Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0251 | 0.0251 |
Schistosoma mansoni | smad | 0.001 | 0.0251 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0251 | 0.0251 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0251 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0251 | 0.0251 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0251 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.793 | 0.793 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.793 | 0.793 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0251 | 0.0251 |
Brugia malayi | Smad1 | 0.001 | 0.0251 | 0.0251 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0251 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.793 | 0.793 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0251 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0251 | 0.0251 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0251 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0251 | 0.0251 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0251 | 0.0251 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | 6.3096 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.