TDR Targets

Basic information

Technical information

TDR Targets ID: 1408159
Name: 3-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)-N-(4-h ydroxyphenyl)propanamide
MW: 332.738 | Formula: C16H13ClN2O4
H donors: 2 H acceptors: 3 LogP: 2.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)O)CCn1c(=O)oc2c1ccc(c2)Cl
InChi: 1S/C16H13ClN2O4/c17-10-1-6-13-14(9-10)23-16(22)19(13)8-7-15(21)18-11-2-4-12(20)5-3-11/h1-6,9,20H,7-8H2,(H,18,21)
InChiKey: NOBPONWGZJHNCY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(6-chloro-2-keto-1,3-benzoxazol-3-yl)-N-(4-hydroxyphenyl)propionamide
STK239101
3-(6-Chloro-2-oxo-benzooxazol-3-yl)-N-(4-hydroxy-phenyl)-propionamide
BAS 13028597
ZINC04511980

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Raf kinase	0.0228	0.2306	0.2306
Echinococcus multilocularis	ras-related protein rab-5	0.0024	0.0159	0.0157
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.0402	0.4141	0.4141
Trypanosoma brucei	Presenilin enhancer-2 subunit of gamma secretase, putative	0.0114	0.1104	0.2636
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0148	0.0317
Onchocerca volvulus		0.0011	0.0024	0.0057
Leishmania major	hypothetical protein, conserved	0.0024	0.0159	0.0344
Schistosoma mansoni	cpg binding protein	0.0037	0.0295	0.0295
Loa Loa (eye worm)	TK/ROR protein kinase	0.0014	0.0054	0.0052
Trypanosoma brucei	polo-like protein kinase	0.0277	0.2825	0.6808
Echinococcus multilocularis	rab protein 3	0.0024	0.0159	0.0157
Onchocerca volvulus	Tyrosine kinase homolog	0.0372	0.3828	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0274	0.0274
Schistosoma mansoni	tyrosine kinase	0.0246	0.2498	0.2498
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0148	0.9232
Echinococcus granulosus	presenilin	0.0402	0.4141	0.414
Schistosoma mansoni	hypothetical protein	0.0011	0.0024	0.0024
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.0402	0.4141	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0011	0.0021	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0014	0.0057	0.0057
Echinococcus granulosus	lachesin	0.0014	0.0057	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0196	0.1972	0.197
Trypanosoma brucei	Nicastrin, putative	0.0072	0.0667	0.1576
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0159	0.0157
Trypanosoma cruzi	Nicastrin, putative	0.0072	0.0667	0.1576
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0014	0.0057	0.0055
Schistosoma mansoni	titin	0.0014	0.0057	0.0057
Loa Loa (eye worm)	presenilin spe-4	0.0141	0.1391	0.139
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0148	0.0317
Schistosoma mansoni	protein kinase C mu	0.0011	0.0021	0.0021
Schistosoma mansoni	glutaminase	0.033	0.3384	0.3384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Onchocerca volvulus	Mitochondrial Rho GTPase homolog	0.0024	0.0159	0.041
Toxoplasma gondii	hypothetical protein	0.0114	0.1104	0.7912
Onchocerca volvulus		0.0359	0.3683	0.9621
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0159	0.0157
Echinococcus multilocularis	Nicastrin	0.0196	0.1972	0.197
Giardia lamblia	Kinase, PLK	0.0277	0.2825	1
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0402	0.4141	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0159	0.0159
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0014	0.0057	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0011	0.0021	0.0021
Schistosoma mansoni	protein kinase	0.001	0.0017	0.0017
Echinococcus granulosus	protein kinase c iota type	0.0011	0.0021	0.0019
Chlamydia trachomatis	SWIB complex protein	0.0011	0.0024	0.5
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0011	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0148	0.5
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0014	0.0057	0.0057
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0246	0.2498	0.2498
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0148	0.0302
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0763	0.7936	0.7936
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.001	0.0017	0.0015
Echinococcus granulosus	GTP binding protein Parf	0.0024	0.0159	0.0157
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0374	0.3846	0.3845
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0277	0.2825	0.6808
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0159	0.0344
Trypanosoma brucei	Aph-1 protein, putative	0.0374	0.3841	0.9272
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0411	0.4238	0.4237
Echinococcus multilocularis	roundabout 2	0.0014	0.0057	0.0055
Trypanosoma brucei	Rab-like 5, small G protein	0.0024	0.0159	0.0344
Entamoeba histolytica	hypothetical protein	0.0024	0.0159	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0014	0.0057	0.0055
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0011	0.0021	0.0021
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0246	0.2498	0.2496
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0148	0.0146
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Echinococcus multilocularis	roundabout 2	0.0014	0.0057	0.0055
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Brugia malayi	Ras-related protein ypt4	0.0024	0.0159	0.0159
Echinococcus multilocularis	presenilin	0.0402	0.4141	0.414
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0014	0.0057	0.0055
Echinococcus granulosus	epidermal growth factor receptor	0.0411	0.4238	0.4237
Brugia malayi	Presenilin family protein	0.0402	0.4141	0.4141
Brugia malayi	brahma associated protein 60 kDa	0.0011	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0065	0.0063
Echinococcus multilocularis	epidermal growth factor receptor	0.0763	0.7936	0.7936
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0883	0.2086
Brugia malayi	hypothetical protein	0.0196	0.1972	0.1972
Brugia malayi	hypothetical protein	0.0141	0.1391	0.1391
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0159	0.0157
Schistosoma mansoni	septate junction protein	0.0014	0.0057	0.0057
Echinococcus multilocularis	roundabout 2	0.0014	0.0057	0.0055
Brugia malayi	RAB, member of RAS oncogene family-like 5	0.0024	0.0159	0.0159
Brugia malayi	Peroxidasin	0.0015	0.0065	0.0065
Brugia malayi	Presenilin spe-4	0.0141	0.1391	0.1391
Onchocerca volvulus		0.0035	0.0274	0.0711
Brugia malayi	Furin-like cysteine rich region family protein	0.0763	0.7936	0.7936
Brugia malayi	hypothetical protein	0.0141	0.1391	0.1391
Echinococcus multilocularis	lachesin	0.0014	0.0057	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0159	0.0328
Trichomonas vaginalis	hypothetical protein	0.0024	0.0159	0.0328
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0277	0.2825	0.6808
Brugia malayi	hypothetical protein	0.0196	0.1972	0.1972
Brugia malayi	Protein kinase domain containing protein	0.0558	0.5778	0.5778
Schistosoma mansoni	tyrosine kinase	0.0404	0.4158	0.4158
Schistosoma mansoni	hypothetical protein	0.0011	0.0024	0.0024
Echinococcus multilocularis	nicalin	0.0072	0.0667	0.0665
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0002	0.0002
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0601	0.4247
Schistosoma mansoni	tyrosine kinase	0.0022	0.0137	0.0137
Schistosoma mansoni	tyrosine kinase	0.0763	0.7936	0.7936
Echinococcus multilocularis	peroxidasin	0.0015	0.0065	0.0063
Chlamydia trachomatis	DNA topoisomerase I	0.0011	0.0024	0.5
Trichomonas vaginalis	glutaminase, putative	0.033	0.3384	0.8161
Trichomonas vaginalis	Nicastrin precursor, putative	0.0196	0.1972	0.4731
Echinococcus granulosus	roundabout 2	0.0014	0.0057	0.0055
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0057	0.0057
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0021	0.0021
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0057	0.0055
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0011	0.0024	0.0022
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0148	0.0302
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0021	0.0021
Echinococcus multilocularis	tyrosine protein kinase otk	0.0014	0.0057	0.0055
Echinococcus multilocularis	protein kinase c epsilon type	0.0011	0.0021	0.0019
Brugia malayi	hypothetical protein	0.0141	0.1391	0.1391
Echinococcus multilocularis	presenilin enhancer 2	0.0377	0.3881	0.388
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0148	0.0317
Entamoeba histolytica	hypothetical protein	0.0012	0.0037	0.0048
Echinococcus granulosus	SWI:SNF matrix associated	0.0011	0.0024	0.0022
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0148	0.0146
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0277	0.2825	0.7377
Schistosoma mansoni	ap endonuclease	0.0023	0.0148	0.0148
Echinococcus multilocularis	cpg binding protein	0.0037	0.0295	0.0293
Echinococcus granulosus	nicalin	0.0072	0.0667	0.0665
Plasmodium falciparum	ras-related protein Rab-5A	0.0024	0.0159	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0148	0.0148
Entamoeba histolytica	hypothetical protein	0.0072	0.0667	0.1576
Schistosoma mansoni	tyrosine kinase	0.0404	0.4158	0.4158
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Loa Loa (eye worm)	TK/INSR protein kinase	0.0246	0.2498	0.2496
Brugia malayi	Prion-like-	0.0014	0.0057	0.0057
Echinococcus multilocularis	protein kinase c iota type	0.0011	0.0021	0.0019
Echinococcus granulosus	neuroglian	0.0014	0.0057	0.0055
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0014	0.0054	0.0052
Schistosoma mansoni	tyrosine kinase	0.0411	0.4238	0.4238
Echinococcus multilocularis	hemicentin 1	0.0014	0.0057	0.0055
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0011	0.0021	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0002	0.0002
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0011	0.0024	0.0474
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0022	0.002
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0017	0.0085	0.0083
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0218	0.2202	0.22
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Brugia malayi	gamma-secretase subunit pen-2	0.0377	0.3881	0.3881
Schistosoma mansoni	tyrosine kinase	0.0404	0.4158	0.4158
Trichomonas vaginalis	TKL family protein kinase	0.0012	0.0037	0.0032
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0558	0.5778	0.5777
Echinococcus granulosus	Nicastrin	0.0196	0.1972	0.197
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0402	0.4141	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0277	0.2825	0.6808
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0883	0.2086
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0159	0.0344
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Echinococcus granulosus	Protein kinase C brain isozyme	0.0011	0.0021	0.0019
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0011	0.0024	0.0474
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0561	0.5817	0.5817
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0148	0.9193
Brugia malayi	SWIB/MDM2 domain containing protein	0.0011	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0011	0.0024	0.0024
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.002	0.002
Brugia malayi	Protein kinase c protein 2	0.0011	0.0021	0.0021
Loa Loa (eye worm)	glutaminase	0.033	0.3384	0.3383
Echinococcus multilocularis	SWI:SNF matrix associated	0.0011	0.0024	0.0022
Trypanosoma cruzi	Rab-like 5, small G protein	0.0024	0.0159	0.0344
Brugia malayi	Presenilin spe-4	0.0141	0.1391	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Trypanosoma cruzi	Aph-1 protein, putative	0.0374	0.3841	0.9272
Schistosoma mansoni	cpg binding protein	0.0035	0.0274	0.0274
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.0402	0.4141	1
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0021	0.0021
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0148	0.5
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0218	0.2202	0.22
Trypanosoma cruzi	polo-like protein kinase, putative	0.0277	0.2825	0.6808
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0011	0.0021	0.0019
Trichomonas vaginalis	Nicastrin precursor, putative	0.0196	0.1972	0.4731
Echinococcus granulosus	rab protein 3	0.0024	0.0159	0.0157
Echinococcus granulosus	contactin	0.0014	0.0057	0.0055
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0277	0.2825	0.2823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Brugia malayi	Presenilin-like protein At2g29900	0.0141	0.1391	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Brugia malayi	protein kinase C II.	0.0011	0.0021	0.0021
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0136	0.1345	0.1344
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0022	0.002
Schistosoma mansoni	septate junction protein	0.0014	0.0057	0.0057
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0011	0.0024	0.0049
Leishmania major	hypothetical protein, conserved	0.0024	0.0159	0.0344
Schistosoma mansoni	atypical protein kinase C	0.0011	0.0021	0.0021
Trypanosoma cruzi	Nicastrin, putative	0.0072	0.0667	0.1576
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0277	0.2825	0.2823
Echinococcus multilocularis	epidermal growth factor receptor	0.0411	0.4238	0.4237
Toxoplasma gondii	exonuclease III APE	0.0023	0.0148	0.0953
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0057	0.0055
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0558	0.5778	0.5777
Echinococcus granulosus	raf serine:threonine protein kinase	0.0236	0.239	0.2389
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0402	0.4141	1
Echinococcus multilocularis	insulin receptor	0.0246	0.2498	0.2496
Echinococcus granulosus	peroxidasin	0.0015	0.0065	0.0063
Echinococcus granulosus	presenilin enhancer 2	0.0377	0.3881	0.388
Schistosoma mansoni	tyrosine kinase	0.0246	0.2498	0.2498
Echinococcus granulosus	roundabout 2	0.0014	0.0057	0.0055
Schistosoma mansoni	serine/threonine protein kinase	0.0277	0.2825	0.2825
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0057	0.0057
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0011	0.0021	0.0019
Toxoplasma gondii	hypothetical protein	0.0141	0.1391	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0148	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0021	0.0021
Loa Loa (eye worm)	glutaminase 2	0.033	0.3384	0.3383
Echinococcus multilocularis	SWI:SNF matrix associated	0.0011	0.0024	0.0022
Brugia malayi	protein unc-22	0.0009	0.0002	0.0002
Echinococcus granulosus	roundabout 2	0.0014	0.0057	0.0055
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Schistosoma mansoni	ap endonuclease	0.0023	0.0148	0.0148
Schistosoma mansoni	nephrin	0.0014	0.0057	0.0057
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0402	0.4141	1
Brugia malayi	C1-like domain containing protein	0.0011	0.0021	0.0021
Plasmodium vivax	ras-related protein Rab-5A, putative	0.0024	0.0159	1
Brugia malayi	glutaminase DH11.1	0.033	0.3384	0.3384
Echinococcus multilocularis	hemicentin 1	0.0014	0.0057	0.0055
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0014	0.0054	0.0052
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0683	0.0683
Schistosoma mansoni	hypothetical protein	0.0196	0.1972	0.1972
Brugia malayi	hypothetical protein	0.0024	0.0159	0.0159
Loa Loa (eye worm)	brahma associated protein	0.0011	0.0024	0.0022
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0277	0.2825	0.2823
Echinococcus multilocularis	neuroglian	0.0014	0.0057	0.0055
Brugia malayi	brahma associated protein 60 kDa	0.0011	0.0024	0.0024
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0014	0.0057	0.0144
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0148	0.0317
Schistosoma mansoni	neuroglian	0.0014	0.0057	0.0057
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0402	0.4141	1
Leishmania major	hypothetical protein, conserved	0.0114	0.1104	0.2636
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0022	0.002
Echinococcus granulosus	epidermal growth factor receptor	0.0763	0.7936	0.7936
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0002	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0021	0.0021
Schistosoma mansoni	cpg binding protein	0.0037	0.0295	0.0295
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Echinococcus granulosus	hemicentin 1	0.0014	0.0057	0.0055
Entamoeba histolytica	hypothetical protein	0.0024	0.0159	0.0344
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.0017	0.0015
Loa Loa (eye worm)	TK protein kinase	0.0014	0.0054	0.0052
Schistosoma mansoni	roundabout	0.0014	0.0057	0.0057
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0148	0.0317
Echinococcus multilocularis	Nicastrin	0.0196	0.1972	0.197
Trypanosoma cruzi	Aph-1 protein, putative	0.0374	0.3841	0.9272
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0011	0.0024	0.0022
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0011	0.0024	0.0022
Schistosoma mansoni	kinase	0.0402	0.4144	0.4144
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Trichomonas vaginalis	GTP binding protein rare7l, putative	0.0024	0.0159	0.0328
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0014	0.0057	0.0055
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0159	0.0344
Echinococcus multilocularis	activin receptor type	0.001	0.0017	0.0015
Echinococcus granulosus	protein kinase c epsilon type	0.0011	0.0021	0.0019
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0011	0.0021	0.0019
Echinococcus granulosus	tyrosine protein kinase otk	0.0014	0.0057	0.0055
Schistosoma mansoni	titin	0.0009	0.0002	0.0002
Onchocerca volvulus	Peroxidasin homolog	0.0011	0.003	0.0073
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0057	0.0057
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0274	0.0272
Echinococcus granulosus	cpg binding protein	0.0037	0.0295	0.0293
Schistosoma mansoni	tyrosine kinase	0.0411	0.4238	0.4238
Trichomonas vaginalis	CAMK family protein kinase	0.0277	0.2825	0.6803
Onchocerca volvulus		0.0024	0.0159	0.041
Echinococcus multilocularis		0.0235	0.2383	0.2381
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0148	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.001	0.0017	0.0015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0374	0.3846	0.3846
Brugia malayi	serine/threonine-protein kinase plk-2	0.0277	0.2825	0.2825
Schistosoma mansoni	protein kinase	0.001	0.0017	0.0017
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0057	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0055
Schistosoma mansoni	protein kinase	0.001	0.0017	0.0017
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0014	0.0057	0.0055
Schistosoma mansoni	brg-1 associated factor	0.0011	0.0024	0.0024
Echinococcus multilocularis	GTP binding protein Parf	0.0024	0.0159	0.0157
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0236	0.239	0.2389
Entamoeba histolytica	presenilin 1 peptidase, putative	0.0402	0.4141	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0057	0.0057
Loa Loa (eye worm)	raf kinase	0.0228	0.231	0.2308
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0011	0.0024	0.0049
Schistosoma mansoni	serine/threonine protein kinase	0.0236	0.239	0.239
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0246	0.2498	0.2496
Mycobacterium ulcerans	glutaminase	0.033	0.3384	1
Brugia malayi	Presenilin spe-4	0.0141	0.1391	0.1391
Echinococcus granulosus	insulin receptor	0.0246	0.2498	0.2496
Loa Loa (eye worm)	gamma-secretase subunit pen-2	0.0377	0.3881	0.388
Echinococcus granulosus	activin receptor type	0.001	0.0017	0.0015
Echinococcus multilocularis	SWI:SNF matrix associated	0.0011	0.0024	0.0022
Brugia malayi	protein kinase C3,putative	0.0011	0.0021	0.0021

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	25.18 uM	PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.3714 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1543989

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1408159