 0.041 0.4142 1
Trypanosoma cruzi cysteine proteinase, putative 0.0213 0.2117 0.5111
Schistosoma mansoni ap endonuclease 0.0008 0.0009 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0276 0.2761 0.6659
Schistosoma mansoni hypothetical protein 0.0045 0.0382 0.045
Treponema pallidum ATP-dependent RNA helicase 0.0011 0.0033 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0121 0.117 0.1377
Echinococcus multilocularis cathepsin L cysteine protease 0.041 0.4142 0.4136
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0043 0.0369 0.0434
Onchocerca volvulus 0.041 0.4142 1
Trichomonas vaginalis importin beta-1, putative 0.0011 0.0036 0.0067
Plasmodium falciparum serine repeat antigen 8 0.0079 0.0736 0.1777
Trypanosoma brucei importin beta-1 subunit, putative 0.0014 0.0063 0.0153
Entamoeba histolytica hypothetical protein 0.0011 0.0036 0.0067
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.001 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0079 0.0736 0.1777
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0032 0.0571
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0081
Echinococcus multilocularis cathepsin b 0.0216 0.214 0.2133
Onchocerca volvulus 0.041 0.4142 1
Plasmodium falciparum serine repeat antigen 2 0.0079 0.0736 0.1777
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0736 0.1777
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0011 0.0032 0.0571
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0207 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0079 0.0736 0.176
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Giardia lamblia Cathepsin B precursor 0.0121 0.117 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.001 0.0026 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.2117 0.51
Trichomonas vaginalis penicillin-binding protein, putative 0.0017 0.01 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.01 0.0241
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.001 0.0026 0.0063
Giardia lamblia Cathepsin L precursor 0.0079 0.0736 0.629
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0115 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0207 0.05
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.041 0.4142 1
Plasmodium falciparum importin beta, putative 0.0014 0.0063 0.0153
Loa Loa (eye worm) hypothetical protein 0.0034 0.0267 0.0645
Schistosoma mansoni Smad4 0.001 0.003 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0017 0.01 0.0908
Trichomonas vaginalis ran, putative 0.001 0.0026 0.0041
Echinococcus multilocularis dna polymerase eta 0.0024 0.0173 0.0165
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Loa Loa (eye worm) beta-lactamase 0.0017 0.01 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0561 0.0552
Mycobacterium tuberculosis Conserved protein 0.0017 0.01 0.0908
Echinococcus multilocularis muscleblind protein 0.0344 0.346 0.3454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Entamoeba histolytica hypothetical protein 0.0079 0.0736 0.176
Echinococcus multilocularis cysteine protease 0.041 0.4142 0.4136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0213 0.2117 0.2491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0267 0.0314
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0021 0.0139 0.0335
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0019 0.0116 0.1061
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0254 0.0289
Mycobacterium leprae conserved hypothetical protein 0.0017 0.01 0.8079
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Trypanosoma cruzi cysteine proteinase, putative 0.0213 0.2117 0.5111
Mycobacterium tuberculosis Probable hydrolase 0.0017 0.01 0.0908
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0008 0.0004 0.5
Echinococcus granulosus cysteine protease 0.0213 0.2117 0.2483
Plasmodium vivax importin-beta 2, putative 0.0014 0.0063 0.0153
Onchocerca volvulus 0.0017 0.01 0.0165
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0011 0.0032 0.0571
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0207 0.05
Entamoeba histolytica cysteine proteinase, putative 0.0213 0.2117 0.51
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0147 0.143 0.3452
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.001 0.0026 0.0221
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.001
Schistosoma mansoni smad1 5 8 and 0.001 0.003 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0213 0.2117 0.5111
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0267 0.0645
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0079 0.0736 0.176
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0561 0.5277
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Leishmania major hypothetical protein, conserved 0.0028 0.0207 0.05
Echinococcus granulosus importin subunit beta 1 0.0014 0.0063 0.0064
Onchocerca volvulus 0.041 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0011 0.0036 0.0067
Brugia malayi hypothetical protein 0.0018 0.0106 0.0256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0017 0.01 0.0908
Plasmodium vivax vivapain-2 0.041 0.4142 1
Onchocerca volvulus Cathepsin L homolog 0.041 0.4142 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0173 0.0419
Leishmania major DNA polymerase eta, putative 0.0024 0.0173 0.0419
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0241
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0032 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.0577
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Entamoeba histolytica hypothetical protein 0.0043 0.0369 0.0872
Entamoeba histolytica acyl-coA synthetase, putative 0.0011 0.0032 0.0056
Giardia lamblia Cathepsin B precursor 0.0079 0.0736 0.629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.0577
Echinococcus granulosus beta LACTamase domain containing family member 0.0017 0.01 0.0107
Trichomonas vaginalis esterase, putative 0.0017 0.01 0.022
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0736 0.1777
Onchocerca volvulus Cathepsin F homolog 0.041 0.4142 1
Mycobacterium tuberculosis Conserved protein 0.0017 0.01 0.0908
Toxoplasma gondii HEAT repeat-containing protein 0.0014 0.0063 0.0153
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0021 0.0139 0.0314
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Echinococcus multilocularis beta LACTamase domain containing family member 0.0017 0.01 0.0091
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0079 0.0736 0.1777
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0139 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0736 0.176
Trichomonas vaginalis inositol monophosphatase, putative 0.0021 0.0139 0.0314
Loa Loa (eye worm) hypothetical protein 0.0134 0.1303 0.3145
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.01 0.0241
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0736 0.1777
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Schistosoma mansoni smad1 5 8 and 0.001 0.003 0.0035
Giardia lamblia Encystation-specific protease 0.0079 0.0736 0.629
Echinococcus granulosus eukaryotic initiation factor 4A 0.0011 0.0033 0.0029
Brugia malayi Pre-SET motif family protein 0.0034 0.0267 0.0645
Mycobacterium ulcerans esterase/lipase LipP 0.0017 0.01 0.1782
Brugia malayi Inositol-1 0.0021 0.0139 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2761 0.6659
Schistosoma mansoni hypothetical protein 0.0019 0.0115 0.0135
Brugia malayi cathepsin B-like cysteine proteinase 0.0216 0.214 0.5167
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0079 0.0736 0.1777
Entamoeba histolytica cysteine protease, putative 0.0079 0.0736 0.176
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0011 0.0033 0.0039
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0139 0.0335
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0207 0.05
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0173 0.1604
Loa Loa (eye worm) hypothetical protein 0.0019 0.0115 0.0278
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.001 0.0026 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1303 0.3145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0011 0.0033 0.0059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0017 0.01 0.0241
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0216 0.214 0.5167
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0032 0.0077
Entamoeba histolytica cysteine protease, putative 0.0213 0.2117 0.51
Plasmodium falciparum serine repeat antigen 9 0.0079 0.0736 0.1777
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0139 0.0314
Echinococcus multilocularis smad 0.001 0.003 0.0021
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0736 0.1777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Onchocerca volvulus 0.0276 0.2761 0.664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.041 0.4142 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0736 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0079 0.0736 0.176
Echinococcus multilocularis cathepsin L 0.0213 0.2117 0.211
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0121 0.117 0.281
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0011 0.0033 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0736 0.176
Toxoplasma gondii cathepsin CPC1 0.0079 0.0736 0.1777
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0173 0.0419
Brugia malayi Cathepsin L-like precursor 0.0134 0.1303 0.3145
Leishmania major cathepsin L-like protease 0.041 0.4142 1
Brugia malayi MH1 domain containing protein 0.001 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0077
Brugia malayi cathepsin L-like cysteine proteinase 0.0079 0.0736 0.1777
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0419
Echinococcus granulosus dna polymerase eta 0.0024 0.0173 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.041 0.4142 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0213 0.2117 0.51
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0339 0.0819
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.214 0.2518
Schistosoma mansoni hypothetical protein 0.0019 0.0115 0.0135
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0021 0.0139 0.2475
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.2117 0.5111
Brugia malayi MH2 domain containing protein 0.0154 0.1503 0.3629
Plasmodium vivax unspecified product 0.0134 0.1303 0.3145
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0532 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0736 0.176
Brugia malayi Cathepsin L-like precursor 0.041 0.4142 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0216 0.214 0.2518
Loa Loa (eye worm) hypothetical protein 0.0219 0.2178 0.5258
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0008 0.0009 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0032 0.0077
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0736 0.1777
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0561 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0736 0.1777
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.049 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.041 0.4142 1
Echinococcus multilocularis cathepsin b 0.0216 0.214 0.2133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.041 0.4142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2761 0.6659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0736 0.176

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.206 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 0.3294 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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