Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3157 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.3157 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0053 | 0.0167 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.3157 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.3157 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.3157 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0053 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.3157 | 0.3624 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.3157 | 0.3624 |
Schistosoma mansoni | kinase | 0.0058 | 0.0925 | 0.281 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.3157 | 0.3121 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0053 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3157 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.3157 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8618 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.3157 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3157 | 0.2509 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8618 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.3157 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.8336 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.